Anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof

Abstract

The invention discloses an anti-fatigue traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the anti-fatigue traditional Chinese medicine composition comprises the following components in parts by weight: 5-100 parts of malt, 5-30 parts of codonopsis pilosula, 5-50 parts of astragalus membranaceus, 2-20 parts of pericarpium citri reticulatae, 2-20 parts of liquorice and 1-10 parts of jujube. The anti-fatigue traditional Chinese medicine composition can regulate qi and blood and harmonize liver and spleen, and is suitable for fatigue sub-health and chronic disease fatigue people with qi and blood deficiency and liver and spleen disharmony. Meanwhile, the traditional Chinese medicine composition is prepared from medicinal and edible medicinal materials, so that the safety of the product is ensured, and the traditional Chinese medicine composition is mild in medicine property, can soothe liver and regulate qi without hurting yin and consuming qi, can invigorate qi and blood without moistening greasy stomach, has long-term applicability, is particularly suitable for sub-healthy people in a pressure environment for a long time, and can be taken for a long time to achieve the effects of relieving fatigue and relieving pain by tonifying qi and blood and soothing viscera. And the anti-fatigue / anti-fatigue capability is fundamentally enhanced.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to an anti-fatigue traditional Chinese medicine composition, a preparation method and an application thereof. Background Art

[0002] Fatigue is a common symptom, manifesting as tiredness, weakness, dizziness, loss of appetite, and body aches. It is not only a key symptom of a variety of diseases, including diabetes, coronary heart disease, malignant tumors, stroke, multiple sclerosis, systemic lupus erythematosus, and chronic obstructive pulmonary disease, but is also common among people with sub-health conditions.

[0003] Traditional Chinese Medicine (TCM) categorizes fatigue as a "deficiency syndrome" or "conjunctivitis," with its core pathogenesis typically linked to Qi and blood deficiency. The Yellow Emperor's Classic of Internal Medicine states, "Human possessions consist of blood and Qi," and "Loose limbs are due to the dysfunction of the spleen essence." This emphasizes the importance of sufficient and balanced Qi and blood, as well as spleen and stomach function, in maintaining normal physiological activity. Insufficient Qi and blood, coupled with spleen dysfunction, lead to insufficient nourishment of the internal organs and meridians, resulting in symptoms such as fatigue. Modern people experience chronic stress, and liver depression has become a primary and significant factor in fatigue. Traditional Chinese Medicine states, "Seeing liver disease, one must know that the liver transmits it to the spleen," and "Liver depression overcomes the spleen." Prolonged liver depression inevitably leads to spleen deficiency, or even inherent spleen deficiency, which can further exacerbate spleen deficiency, creating a vicious cycle that ultimately results in liver depression and spleen deficiency, manifesting as both mental and physical fatigue.

[0004] Currently, there are many anti-fatigue products on the market, but their efficacy varies. Therefore, there is an urgent need to develop an anti-fatigue product that focuses on regulating Qi and blood, harmonizing the liver and spleen, and is suitable for people with fatigue-related sub-health and chronic fatigue caused by Qi and blood deficiency, liver and spleen disharmony. Summary of the Invention

[0005] In order to solve the above technical problems, the present invention provides an anti-fatigue Chinese medicine composition, a preparation method and application thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions: In a first aspect, the present invention provides an anti-fatigue Chinese medicine composition comprising malt, codonopsis pilosula, astragalus root, tangerine peel, liquorice and jujube.

[0007] The Chinese medicine composition of the present invention is adapted from a classic Chinese medicine formula. Its formula is derived from Huangqi Liuyi Decoction in the Taiping Huimin Hejijufang (prescriptions for the prescriptions of the Ministry of Health) and Ganmai Dazao Decoction in the Jinkui Yaolue (complementary texts of the Golden Chamber). Fatigue has been common since ancient times, often associated with ailments such as "consumption fatigue," "visceral agitation," and "lily disease." Huangqi Liuyi Decoction "can effectively treat various deficiencies in men and women, as well as fatigue and tiredness of the limbs. Regular use can replenish qi and blood, and soothe the internal organs." It is used to treat various deficiency syndromes and symptoms such as fatigue due to deficiency or overuse. Long-term use can also replenish qi and blood, harmonize the functions of the internal organs, and achieve a healthy physiological state of balanced yin and yang, with the spirit restored. The original formula uses a 6:1 ratio of Huangqi to licorice. Ganmai Dazao Decoction is commonly used to treat emotional disorders such as insomnia, hysteria, menopausal syndrome, and neurasthenia, as well as symptoms of languor, fatigue, and drowsiness caused by insufficient yang qi. The Huangdi Neijing states, "Lack of limbs is a sign of dysfunction of spleen essence." The addition of Codonopsis pilosula, a commonly used herb known for tonifying the middle qi and replenishing qi, is effective for treating spleen deficiency, fatigue, poor appetite, and loose stools. Tangerine peel is also added to regulate qi, soothe the stomach, and strengthen the spleen. Together, these two formulas replenish qi, nourish blood, and strengthen the spleen, addressing both mental and physical fatigue symptoms. However, fatigue symptoms in modern people are often caused by mental and physical overwork. People from all walks of life face chronic stress, with students and professionals experiencing a higher prevalence. Fatigue is also occurring at a younger age, suggesting that liver depression is a more prominent factor in modern fatigue. Liver depression is the initiating factor, while spleen deficiency is the pathological characteristic. Therefore, by replacing the wheat in the original formula with malt, while incorporating the licorice and jujube root of Ganmai Dazao Decoction, this recipe not only promotes qi and strengthens the spleen, but also soothes the liver. This liver-soothing effect has been used since ancient times to treat liver depression, qi stagnation, or liver-spleen disharmony.

[0008] The Chinese medicine of the present invention is a processed or unprocessed Chinese medicinal piece, for example, the astragalus is raw or roasted, the tangerine peel is raw, tangerine peel, or steamed tangerine peel, the malt is raw or roasted, the codonopsis is raw or cooked, the licorice is raw or honey-roasted, and the jujube is raw, roasted, steamed, or black.

[0009] In some embodiments, the anti-fatigue traditional Chinese medicine composition comprises, by weight, 5-100 parts of malt, 5-30 parts of codonopsis pilosula, 5-50 parts of astragalus, 2-20 parts of tangerine peel, 2-20 parts of liquorice and 1-10 parts of jujube.

[0010] In some embodiments, the anti-fatigue Chinese medicine composition comprises, by weight, 45-55 parts of malt, 18-22 parts of codonopsis pilosula, 27-33 parts of astragalus, 9-11 parts of tangerine peel, 4-6 parts of liquorice and 1-3 parts of jujube.

[0011] In some embodiments, the ratio of the total weight of the malt and astragalus to the total weight of the codonopsis pilosula and tangerine peel is 8:3.

[0012] In some embodiments, the weight ratio of malt to astragalus is 5:3.

[0013] In some embodiments, the weight ratio of Codonopsis pilosula to dried tangerine peel is 2:1.

[0014] Preferably, the anti-fatigue Chinese medicine composition comprises, by weight, 50 parts of malt, 20 parts of codonopsis pilosula, 30 parts of astragalus, 10 parts of tangerine peel, 5 parts of liquorice and 2 parts of jujube.

[0015] In a second aspect, the present invention provides a method for preparing the above-mentioned anti-fatigue Chinese medicine composition, comprising the following steps: extracting malt, codonopsis pilosula, astragalus root, tangerine peel, licorice and jujube with water, separating the solid and liquid, and combining the filtrate to obtain the anti-fatigue Chinese medicine composition.

[0016] In some embodiments, the amount of water is 8-15 times the total weight of malt, codonopsis pilosula, astragalus root, tangerine peel, liquorice and jujube; preferably 8-12 times; more preferably 8-10 times.

[0017] In some embodiments, the extraction is performed at least once, and the time for each extraction is 0.5-2 hours; preferably, the extraction is performed 1-5 times, and more preferably 1-3 times.

[0018] In some embodiments, the extraction is performed 1-3 times, and the duration of each extraction is 1-2 hours.

[0019] The purpose of the "solid-liquid separation" described in the present invention is to achieve separation of the solid phase and the liquid phase, and conventional technical means such as filtration, centrifugation, filter pressing or purification separation can be used, preferably filtration.

[0020] In a third aspect, the present invention provides use of the anti-fatigue Chinese medicine composition in the preparation of anti-fatigue food.

[0021] In some embodiments, the anti-fatigue food is in the form of tablets, powders, granules, capsules, oral liquids, pills, alcoholic beverages, ointments, or beverages.

[0022] In a fourth aspect, the present invention provides an anti-fatigue food, comprising the anti-fatigue Chinese medicine composition and excipients acceptable for health care products.

[0023] In a fifth aspect, the present invention provides use of the anti-fatigue Chinese medicine composition in the preparation of an anti-fatigue pharmaceutical preparation.

[0024] In a sixth aspect, the present invention provides an anti-fatigue pharmaceutical preparation comprising the above-mentioned anti-fatigue Chinese medicine composition and pharmaceutically acceptable excipients.

[0025] In some embodiments, the pharmaceutical preparation is in the form of a tablet, capsule, granule, pill, powder, syrup, oral solution, oral suspension, oral emulsion, or mixture.

[0026] The beneficial effects of the present invention are: (1) The present invention uses malt and astragalus as the main ingredients. Malt is used to soothe the liver and spleen, regulate the qi, and help the spleen transport and transform, so as to provide the source of qi and blood biochemical transformation. Astragalus is sweet and warm, replenishes qi and nourishes blood, raises yang and strengthens the exterior, and enters the spleen meridian. It is a key medicine for replenishing the spleen. Codonopsis and dried tangerine peel are used as auxiliary ingredients. Codonopsis has the effects of replenishing the spleen and lungs, nourishing blood and promoting fluid production. When combined with astragalus, it can enhance the function of replenishing qi and blood. Tangerine peel is warm in nature, regulates qi, strengthens the spleen and harmonizes the stomach, and helps malt soothe the liver and spleen, enhances the function of spleen and stomach transport and transformation, makes qi and blood biochemical active, and prevents greasy stomach from being blocked, so that the other ingredients can replenish without stagnation. Jujube is sweet, warm and moist, replenishes qi and harmonizes the middle, replenishes blood and calms the mind. Together with Codonopsis and astragalus, it promotes the generation and nourishment of qi and blood, and serves as an adjuvant. In addition, it increases the sweetness of the whole prescription, which can make the taste better. Roasted licorice root (Licorice root) is sweet and mild, invigorating Qi and harmonizing the middle. It not only enhances the Qi-tonifying and middle-tonifying effects of Codonopsis and Astragalus, but also harmonizes the other herbs, making it a guiding herb. Combined, these herbs balance Qi and blood, balancing the liver and spleen. This prescription focuses on treating symptoms such as fatigue, heaviness in the limbs, and intolerance caused by spleen and stomach deficiency, poor digestion, and liver depression. This compound, building on the traditional Qi-tonifying, blood-nourishing, and spleen-tonifying formulas, also soothes the liver. While it soothes the liver and regulates Qi, it avoids the potential for Qi depletion and Yin damage caused by prolonged use. Compared to traditional formulas, it better aligns with the etiology and pathogenesis of fatigue in modern people.

[0027] (2) Based on the ancient prescriptions of Huangqi Liuyi Decoction and Ganmai Dazao Decoction for nourishing qi, blood and spleen, this invention innovatively adds malt to relieve liver fatigue in response to the characteristics of modern people's fatigue. It helps to relieve psychological fatigue caused by negative emotions such as stress and anxiety. It complements the tonic effects of Astragalus, Codonopsis and other medicinal materials to relieve physical fatigue. It can regulate qi and blood and harmonize the liver and spleen. It is suitable for people with fatigue-related sub-health and chronic disease fatigue caused by insufficient qi and blood, liver and spleen disharmony.

[0028] (3) The prescriptions of the Chinese medicine composition of the present invention are all medicinal materials with medicinal and edible properties, ensuring the safety of the product. By controlling the specific types and ratios of the active ingredients of the medicine, the synergistic effect between the components is improved, and the anti-fatigue effect is improved. The medicinal properties are mild, soothing the liver and regulating qi without damaging yin and consuming qi, and replenishing qi and blood without being greasy and obstructing the stomach. It has long-term applicability and is especially suitable for sub-healthy people who are under long-term stress. Long-term intake can fundamentally enhance the body's anti-fatigue ability by balancing qi and blood, calming the internal organs, and soothing the body's internal organs.

[0029] (4) The Chinese medicine composition of the present invention has high bioavailability, clear ingredients, and good therapeutic effects. In the short term, the active ingredients of the medicine can quickly relieve fatigue to treat the symptoms, help users quickly restore their energy, and meet the modern people's demand for quick relief from fatigue. Moreover, through long-term use, it can balance qi and blood, regulate the functions of organs such as the liver and spleen, and achieve a state of harmony and healthy balance between body and mind, thereby achieving the effect of treating the root cause. DETAILED DESCRIPTION

[0030] The following describes the embodiments of the present invention through specific examples. Those skilled in the art will readily understand the other advantages and benefits of the present invention from the disclosure herein. The present invention may also be implemented or applied through various other specific embodiments, and the details in this specification may be modified or altered based on different viewpoints and applications without departing from the spirit of the present invention.

[0031] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0032] When numerical ranges are given in the examples, it should be understood that, unless otherwise specified herein, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention belongs.

[0033] As used herein, "pharmaceutically acceptable" ingredients are substances suitable for use in humans and / or animals without undue adverse side effects (such as toxicity, irritation, and allergic reactions), that is, substances with a reasonable benefit / risk ratio. "Pharmaceutically acceptable excipients" include inert diluents, dispersants and / or granulating agents, surfactants and / or emulsifiers, disintegrants, binders, preservatives, buffers, lubricants, and / or oils. Excipients (such as cocoa butter and suppository waxes), colorants, coating agents, sweeteners, and flavoring agents may also be present in the pharmaceutical composition.

[0034] The "pharmaceutical preparations" described herein can be prepared by any method known in pharmacy. Generally speaking, these preparation methods include combining the Chinese medicine composition (i.e., the sole active ingredient) with a carrier or excipient and / or one or more other auxiliary ingredients, and then, if necessary and / or desired, shaping and / or packaging the product into a desired single-dose or multi-dose unit.

[0035] The pharmaceutical preparations of the present invention can be prepared according to known methods, such as those described in the general rules for preparation in the Chinese Pharmacopoeia (2020 edition), the Japanese Pharmacopoeia (16th edition), the United States Pharmacopoeia (USP), and the European Pharmacopoeia (EP), 9th edition. The specific preparation method depends on the dosage form.

[0036] The sole active ingredient, pharmaceutically acceptable excipient, in the "pharmaceutical formulations" described herein will vary depending on the identity, size, and / or condition of the subject being treated and further depending on the route of administration of the composition. The pharmaceutical formulation may contain between 0.1% and 100% (w / w) of the first active ingredient.

[0037] As used herein, "treating," unless otherwise indicated, means reversing, alleviating, inhibiting the progression of, or preventing the condition or disorder to which the term applies, or one or more symptoms of such condition or disorder. The term "treating," as used herein, refers to the act of treating, as "treating" is defined immediately above.

[0038] As used herein, an "effective amount" refers to an amount sufficient to elicit a desired biological response. The effective amount of the active ingredients of the present invention may vary depending on factors such as the desired biological endpoint, the pharmacokinetics of the compound, the condition being treated, the mode of administration, and the age and health of the subject. In certain embodiments, an effective amount is a therapeutically effective amount. An effective amount is the amount of the only active ingredient described herein in a single dose. In certain embodiments, an effective amount is the combined amount of the only active ingredients described herein in multiple doses.

[0039] The present invention does not limit the sources of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all commonly available commercially in the art. For example, the raw materials were purchased from the Guangdong Provincial Medicinal Materials Company Chinese Medicine Piece Factory, including malt (M4124113), jujube (D5524321), codonopsis (D4324322), tangerine peel (C1724131), roasted licorice root (G0424211), and astragalus (H5124511).

[0040] Examples 1-3 Chinese medicine composition According to Table 1, the formulated amounts of malt, codonopsis pilosula, astragalus root, tangerine peel, roasted licorice root and jujube were taken, and water was added and heated for extraction twice, each time for 1.5 hours (starting from boiling), with 10 times the amount of water added for the first time and 8 times the amount of water added for the second time. The mixture was filtered through 200-mesh gauze, and the filtrates were combined to obtain the traditional Chinese medicine composition.

[0041] Table 1

[0042] Comparative Example 1 The anti-fatigue Chinese medicine composition comprises the following raw materials, by weight: 50 parts of wheat, 20 parts of codonopsis pilosula, 30 parts of astragalus, 10 parts of bergamot, 5 parts of liquorice and 2 parts of jujube.

[0043] The preparation method is as follows: take a formula amount of wheat (Gramineae wheat Triticum aestivum L. Dried mature fruit of Codonopsis pilosula, Astragalus root, Citron (Citrus palmatum of Rutaceae) Citrus medica L. var. sarcodactylis Swingle The dried fruit of the herb, roasted licorice root and jujube were added with water and heated for extraction twice, each time for 1.5 hours (starting from boiling), 10 times the amount of water was added for the first time, and 8 times the amount of water was added for the second time, filtered through 200 mesh gauze, and the filtrates were combined to obtain the traditional Chinese medicine composition.

[0044] Comparative Example 2 The difference between this comparative example and Example 1 is that it does not contain dried tangerine peel.

[0045] The anti-fatigue Chinese medicine composition comprises the following raw materials by weight: 50 parts of malt, 30 parts of codonopsis pilosula, 30 parts of astragalus root, 5 parts of liquorice and 2 parts of jujube.

[0046] The preparation method comprises the following steps: taking a formulated amount of malt, codonopsis pilosula, astragalus root, roasted licorice root and jujube, adding water and heating for extraction twice, each time for 1.5 hours (starting from boiling), adding 10 times the amount of water for the first time and 8 times the amount of water for the second time, filtering through 200-mesh gauze, combining the filtrates, and obtaining the traditional Chinese medicine composition.

[0047] Comparative Example 3 The difference between this comparative example and Example 1 is that the ratio of the total weight of malt and astragalus to the total weight of the codonopsis pilosula and tangerine peel is different. The anti-fatigue Chinese medicine composition comprises the following raw materials by weight: 45 parts of malt, 28 parts of codonopsis pilosula, 27 parts of astragalus root, 14 parts of tangerine peel, 5 parts of liquorice and 2 parts of jujube.

[0048] The preparation method is the same as that of Example 1.

[0049] Comparative Example 4 The difference between this comparative example and Example 1 is that the ratio of the total weight of malt and astragalus to the total weight of the codonopsis pilosula and tangerine peel, the weight ratio of malt and astragalus, and the weight ratio of codonopsis pilosula and tangerine peel are different. Specifically as follows: The anti-fatigue Chinese medicine composition comprises the following raw materials by weight: 30 parts of malt, 30 parts of codonopsis pilosula, 30 parts of astragalus root, 20 parts of dried tangerine peel, 5 parts of roasted liquorice root and 2 parts of jujube.

[0050] The preparation method is the same as that of Example 1.

[0051] [Anti-fatigue efficacy study] 1. Experimental Materials 1.1 Experimental Animals Male KM mice, 4–6 weeks old, SPF grade, weighing 40.88 ± 1.4 g, were purchased from Spefoc Biotechnology (Beijing) Co., Ltd., Animal Production Certificate No. SYXK (Yue)-2022-0125. The experimental period began after 7 days of adaptive feeding.

[0052] 1.2 Experimental drugs The traditional Chinese medicine compositions prepared in the examples and comparative examples were concentrated at 60° C. to 1.0 g crude drug / mL and set aside.

[0053] 1.3 Experimental Reagents BUN detection kit, LD detection kit, SOD detection kit, and MDA kit were all purchased from Nanjing Jiancheng Biotechnology Co., Ltd.

[0054] 2. Experimental methods 2.1 Animal grouping: After 7 days of adaptive feeding, male KM mice were randomly divided into 8 groups, 8 mice in each group, namely blank control group, implementation group 1 to group 3, and comparative example group 1 to comparative example group 4. Each medication group was gavage-administered the Chinese medicine composition of the corresponding embodiment and comparative example at a dose of 4.5 g / kg per day, and the blank control group was gavage-administered with an equal amount of normal saline for 30 consecutive days.

[0055] 2.2 Modeling method Each group of mice underwent adaptive swimming training once a week for 5 minutes each time. 30 minutes after the last gavage, a lead bar weighing 5% of the mouse's body weight was tied to the mouse's tail to ensure that the lead bar was fixed on the mouse's tail without loosening. The mouse was placed in a swimming box with a water depth of 30 cm and the water temperature was controlled at (26.0±0.5)℃. The swimming time of the mouse was then recorded until its nostril could not float above the water within 10 seconds. The swimming time at this time was the mouse's exhaustive swimming time.

[0056] After the exhaustive swimming experiment, mice rested for 30 minutes and immediately collected blood from their eyeballs. The blood was placed in a 4°C refrigerator for about 3 hours. After the blood coagulated, it was centrifuged at 2000 rpm for 15 minutes and the serum was collected for later use.

[0057] 3. Statistical methods The data were analyzed using software and normality test was performed. One-way analysis of variance was used for comparison among multiple groups, and independent sample t-test was used for comparison between two groups. The results were expressed as mean ± standard error (Mean ± SEM). P < 0.05 was considered statistically significant, and P < 0.01 was considered statistically significant.

[0058] 4. Experimental results 4.1 Statistics of Exhaustive Swimming Time Improved exercise endurance is the most direct manifestation of enhanced fatigue resistance, and the length of swimming time can reflect the degree of exercise fatigue in animals. The exhaustive swimming time of mice in each group is shown in Table 2.

[0059] Table 2

[0060] Note: *P<0.05 compared with blank control group.

[0061] The results showed that compared with the blank control group, the exhausted swimming time of the mice in Example 1 to Example 3 groups was significantly prolonged (P < 0.05), and the exhausted swimming time of the mice in Comparative Example 1 to Comparative Example 4 groups did not change significantly (P > 0.05), indicating that the Chinese medicine composition prepared in Examples 1 to 3 can effectively prolong the exhausted swimming time of mice and has anti-fatigue effect.

[0062] Comparison of Comparative Example 1 to Comparative Example 4 and Example 1 shows that, compared with the conventional modified prescriptions of Huangqi Liuyi Decoction and Ganmai Dazao Decoction, the anti-fatigue Chinese medicine composition of the present invention has a better and more prominent anti-fatigue effect, achieving unexpected technical effects.

[0063] 4.2 Serological test results The serum of mice in each group was collected and the levels of serum urea nitrogen (BUN), lactic acid (LD), superoxide dismutase (SOD), and malondialdehyde (MDA) were detected using kits. The results are shown in Table 3.

[0064] Table 3

[0065] Note: *P<0.05 compared with blank control group.

[0066] The results showed that compared with the blank control group, the levels of urea nitrogen, lactic acid, and malondialdehyde in the serum of mice in Example 1-Example 3 were significantly reduced (P < 0.05), and the level of superoxide dismutase was significantly increased (P < 0.05). This indicates that the Chinese medicine compositions of Examples 1-Example 3 of the present invention can reduce the levels of uric acid nitrogen and lactic acid in the blood, and have the effect of improving exercise-induced fatigue. At the same time, they can also reduce the level of malondialdehyde in fatigued mice and enhance superoxide dismutase activity. To a certain extent, they can enhance the antioxidant capacity of skeletal muscle and delay the onset of fatigue.

[0067] Comparison of Comparative Example Group 1 to Comparative Example Group 4 and Example Group 1 shows that, compared with the conventional modified prescriptions of Huangqi Liuyi Decoction and Ganmai Dazao Decoction, the anti-fatigue Chinese medicine composition of the present invention is more effective in improving sports fatigue and enhancing the antioxidant capacity of skeletal muscle, achieving unexpected technical effects.

[0068] The above further describes the present invention in conjunction with specific embodiments. However, these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solutions of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, and such modifications and replacements shall fall within the scope of protection of the present invention.

Claims

1. An anti-fatigue Chinese medicine composition, characterized in that: The invention comprises, by weight, 5-100 parts of malt, 5-30 parts of codonopsis pilosula, 5-50 parts of astragalus root, 2-20 parts of dried tangerine peel, 2-20 parts of liquorice and 1-10 parts of jujube.

2. The anti-fatigue Chinese medicine composition according to claim 1, characterized in that The invention comprises, by weight, 50 parts of malt, 20 parts of codonopsis pilosula, 30 parts of astragalus root, 10 parts of dried tangerine peel, 5 parts of liquorice and 2 parts of jujube.

3. The anti-fatigue Chinese medicine composition according to claim 1, characterized in that The ratio of the total weight of the malt and astragalus to the total weight of the codonopsis pilosula and tangerine peel is 8:

3.

4. The method for preparing the anti-fatigue Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: extracting malt, codonopsis pilosula, astragalus root, tangerine peel, liquorice and jujube with water, separating the solid and liquid, and combining the filtrate to obtain the anti-fatigue traditional Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that The amount of water used is 8-15 times the total weight of malt, codonopsis pilosula, astragalus root, tangerine peel, liquorice and jujube; the extraction is performed at least once, and the time for each extraction is 0.5-2 hours.

6. Use of the anti-fatigue Chinese medicine composition according to any one of claims 1 to 3 in the preparation of anti-fatigue food or anti-fatigue pharmaceutical preparations.

7. The use according to claim 6, characterized in that The dosage form of the anti-fatigue food is tablets, powders, granules, capsules, oral liquids, pills, wine preparations, ointments or beverages.

8. The use according to claim 6, characterized in that The dosage form of the pharmaceutical preparation is tablet, capsule, granule, pill, powder, syrup, oral solution, oral suspension, oral emulsion or mixture.

9. An anti-fatigue food, characterized in that: The anti-fatigue Chinese medicine composition comprises the anti-fatigue Chinese medicine composition according to any one of claims 1 to 3 and excipients acceptable for health care products.

10. An anti-fatigue pharmaceutical preparation comprising the anti-fatigue Chinese medicine composition according to any one of claims 1 to 3 and pharmaceutically acceptable excipients.

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