Compound with effect of drastically draining water as well as preparation method and application of compound

By extracting and purifying nephrodisiac from the water lily plant and preparing it into a pharmaceutically acceptable dosage form, the problems of unsatisfactory efficacy and high toxicity of existing ascites treatment methods are solved, and a safe and efficient ascites drainage effect is achieved.

CN120718084AActive Publication Date: 2025-09-30SICHUAN LANYING PHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202510856631.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-25
Publication Date
2025-09-30
Estimated Expiration
2045-06-25

AI Technical Summary

Technical Problem

The existing treatments for ascites are not ideal, the components and mechanisms of Chinese medicine for diuresis are unclear, and they are highly toxic. There is a lack of new safe and effective drugs for diuresis.

Method used

Provided is a novel small molecule compound, euphorbia pulexin, which has a purgative and diuretic effect. The compound is extracted and purified from the euphorbia pulex plant to prepare a pharmaceutically acceptable dosage form for the treatment of ascites.

Benefits of technology

Polypogonin significantly promotes the rapid discharge of accumulated fluid from the intestine, has significant therapeutic effects, good safety, low cost, is suitable for large-scale production, and has stable chemical properties.

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Abstract

The invention discloses a compound with an effect of drastically draining water. The compound has a chemical structural formula as shown in a formula (I). The compound belongs to a novel tetracyclic triterpenoid natural product, has good fat solubility and chemical stability, and can be conveniently extracted from the rhizome of a herbal medicine Polygala fallax Hemsl. And prepared into an oral or injection form. The invention also provides a preparation method and application of the compound. The compound provided by the invention can obviously inhibit the increase of abdominal volume and ascites weight of mice, is in a dose-dependent relationship, and is a novel drainage medicine with great potential.
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