Traditional Chinese medicine composition for treating tremor

Abstract

The invention belongs to the field of tremor treatment, and particularly relates to a traditional Chinese medicine composition for treating tremor, which comprises the following components: uncaria, astragalus membranaceus, gastrodia elata, cistanche, rose, dendrobe, dandelion, earthworm, fructus amomi, elecampane, liquorice and coptis chinensis. The traditional Chinese medicine composition has the effects of replenishing qi to invigorate the spleen, tonifying the kidney and nourishing the liver, and has the advantages of remarkable effect and quick response by enhancing the physique of a patient for adjuvant therapy.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine compositions for treating tremor, in particular to a traditional Chinese medicine composition for treating tremor. Background Art

[0002] Parkinson's disease (PD) is a complex central nervous system disorder that commonly affects middle-aged and elderly individuals. Clinically, it presents with motor symptoms such as postural gait disturbances, resting tremor, bradykinesia, and muscle rigidity, as well as non-motor symptoms such as autonomic dysfunction, mood disorders, and sleep disturbances. Epidemiological studies have found that the incidence of PD in people over 65 years old is approximately 2%, and its incidence is closely related to environmental, genetic, aging, and oxidative stress factors. Currently, treatment for PD in China and abroad primarily focuses on dopamine replacement therapy, but long-term use of these medications is prone to adverse reactions such as tachycardia, diarrhea, and central and peripheral nervous system damage. Compared with Western medicine, Traditional Chinese Medicine (TCM) has attracted considerable attention and recognition for its long-lasting efficacy, minimal side effects, and holistic, multi-target regulation and synergistic effects.

[0003] Currently, the mainstream treatment for Parkinson's disease in China is dopamine tablets. Since Parkinson's disease is generally seen in the elderly, who often experience a decline in kidney essence, liver and kidney yin deficiency is the most common clinical syndrome. Therefore, clinical treatment often focuses on tonifying the liver and kidneys, calming the liver and suppressing yang, clearing heat, activating blood circulation, and removing blood stasis. This can result in dopamine tablets being ineffective or causing side effects.

[0004] Therefore, we have made improvements to this and proposed a Chinese medicine composition for treating tremor. Summary of the Invention

[0005] In order to make up for the shortcomings of the existing technology and solve the problem that some patients are weak and the efficacy of dopamine tablets is not obvious or side effects occur.

[0006] The technical solution adopted by the present invention to solve the technical problem is: to provide a traditional Chinese medicine composition for treating tremor, comprising the following ingredients: Uncaria rhynchophylla, Astragalus membranaceus, Gastrodia elata, Cistanche deserticola, Rose flower, Dendrobium candidum, Taraxacum mongolicum, Earthworm, Amomum villosum, Costus root, Licorice root and Coptis chinensis.

[0007] Furthermore, 15 grams of Uncaria rhynchophylla, 15 grams of Astragalus membranaceus, 10 grams of Gastrodia elata, 10 grams of Cistanche deserticola, 10 grams of Rose, 10 grams of Dendrobium candidum, 10 grams of Taraxacum mongolicum, 10 grams of Earthworm, 10 grams of Amomum villosum, 10 grams of Costus root, 10 grams of Licorice, and 6 grams of Coptis chinensis.

[0008] Furthermore, 12 grams of Uncaria rhynchophylla, 12 grams of Astragalus membranaceus, 8 grams of Gastrodia elata, 8 grams of Cistanche deserticola, 8 grams of Rose, 8 grams of Dendrobium candidum, 8 grams of Taraxacum mongolicum, 8 grams of Earthworm, 8 grams of Amomum villosum, 8 grams of Costus root, 8 grams of Licorice root, and 5 grams of Coptis chinensis.

[0009] Furthermore, 9 grams of Uncaria rhynchophylla, 9 grams of Astragalus membranaceus, 6 grams of Gastrodia elata, 6 grams of Cistanche deserticola, 6 grams of Rose, 6 grams of Dendrobium candidum, 6 grams of Taraxacum mongolicum, 6 grams of Earthworm, 6 grams of Amomum villosum, 6 grams of Costus root, 6 grams of Licorice root, and 4 grams of Coptis chinensis.

[0010] The specific beneficial effects are as follows: Gastrodia elata belongs to the liver meridian and is good for treating cramps in the limbs. It is often used in combination with Uncaria rhynchophylla to calm the liver, calm wind, and stop tremors. Rose flower soothes the liver, relieves depression, invigorates the spleen, and calms the mind. Because it enters the blood, it also has the effect of promoting blood circulation and dispersing blood stasis. Dendrobium and dandelion are used together to nourish stomach yin and clear stomach heat. Cistanche deserticola nourishes the kidneys and strengthens essence. Roasted licorice, astragalus, amomum, and costus root invigorate qi and strengthen the spleen, harmonizing the various herbs. The entire formula combines tonification and purgation, with tonification incorporated into purgation, to tonify the kidneys and liver, calm wind, and stop tremors. Earthworm has diuretic, analgesic, antihypertensive, and antipyretic properties, while coptis root has antibacterial and anti-inflammatory effects. In addition, the spleen and stomach are the source of qi and blood production, so clinical medication should be carefully considered to protect them. Avoid using overly nourishing and greasy drugs that are stomach-damaging or bitter and cold. Add herbs such as stir-fried buds of safflower (Schisandra chinensis) to strengthen the spleen and stomach. Also, consider combining herbs that calm the liver and wind, as well as clear heat and detoxify. For patients with long-term constipation and essence deficiency, laxatives such as cypress seeds can be added. For patients with severe blood stasis, herbs such as whole worms, Chuanxiong, angelica, and safflower can be added. For patients with severe kidney deficiency, herbs such as prepared rehmannia root and cornus officinalis can be added to invigorate the kidneys and replenish essence. This study showed that a self-prescribed kidney-tonifying and liver-nourishing formula combined with dopamine tablets significantly improved the therapeutic efficacy of PD patients, reducing UPDRS scores, PDQ-39 scores, TCM syndrome scores, and major syndrome scores, improving serum Hcy, hs-CRP, and UA levels, and reducing adverse drug reactions. This formula has high clinical value. DETAILED DESCRIPTION

[0011] To facilitate understanding of the technical means, creative features, objectives, and efficacy of the present invention, the present invention is further described below in conjunction with specific embodiments. The present invention provides a traditional Chinese medicine composition for treating tremor, comprising the following ingredients: Uncaria rhynchophylla, Astragalus membranaceus, Gastrodia elata, Cistanche deserticola, Rosa rugosa, Dendrobium candidum, Taraxacum mongolicum, Pheretima lumbarum, Amomum villosum, Costus root, Licorice root, and Coptis chinensis.

[0012] As a specific embodiment of the present invention, 15 grams of Uncaria rhynchophylla, 15 grams of Astragalus membranaceus, 10 grams of Gastrodia elata, 10 grams of Cistanche deserticola, 10 grams of Rose, 10 grams of Dendrobium candidum, 10 grams of Taraxacum mongolicum, 10 grams of Earthworm, 10 grams of Amomum villosum, 10 grams of Costus root, 10 grams of Licorice root, and 6 grams of Coptis chinensis.

[0013] As a specific embodiment of the present invention, 12 grams of Uncaria rhynchophylla, 12 grams of Astragalus membranaceus, 8 grams of Gastrodia elata, 8 grams of Cistanche deserticola, 8 grams of Rose, 8 grams of Dendrobium candidum, 8 grams of Taraxacum mongolicum, 8 grams of Earthworm, 8 grams of Amomum villosum, 8 grams of Costus root, 8 grams of Licorice, and 5 grams of Coptis chinensis.

[0014] As a specific embodiment of the present invention, 9 grams of Uncaria rhynchophylla, 9 grams of Astragalus membranaceus, 6 grams of Gastrodia elata, 6 grams of Cistanche deserticola, 6 grams of Rose flower, 6 grams of Dendrobium candidum, 6 grams of Taraxacum mongolicum, 6 grams of Earthworm, 6 grams of Amomum villosum, 6 grams of Aucklandia lappa, 6 grams of Licorice, and 4 grams of Coptis chinensis.

[0015] A method for preparing a traditional Chinese medicine composition for treating tremor disease comprises the following steps: S1: Weigh each Chinese medicine component according to the weight ratio; S2: Pour the herbs into the pot, add appropriate amount of cold water, and rinse quickly; S3: Leave the rinsed herbs in the pot and add cold water to soak. The amount of water is generally 5-8 times the weight of the herbs, or ensure that the water level is 3-5 cm above the surface of the herbs. The soaking time is 30 minutes to 1 hour. S4: Place the soaked herbs together with the soaking water on the stove, first boil over high heat, then reduce to low heat and simmer for another 30-40 minutes, decocting twice in total. Special treatment: Add roses to the pot 5-10 minutes before turning off the heat. Roses contain volatile components, which are easily lost if simmered for a long time, so add them last, cover the pot, and continue simmering over low heat for 5-10 minutes. S5: Filter and extract juice: After the time is up, turn off the heat, filter the medicine liquid with clean gauze or filter, and pour the medicine liquid into a clean container.

[0016] The beneficial effects of the above steps are as follows: S2 primarily removes dust, and prolonged washing is not recommended to prevent loss of active ingredients. S3 allows the herbs to fully absorb water and swell, facilitating the extraction of active ingredients. The rose flowers in S4 contain volatile components that can be lost over extended cooking times, so they should be added later. Cover the pot and continue simmering over low heat for 5-10 minutes.

[0017] The method of treating tremor with a traditional Chinese medicine composition includes: a control group and an observation group; Control group: Oral administration of dopamine tablets, 125 mg / time, 3 times / day. According to the principle of "dose titration", the dosage was adjusted in time according to the changes in the patient's condition.

[0018] The observation group received the same treatment as the control group, supplemented with a self-prescribed prescription for invigorating the kidneys and nourishing the liver. The prescription consisted of 15g each of Gastrodia elata, Uncaria rhynchophylla, Cistanche deserticola, Taraxacum mongolicum, and Dendrobium candidum, and 10g each of Rose flower and Roasted Licorice root. The dosage was adjusted based on symptoms. All of the above medications were provided by the pharmacy of Hubei Provincial Hospital of Traditional Chinese Medicine. One dose (200mL) was taken daily, warm, 30 minutes after meals, morning and evening. Both groups were treated for 8 consecutive weeks, with follow-up visits every two weeks for medication adjustments.

[0019] Efficacy evaluation: According to UPDRS efficacy evaluation. The calculation formula (nimodipine method) is: [(pre-treatment score-post-treatment score) ÷ pre-treatment score] x 100%. Marked effect: UPDRS score reduction ≥ 50%; Effective: 50% > UPDRS score reduction ≥ 20%; Ineffective: UPDRS score reduction < 20%.

[0020] Observation index: (1) UPDRS score: evaluated once before and after treatment. (2) PDQ-39 score: the lower the score, the higher the quality of life. (3) TCM syndrome score and main syndrome score: develop evaluation criteria, divide the main symptoms into 4 levels according to the degree of manifestation, and score 0, 2, 4, and 6 points respectively; the secondary symptoms are divided into 4 levels, and score 0, 1, 2, and 3 points respectively, the higher the score, the more serious the symptoms. (4) Changes in serum Hcy, hs-CRP, and UA. (5) Adverse reactions: compare nausea, vomiting, constipation, insomnia, and liver and kidney function indicators.

[0021] Result analysis: According to the composition of Gouteng 15g, Huangqi 15g, Tianma 10g, Ruikong 10g, Meigui 10g, Shihu 10g, Pugongying 10g, Dilong 10g, Sharen 10g, Muxiang 10g, Gancao 10g, and Huanglian 6g, the clinical efficacy of the two groups was compared (cases): According to the composition of Gouteng 15g, Huangqi 15g, Tianma 10g, Ruikong 10g, Meigui 10g, Shihu 10g, Pugongying 10g, Dilong 10g, Sharen 10g, Muxiang 10g, Gancao 10g, and Huanglian 6g, the UPDRS and PDQ-39 scores of the two groups before and after treatment were compared : According to the composition of Gouteng 12g, Huangqi 12g, Tianma 8g, Ruikong 8g, Meigui 8g, Shihu 8g, Pugongying 8g, Dilong 8g, Sharen 8g, Muxiang 8g, Gancao 8g, and Huanglian 5g, the clinical efficacy of the two groups was compared (cases): According to the composition of Gouteng 12g, Huangqi 12g, Tianma 8g, Ruikong 8g, Meigui 8g, Shihu 8g, Pugongying 8g, Dilong 8g, Sharen 8g, Muxiang 8g, Gancao 8g, and Huanglian 5g, the UPDRS and PDQ-39 scores of the two groups before and after treatment were compared According to the composition of Gouteng 9g, Huangqi 9g, Tianma 6g, Ruikong 6g, Meigui 6g, Shihu 6g, Pugongying 6g, Dilong 6g, Sharen 6g, Muxiang 6g, Gancao 6g, and Huanglian 4g, the clinical efficacy of the two groups was compared (cases): According to the prescription Gouteng 9g, Huangqi 9g, Tianma 6g, Cogongrass 6g, Rose 6g, Shihu 6g, Pugongying 6g, Dilong 6g, Sharen 6g, Muxiang 6g, Gancao 6g, Huanglian 4g, two groups of UPDRS, PDQ-39 scores before and after treatment are compared The specific beneficial effects are as follows: Gouteng 9g, Huangqi 9g, Tianma 6g, Cogongrass 6g, Rose 6g, Shihu 6g, Pugongying 6g, Dilong 6g, Sharen 6g, Muxiang 6g, Gancao 6g, Huanglian 4g, two groups of UPDRS, PDQ-39 scores before and after treatment are compared; The results of the study show that the self-made Yishen Zigan Decoction combined with levodopa can significantly improve the treatment effect of PD patients, reduce UPDRS score, PDQ-39 score, TCM syndrome score and main syndrome score, improve serum Hcy, hs-CRP and UA levels, reduce adverse reactions of drugs, and has high clinical application value.

[0022] In the description of the present application, it should be understood that the orientations or positional relationships indicated by the terms "intermediate", "longitudinal", "transverse", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the scope of protection of the present application.

[0023] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art will appreciate that the present invention is not limited to the foregoing embodiments. The foregoing embodiments and descriptions are merely illustrative of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating tremor, characterized in that: The prescription includes the following ingredients: Uncaria rhynchophylla, Astragalus membranaceus, Gastrodia elata, Cistanche deserticola, Rose, Dendrobium candidum, Taraxacum mongolicum, Earthworm, Amomum villosum, Costus root, Licorice root, Coptis chinensis.

2. A Chinese medicine composition for treating tremor according to claim 1, characterized in that: 15 grams of Uncaria rhynchophylla, 15 grams of Astragalus membranaceus, 10 grams of Gastrodia elata, 10 grams of Cistanche deserticola, 10 grams of Rose, 10 grams of Dendrobium candidum, 10 grams of Taraxacum mongolicum, 10 grams of Earthworm, 10 grams of Amomum villosum, 10 grams of Costus root, 10 grams of Licorice root, and 6 grams of Coptis chinensis.

3. A Chinese medicine composition for treating tremor according to claim 2, characterized in that: 12 grams of Uncaria rhynchophylla, 12 grams of Astragalus membranaceus, 8 grams of Gastrodia elata, 8 grams of Cistanche deserticola, 8 grams of Rose, 8 grams of Dendrobium candidum, 8 grams of Taraxacum mongolicum, 8 grams of Earthworm, 8 grams of Amomum villosum, 8 grams of Costus root, 8 grams of Licorice root, and 5 grams of Coptis chinensis.

4. A Chinese medicine composition for treating tremor according to claim 3, characterized in that: 9 grams of Uncaria rhynchophylla, 9 grams of Astragalus membranaceus, 6 grams of Gastrodia elata, 6 grams of Cistanche deserticola, 6 grams of Rose flower, 6 grams of Dendrobium candidum, 6 grams of Taraxacum mongolicum, 6 grams of Earthworm, 6 grams of Amomum villosum, 6 grams of Costus root, 6 grams of Licorice root, and 4 grams of Coptis chinensis.

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