High-food-calling pet parasite expelling tablet and preparation method thereof

Abstract

The invention discloses a high-food-calling pet parasite expelling tablet and a preparation method thereof, and relates to the technical field of pet parasite expelling tablets, the high-food-calling pet parasite expelling tablet is composed of a traditional Chinese medicine extract, a tablet auxiliary material and a food-calling auxiliary material, the traditional Chinese medicine extract is composed of a quispualis indica extract, a betel nut extract, a dark plum extract, a cyrtomium fortunei extract, a radix stemonae extract and a fructus cnidii extract; the tablet auxiliary materials comprise maltodextrin, microcrystalline cellulose, corn starch, anhydrous calcium sulfate and magnesium stearate. According to the high-food-calling pet parasite expelling tablet and the preparation method thereof, the self-help feeding rate of pets reaches up to 90% or above, and the operation complexity of pet owners in the parasite expelling process is reduced; meanwhile, a good expelling and killing effect is achieved on various common parasites such as roundworms, tapeworms, hookworms, pinworms and trichomonads of dogs and cats, and the excellent broad-spectrum insect expelling effect is achieved while good palatability is kept.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pet deworming tablets, more particularly to a high palatability pet deworming tablet and a preparation method thereof. BACKGROUND

[0002] Pet deworming drugs are used to help pets eliminate internal or external parasites. These parasites include but are not limited to fleas, ticks, roundworms, hookworms, and heartworms, which not only pose a threat to the health of pets, but in some cases can also affect human health. Therefore, regular use of deworming drugs is very important for maintaining the health of pets.

[0003] However, current deworming drugs still have the following problems:

[0004] 1. Some deworming drugs contain a variety of herbs with irritating odors, which are not friendly to pets. Some deworming drugs may have a bitter taste or strong odor, which can make pets feel uncomfortable or even repulsive, resulting in low attractiveness of the deworming drug to pets, low voluntary feeding rate of pets, and resistance to feeding by pets. The owner needs to use a feeding device or wrap the deworming drug in food to force the pet to eat, which is a tedious process and can cause stress reactions in pets.

[0005] 2. Many existing drugs only target a single or a few types of parasites, making it difficult to cover multiple common parasites such as roundworms, tapeworms, hookworms, pinworms, and trichomonas. In addition, the worm body may break and remain in the body, affecting the deworming effect. Moreover, deworming can only eliminate adult worms, and the effect on killing eggs is limited, which can lead to the spread of eggs in the environment and cause repeated infections.

[0006] 3. Common dosage forms of pet deworming drugs are tablets and capsules, which require disintegration into small particles in the pet's body before further dissolution and absorption. If the disintegration time is too long, the drug cannot be released in time, which can delay the absorption of effective ingredients and affect the deworming effect. If the disintegration is too fast, the drug is released prematurely before reaching the target site (such as the intestinal tract), which can lead to waste of the drug or side effects such as gastrointestinal irritation. In addition, the high concentration of the drug can increase the risk of toxicity, such as neurotoxicity. Therefore, a suitable disintegration time is essential for effective deworming.

[0007] Therefore, there is an urgent need for a high palatability pet deworming tablet and a preparation method thereof to solve the problems of low pet tablet feeding rate and poor control of drug disintegration time. SUMMARY

[0008] The present application provides a high palatability pet deworming tablet and a preparation method thereof to solve the problems in the background art.

[0009] To achieve the above-mentioned purpose, the present application specifically adopts the following technical solutions:

[0010] A high-attractability pet deworming tablet and a preparation method thereof, comprising a traditional Chinese medicine extract, tablet excipients and attractant excipients, wherein:

[0011] The proportion of each component in the total mass of the traditional Chinese medicine extract is as follows: Quisqualis extract 3%-8%, Areca extract 3%-8%, Fructus Mume extract 2%-5%, Piperis Extensifl 5%-10%, Stemona extract 1%-4%, Cnidium extract 1%-5%.

[0012] The proportion of each component in the total mass of the tablet excipients is as follows: malt dextrin 8%-30%, microcrystalline cellulose 1%-10%, corn starch 5%-10%, anhydrous calcium sulfate 1%-5%, and magnesium stearate 0.5%-1%.

[0013] The attractant excipients are composed of 1%-2% chicken liver liquid and 28%-49% meat powder, and the meat powder is one or a mixture of more than one of beef powder, chicken powder, fish powder, chicken liver powder, and duck meat powder.

[0014] Preferably, the Quisqualis medicinal material is washed, crushed, and put into an extraction tank, 10 times water is added for the first time for extraction for 1 hour, 8 times water is added for the second time for extraction for 1 hour, the extraction liquids are combined and concentrated to 1:1, an enzyme complex is added for enzymolysis, and the extraction liquid after enzymolysis is continuously concentrated to a ratio of medicinal material: medicinal liquid = 1.5:1, and a spray dryer is used to spray powder to obtain the Quisqualis extract.

[0015] The enzyme complex includes one or more of cellulase, hemicellulase, protease, and pectinase, and is optimized under different extraction liquid PH conditions and enzymolysis time lengths, the PH conditions are respectively PH4, PH6, PH8, and PH10, and the enzymolysis time lengths are 2h, 6h, 10h, and 18h, preferably, the enzyme complex is composed of cellulase and proteolytic enzyme at a ratio of 1:1, the extraction liquid PH condition is PH10, and the preferred enzymolysis time length is 10h.

[0016] Preferably, the preparation method of the Areca extract is as follows: the Areca is washed, crushed, and powder is obtained; an alkaline aqueous solution with pH≥8.0 is used as a binder, and the Areca powder is fluidized and granulated at 25°C to obtain Areca granules, 10 times water at 70°C is added for the first time to hot soak the Areca granules, and extraction is performed for 1 hour, 8 times water at 70°C is added for the second time to hot soak the Areca granules, and extraction is performed for 1 hour, the extraction liquids are combined and concentrated to 1:1, an enzyme complex is added for enzymolysis extraction, the extraction liquid after extraction is concentrated to a ratio of medicinal material: medicinal liquid = 1.5:1, and a spray dryer is used to spray powder to obtain the Areca extract.

[0017] The enzyme complex is one or a mixture of cellulase and pectinase, and ultrasonic-assisted enzymatic extraction is used, the ultrasonic power is 300W, 500W, 800W, the ultrasonic enzymolysis time is 0.5h, 1h, 1.5h, preferably, the ultrasonic-assisted enzymatic extraction scheme is that cellulase:pectinase is 2:1, the ultrasonic power is 500W, and the enzymolysis time is 1h.

[0018] Preferably, the preparation method of the Fructus Mume extract is as follows: the Fructus Mume is washed and dried in a 60℃ drying box until the weight is constant, then the Fructus Mume powder with a particle size of 2-3mm is obtained by crushing with a crusher, and the Fructus Mume powder is subjected to Soxhlet extraction and defatting treatment by soaking in petroleum ether and refluxing at 60℃ for 2 times, and then extracting twice by hot refluxing with anhydrous ethanol to remove monosaccharides, oligosaccharides and other substances in the Fructus Mume, and the defatted powder is dried at 60℃ until the weight is constant.

[0019] The petroleum ether is any one of the heating ranges of 30-60℃, 60-90℃ and 90-120℃, the temperature for the hot refluxing with anhydrous ethanol is any one of 60℃, 70℃ and 80℃, and preferably, the petroleum ether is petroleum ether (60-90℃) and the temperature for the hot refluxing is 80℃.

[0020] Preferably, the preparation method of the Radix Adianti extract is as follows: the Radix Adianti medicinal material is first washed and crushed into granules, then the crushed granules are placed in an extraction tank, 70% ethanol and calcium hydroxide are then added, stirring and heating to 50℃ are performed, and twice extraction is performed, each for 2 hours; the two extraction liquids are combined and filtered, the pH value is adjusted to 5 with hydrochloric acid, then ethanol is recovered under reduced pressure until the solution concentration is reduced to 40%, the precipitate is filtered out after standing for 12 hours, the precipitate is dissolved with chloroform, activated carbon is added for decolorization for 2 hours, then filtration is performed again, chloroform is recovered and dried, the dried substance is loaded into a short column, methanol is used for flushing to remove impurities, and then ethyl acetate is used for elution, the eluate is collected and dried, and finally the eluate is placed to promote the formation of crystals, the crystals are filtered out, dissolved again, subjected to low-temperature freeze-drying, and the Radix Adianti extract is finally obtained.

[0021] Preferably, the preparation method of the Stemona extract is as follows: the Stemona medicinal material is first washed and crushed, then put into an extraction tank, and the Stemona alkaloids are extracted by a two-phase aqueous extraction method, then ultrasonic extraction is performed for 0.5 hours, the filtrate is placed in a layered barrel for static layering after suction filtration, the upper PEG1000 solution is taken, concentrated and solvent is recovered under reduced pressure at 50℃, and finally low-temperature freeze-drying is performed to obtain the Stemona extract.

[0022] The two-phase solvent is a mixed solution of a polyethylene glycol solution and a sulfate salt solution or a phosphate salt solution, and preferably is a polyethylene glycol solution and a sulfate salt solution, with a volume ratio of 3:2.

[0023] Preferably, the preparation method of the extract of cnidium is as follows: the washed cnidium is crushed, and then extracted by a surfactant cloud point extraction method; specifically, 8 times of 75% ethanol solution containing a surfactant is added for percolation extraction, the surfactant is one or more of soapnut saponin, saponin, Tween, and Span, preferably, Tween 80 and Span 80 are extracted at a ratio of 1:1; the combined extract is concentrated under reduced pressure until there is no alcohol taste, then 5 times of pure water is added and stirred uniformly, and finally, the powder is obtained by using a spray dryer, thereby obtaining the extract of cnidium.

[0024] Preferably, the preparation method of the chicken liver liquid is as follows: the fresh chicken liver is minced, subjected to enzymatic treatment of papain and trypsin (at a ratio of 3:2), boiled in 10 times of water, and then cooled to obtain the chicken liver liquid.

[0025] Preferably, the preparation method of the meat powder is as follows: one or more of beef powder, chicken meat powder, fish meat powder, chicken liver powder, and duck meat powder is cut into pieces, the pieces are cooked, taken out, and dried, the dried material is ground into powder, and the powder is screened through an 80-mesh screen, thereby obtaining the finished meat powder.

[0026] A preparation method of a high-feeding-attracting pet deworming tablet comprises the following steps:

[0027] S1, mixing: the ingredients are mixed by sandwich method, one half of the traditional Chinese medicine extract is first put into a mixer, then the tablet auxiliary materials are put into the mixer for mixing, then the remaining one half of the traditional Chinese medicine extract is put in, the mixture is mixed again with feeding-attracting auxiliary materials, and 1% of the meat powder in the feeding-attracting auxiliary materials is reserved as a coating material;

[0028] S2, granulation: the mixture is granulated by wet granulation, and the chicken liver liquid is added to the mixture to make the material into soft material;

[0029] S3, drying and tabletting: the soft material is dried at 60 DEG C and then pressed into shape by a tablet press, a small amount of chicken liver liquid is sprayed on the tablet to wet the surface, 1% of the meat powder is sprinkled and rolled to ensure uniform coating, and the excess meat powder is removed by shaking the screen, thereby obtaining the finished deworming tablet.

[0030] Compared with the prior art, the deworming tablet has the following advantages:

[0031] 1. The deworming tablet has high protein and low fat, and the unique surface coating process makes the self-feeding rate of pets reach more than 90%, so that pets can take the tablet voluntarily like eating snacks, and the operation complexity of pet owners in the deworming process is reduced; at the same time, the feeding-attracting auxiliary materials are rich in protein, amino acids and trace elements, and can supplement the nutrients of pets while deworming.

[0032] 2、The application has good killing effect on common parasitic worms of dogs and cats such as roundworms, tapeworms, hookworms, pinworms and trichomonas, especially the roundworms (91.5%) and tapeworms (86.0%) are most effectively expelled. The content of Semen Vaccariae and Areca catechu is relatively high, Semen Vaccariae has special effect on roundworms, and Areca catechu has paralyzing effect on tapeworms, which shows significant killing effect on common parasitic worms and their eggs of dogs and cats, while maintaining good palatability, and also showing excellent broad-spectrum deworming effect.

[0033] 3、The modern extraction technologies such as enzymolysis and ultrasonic assistance are adopted to effectively improve the extraction rate and purity of active ingredients of traditional Chinese medicines, so that the tablets can be quickly disintegrated in simulated gastric juice, which is beneficial to the rapid absorption and effect of the drugs, and at the same time, the tablets will not disintegrate too fast to avoid the waste of drugs and the stimulation of the gastrointestinal tract. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the application will be clearly and completely described below in combination with the embodiments of the application. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the application.

[0035] The materials and instruments used in the following embodiments are commercially available.

[0036] I. Palatability test

[0037] The finished deworming tablets for palatability test are composed of traditional Chinese medicine extract, tablet auxiliary materials and food-attracting auxiliary materials, wherein:

[0038] The proportions of the components in the traditional Chinese medicine extract in the total mass are as follows: Semen Vaccariae extract 8%, Areca catechu extract 5%, Fructus Mume extract 5%, Rhizoma Anemarrhenae extract 5%, Radix Stachyuri extract 3%, Fructus Cnidii extract 4%;

[0039] The proportions of the components in the tablet auxiliary materials in the total mass are as follows: malt dextrin 20%, microcrystalline cellulose 4.5%, corn starch 10%, anhydrous calcium sulfate 5%, magnesium stearate 0.5%;

[0040] The food-attracting auxiliary materials are composed of chicken liver liquid and meat powder. The food-attracting auxiliary materials are divided into five groups, and different components of meat powder are used in each group. The steps remain the same except for the different components of meat powder in the food-attracting auxiliary materials in Examples 1 to 5. The specific component table of Examples 1 to 5 is referred to Table 1 below.

[0041] Table 1, specific component table of Examples 1 to 5:

[0042]

[0043]

[0044] The preparation method of each component in the traditional Chinese medicine extract is:

[0045] The preparation method of the Terminalia chebula extract is: the Terminalia chebula medicinal material is washed, crushed, and then put into an extraction tank, 10 times water is added for the first time, and extraction is carried out for 1 hour, 8 times water is added for the second time, and extraction is carried out for 1 hour, the combined extract is concentrated to 1:1, an enzyme complex is added for enzymolysis, and the extract after enzymolysis is continuously concentrated to a ratio of medicinal material: medicinal liquid = 1.5:1, and a spray dryer is used to spray powder to obtain the Terminalia chebula extract;

[0046] The enzyme complex is composed of cellulase and proteolytic enzyme 1:1, and the PH condition of the extract is PH 10, and the preferred enzymolysis time is 10 h.

[0047] The preparation method of the Areca catechu extract is: the Areca catechu is washed, crushed, and then fluidized granulated at 25℃ with an alkaline aqueous solution with pH≥8.0 as a binder to obtain Areca catechu granules, 10 times water is added for the first time to hot soak the Areca catechu granules at 70℃, and extraction is carried out for 1 hour, 8 times water is added for the second time to hot soak the Areca catechu granules at 70℃, and extraction is carried out for 1 hour, the combined extract is concentrated to 1:1, an enzyme complex is added for enzymolysis extraction, the extract after extraction is concentrated to medicinal material: medicinal liquid = 1.5:1, and a spray dryer is used to spray powder to obtain the Areca catechu extract;

[0048] The ultrasonic-assisted enzymolysis extraction scheme is to select cellulase: pectinase 2:1, ultrasonic power 500 W, and enzymolysis time 1 h.

[0049] The preparation method of the Fructus Mume extract is: the Fructus Mume is washed and dried in a 60℃ drying oven to constant weight, then crushed by a crusher to a Fructus Mume powder with a particle size of 2-3 mm, the Fructus Mume powder is subjected to Soxhlet extraction and defatting treatment, soaked with 60℃ petroleum ether, and extracted by refluxing at 80℃ for 2 times, and then extracted by hot refluxing with anhydrous ethanol for 2 times, so as to remove monosaccharides, oligosaccharides and other substances in the Fructus Mume, and the defatted powder is dried at 60℃ to constant weight.

[0050] The preparation method of the tuber fleeceflower root extract is as follows: first, the tuber fleeceflower root medicinal material is washed clean and crushed into granules, then the crushed granules are placed in an extraction tank, 70% ethanol and calcium hydroxide are added, stirring and heating to 50℃, and twice extraction is carried out, each time for 2 hours; the two times of extraction liquid are combined and filtered, and the pH value is adjusted to 5 with hydrochloric acid, then the ethanol is recovered under reduced pressure until the solution concentration is reduced to 40%, the precipitate is filtered out after standing for 12 hours, the precipitate is dissolved with chloroform by reflux, activated carbon is added for decolorization for 2 hours and then filtered again, the chloroform is recovered and dried; the dried material is loaded into a short column, first washed with methanol to remove impurities, then eluted with ethyl acetate, the eluate is collected and dried; finally, the eluate is placed to promote the formation of crystals, the crystals are filtered out and dissolved again, and finally the tuber fleeceflower root extract is obtained by freeze-drying at low temperature.

[0051] The preparation method of the stemona extract is as follows: first, the stemona medicinal material is washed and crushed, and then the stemona alkaloids are extracted by the aqueous two-phase extraction method, followed by ultrasonic extraction for 0.5 hours, and the filtrate is placed in a layered barrel for static layering, the upper layer PEG1000 solution is taken, and the solvent is recovered by concentration under reduced pressure at 50℃, and finally freeze-dried to obtain the stemona extract; the volume ratio of polyethylene glycol solution to sulfate solution is 3:2.

[0052] The preparation method of the corydalis extract is as follows: the washed corydalis is crushed, and then extracted by surfactant cloud point extraction method, the specific operation steps are as follows: 8 times the amount of 75% ethanol solution containing surfactant is added for percolation extraction, the surfactant is Tween 80 and Span 80 in a ratio of 1:1; the combined extract is concentrated under reduced pressure to remove alcohol, then 5 times the amount of pure water is added and stirred uniformly, and finally the spray dryer is used to spray powder, thereby obtaining the corydalis extract.

[0053] The preparation method of the chicken liver liquid is as follows: fresh chicken liver is minced, subjected to enzymatic hydrolysis treatment with papain and trypsin (ratio of 3:2), then boiled in 10 times water, and cooled to obtain.

[0054] The preparation method of the meat powder is as follows: one or more kinds of raw materials such as beef powder, chicken meat powder, fish meat powder, chicken liver powder and duck meat powder are cut into pieces, then the cut pieces are cooked, taken out and dried, finally the dried material is powdered and sieved through an 80 mesh screen to obtain the finished product meat powder.

[0055] A preparation method of a high-attractiveness pet deworming tablet, comprising the following steps:

[0056] S1, mixing: using sandwich method, first half of the traditional Chinese medicine extract is put into the mixer, then the tablet excipients are put into the mixer for mixing, then the remaining half of the traditional Chinese medicine extract is put in, and the mixture is mixed again after being mixed evenly, and the mixed material is obtained, wherein 1% of the meat powder in the attractant is left as the coating material;

[0057] S2, granulation: using wet granulation, chicken liver liquid is added to the mixed material to make the material into soft material;

[0058] S3, drying and tabletting: after drying at 60°C, the soft material is pressed into shape using a tablet press, and a small amount of chicken liver liquid is sprayed on the tablet to moisten its surface, 1% of meat powder is sprinkled and rolled to ensure uniform coating, and the excess meat powder is removed by shaking the screen, thus obtaining the finished product, the worm-repelling tablet.

[0059] The palatability of the finished worm-repelling tablets prepared in Examples 1 to 5 is tested as follows:

[0060] Pre-experiment palatability check: randomly select 10 dogs and cats for pre-experiment palatability test, and test the palatability of Examples 1 to 5, respectively. The palatability is shown in Table 2 below.

[0061] Table 2, palatability

[0062]

[0063]

[0064] Scoring requirements: 1 point for "not eating", 2 points for "eating and then spitting out", 3 points for "eating with other attractants", 4 points for "not happy but can eat", and 5 points for "happy to eat".

[0065] Results: As shown in the above table, dogs and cats prefer beef powder, chicken powder and fish powder, and the average palatability is also higher, and the lowest is duck meat powder. Because beef produces more volatile amino acids, aldehydes, ketones and other substances during processing. For example, sulfur compounds (such as dimethyl sulfide) and unsaturated fatty acid oxidation products in beef can form a unique meat aroma, which has a strong attractive force for pets.

[0066] The smell of duck meat and chicken liver is relatively light, while the smell of beef is stronger and unique. The olfactory receptors of pets are more sensitive to high-intensity and high-recognition odors, so the worm-repelling tablets made of beef powder are more likely to attract the attention and appetite of pets.

[0067] Therefore, in the subsequent optimization examples, the three kinds of meat powder are used as the main attractant excipients.

[0068] II. Disintegration time test

[0069] Adjust the ratio of traditional Chinese medicine extract, tablet excipients and attractant excipients to form five groups of examples, the five groups of examples are example 6, example 7, example 8, example 9 and example 10, the ratio of each component of each group is as follows:

[0070] Table 3, each component table of examples 6 to 10

[0071]

[0072]

[0073] The examples in the above disintegration time test are different from the palatability test in terms of the ratio of each component, and the rest of the production steps and methods are the same as the palatability test.

[0074] The disintegration time test procedure is as follows:

[0075] Step 1, preparation of simulated gastric juice: take 8.3 mL of concentrated hydrochloric acid (37%), dilute to 1000 mL to get 0.1 moL / L hydrochloric acid solution, take appropriate amount of the above hydrochloric acid solution, add 2.0 g of sodium chloride and stir to dissolve, add 3.2 g of pepsin and stir to dissolve, adjust the PH to 1-2;

[0076] Step 2, crushing the tablets to simulate oral chewing, this step does not simulate the action of salivary enzymes during chewing;

[0077] Step 3, simulate gastric peristalsis: put the crushed tablets into the simulated gastric juice, stir in a 37℃ water bath, observe the dissolution of the tablets, and record the time of complete disintegration.

[0078] Step 4, active feeding investigation: randomly select 400 dogs and cats that have not been treated for internal and external deworming for three to four months, have loss of appetite, vomiting and diarrhea, weight loss and other abnormal conditions, and divide them into 5 groups (n=80), each group is randomly divided into 5 subgroups (n=16), each subgroup places the tablets in the food bowl before feeding the pet food in the morning every day, and the pet actively feeds on them, taking for 5 consecutive days; those who cannot actively feed will put the deworming tablets into the pet food, and observe whether they can eat, and record it every day.

[0079] Step 5, deworming effect investigation: deworming tablets need to be taken for 5 days a month, and observe whether there are worm corpses in the pet's feces; since the eggs are too small to be seen with the naked eye, pet feces are collected for microscopic observation to find worm corpses and eggs as the investigation standard.

[0080] The disintegration of the deworming tablets, active feeding and deworming are compared as follows:

[0081] (1) Disintegration of deworming tablets

[0082] Table 4, disintegration time limit test results

[0083]

[0084] From the above table, the disintegration time of all examples in simulated gastric fluid is within 3 minutes, meeting the requirements of tablets, among which example 4 disintegrates the fastest (1 minute 48 seconds).

[0085] (2) Active feeding condition

[0086] Table 5, active feeding test results

[0087]

[0088] As shown, the active feeding rate of example 1 is the highest, reaching 96.25%. Analyzing its formula, the content of beef powder in the baiting adjuvant is the highest (15%), and the combination ratio of beef powder, chicken powder and fish powder (15:5:10) forms the most popular compound flavor for dogs and cats, thereby obtaining the best palatability.

[0089] (3) Repellent condition

[0090] Table 6, repellent test results

[0091]

[0092]

[0093] From the above, all formulas show broad-spectrum anthelmintic activity. Among them, example 1 has the most significant expelling effect on roundworms (91.5%) and tapeworms (86.0%). This may be due to the high content of Semen Vaccariae (8%) and Areca Nuts (8%) in its formula, and modern pharmacological research confirms that Semen Vaccariae is effective against roundworms, and Areca Nuts have a paralyzing effect on tapeworms. In summary, example 1 not only maintains the highest palatability, but also exhibits excellent broad-spectrum anthelmintic effect, and is the best embodiment of the present application.

[0094] Conclusion: The experimental results show that the pet in vivo anthelmintic tablet of the present application exhibits a significant killing effect on common parasites and their eggs of dogs and cats. In addition, the self-feeding rate of pets is more than 90%, effectively simplifying the cumbersome process of feeding pets. The baiting adjuvant in the anthelmintic tablet is rich in various amino acids and trace elements, which not only can expel parasites, but also provides necessary nutritional supplements for the health of pets.

Claims

1. A highly appetizing pet deworming tablet, characterized by: It is composed of Chinese herbal medicine extracts, tablet excipients and appetizing excipients, including: The proportion of each component in the total weight of the Chinese herbal medicine extract is as follows: 3%-8% of Quisqualis chinensis extract, 3%-8% of Areca catechu extract, 2%-5% of Prunus mume extract, 5%-10% of Cyperus rotundus extract, 1%-4% of Stemona tuber extract, and 1%-5% of Cnidium monnieri extract; The proportion of each component in the tablet excipients in the total mass is: maltodextrin 8%-30%, microcrystalline cellulose 1%-10%, corn starch 5%-10%, anhydrous calcium sulfate 1%-5%, magnesium stearate 0.5%-1%; The attractant auxiliary material consists of 1%-2% chicken liver liquid and 28%-49% meat powder, wherein the meat powder is a mixture of one or more of beef powder, chicken powder, fish powder, chicken liver powder and duck powder.

2. A highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The preparation method of the quisqualis chinensis extract comprises the following steps: washing the quisqualis chinensis medicinal material, crushing the material, and putting the material into an extraction tank; adding 10 times the amount of water for the first extraction for 1 hour; adding 8 times the amount of water for the second extraction for 1 hour; combining the extracts and concentrating the solution to a ratio of 1:1; adding an enzyme complex for enzymolysis; and further concentrating the extract after enzymolysis to a ratio of medicinal material to liquid medicine of 1.5:1; and spraying the extract with a spray dryer to obtain the quisqualis chinensis extract; The enzyme complex includes one or more of cellulase, hemicellulase, protease, and pectinase, and is optimized under different extract pH conditions and enzymatic hydrolysis times. The pH conditions are PH4, PH6, PH8, and PH10, and the enzymatic hydrolysis times are 2h, 6h, 10h, and 18h. Preferably, the enzyme complex is composed of cellulase and proteolytic enzyme in a 1:1 ratio, the extract pH condition is PH10, and the enzymatic hydrolysis time is preferably 10h.

3. A highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The preparation method of the betel nut extract comprises the following steps: washing the betel nut and then crushing it to obtain betel nut powder; then using an alkaline aqueous solution with a pH value of 8.0 or higher as a binder, fluidizing the betel nut powder at 25° C. to obtain betel nut particles; adding 10 times the amount of water and hot-soaking the betel nut particles at 70° C. for the first time, extracting for 1 hour; adding 8 times the amount of water and hot-soaking the betel nut particles at 70° C. for the second time, extracting for 1 hour; combining the extracts and concentrating them to a ratio of 1:1; adding an enzyme complex for enzymatic extraction; concentrating the extracts after extraction to a ratio of medicinal material to medicinal solution of 1.5:1; and spraying the extracts with a spray dryer to obtain the betel nut extract; The enzyme complex is one of cellulase and pectinase or a mixture of the two, and ultrasound-assisted enzymatic hydrolysis and extraction are used. The selected ultrasonic power is 300W, 500W, and 800W, and the ultrasonic enzymatic hydrolysis time is 0.5h, 1h, and 1.5h. Preferably, the ultrasonic-assisted enzymatic hydrolysis and extraction scheme is to select a 2:1 ratio of cellulase: pectinase, an ultrasonic power of 500W, and an enzymatic hydrolysis time of 1h.

4. A highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The preparation method of the black plum extract comprises the following steps: washing the black plums and placing them in a drying oven at 60° C. to dry to constant weight, then using a grinder to grind the black plum powder into a particle size of 2-3 mm, performing Soxhlet extraction and defatting on the black plum powder, soaking it in petroleum ether, performing reflux extraction at 60° C. twice, and then performing hot reflux extraction with anhydrous ethanol twice to remove monosaccharides, oligosaccharides and the like in the black plums, and drying the defatted powder at 60° C. to constant weight; The petroleum ether is heated in any one of a range of 30-60°C, 60-90°C, and 90-120°C, and the temperature used for the reflux of anhydrous ethanol is any one of 60°C, 70°C, and 80°C. Preferably, the petroleum ether is petroleum ether (60-90°C), and the reflux temperature is 80°C.

5. The highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The preparation method of the smilax china extract is as follows: first, the smilax china medicinal material is cleaned and crushed into particles, and then the crushed particles are placed in an extraction tank, then, 70% ethanol and calcium hydroxide are added, stirred and heated to 50°C, and two extractions are performed, each extraction time is 2 hours; the two extracts are combined and filtered, and the pH value is adjusted to 5 with hydrochloric acid, and then the ethanol is recovered under reduced pressure until the solution concentration drops to 40%, and the precipitate is filtered out after standing for 12 hours, and the precipitate is dissolved by refluxing with chloroform, and activated carbon is added for decolorization for 2 hours and then filtered again, the chloroform is recovered and dried; the dried material is loaded into a short thick column, first rinsed with methanol to remove impurities, and then eluted with ethyl acetate, and the eluate is collected and dried; finally, the eluate is allowed to stand to promote crystallization, and the crystals are filtered out and dissolved again, and then freeze-dried to finally obtain the smilax china extract.

6. The highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The preparation method of the Stemona extract is as follows: first, the Stemona medicinal material is washed and crushed, and placed in an extraction tank, and the Stemona alkaloids are extracted by two-phase aqueous extraction, followed by ultrasonic extraction for 0.5 hours, and after filtration, the filtrate is placed in a separation barrel and allowed to stand for separation, and the upper layer of PEG1000 solution is taken, and the solvent is recovered by vacuum concentration at 50° C., and finally, the Stemona extract is obtained by low-temperature freeze-drying; The biphasic solvent is a mixed solution of polyethylene glycol solution and sulfate solution or phosphate solution, preferably polyethylene glycol solution and sulfate solution, with a volume ratio of 3:

2.

7. The highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The preparation method of the Cnidium monnieri extract comprises the following steps: crushing the washed Cnidium monnieri, and then extracting the Cnidium monnieri by using a surfactant turbidity point extraction method, wherein the specific operation steps are: adding 8 times the amount of a 75% ethanol solution containing a surfactant for percolation extraction, wherein the surfactant is one or more of soapberry saponin, saponin, Tween, and Span, and preferably extracting with Tween 80 and Span 80 in a ratio of 1:1; decompressing and concentrating the combined extract until there is no alcohol taste, then adding 5 times the amount of pure water and stirring evenly, and finally spraying with powder using a spray dryer, thereby obtaining the Cnidium monnieri extract.

8. The highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The chicken liver liquid is prepared by beating fresh chicken liver into minced meat, subjecting the minced meat to enzymatic hydrolysis with papain and trypsin (in a ratio of 3:2), boiling the minced meat in 10 times the amount of water, and then cooling the minced meat.

9. The highly appetizing pet insect repellent tablet according to claim 1, characterized in that: The meat powder is prepared by cutting one or more raw materials selected from beef powder, chicken powder, fish powder, chicken liver powder, and duck powder into pieces; then, cooking the pieces, removing them from the pieces, and drying them; finally, pulverizing the dried materials and screening them through an 80-mesh sieve to obtain finished meat powder.

10. A method for preparing a highly appetitive pet anthelmintic tablet, for preparing the highly appetitive pet anthelmintic tablet according to claim 1, characterized in that: The following steps are involved: S1. Mixing: Using a sandwich method, first add half of the Chinese herbal extract into a mixer, then add the tablet excipients into the mixer for mixing, then add the remaining half of the Chinese herbal extract, mix evenly, and then add the appetizing excipients and mix again to obtain a mixture, wherein 1% of the meat powder is reserved in the appetizing excipients as a coating material; S2. Granulation: Using wet granulation, chicken liver liquid is added to the mixture to make the material into a soft material; S3. Drying and tableting: Dry the soft material at 60℃ and press it into tablets using a tablet press. After tableting, spray a small amount of chicken liver liquid on the tablets to moisten their surface. Sprinkle 1% meat powder and roll to ensure that the meat powder is evenly applied. Shake off the excess meat powder with a sieve to obtain the finished anthelmintic tablets.

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