Antibacterial anti-dandruff shampoo and preparation method thereof
Through the synergistic effect of tea tree oil, mango peel extract-chitosan complex and licorice extract, the problem of long-term use of existing shampoos damaging the scalp barrier is solved, achieving highly effective antibacterial and dandruff-removing effects and scalp microecological regulation, and enhancing the antibacterial durability and antifungal ability.
Patent Information
- Application Number
- CN202511092072.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-05
- Publication Date
- 2025-11-04
AI Technical Summary
Existing anti-dandruff shampoos contain chemically synthesized antibacterial ingredients that can damage the scalp's natural barrier with long-term use, limiting their applicability. There is a lack of shampoos that are highly effective in antibacterial and anti-dandruff removal and can synergistically regulate the scalp's microecology.
The synergistic effect of tea tree oil, mango peel extract-chitosan complex, and licorice extract, combined with the natural antibacterial properties of tea tree oil, the antioxidant and antibacterial properties of chitosan derivatives and polyphenols in mango peel extract-chitosan complex, and the anti-inflammatory components of licorice extract, synergistically inhibits the proliferation of Malassezia, soothes inflammatory responses, and regulates keratin metabolism.
It achieves multi-dimensional antibacterial and dandruff-removing effects. The tea tree oil and mango peel extract-chitosan complex enhance the ability to inhibit fungi, while licorice extract relieves inflammation and reduces dandruff production. Furthermore, the quaternary ammonium salt groups and Ag+ in the complex enhance the antibacterial durability, forming a film that adheres to the scalp surface and improves the antibacterial effect.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of daily chemical, in particular to an antibacterial and anti-dandruff shampoo and a preparation method thereof. BACKGROUND
[0002] Dandruff is a common scalp problem caused by abnormal shedding of the scalp stratum corneum, which is closely related to excessive proliferation of fungi such as Malassezia, scalp inflammatory response, keratin metabolism imbalance and abnormal sebum secretion. At present, the anti-dandruff shampoo on the market mainly inhibits microbial reproduction by adding antibacterial ingredients or improves keratin metabolism by adding keratin-regulating ingredients to achieve the purpose of reducing dandruff. In the prior art, the commonly used antibacterial and anti-dandruff ingredients are mostly chemical synthetic substances, such as zinc pyrithione (ZPT), selenium disulfide and ketoconazole. Although these ingredients can inhibit fungal activity in the short term, long-term use can easily damage the natural barrier of the scalp, limiting their scope of application. Therefore, developing a shampoo that has both high antibacterial and anti-dandruff effects and can synergistically regulate the scalp microecology has become a research hotspot in the field of daily chemicals. SUMMARY
[0003] (I) Technical problems solved
[0004] In view of the deficiencies of the prior art, the present application provides an antibacterial and anti-dandruff shampoo and a preparation method thereof, which has good antibacterial and anti-dandruff effects.
[0005] (II) Technical solutions
[0006] To achieve the above-mentioned purpose, the present application provides the following technical solutions: an antibacterial and anti-dandruff shampoo, comprising the following components by weight: 0.4-0.7 parts by weight of tea tree oil, 0.8-1 part by weight of mango peel extract-chitosan complex, 0.7-0.8 parts by weight of licorice extract, 1-2.5 parts by weight of sodium cocoyl methyl taurate, 0.5-0.8 parts by weight of sodium dodecylbenzenesulfonate, 0.8-1.2 parts by weight of glycerol, and 55-60 parts by weight of deionized water.
[0007] Further, the preparation method of the mango peel extract-chitosan complex is as follows:
[0008] S1. Wash the fresh mango peel with double-distilled water, cut it into small pieces, take 45-50g of mango peel, put it into a juicer, add 145-155mL of double-distilled water, and squeeze it into mango juice. Heat the mango mixture in a water bath at 75-80℃ for 36-40min, then naturally cool it to room temperature, vacuum filter, centrifuge, vacuum filter the supernatant after centrifugation, and filter it with a microporous filter membrane to obtain mango peel extract;
[0009] S2. 1-1.2 g of chitosan and 2.7-3 g of 3-chloro-2-hydroxypropyl trimethyl ammonium chloride were added into a reactor, then 90-100 mL of NaOH solution with pH of 9 was added, and the reaction was carried out at elevated temperature for 9-10 h. After the reaction was stopped, three times volume of acetone was added into the reaction solution, which was then frozen in a refrigerator overnight, and then suction filtration was carried out. The crude product was soaked in ethanol for 2 days, and then suction filtration was carried out, to obtain the quaternary ammonium salt modified chitosan;
[0010] S3. The chitosan quaternary ammonium salt was added into a reactor containing dimethyl sulfoxide, and magnetic stirring was carried out for 20-23 h. Then triethylamine and lauroyl chloride were added, and the reaction was carried out at room temperature under magnetic stirring for 2-3 h. After the reaction was completed, ethanol was added to precipitate the product, and the crude product was purified by a Soxhlet extraction device, to obtain the intermediate 1.
[0011] S4. 3-4 mL of mango extract, 4-5 mmol of intermediate 1, and 2-3 mmol of cinnamic acid were added into a reactor, and stirring was carried out. Then 30-32 mL of 1.0 mmol / L AgNO3 was slowly added dropwise under stirring at room temperature, and after the addition was completed, magnetic stirring was continued, to obtain the mango peel extract-chitosan complex.
[0012] Further, the centrifugation time in S1 is 8-10 min.
[0013] Further, the temperature of the elevated temperature in S2 is 76-80℃.
[0014] Further, the amount ratio of chitosan quaternary ammonium salt, dimethyl sulfoxide, triethylamine, and lauroyl chloride in S3 is 6-6.4 mmol: 50-55 mL: 0.1-0.2 mmol: 5-6.1 mmol.
[0015] Further, the magnetic stirring time in S4 is 12-16 min.
[0016] Further, the preparation method of the liquorice extract is as follows: 1-2 parts by weight of liquorice was soaked in 5 times of water, and after soaking for 2-3 h, the soaking was carried out at a temperature of 55-60℃ by using an ultrasonic extraction device with a frequency of 100 kHz for 35-40 min. Filtration was carried out, and the liquorice extract was obtained by concentration under reduced pressure.
[0017] Further, the preparation method of the antibacterial and anti-dandruff shampoo is as follows:
[0018] Step one: heat the deionized water to 50-55 DEG C, then add glycerin, keep the temperature stirring for 4-5 min, then add tea tree oil, sodium cocoyl methyl taurate, sodium dodecyl benzene sulfonate to it, continue to stir for 3-6 min, then add mango peel extract-chitosan complex, liquorice extract, stir for 2-3 min, after the end, cool to room temperature naturally, to obtain the antibacterial and antidandruff shampoo.
[0019] (Three) beneficial technical effects
[0020] The application realizes excellent antibacterial and antidandruff effects through the synergistic effect of tea tree oil, mango peel extract-chitosan complex and liquorice extract. The tea tree oil is a natural antibacterial agent, which can directly inhibit the proliferation of dandruff-causing fungi such as Malassezia; the mango peel extract-chitosan complex combines the cationic antibacterial property of the chitosan derivative with the antioxidant and antibacterial activity of the polyphenols in the mango peel extract, not only enhancing the inhibition of fungi, but also prolonging the antibacterial duration; the liquorice extract relieves the inflammatory reaction of the scalp through anti-inflammatory ingredients, reducing the abnormal shedding of keratin caused by inflammation. The three synergistically inhibit fungi, relieve inflammation and regulate keratin metabolism to reduce dandruff generation in multiple dimensions. The introduction of the quaternary ammonium salt group, Ag + in the mango peel extract-chitosan complex further enhances the antibacterial durability of the complex; and the hydroxyl group in the mango peel extract-chitosan complex and the carboxyl group in the cinnamic acid will be adsorbed on the surface of the hair through hydrogen bonds to form a film, and the long chain in the mango peel extract-chitosan complex will also be adsorbed on the surface of the scalp, so that the antibacterial ions can further play a role, achieving good antibacterial effect. BRIEF DESCRIPTION OF DRAWINGS
[0021] Figure 1 is the reaction formula of the quaternary ammonium salt modified chitosan. DETAILED DESCRIPTION
[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present application more clear, the technical scheme in the embodiments of the present application is described clearly and completely, obviously, the described embodiments are part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the present application.
[0023] In order to better understand the above technical scheme, the above technical scheme will be described in detail in combination with the drawings in the specification and specific embodiments.
[0024] The concentration of cinnamic acid is 400ug / mL.
[0025] 1.0 mmol / L AgNO3 preparation: accurately weigh 0.0849 g of silver nitrate solid powder with an electronic balance, add it into a 100 mL beaker, then add appropriate amount of double distilled water to dissolve the silver nitrate, use a glass rod to guide the silver nitrate solution in the beaker into a 500 mL volumetric flask, rinse the beaker with double distilled water three times and guide the washing liquid into the volumetric flask, make up the volume, shake well, store in low temperature and avoid light.
[0026] Chitosan, analytical pure.
[0027] Example 1
[0028] An antibacterial and dandruff-removing shampoo includes the following components by weight: 0.4 parts by weight of tea tree oil, 0.8 parts by weight of mango peel extract-chitosan complex, 0.7 parts by weight of licorice extract, 1 part by weight of sodium cocoyl methyl taurate, 0.5 parts by weight of sodium dodecyl benzene sulfonate, 0.8 parts by weight of glycerol, 55 parts by weight of deionized water.
[0029] The preparation method of the mango peel extract-chitosan complex is as follows:
[0030] S1. Wash the fresh mango peel with double distilled water, cut it into small pieces, take 45 g of mango peel and put it into a juicer, add 145 mL of double distilled water to squeeze into mango juice, heat the mango mixture in a 75℃ water bath for 36 min, then naturally cool to room temperature, vacuum filter, centrifuge for 8 min, vacuum filter the supernatant after centrifugation, and filter with a microporous filter membrane to obtain mango peel extract;
[0031] S2. Put 1 g of chitosan and 2.7 g of 3-chloro-2-hydroxypropyl trimethyl ammonium chloride into a reactor, then add 90 mL of NaOH solution with pH 9, heat to 76℃ and react for 9 h, after the reaction is stopped, add three times the volume of acetone to the reaction solution, put it in the refrigerator to freeze overnight, then filter, soak the crude product in ethanol for 2 days, filter to obtain quaternary ammonium salt modified chitosan;
[0032] S3. Put 6 mmol of chitosan quaternary ammonium salt into a 50 mL dimethyl sulfoxide reactor, magnetically stir for 20 h, then add 0.1 mmol of triethylamine and 5 mmol of lauroyl chloride, magnetically stir at room temperature, react for 2 h, then add ethanol to precipitate the precipitate, purify the crude product with a Soxhlet extraction device to obtain intermediate 1;
[0033] S4. Put 3 mL of mango extract, 4 mmol of intermediate 1, and 2 mmol of cinnamic acid into a reactor, stir and mix, slowly add 30 mL of 1.0 mmol / L AgNO3 dropwise under stirring at room temperature, continue to magnetically stir for 12 min after the addition is completed to obtain the mango peel extract-chitosan complex.
[0034] The preparation method of the licorice extract is as follows: 1 part by weight of licorice is soaked in 5 times water, after soaking for 2 hours, the extraction is carried out at a temperature of 55°C for 35 minutes by using an ultrasonic extraction device with a frequency of 100 kHz, filtration and concentration under reduced pressure to obtain the licorice extract.
[0035] The preparation method of the antibacterial and dandruff-removing shampoo is as follows:
[0036] Step one: deionized water is heated to 50°C, then glycerol is added, the temperature is kept and stirred for 4 minutes, then tea tree oil, sodium cocoyl methyl taurate and sodium dodecyl benzene sulfonate are added, stirring is continued for 3 minutes, then mango peel extract-chitosan complex and licorice extract are added, stirring is carried out for 2 minutes, after the end, natural cooling to room temperature is carried out to obtain the antibacterial and dandruff-removing shampoo.
[0037] Example 2
[0038] An antibacterial and dandruff-removing shampoo, comprising the following components by weight: 0.7 parts by weight of tea tree oil, 1 part by weight of mango peel extract-chitosan complex, 0.8 parts by weight of licorice extract, 2.5 parts by weight of sodium cocoyl methyl taurate, 0.8 parts by weight of sodium dodecyl benzene sulfonate, 1.2 parts by weight of glycerol, 60 parts by weight of deionized water.
[0039] The preparation method of the mango peel extract-chitosan complex is as follows:
[0040] S1. Fresh mango peel is washed with double-distilled water, then cut into small pieces, 50 g of the mango peel is put into a juicer, and 155 mL of double-distilled water is added to extract the mango juice, the mango mixture is heated in a water bath at 80°C for 40 minutes, then naturally cooled to room temperature, vacuum filtration and centrifugation for 10 minutes are carried out, the supernatant after centrifugation is vacuum filtered and filtered with a microporous filter membrane to obtain the mango peel extract;
[0041] S2. 1.2 g of chitosan and 3 g of 3-chloro-2-hydroxypropyltrimethylammonium chloride are added into a reactor, then 100 mL of NaOH solution with a pH of 9 is added, the temperature is raised to 80°C and reaction is carried out for 10 hours, after the reaction is stopped, three times the volume of acetone is added into the reaction solution, which is placed in a refrigerator to freeze overnight, then vacuum filtration is carried out, the crude product is soaked in ethanol for 2 days, vacuum filtration is carried out to obtain the quaternary ammonium salt modified chitosan;
[0042] S3. 6.4 mmol of the quaternary ammonium salt of chitosan is added into a reactor containing 55 mL of dimethyl sulfoxide, magnetic stirring is carried out for 23 hours, then 0.2 mmol of triethylamine and 6.1 mmol of lauroyl chloride are added, magnetic stirring reaction is carried out at room temperature, the reaction is carried out for 3 hours, after the end, ethanol is added to precipitate, the crude product is purified by using a Soxhlet extraction device to obtain the intermediate 1;
[0043] S4. Add 4 mL of mango extract, 5 mmol of intermediate 1, and 3 mmol of cinnamic acid into a reactor, stir and mix, slowly drop 32 mL of 1.0 mmol / L AgNO3 into the mixture under stirring at room temperature, continue stirring for 16 min after the dropping is completed, and obtain a mango peel extract-chitosan complex.
[0044] The licorice extract is prepared by the following method: 2 parts by weight of licorice is soaked in 5 times of water, soaked for 3 h, then oscillated and extracted at 60℃ for 40 min by using an ultrasonic extraction device with a frequency of 100 kHz, filtered, and concentrated under reduced pressure to obtain the licorice extract.
[0045] The preparation method of the antibacterial anti-dandruff shampoo is as follows:
[0046] Step one: heat the deionized water to 55℃, then add glycerol, keep the temperature and stir for 5 min, then add tea tree oil, sodium cocoyl methyl taurate, and sodium dodecyl benzene sulfonate into the mixture, continue stirring for 6 min, then add the mango peel extract-chitosan complex and licorice extract, stir for 3 min, and then naturally cool to room temperature after the end to obtain the antibacterial anti-dandruff shampoo.
[0047] Example 3
[0048] An antibacterial anti-dandruff shampoo, comprising the following components by weight: 0.6 parts by weight of tea tree oil, 0.9 parts by weight of mango peel extract-chitosan complex, 0.75 parts by weight of licorice extract, 1.5 parts by weight of sodium cocoyl methyl taurate, 0.7 parts by weight of sodium dodecyl benzene sulfonate, 1.0 parts by weight of glycerol, and 58 parts by weight of deionized water.
[0049] The preparation method of the mango peel extract-chitosan complex is as follows:
[0050] S1. Wash the fresh mango peel with double-distilled water, cut into small pieces, take 47 g of mango peel, put it into a juicer, and add 150 mL of double-distilled water to extract the mango juice, heat the mango mixture in a water bath at 78℃ for 37 min, then naturally cool to room temperature, vacuum filter, centrifuge for 9 min, vacuum filter the supernatant after centrifugation, and filter with a microporous filter membrane to obtain a mango peel extract.
[0051] S2. Add 1.1 g of chitosan and 2.9 g of 3-chloro-2-hydroxypropyltrimethylammonium chloride into a reactor, then add 95 mL of NaOH solution with a pH of 9, heat to 78℃ and react for 10 h, after the reaction is stopped, add three times the volume of acetone into the reaction solution, put it in the refrigerator to freeze overnight, then filter, soak the crude product in ethanol for 2 days, filter, and obtain a quaternary ammonium salt modified chitosan.
[0052] S3. 6.2 mmol of quaternary ammonium salt of chitosan was added into a reactor containing 53 mL of dimethyl sulfoxide, and was stirred magnetically for 22 h. Then, 0.15 mmol of triethylamine and 5.4 mmol of lauroyl chloride were added, and the reaction was stirred magnetically at room temperature for 2.5 h. After the reaction was completed, ethanol was added to precipitate the product. The crude product was purified by a Soxhlet extraction device to obtain intermediate 1;
[0053] S4. 3.5 mL of mango extract, 4.6 mmol of intermediate 1, and 2.6 mmol of cinnamic acid were added into a reactor, and were stirred and mixed. Then, 31 mL of 1.0 mmol / L AgNO3 was slowly added dropwise while stirring at room temperature. After the addition was completed, the mixture was stirred magnetically for 14 min to obtain a mango peel extract-chitosan complex.
[0054] The licorice extract was prepared by the following method: 1.5 parts by weight of licorice was soaked in 5 times the amount of water, and was soaked for 2.4 h. Then, the mixture was oscillated by an ultrasonic extraction device with a frequency of 100 kHz at a temperature of 57℃ for 36 min. After filtration, the licorice extract was obtained by concentration under reduced pressure.
[0055] The preparation method of the antibacterial anti-dandruff shampoo is as follows:
[0056] Step one: deionized water was heated to 53℃, then glycerol was added, and the temperature was maintained while stirring for 4.6 min. Then, tea tree oil, sodium cocoyl methyl taurate, and sodium dodecyl benzene sulfonate were added, and the mixture was stirred for 5 min. Then, the mango peel extract-chitosan complex and the licorice extract were added, and the mixture was stirred for 2 min. After the reaction was completed, the mixture was naturally cooled to room temperature to obtain the antibacterial anti-dandruff shampoo.
[0057] Example 4
[0058] An antibacterial anti-dandruff shampoo, comprising the following components by weight: 0.4 parts by weight of tea tree oil, 0.8 parts by weight of mango peel extract-chitosan complex, 0.7 parts by weight of licorice extract, 1 part by weight of sodium cocoyl methyl taurate, 0.5 parts by weight of sodium dodecyl benzene sulfonate, 0.8 parts by weight of glycerol, and 55 parts by weight of deionized water.
[0059] The preparation method of the mango peel extract-chitosan complex is as follows:
[0060] S1. Fresh mango peel was washed with double-distilled water, and was cut into small pieces. Then, 45 g of the mango peel was put into a juicer, and 145 mL of double-distilled water was added to extract the mango juice. The mixture was heated in a water bath at 75℃ for 36 min, and was naturally cooled to room temperature. The mixture was vacuum-filtered and centrifuged for 8 min. The supernatant was vacuum-filtered, and was filtered by a microporous filter membrane to obtain a mango peel extract.
[0061] S2. 1.2 g of chitosan and 3 g of 3-chloro-2-hydroxypropyl trimethyl ammonium chloride were added into a reactor, then 100 mL of NaOH solution with pH of 9 was added, and the temperature was raised to 80°C for 10 h of reaction. After the reaction was stopped, three times the volume of acetone was added into the reaction solution, which was then placed in a refrigerator for freezing overnight, and then suction filtration was performed. The crude product was soaked in ethanol for 2 days, and then suction filtration was performed to obtain the quaternary ammonium salt modified chitosan;
[0062] S3. 6.4 mmol of chitosan quaternary ammonium salt was added into a reactor containing 55 mL of dimethyl sulfoxide, and magnetic stirring was performed for 23 h. Then, 0.2 mmol of triethylamine and 6.1 mmol of lauroyl chloride were added, and magnetic stirring was performed at room temperature for 3 h of reaction. After the reaction was completed, ethanol was added to precipitate the product, and a Soxhlet extraction device was used to purify the crude product to obtain intermediate 1.
[0063] S4. 3.5 mL of mango extract, 4.6 mmol of intermediate 1, and 2.6 mmol of cinnamic acid were added into a reactor, and stirring was performed for mixing. At room temperature, 31 mL of 1.0 mmol / L AgNO3 was slowly added dropwise while stirring, and after the addition was completed, magnetic stirring was continued for 14 min to obtain the mango peel extract-chitosan complex.
[0064] The preparation method of the liquorice extract is as follows: 1.5 parts by weight of liquorice was soaked in 5 times the amount of water, and after soaking for 2.4 h, an ultrasonic extraction device with a frequency of 100 kHz was used for oscillation extraction at a temperature of 57°C for 36 min. Filtration and concentration under reduced pressure were performed to obtain the liquorice extract.
[0065] The preparation method of the antibacterial anti-dandruff shampoo is as follows:
[0066] Step one: deionized water was heated to 53°C, and then glycerol was added. The temperature was maintained and stirring was performed for 4.6 min. Then, tea tree oil, sodium cocoyl methyl taurate, and sodium dodecyl benzene sulfonate were added, and stirring was continued for 5 min. Then, the mango peel extract-chitosan complex and the liquorice extract were added, and stirring was performed for 2 min. After the reaction was completed, natural cooling to room temperature was performed to obtain the antibacterial anti-dandruff shampoo.
[0067] Comparative Example 1
[0068] The difference between this comparative example and Example 4 is that the mango peel extract-chitosan complex was replaced by mango peel extract.
[0069] Comparative Example 2
[0070] The difference between this comparative example and Example 4 is that the mango peel extract-chitosan complex was replaced by quaternary ammonium salt modified chitosan.
[0071] Performance test
[0072] The test method is to test the anti-dandruff effect of the obtained shampoo according to the Group Standard for Test Method for Anti-dandruff Effect of Cosmetics (standard number: T / ZHCA019-2022). Among them, the scalp and hair root of the testee are evaluated for dandruff, and the score grade is recorded (0 level: no dandruff; 1-2 level: small, powdery, grayish rough scales; 3-4 level: small to moderate scales; 5-6 level: large and thin scales loosely connected on the scalp; 7-8 level: adherent scales; 9-10 level: thick scales of white to yellow attached to the scalp).
[0073] Table 1: Anti-dandruff test.
[0074] Project Dandruff rating Example 1 0 grade Example 2 0 grade Example 3 0 grade Example 4 0 grade Comparative Example 1 1 grade Comparative Example 2 1 grade
[0075] As can be seen from Table 1, the examples 1-4 of the present application have better anti-dandruff effect than the comparative examples 1-2.
[0076] The samples obtained from different examples and comparative examples are respectively diluted into test solutions with different concentrations by using Leeming & Notman liquid medium for multiple serial dilutions, 0.1 mL of 10 6 CFU / mL Malassezia suspension is inoculated into 1 mL of the above test solution with different concentrations, and cultured at 37℃ for 48h. When no bacterial growth is observed in the test sample with the lowest concentration, the minimum inhibitory concentration of the corresponding sample is obtained.
[0077] Table 2: Anti-bacterial test.
[0078]
[0079]
[0080] As can be seen from Table 2, the examples 1-4 of the present application have better anti-bacterial effect than the comparative examples 1-2.
[0081] It should be noted that in this document, the terms “comprising”, “including” or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or apparatus including a series of elements not only includes those elements, but also includes other elements not explicitly listed or inherent to such a process, method, article or apparatus. Without more limitations, the element defined by the statement “comprising a…” does not exclude the presence of additional identical elements in the process, method, article or apparatus including the element.
[0082] The above examples are only used to illustrate the technical solutions of the present application, but not to limit the present application; although the present application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that the technical solutions recorded in the foregoing examples can be modified, or some technical features can be replaced by equivalent ones; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.
[0083] Those skilled in the art should understand that the above only describes several specific embodiments of the present application, but not all embodiments.
Claims
1. An antibacterial and anti-dandruff shampoo, characterized in that, It comprises the following components by weight: 0.4-0.7 parts by weight of tea tree oil, 0.8-1 parts by weight of mango peel extract-chitosan complex, 0.7-0.8 parts by weight of licorice extract, 1-2.5 parts by weight of sodium cocoyl methyl taurate, 0.5-0.8 parts by weight of sodium dodecylbenzene sulfonate, 0.8-1.2 parts by weight of glycerin, and 55-60 parts by weight of deionized water.
2. The antibacterial and anti-dandruff shampoo according to claim 1, characterized in that, The preparation method of the mango peel extract-chitosan complex is as follows: S1. Wash the fresh mango peel with double-distilled water, cut it into small pieces, put 45-50g of mango peel into a juicer, add 145-155mL of double-distilled water and juice the mango. Heat the mango mixture in a water bath at 75-80℃ for 36-40 minutes, then let it cool naturally to room temperature. Vacuum filter, centrifuge, vacuum filter the supernatant after centrifugation, and filter it with a microporous membrane to obtain the mango peel extract. S2. Add 1-1.2g of chitosan and 2.7-3g of 3-chloro-2-hydroxypropyltrimethylammonium chloride to a reactor, then add 90-100mL of NaOH solution with pH 9, heat the mixture and react for 9-10h. After the reaction stops, add three times the volume of acetone to the reaction solution, freeze it overnight, then filter it. Soak the crude product in ethanol for 2 days, filter it again, and obtain quaternary ammonium salt modified chitosan. S3. Chitosan quaternary ammonium salt was added to a reactor containing dimethyl sulfoxide and magnetically stirred for 20-23 hours. Then triethylamine and lauroyl chloride were added and the mixture was magnetically stirred at room temperature for 2-3 hours. After the reaction was completed, ethanol was added to precipitate the product. The crude product was purified by Soxhlet extraction to obtain intermediate 1. S4. Add 3-4 mL of mango extract, 4-5 mmol of intermediate 1, and 2-3 mmol of cinnamic acid to the reactor and stir to mix. Under room temperature conditions, slowly add 30-32 mL of 1.0 mmol / L AgNO3 dropwise while stirring. After the addition is complete, continue magnetic stirring to obtain the mango peel extract-chitosan complex.
3. The antibacterial and anti-dandruff shampoo according to claim 2, characterized in that, The centrifugation time in S1 is 8-10 min.
4. The antibacterial and anti-dandruff shampoo according to claim 2, characterized in that, The temperature during the heating process in S2 is 76-80℃.
5. The antibacterial and anti-dandruff shampoo according to claim 2, characterized in that, The ratio of chitosan quaternary ammonium salt, dimethyl sulfoxide, triethylamine, and lauroyl chloride in S3 is 6-6.4 mmol: 50-55 mL: 0.1-0.2 mmol: 5-6.1 mmol.
6. The antibacterial and anti-dandruff shampoo according to claim 2, characterized in that, The magnetic stirring time in S4 is 12-16 minutes.
7. The antibacterial and anti-dandruff shampoo according to claim 1, characterized in that, The method for preparing the licorice extract is as follows: 1-2 parts by weight of licorice are soaked in 5 times the amount of water for 2-3 hours. Then, the licorice is extracted by oscillation at 55-60℃ using an ultrasonic extraction device with a frequency of 100kHz for 35-40 minutes. After filtration and concentration under reduced pressure, the licorice extract is obtained.
8. A method for preparing an antibacterial and anti-dandruff shampoo as described in any one of claims 1-7, characterized in that, The preparation method of the antibacterial and anti-dandruff shampoo is as follows: Step 1: Heat deionized water to 50-55℃, then add glycerin and stir for 4-5 minutes while maintaining the temperature. Next, add tea tree oil, sodium cocoyl methyl taurate, and sodium dodecylbenzene sulfonate, and continue stirring for 3-6 minutes. Then add mango peel extract-chitosan complex and licorice extract, and stir for 2-3 minutes. After that, let it cool naturally to room temperature to obtain an antibacterial and anti-dandruff shampoo.