Application of rosa rugosa in preparation of medicine for treating IBD (infectious bursal disease)

By studying the mechanism of action of rose water extract in an IBD mouse model, it was found that it can upregulate the expression of barrier proteins OCC and ZO-1, downregulate TLR4 and TLR9 receptors, and inhibit pro-inflammatory factors, thus solving the problems of immune tolerance and side effects in existing IBD treatments and providing a safe and effective treatment method.

CN120754163APending Publication Date: 2025-10-10XINJIANG MEDICAL UNIV
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Patent Information

Application Number
CN202511047821.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-29
Publication Date
2025-10-10

AI Technical Summary

Technical Problem

Existing IBD treatment drugs have immune tolerance and side effects and lack a complete cure. Active ingredients of traditional Chinese medicine have advantages in the treatment of IBD, but their underlying mechanisms have not been fully elucidated.

Method used

The aqueous extract of Rosa microcarpa was used to intervene in an IBD mouse model to study its effects on intestinal barrier integrity and anti-inflammatory effects. It was found that it could upregulate the expression of barrier proteins OCC and ZO-1, downregulate TLR4 and TLR9 receptors, inhibit the expression of proinflammatory cytokines TNF-α, IL-6, CXCL-1 and MPO, and alleviate the inflammatory response.

Benefits of technology

The water extract of Rosa microcarpa has been shown to promote intestinal barrier integrity, have anti-inflammatory effects, and reduce the expression of pro-inflammatory factors in the treatment of IBD, providing a safe and effective comprehensive intervention method and a new target for the clinical treatment of IBD.

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Abstract

The invention relates to application of rosa rugosa in preparation of a medicine for treating IBD (infectious bursal disease). According to the invention, firstly, it is found that the branchlet rose has a repairing effect on damage caused by IBD; researches find that the aqueous extract of rugosa branchlet can play a role by repairing intestinal barriers and inhibiting TLR4, TLR9 and proinflammatory cytokines, so that the aqueous extract of rugosa branchlet is beneficial to treatment of IBD. The invention provides an application prospect of the rosa rugosa in preparation of the medicine for treating IBD.
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