Method, system, equipment, medium and product for constructing liver ischemia-reperfusion injury ligand-receptor interaction communication network combining diseases and syndromes of traditional Chinese medicine and western medicine

Abstract

The invention discloses a traditional Chinese and western medicine disease and syndrome combined hepatic ischemia-reperfusion injury ligand and receptor interaction communication network construction method, system and device, a medium and a product, and relates to the field of medicine. Traditional Chinese medicinal materials related to occurrence and development of the hepatic ischemia-reperfusion injury are identified from Chinese literatures and Chinese patents; constructing a traditional Chinese medicine target group based on traditional Chinese medicines; keywords are set based on pathological knowledge of western medicine, and biomarkers or target protein groups related to occurrence and development of hepatic ischemia-reperfusion injury are identified from different literatures; constructing a disease target group based on the biomarker or the target protein group; the traditional Chinese medicine target group and the disease target group form a liver transplantation HIRI target network; and performing network topology comparison on the traditional Chinese medicine target group and the disease target group to determine an optimal traditional Chinese medicine. According to the application, the advantages of combination of traditional Chinese medicine and western medicine are exerted, and the corresponding traditional Chinese medicinal materials are determined by constructing the liver transplantation HIRI target network.

Description

Technical Field

[0001] The present application relates to the field of medicine, and in particular to a method, system, equipment, medium and product for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury that combines traditional Chinese and Western medicine. Background Art

[0002] Ischemia-reperfusion injury (HIRI) during liver transplantation surgery is a core issue affecting graft function recovery and patient prognosis. Existing technologies mostly focus on single-dimensional biomarker screening or target verification, lacking innovative analytical methods that systematically integrate the pathological mechanisms of traditional Chinese and Western medicine, making it impossible to identify traditional Chinese medicine herbs for the treatment of HIRI. Summary of the Invention

[0003] In order to solve the above problems, the present application provides a method, system, equipment, medium and product for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury that combines traditional Chinese and Western medicine.

[0004] To achieve the above objectives, this application provides the following solutions: In the first aspect, the present application provides a method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury that combines traditional Chinese and Western medicine, comprising: Keywords are established based on the understanding of TCM pathogenesis and are determined to be TCM keywords; Based on the TCM keywords, Chinese medicinal materials related to the occurrence and development of liver ischemia-reperfusion injury were identified from Chinese literature and Chinese patents; Constructing a Chinese medicinal material target group based on the Chinese medicinal materials; Keywords are established based on the pathological understanding of Western medicine and are determined to be Western medicine keywords; Based on the Western medicine keywords, biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury are identified from Chinese and English literature; Constructing a disease target group based on a biomarker or target protein group; the Chinese medicinal material target group and the disease target group constitute a liver transplantation HIRI target network; The target groups of Chinese medicinal materials and the target groups of disease are compared by network topology to determine the optimal Chinese medicinal materials.

[0005] In a second aspect, the present application provides a system for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury that combines traditional Chinese and Western medicine, including: A TCM keyword determination module is used to establish keywords based on TCM's understanding of pathogenesis and determine them as TCM keywords; A Chinese medicinal material identification module, used to identify Chinese medicinal materials related to the occurrence and development of liver ischemia-reperfusion injury from Chinese literature and Chinese patents based on the Chinese medicine keywords; A Chinese medicinal material target group construction module, used to construct a Chinese medicinal material target group based on the Chinese medicinal materials; A Western medicine keyword determination module is used to establish keywords based on Western medicine's understanding of pathology and determine them as Western medicine keywords; A biomarker or target protein group identification module, used to identify biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury from Chinese and English literature based on the Western medicine keywords; A disease target group construction module is used to construct a disease target group based on a biomarker or a target protein group; the Chinese medicinal material target group and the disease target group constitute a liver transplantation HIRI target network; The optimal Chinese medicinal material determination module is used to perform network topology comparison between the Chinese medicinal material target group and the disease target group to determine the optimal Chinese medicinal material.

[0006] In a third aspect, the present application provides a computer device comprising: a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the computer program to implement the above-mentioned method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine.

[0007] In a fourth aspect, the present application provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the above-mentioned method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine.

[0008] In a fifth aspect, the present application provides a computer program product, including a computer program, which, when executed by a processor, implements the above-mentioned method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine.

[0009] According to the specific embodiments provided in this application, this application has the following technical effects: (1) This application integrates the understanding of the pathogenesis and pathology of liver transplantation ischemia-reperfusion injury by traditional Chinese medicine and Western medicine, giving full play to the advantages of combining traditional Chinese and Western medicine.

[0010] (2) This application constructs a target group of Chinese medicinal materials based on the Chinese medicinal materials, and constructs a disease target group based on biomarkers or target protein groups, breaking through the traditional static analysis model of fixed syndromes corresponding to fixed targets. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0012] Figure 1 A flowchart of a method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine provided in one embodiment of the present application; Figure 2 This is a schematic diagram of the disease target group; Figure 3 This is a schematic diagram of the target group of traditional Chinese medicine; Figure 4 This is a schematic diagram of the Jacard similarity coefficient of targets in the TCM target group; Figure 5 A schematic diagram of the structure of a computer device provided in one embodiment of the present application. DETAILED DESCRIPTION

[0013] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0014] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the present application is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0015] In an exemplary embodiment, Figure 1 As shown, a method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine is provided. The method is executed by a computer device, specifically a computer device such as a terminal or a server, or a terminal and a server. In the embodiment of the present application, the method is applied to a server as an example for explanation, and includes the following steps S1 to S7. Among them: S1: Keywords are established based on the understanding of TCM pathogenesis and are determined to be TCM keywords. The TCM keywords include: liver transplantation and Chinese medicinal materials, or liver ischemia-reperfusion injury and Chinese medicinal materials, or toxic heat and Chinese medicinal materials, or liver and kidney yin deficiency and Chinese medicinal materials.

[0016] Specifically, using TCM's understanding of the pathogenesis of liver transplantation and hepatic ischemia-reperfusion injury (the early manifestations are mainly "excessive liver and gallbladder fire" and "intense heat and toxicity", the middle stage is mainly "spleen and stomach dampness and heat", the late stage is mainly "liver and kidney yin deficiency", and "kidney yang deficiency syndrome" may also appear; TCM syndrome differentiation and treatment of liver transplantation has a relatively unified understanding of "deficiency syndrome", "dampness syndrome" and "blood stasis"), the corresponding keywords are set as: (Topic: liver transplantation) OR (Topic: hepatic ischemia-reperfusion injury) AND (Topic: traditional Chinese medicine), or (Topic: intense heat and toxicity) OR (Topic: liver and kidney yin deficiency) AND (Topic: traditional Chinese medicine).

[0017] S2: Based on the TCM keywords, identify Chinese medicinal materials related to the occurrence and development of liver ischemia-reperfusion injury from Chinese literature and Chinese patents.

[0018] Specifically, we identified Chinese medicinal herbs related to the development and progression of liver ischemia-reperfusion injury from Chinese literature and patents using large language models, text mining, and entity extraction. The acquired data was stored in a MongoDB database.

[0019] S3: Construct a Chinese medicinal material target group based on the Chinese medicinal materials.

[0020] After obtaining the Chinese medicinal materials in step S1, the active ingredients (such as geniposide and emodin) are matched through the TCMSP database to construct a three-level mapping table of "Chinese medicine-ingredient-target" as follows: Figure 3 The target groups of traditional Chinese medicines are shown.

[0021] S4: Keywords are established based on Western medicine pathological knowledge and are determined to be Western medicine keywords. The Western medicine keywords include: liver transplantation and mechanism, or liver ischemia-reperfusion injury and mechanism, liver transplantation and target, or liver ischemia-reperfusion injury and target.

[0022] Specifically, using Western medicine's understanding of the pathology of ischemia-reperfusion injury in liver transplantation, we set up corresponding keywords: (Topic: liver transplantation) OR (Topic: liver ischemia-reperfusion injury) AND (Topic: mechanism), or (Topic: liver transplantation ischemia-reperfusion injury) OR (Topic: liver transplantation) AND (Topic: target).

[0023] S5: Based on the Western medicine keywords, biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury were identified from Chinese and English literature.

[0024] Specifically, biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury are identified from Chinese and English literature through large language models, text mining, entity extraction, etc.

[0025] Furthermore, in steps S2 and S5, entities can be identified from documents or patents based on the BERT model.

[0026] The BERT model is a deep learning model based on the Transformer architecture. It uses a bidirectional training mechanism to pre-train text data. This means that during training, the BERT model considers both the preceding and following context of a word to better understand the meaning of a word in a specific context. In entity extraction tasks, the BERT model is typically used as a feature extractor, converting the input text into fixed-size vector representations. These representations are then passed to one or more classification layers to identify specific entities in the text.

[0027] Assume that the sequence obtained after word segmentation of the input text is .

[0028] Among them, X represents a sentence, n represents the length of the sequence after the BERT model segmentation, and i represents the index. It is the Token under the i-th index.

[0029] The BERT model generates three vectors: Token Embedding, Position Embedding, and Segment Embedding. These three vectors are added together to form the final input representation: in, Represents the text vector of the Token under the i-th index, Represents the position vector of the Token under the i-th index, Represents the interval vector of the Token under the i-th index (is the Token in the first sentence or the second sentence), represents BERT layer 0 (BERT input layer), which is also the sum of the above three vectors.

[0030] The BERT model uses a multi-layer Transformer encoder to transform these initial representations. For the l-th layer Transformer encoder, its output can be expressed as: in, It is the main architecture layer of the BERT model. express In the layer The vector below, express exist -1st floor The vector below.

[0031] A linear classifier is added to the last layer output of the BERT model to predict the entity label. Its formula is expressed as: in, express The output vector of the last layer, W is the learning weight of the BERT model, b is the bias term, is the unnormalized score of the token at index i.

[0032] To convert these unnormalized scores into a probability distribution, the Softmax function is applied: in, represents the score of category c, Represents the probability distribution of belonging to each category.

[0033] For linear classifiers, cross entropy is usually used as the loss function: Where L represents the loss function.

[0034] S6: Constructing a disease target cluster based on the biomarker or target protein cluster; the Traditional Chinese Medicine target cluster and the disease target cluster constitute a liver transplantation HIRI target network. Specifically, the disease target cluster is constructed based on protein-protein interactions and biomarkers, or based on protein-protein interactions and target protein clusters.

[0035] Based on protein-protein interactions and biomarkers, or based on protein-protein interactions and target protein groups, the STRING database was used to construct an initial PPI network, and high-quality interactions with a confidence level > 0.7 were screened to construct a network such as Figure 2 The disease target groups shown.

[0036] Assign weights to the targets screened by the PPI network, where the weight values The percentage of each gene in the whole after entity extraction from literature targets is calculated as follows: in, is the weight value of target i in the disease target group D, is the frequency of s-type genes in the g gene set, is the frequency of all genes in the g gene set.

[0037] S7: Perform a network topology comparison of the TCM target cluster and the disease target cluster to determine the optimal TCM. This includes calculating the Jacard similarity coefficient between each target in the TCM target cluster and each target in the disease target cluster; and selecting the target in the TCM target cluster with the largest Jacard similarity coefficient as the optimal TCM.

[0038] In the study of integrated Chinese and Western medicine treatment of liver transplant ischemia-reperfusion injury (HIRI), target network distance calculation based on the Jaccard similarity coefficient is the core method for evaluating the matching degree between the target group of Chinese herbal medicine and the target group of disease. The calculation formula of the Jaccard similarity coefficient is as follows: in, represents the Jaccard similarity coefficient, D represents the disease target group, and H represents the traditional Chinese medicine target group. Represents the intersection of disease target group and Chinese medicinal material target group, Represents the union of the disease target group and the Chinese medicinal material target group, represents the weight of target t in the disease target group D appearing in the literature, Indicates targets in disease target group D The weight of appearance in the literature.

[0039] from Figure 4 It can be seen that promoting blood circulation and removing blood stasis as well as invigorating qi and nourishing yin are closely related to liver transplantation and liver ischemia-reperfusion injury. Therefore, Chinese herbal medicines related to promoting blood circulation and removing blood stasis as well as invigorating qi and nourishing yin can be used as the best Chinese herbal medicines.

[0040] The advantages of this application are mainly reflected in the following three aspects: (1) This application integrates the understanding of liver transplantation ischemia-reperfusion injury and related molecular characteristics of traditional Chinese medicine and Western medicine, giving full play to the advantages of combining traditional Chinese and Western medicine.

[0041] (2) The liver transplantation HIRI target network constructed in this application reflects ligand-receptor interactions, which in turn directly affect signaling pathway proteins. Therefore, this application comprehensively considers ligand-receptor interactions and their upstream and downstream signaling pathway proteins, and for the first time forms a new method for constructing a "disease-syndrome" molecular network from the perspective of intercellular communication.

[0042] (3) The liver transplantation HIRI target network constructed in this application retains the weights of the nodes and more accurately reflects the relationship between different network nodes and the occurrence and development of liver ischemia-reperfusion injury.

[0043] Based on the same inventive concept, the present application also provides a system for constructing a ligand receptor interaction communication network for liver ischemia-reperfusion injury that integrates traditional Chinese and Western medicine. The implementation solution provided by this system is similar to the implementation solution described in the above-mentioned method. Therefore, the specific limitations of one or more embodiments of the system for constructing a ligand receptor interaction communication network for liver ischemia-reperfusion injury that integrates traditional Chinese and Western medicine can be found in the limitations of the method for constructing a ligand receptor interaction communication network for liver ischemia-reperfusion injury that integrates traditional Chinese and Western medicine, and will not be repeated here.

[0044] In an exemplary embodiment, a system for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine is provided, comprising: The TCM keyword determination module is used to establish keywords based on the TCM understanding of pathogenesis and determine them as TCM keywords.

[0045] The Chinese medicinal material identification module is used to identify Chinese medicinal materials related to the occurrence and development of liver ischemia-reperfusion injury from Chinese literature and Chinese patents based on the Chinese medicine keywords.

[0046] The Chinese medicinal material target group construction module is used to construct a Chinese medicinal material target group based on the Chinese medicinal materials.

[0047] The Western medicine keyword determination module is used to establish keywords based on Western medicine's understanding of pathology and determine them as Western medicine keywords.

[0048] A biomarker or target protein group identification module is used to identify biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury from Chinese and English literature based on the Western medicine keywords.

[0049] The disease target group construction module is used to construct a disease target group based on a biomarker or a target protein group; the Chinese medicinal material target group and the disease target group constitute a liver transplantation HIRI target network.

[0050] The optimal Chinese medicinal material determination module is used to perform network topology comparison between the Chinese medicinal material target group and the disease target group to determine the optimal Chinese medicinal material.

[0051] In an exemplary embodiment, a computer device is provided, including a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the steps in the above-mentioned method embodiments. The computer device can be a server or a terminal, and its internal structure can be as shown in FIG. Figure 5As shown. The computer device includes a processor, a memory, an input / output interface (Input / Output, abbreviated as I / O) and a communication interface. The processor, memory and input / output interface are connected via a system bus, and the communication interface is connected to the system bus via the input / output interface. The processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and computer program in the non-volatile storage medium. The database of the computer device is used to store data to be processed. The input / output interface of the computer device is used to exchange information between the processor and an external device. The communication interface of the computer device is used to communicate with an external terminal via a network connection. When the computer program is executed by the processor, it realizes the above-mentioned method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine.

[0052] Those skilled in the art will understand that Figure 5 The structure shown in the figure is merely a block diagram of a portion of the structure related to the solution of the present application and does not constitute a limitation on the computer device to which the solution of the present application is applied. A specific computer device may include more or fewer components than shown in the figure, or combine certain components, or have a different component arrangement. In an exemplary embodiment, a computer device is provided, including a memory and a processor. The memory stores a computer program, and the processor implements the steps of the above-mentioned method embodiments when executing the computer program.

[0053] In an exemplary embodiment, a computer-readable storage medium is provided, storing a computer program. When the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented.

[0054] In an exemplary embodiment, a computer program product is provided, including a computer program. When the computer program is executed by a processor, the steps in the above method embodiments are implemented.

[0055] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data must comply with relevant regulations.

[0056] Those skilled in the art will appreciate that all or part of the processes in the above-mentioned embodiments can be implemented by instructing the relevant hardware through a computer program. The computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the above-mentioned embodiments. In particular, any reference to memory, database, or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM may be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0057] The databases involved in the various embodiments provided herein may include at least one of a relational database and a non-relational database. Non-relational databases may include, but are not limited to, distributed databases based on blockchains. The processors involved in the various embodiments provided herein may include, but are not limited to, general-purpose processors, central processing units, graphics processing units, digital signal processors, programmable logic units, data processing logic units based on quantum computing, and the like.

[0058] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0059] This document uses specific examples to illustrate the principles and implementation methods of this application. The description of the above examples is only intended to help understand the method and core concept of this application. At the same time, for those skilled in the art, based on the concept of this application, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting this application.

Claims

1. A method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine, characterized in that: include: Keywords are established based on the understanding of TCM pathogenesis and are determined to be TCM keywords; Based on the TCM keywords, Chinese medicinal materials related to the occurrence and development of liver ischemia-reperfusion injury were identified from Chinese literature and Chinese patents; Constructing a Chinese medicinal material target group based on the Chinese medicinal materials; Keywords are established based on the pathological understanding of Western medicine and are determined to be Western medicine keywords; Based on the Western medicine keywords, biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury are identified from Chinese and English literature; Constructing a disease target group based on a biomarker or target protein group; the Chinese medicinal material target group and the disease target group constitute a liver transplantation HIRI target network; The target groups of Chinese medicinal materials and the target groups of disease are compared by network topology to determine the optimal Chinese medicinal materials.

2. The method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to claim 1, characterized in that: The TCM keywords include: liver transplantation and Chinese medicinal materials, or liver ischemia-reperfusion injury and Chinese medicinal materials, or intense heat and Chinese medicinal materials, or liver and kidney yin deficiency and Chinese medicinal materials.

3. The method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to claim 1, characterized in that: Constructing a Chinese medicinal material target group based on the Chinese medicinal materials specifically includes: Based on the Chinese medicinal materials, active ingredients are matched through the TCMSP database to construct a Chinese medicinal material target group.

4. The method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to claim 1, characterized in that: The Western medicine keywords include: liver transplantation and mechanism, or liver ischemia-reperfusion injury and mechanism, liver transplantation and target, or liver ischemia-reperfusion injury and target.

5. The method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to claim 1, characterized in that: Construct disease target groups based on biomarkers or target protein groups, specifically including: Disease target groups are constructed based on protein-protein interactions and biomarkers, or based on protein-protein interactions and target protein groups.

6. The method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to claim 1, characterized in that: Perform network topology comparison between the TCM target group and the disease target group to determine the optimal TCM, specifically including: Calculate the Jacard similarity coefficient between each target in the TCM target group and each target in the disease target group; The target in the TCM target group corresponding to the largest Jacard similarity coefficient is selected as the optimal TCM.

7. A system for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine, characterized by: include: A TCM keyword determination module is used to establish keywords based on TCM's understanding of pathogenesis and determine them as TCM keywords; A Chinese medicinal material identification module, used to identify Chinese medicinal materials related to the occurrence and development of liver ischemia-reperfusion injury from Chinese literature and Chinese patents based on the Chinese medicine keywords; A Chinese medicinal material target group construction module, used to construct a Chinese medicinal material target group based on the Chinese medicinal materials; A Western medicine keyword determination module is used to establish keywords based on Western medicine's understanding of pathology and determine them as Western medicine keywords; A biomarker or target protein group identification module, used to identify biomarkers or target protein groups related to the occurrence and development of liver ischemia-reperfusion injury from Chinese and English literature based on the Western medicine keywords; A disease target group construction module is used to construct a disease target group based on a biomarker or a target protein group; the Chinese medicinal material target group and the disease target group constitute a liver transplantation HIRI target network; The optimal Chinese medicinal material determination module is used to perform network topology comparison between the Chinese medicinal material target group and the disease target group to determine the optimal Chinese medicinal material.

8. A computer device comprising: A memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the computer program to implement the method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to any one of claims 1-6.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to any one of claims 1 to 6 is implemented.

10. A computer program product comprising a computer program, characterized in that When the computer program is executed by a processor, the method for constructing a ligand-receptor interaction communication network for liver ischemia-reperfusion injury combining traditional Chinese and Western medicine according to any one of claims 1 to 6 is implemented.

Images