Traditional Chinese medicine accelerant for improving milk yield of sows and preparation method of traditional Chinese medicine accelerant

Abstract

The invention belongs to the technical field of feed additives, and particularly discloses a traditional Chinese medicine accelerant for improving the lactation yield of sows and a preparation method thereof.The traditional Chinese medicine accelerant is prepared from modified astragalus polysaccharide extract, composite flavone nanoparticles, cowherb seed extract, ricepaperplant pith extract, plant source prebiotics compound, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer; through the synergistic effect of physiological regulation, nutrition guarantee and component stability, the problems that an existing feed is insufficient in functional component and low in utilization rate are solved, through the cooperative effect of all the components, the milk yield of sows is remarkably increased, meanwhile, it is guaranteed that piglets obtain sufficient high-quality milk, the weaning weight and the survival rate are increased, and the breeding cost is reduced. The invention provides an efficient and safe milk production promoting scheme for the pig raising industry, and has extremely high practical value.

Description

Technical Field

[0001] This application relates to the field of feed additive technology, specifically to a traditional Chinese medicine promoter for increasing milk production in sows and its preparation method. Background Technology

[0002] In the pig farming industry, sow milk production is one of the core factors determining the growth, development, and survival rate of piglets. Piglets aged 1-21 days after birth mainly rely on sow's milk for nutrition. Sufficient milk not only provides piglets with essential nutrients such as protein, lactose, and immunoglobulins, but also enhances their immunity, reduces the incidence of diarrhea, respiratory diseases, and other ailments, directly affecting their weaning weight and subsequent growth performance.

[0003] Feed is a crucial source of nutrition for sows during lactation, and its formulation and nutritional adequacy directly impact milk production. Ideal lactation feed should meet the sow's needs for energy, protein, minerals, and functional components. However, if the feed lacks components that promote mammary gland development and regulate prolactin, or if the digestibility and absorption of nutrients are low, it can lead to limited lactation in sows.

[0004] Currently, existing feed feeding programs generally suffer from insufficient milk production: traditional feeds focus on basic nutritional supplementation and lack targeted functional components, such as the inability to effectively regulate the levels of prolactin and estrogen in sows, and the difficulty in enhancing the sow's immunity to cope with lactation stress. These problems result in most sows having low daily milk production during lactation, which is far from meeting the growth needs of piglets and restricts the improvement of the efficiency of the pig farming industry. Summary of the Invention

[0005] In view of this, the purpose of this invention is to overcome the shortcomings of the prior art by proposing a traditional Chinese medicine promoter for increasing milk production in sows and its preparation method, so as to solve the problems existing in the prior art.

[0006] To achieve the above objectives, this invention provides a traditional Chinese medicine promoter for increasing milk production in sows. The components, by weight, are: 18-22 parts modified Astragalus polysaccharide extract, 9-12 parts compound flavonoid nanoparticles, 7-9 parts Vaccaria segetalis extract, 6-7 parts Tetrapanax papyrifer extract, 3.8-4.5 parts plant-derived prebiotic complex, 0.8-1.2 parts xylooligosaccharides, 0.12-0.25 parts nano-selenium microcapsules, and 2.2-3.5 parts trehalose stabilizer.

[0007] As a further technical solution, the preparation method of the modified Astragalus polysaccharide extract is as follows: Astragalus polysaccharide is mixed with a citric acid solution with a mass concentration of 10%-15% at a solid-liquid ratio of 1:8-14, and stirred at 58℃-65℃ for 2-3 hours. Then, 0.7wt%-1wt% of a compound enzyme is added for enzymatic hydrolysis for 1-1.5 hours, and finally the product is obtained by vacuum freeze-drying. The compound enzyme is composed of cellulase and pectinase mixed in a 1:1 mass ratio; The vacuum freeze-drying parameters are a vacuum degree of 0.08MPa-0.1MPa and a temperature of -40℃ to -30℃.

[0008] As a further technical solution, the preparation method of the composite flavonoid nanoparticles is as follows: kudzu root flavonoids and ginkgo leaf flavonoids are mixed at a mass ratio of 4:2-3, and a polyvinylpyrrolidone solution with a mass concentration of 5%-8% is added at a solid-liquid ratio of 1:10-1:15. After being treated by a high-pressure homogenizer, the mixture is filtered through a nanomembrane to retain a molecular weight cutoff of 5000-8000, and then freeze-dried to obtain nanoparticles. The parameters for the high-pressure homogenizer are: pressure 80MPA-100MPA, cycle 3-5 times; The freeze-drying parameters are: temperature -50℃ to -45℃, vacuum degree 0.09MPA-0.1MPA.

[0009] As a further technical solution, the preparation method of the Wangbuliuxing extract includes: Vaccaria seeds were extracted with microwave assistance, and the extract was purified by macroporous resin-8 with 70% ethanol as the eluent. Micro powder with a particle size ≤10μm was prepared by low-temperature spray drying; The microwave-assisted extraction parameters were 800W power, 50℃ temperature, and 20min time. The extraction solution was purified by macroporous resin-8 with the following parameters: sample volume ratio 1:5-8, elution flow rate 2 BV / h-3 BV / h; The parameters for low-temperature spray drying are: inlet air temperature 80℃ and outlet air temperature 40℃-45℃.

[0010] As a further technical solution, the preparation method of the Tetrapanax papyrifer extract includes: The pith of Tetrapanax papyriferus was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 for extraction. After filtration and spray drying, the product was obtained.

[0011] As a further technical solution, the preparation method of the plant-derived prebiotic complex is as follows: Konjac oligosaccharide, kudzu powder and chicory inulin are mixed in a mass ratio of 2-3:1:1, and then 5%-8% of the total mass of deionized water is added. The mixture is stirred at 60℃-70℃ for 15min-20min, and then vacuum dried until the moisture content is ≤3%. The mixture is then pulverized and passed through an 80-mesh sieve to obtain the final product. Vacuum drying temperature: 50℃-60℃, vacuum degree: 0.07MPA-0.09MPA.

[0012] As a further technical solution, the preparation method of the nano-selenium microcapsules is as follows: a sodium selenite solution with a concentration of 0.1mol / L-0.2mol / L is mixed with a chitosan solution with a mass concentration of 1%-2% at a volume ratio of 1:4-5, and 0.07%-0.1% vitamin C is added as a reducing agent. The mixture is stirred and reacted at 30℃-40℃ for 1-2 hours, and then spray-dried to obtain microcapsules.

[0013] As a further technical solution, the trehalose stabilizer is prepared by irradiating anhydrous trehalose with γ-rays, and the moisture content of the irradiated trehalose is ≤0.5%; The dose of gamma ray irradiation is 5 kGy-6 kGy, and the irradiation time is 2-3 hours.

[0014] The preparation method of a traditional Chinese medicine promoter to increase milk production in sows includes the following steps: Step 1: Weigh each component according to the stated weight proportions; Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 10-15 minutes at a temperature of 30℃-40℃ and a speed of 1500r / min-2000r / min until the material is uniform and free of lumps. Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing for 8 min-12 min at the above temperature and speed, until uniform and free of lumps; Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill. The particle size of the material after grinding is controlled to be ≤5μm, thus obtaining the traditional Chinese medicine promoter.

[0015] As a further technical solution, the ultrafine grinding pressure in step 4 is 0.6MPA-0.8MPA, and the feeding rate is 12kg / h-15kg / h.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The herbal promoter of this invention, through optimized combination of its components, enhances sow milk production from three aspects: physiological regulation, nutrient absorption, and component stability. The modified Astragalus polysaccharide extract, after citric acid modification and compound enzymatic hydrolysis, exhibits significantly improved water solubility and bioavailability. This not only strengthens the sow's immunity and reduces the risk of lactational diseases but also promotes the proliferation of mammary epithelial cells, providing a physiological basis for milk synthesis. The compound flavonoid nanoparticles, made by combining kudzu root flavonoids and ginkgo leaf flavonoids and homogenizing them under high pressure, can efficiently regulate prolactin secretion in sows, activate mammary gland lactation function, and ensure improved intestinal absorption efficiency through their nano-formation.

[0017] 2. Vaccaria segetalis extract and Tetrapanax papyrifer extract leverage the traditional Chinese medicine effects of promoting lactation. Vaccaria segetalis extract, extracted with microwave assistance and purified using macroporous resin, enhances the purity of its active ingredients, effectively clearing mammary ducts and promoting milk flow. Tetrapanax papyrifer extract, extracted with ethanol, retains its diuretic and lactation-promoting active ingredients. Together, they improve mammary circulation and prevent milk stasis. A plant-derived prebiotic complex and xylooligosaccharides form a gut health protection system. The prebiotic complex promotes the growth of intestinal lactobacilli, while xylooligosaccharides inhibit the growth of Escherichia coli. Together, they improve the digestibility of crude protein and fiber in the sow's intestines, providing sufficient nutrition for lactation. Nano-selenium microcapsules supplement selenium, enhancing the sow's antioxidant capacity, alleviating lactation stress, and further ensuring stable lactation function. Trehalose stabilizer, treated with gamma-ray irradiation, locks in the activity of each component, preventing degradation of active ingredients during storage and ensuring long-term product stability.

[0018] 3. In summary, this invention, through the synergistic effect of physiological regulation, nutritional guarantee, and component stability, not only solves the problems of insufficient functional components and low utilization rate in existing feeds, but also significantly improves the milk production of sows through the combined effect of various components, while ensuring that piglets obtain sufficient high-quality milk, increasing weaning weight and survival rate. It provides an efficient and safe milk production promotion solution for the pig industry and has extremely high practical value. Detailed Implementation

[0019] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to specific examples. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0020] This invention provides a traditional Chinese medicine promoter for increasing milk production in sows. By weight, the components are: 18-22 parts modified Astragalus polysaccharide extract, 9-12 parts compound flavonoid nanoparticles, 7-9 parts Vaccaria segetalis extract, 6-7 parts Tetrapanax papyrifer extract, 3.8-4.5 parts plant-derived prebiotic complex, 0.8-1.2 parts xylooligosaccharide, 0.12-0.25 parts nano-selenium microcapsules, and 2.2-3.5 parts trehalose stabilizer.

[0021] In this invention, the modified Astragalus polysaccharide extract is prepared as follows: Astragalus polysaccharide is mixed with a 10%-15% citric acid solution at a solid-liquid ratio of 1:8-14, and stirred at 58℃-65℃ for 2-3 hours. Then, 0.7wt%-1wt% of a compound enzyme is added for enzymatic hydrolysis for 1-1.5 hours, and finally, the extract is obtained by vacuum freeze-drying. The compound enzyme is composed of a 1:1 mass ratio of cellulase and pectinase. The vacuum freeze-drying parameters are a vacuum degree of 0.08MPA-0.1MPA and a temperature of -40℃ to -30℃. Astragalus polysaccharide, citric acid, cellulase, and pectinase can be obtained using methods well-known to those skilled in the art or through commercial purchases; there are no special restrictions on their sources.

[0022] In this invention, the preparation method of the composite flavonoid nanoparticles is as follows: Pueraria lobata flavonoids and Ginkgo biloba flavonoids are mixed at a mass ratio of 4:2-3, and a 5%-8% polyvinylpyrrolidone solution is added at a solid-liquid ratio of 1:10-1:15. After treatment with a high-pressure homogenizer, the mixture is filtered using a nanomembrane to remove molecular weights of 5000-8000, and then freeze-dried to obtain nanoparticles. The high-pressure homogenizer parameters are: pressure 80MPA-100MPA, cycle 3-5 times; the freeze-drying parameters are: temperature -50℃ to -45℃, vacuum degree 0.09MPA-0.1MPA. This invention does not have special restrictions on the sources of Pueraria lobata flavonoids, Ginkgo biloba flavonoids, and polyvinylpyrrolidone; commercially available products well-known to those skilled in the art can be used.

[0023] In this invention, the preparation method of the Vaccaria segetalis extract includes: microwave-assisted extraction of Vaccaria segetalis seeds, purification of the extract with macroporous resin-8, and eluent of 70% ethanol (v / v); preparation of micro-powder with a particle size ≤10μm by low-temperature spray drying; microwave-assisted extraction parameters are: power 800W, temperature 50℃, time 20min; macroporous resin-8 purification parameters are: sample volume ratio 1:5-8, elution flow rate 2BV / h-3BV / h; low-temperature spray drying parameters are: inlet air temperature 80℃, outlet air temperature 40℃-45℃. Vaccaria segetalis seeds can be obtained commercially, and conventional commercially available products are also used for reagents such as macroporous resin-8 and ethanol.

[0024] In this invention, the preparation method of the Tetrapanax papyrifer extract includes: pulverizing Tetrapanax papyrifer to 80 mesh, then mixing and extracting it with a 70% ethanol solution at a mass ratio of 1:10 for 4 hours, followed by filtration and spray drying to obtain the extract. Both the Tetrapanax papyrifer raw material and the ethanol solution are commercially available conventional products, and the pulverizing equipment, filtration equipment, and spray drying equipment can be conventional equipment well-known to those skilled in the art.

[0025] In this invention, the preparation method of the plant-derived prebiotic complex is as follows: Konjac oligosaccharide, kudzu root powder, and chicory inulin are mixed in a mass ratio of 2-3:1:1, and then 5%-8% of the total mass of deionized water is added. The mixture is stirred at 60℃-70℃ for 15-20 minutes, followed by vacuum drying until the moisture content is ≤3%, and then pulverized through an 80-mesh sieve. The vacuum drying temperature is 50℃-60℃, and the vacuum degree is 0.07MPA-0.09MPA. Konjac oligosaccharide, kudzu root powder, and chicory inulin are all commercially available conventional products, and there are no special restrictions on their source.

[0026] In this invention, the preparation method of the nano-selenium microcapsules is as follows: a sodium selenite solution with a concentration of 0.1 mol / L-0.2 mol / L is mixed with a chitosan solution with a mass concentration of 1%-2% at a volume ratio of 1:4-5. 0.07%-0.1% vitamin C is added as a reducing agent, and the mixture is stirred and reacted at 30℃-40℃ for 1-2 hours. The microcapsules are then obtained by spray drying. Sodium selenite, chitosan, and vitamin C are all commercially available conventional reagents, and the spray drying equipment is conventional equipment.

[0027] In this invention, the trehalose stabilizer is prepared by irradiating anhydrous trehalose with gamma rays, and the moisture content of the irradiated trehalose is ≤0.5%; the gamma ray irradiation dose is 5kGy-6kGy, and the irradiation time is 2-3h. The anhydrous trehalose is a commercially available conventional product, and the gamma ray irradiation equipment adopts equipment that meets industry standards.

[0028] This invention also provides a method for preparing the above-mentioned traditional Chinese medicine promoter for increasing milk production in sows, comprising the following steps: Step 1: Weigh each component according to the stated weight proportions; Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 10-15 minutes at a temperature of 30℃-40℃ and a speed of 1500r / min-2000r / min until the material is uniform and free of lumps. Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing for 8 min-12 min at the above temperature and speed, until uniform and free of lumps; Step 4: The mixture obtained in Step 3 is subjected to ultrafine pulverization using an air jet mill to control the particle size of the pulverized material to ≤5μm, thus obtaining the traditional Chinese medicine promoter. In Step 4, the pulverization pressure is 0.6MPa-0.8MPa, and the feed rate is 12kg / h-15kg / h. Both the high-speed mixer and the air jet mill are conventional equipment in this field, and there are no special restrictions on the equipment model.

[0029] This invention provides a traditional Chinese medicine (TCM) promoter for increasing milk production in sows. The components work synergistically: modified Astragalus polysaccharide extract enhances the sow's immunity; composite flavonoid nanoparticles regulate hormone levels; Vaccaria selengensis extract and Tetrapanax papyrifer extract have traditional effects in promoting lactation; plant-derived prebiotic complex and xylooligosaccharides improve intestinal health and nutrient absorption efficiency; nano-selenium microcapsules supplement selenium and promote metabolism; and trehalose stabilizer ensures the stability and effectiveness of each component. This TCM promoter effectively increases milk production in sows with high safety and no drug residue risk, thus promoting healthy growth in piglets. Furthermore, its preparation method is simple and controllable, suitable for large-scale production, and can bring significant economic benefits to the pig farming industry.

[0030] To further illustrate the present invention, the following detailed description is provided through the examples and comparative examples. Example 1

[0031] Preparation of modified Astragalus polysaccharide extract: Astragalus polysaccharide was mixed with a 12% citric acid solution at a solid-liquid ratio of 1:11 and stirred at 62℃ for 2.5 h. Then, 0.8 wt% of a compound enzyme (a mixture of cellulase and pectinase at a mass ratio of 1:1) was added for enzymatic hydrolysis for 1.2 h. Finally, the mixture was freeze-dried under vacuum at 0.09 MPa and -35℃ to obtain the modified Astragalus polysaccharide extract.

[0032] Preparation of composite flavonoid nanoparticles: Pueraria lobata flavonoids and Ginkgo biloba flavonoids were mixed at a mass ratio of 4:2.5, and a 6.5% polyvinylpyrrolidone solution was added at a solid-liquid ratio of 1:13. The mixture was then processed by high-pressure homogenizer at a pressure of 90 MPa for 4 cycles. After filtration through a nanomembrane to remove a molecular weight cutoff of 6500, the nanoparticles were freeze-dried at a temperature of -48℃ and a vacuum degree of 0.095 MPa to obtain composite flavonoid nanoparticles.

[0033] Preparation of Vaccaria segetalis extract: Vaccaria segetalis seeds were subjected to microwave-assisted extraction at a power of 800W, a temperature of 50℃, and a time of 20 min. The extract was purified using macroporous resin-8 at a loading volume ratio of 1:6.5, an elution flow rate of 2.5 BV / h, and 70% ethanol as the eluent. The purified extract was then spray-dried at low temperature with an inlet air temperature of 80℃ and an outlet air temperature of 42℃ to prepare Vaccaria segetalis extract powder with a particle size ≤10 μm.

[0034] Preparation of Tetrapanax papyrifer extract: Tetrapanax papyrifer was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 and extracted for 4 hours. After filtration, the filtered extract was spray-dried to obtain Tetrapanax papyrifer extract.

[0035] Preparation of plant-derived prebiotic complex: Konjac oligosaccharide, kudzu root powder and chicory inulin were mixed in a mass ratio of 2.5:1:1, and 6.5% of the total mass of deionized water was added. The mixture was stirred at 65℃ for 18 min, and then vacuum dried at 55℃ and 0.08 MPa until the moisture content was ≤3%. After pulverizing, the mixture was passed through an 80-mesh sieve to obtain the plant-derived prebiotic complex.

[0036] Preparation of nano-selenium microcapsules: A sodium selenite solution with a concentration of 0.15 mol / L and a chitosan solution with a mass concentration of 1.5% were mixed at a volume ratio of 1:4.5. 0.085% vitamin C was added as a reducing agent, and the mixture was stirred at 35°C for 1.5 h. Then, the nano-selenium microcapsules were obtained by spray drying.

[0037] Preparation of trehalose stabilizer: Anhydrous trehalose was irradiated with γ-rays at a dose of 5.5 kGy for 2.5 h to obtain a trehalose stabilizer with a moisture content of ≤0.5%.

[0038] Preparation of Chinese medicine promoters: Step 1: Weigh each component according to the following weight parts: 20 parts modified Astragalus polysaccharide extract, 10.5 parts compound flavonoid nanoparticles, 8 parts Vaccaria selengensis extract, 6.5 parts Tetrapanax papyrifer extract, 4.2 parts plant-derived prebiotic complex, 1.0 part xylooligosaccharide, 0.18 parts nano selenium microcapsules, and 2.8 parts trehalose stabilizer.

[0039] Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 12 minutes at 35°C and 1800 r / min until the material is uniform and free of lumps.

[0040] Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing at 35℃ and 1800r / min for 10min until uniform and free of lumps.

[0041] Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill with a grinding pressure of 0.7 MPa and a feeding rate of 13.5 kg / h. The particle size of the material after grinding is controlled to be ≤5 μm, thus obtaining the traditional Chinese medicine promoter for improving the milk production of sows. Example 2

[0042] Preparation of modified Astragalus polysaccharide extract: Astragalus polysaccharide was mixed with 10% citric acid solution at a solid-liquid ratio of 1:8 and stirred at 58℃ for 2 hours. Then, 0.7wt% of a compound enzyme (a mixture of cellulase and pectinase at a mass ratio of 1:1) was added for enzymatic hydrolysis for 1 hour. Finally, the mixture was freeze-dried under vacuum at 0.08MPa and -40℃ to obtain the modified Astragalus polysaccharide extract.

[0043] Preparation of composite flavonoid nanoparticles: Pueraria lobata flavonoids and Ginkgo biloba flavonoids were mixed at a mass ratio of 4:2, and a 5% polyvinylpyrrolidone solution was added at a solid-liquid ratio of 1:10. The mixture was then processed by high-pressure homogenizer under a pressure of 80 MPa for 3 cycles. After filtration through a nanomembrane to remove a molecular weight cutoff of 5000, the mixture was freeze-dried at a temperature of -50℃ and a vacuum degree of 0.09 MPa to obtain composite flavonoid nanoparticles.

[0044] Preparation of Vaccaria segetalis extract: Vaccaria segetalis seeds were subjected to microwave-assisted extraction at a power of 800 W, a temperature of 50℃, and a time of 20 min. The extract was purified using macroporous resin-8 at a loading volume ratio of 1:5, an elution flow rate of 2 BV / h, and 70% ethanol as the eluent. The purified extract was then spray-dried at low temperature with an inlet air temperature of 80℃ and an outlet air temperature of 40℃ to prepare Vaccaria segetalis extract powder with a particle size ≤10 μm.

[0045] Preparation of Tetrapanax papyrifer extract: Tetrapanax papyrifer was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 and extracted for 4 hours. After filtration, the filtered extract was spray-dried to obtain Tetrapanax papyrifer extract.

[0046] Preparation of plant-derived prebiotic complex: Konjac oligosaccharide, kudzu root powder and chicory inulin were mixed in a mass ratio of 2:1:1, and 5% of the total mass of deionized water was added. The mixture was stirred at 60℃ for 15 min, and then vacuum dried at 50℃ and 0.07 MPa until the moisture content was ≤3%. After pulverizing, the mixture was passed through an 80-mesh sieve to obtain the plant-derived prebiotic complex.

[0047] Preparation of nano-selenium microcapsules: A 0.1 mol / L sodium selenite solution and a 1% chitosan solution were mixed at a volume ratio of 1:4. 0.07% vitamin C was added as a reducing agent, and the mixture was stirred at 30°C for 1 hour. The mixture was then spray-dried to obtain nano-selenium microcapsules.

[0048] Preparation of trehalose stabilizer: Anhydrous trehalose was irradiated with γ-rays at a dose of 5 kGy for 2 h to obtain a trehalose stabilizer with a moisture content of ≤0.5%.

[0049] Preparation of Chinese medicine promoters: Step 1: Weigh each component according to the following weight parts: 18 parts modified Astragalus polysaccharide extract, 9 parts compound flavonoid nanoparticles, 7 parts Vaccaria selengensis extract, 6 parts Tetrapanax papyrifer extract, 3.8 parts plant-derived prebiotic complex, 0.8 parts xylooligosaccharide, 0.12 parts nano selenium microcapsules, and 2.2 parts trehalose stabilizer.

[0050] Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 10 minutes at 30°C and 1500 r / min until the material is uniform and free of lumps.

[0051] Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing at 30℃ and 1500r / min for 8 minutes until uniform and free of lumps.

[0052] Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill with a grinding pressure of 0.6 MPa and a feeding rate of 12 kg / h. The particle size of the material after grinding is controlled to be ≤5 μm, thus obtaining the traditional Chinese medicine promoter for improving the milk production of sows. Example 3

[0053] Preparation of modified Astragalus polysaccharide extract: Astragalus polysaccharide was mixed with 15% citric acid solution at a solid-liquid ratio of 1:14 and stirred at 65℃ for 3 hours. Then, 1 wt% of a compound enzyme (a mixture of cellulase and pectinase at a mass ratio of 1:1) was added for enzymatic hydrolysis for 1.5 hours. Finally, the mixture was freeze-dried under vacuum at 0.1 MPa and -30℃ to obtain the modified Astragalus polysaccharide extract.

[0054] Preparation of composite flavonoid nanoparticles: Pueraria lobata flavonoids and Ginkgo biloba flavonoids were mixed at a mass ratio of 4:3, and 8% polyvinylpyrrolidone solution was added at a solid-liquid ratio of 1:15. The mixture was then processed by high pressure homogenizer at 100 MPa for 5 cycles. After filtration through a nanomembrane to remove a molecular weight cutoff of 8000, the nanoparticles were freeze-dried at -45℃ and 0.1 MPa to obtain composite flavonoid nanoparticles.

[0055] Preparation of Vaccaria segetalis extract: Vaccaria segetalis seeds were subjected to microwave-assisted extraction at a power of 800W, a temperature of 50℃, and a time of 20 min. The extract was purified using macroporous resin-8 at a loading volume ratio of 1:8, an elution flow rate of 3 BV / h, and 70% ethanol as the eluent. The purified extract was then spray-dried at low temperature with an inlet air temperature of 80℃ and an outlet air temperature of 45℃ to prepare Vaccaria segetalis extract powder with a particle size ≤10μm.

[0056] Preparation of Tetrapanax papyrifer extract: Tetrapanax papyrifer was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 and extracted for 4 hours. After filtration, the filtered extract was spray-dried to obtain Tetrapanax papyrifer extract.

[0057] Preparation of plant-derived prebiotic complex: Konjac oligosaccharide, kudzu root powder and chicory inulin were mixed in a mass ratio of 3:1:1, and 8% of the total mass of deionized water was added. The mixture was stirred at 70℃ for 20 min, and then vacuum dried at 60℃ and 0.09 MPa until the moisture content was ≤3%. After pulverizing, the mixture was passed through an 80-mesh sieve to obtain the plant-derived prebiotic complex.

[0058] Preparation of nano-selenium microcapsules: A 0.2 mol / L sodium selenite solution and a 2% chitosan solution were mixed at a volume ratio of 1:5, and 0.1% vitamin C was added as a reducing agent. The mixture was stirred at 40°C for 2 hours and then spray-dried to obtain nano-selenium microcapsules.

[0059] 7. Preparation of trehalose stabilizer: Anhydrous trehalose was irradiated with γ-rays at a dose of 6 kGy for 3 h to obtain a trehalose stabilizer with a moisture content ≤0.5%.

[0060] 8. Preparation of Chinese herbal medicine promoters: Step 1: Weigh each component according to the following weight parts: 22 parts modified Astragalus polysaccharide extract, 12 parts compound flavonoid nanoparticles, 9 parts Vaccaria selengensis extract, 7 parts Tetrapanax papyrifer extract, 4.5 parts plant-derived prebiotic complex, 1.2 parts xylooligosaccharide, 0.25 parts nano selenium microcapsules, and 3.5 parts trehalose stabilizer.

[0061] Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 15 minutes at 40℃ and 2000r / min until the material is uniform and free of lumps.

[0062] Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing at 40℃ and 2000r / min for 12min until uniform and free of lumps.

[0063] Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill with a grinding pressure of 0.8 MPa and a feeding rate of 15 kg / h. The particle size of the material after grinding is controlled to be ≤5 μm, thus obtaining the traditional Chinese medicine promoter for improving the milk production of sows. Example 4

[0064] Preparation of modified Astragalus polysaccharide extract: Astragalus polysaccharide was mixed with 11% citric acid solution at a solid-liquid ratio of 1:9 and stirred at 60℃ for 2.2h. Then, 0.75wt% of a compound enzyme (a mixture of cellulase and pectinase at a mass ratio of 1:1) was added for enzymatic hydrolysis for 1.1h. Finally, the mixture was freeze-dried under vacuum at 0.085MPa and -38℃ to obtain the modified Astragalus polysaccharide extract.

[0065] Preparation of composite flavonoid nanoparticles: Pueraria lobata flavonoids and Ginkgo biloba flavonoids were mixed at a mass ratio of 4:2.2, and a 6% polyvinylpyrrolidone solution was added at a solid-liquid ratio of 1:11. The mixture was then processed by high-pressure homogenizer at a pressure of 85 MPa for 3 cycles. After filtration through a nanomembrane to a molecular weight cutoff of 5500, the nanoparticles were freeze-dried at a temperature of -49℃ and a vacuum degree of 0.092 MPa to obtain composite flavonoid nanoparticles.

[0066] Preparation of Vaccaria segetalis extract: Vaccaria segetalis seeds were subjected to microwave-assisted extraction at a power of 800 W, a temperature of 50℃, and a time of 20 min. The extract was purified using macroporous resin-8 at a loading volume ratio of 1:6, an elution flow rate of 2.2 BV / h, and 70% ethanol as the eluent. The purified extract was then spray-dried at low temperature with an inlet air temperature of 80℃ and an outlet air temperature of 41℃ to prepare Vaccaria segetalis extract powder with a particle size ≤10 μm.

[0067] Preparation of Tetrapanax papyrifer extract: Tetrapanax papyrifer was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 and extracted for 4 hours. After filtration, the filtered extract was spray-dried to obtain Tetrapanax papyrifer extract.

[0068] Preparation of plant-derived prebiotic complex: Konjac oligosaccharide, kudzu root powder and chicory inulin were mixed in a mass ratio of 2.2:1:1, and 6% of the total mass of deionized water was added. The mixture was stirred at 62℃ for 16 min, and then vacuum dried at 52℃ and 0.075 MPa until the moisture content was ≤3%. After pulverizing, the mixture was passed through an 80-mesh sieve to obtain the plant-derived prebiotic complex.

[0069] Preparation of nano-selenium microcapsules: A sodium selenite solution with a concentration of 0.12 mol / L and a chitosan solution with a mass concentration of 1.2% were mixed at a volume ratio of 1:4.2. 0.075% vitamin C was added as a reducing agent, and the mixture was stirred at 32°C for 1.2 h. The mixture was then spray-dried to obtain nano-selenium microcapsules.

[0070] Preparation of trehalose stabilizer: Anhydrous trehalose was irradiated with γ-rays at a dose of 5.2 kGy for 2.2 h to obtain a trehalose stabilizer with a moisture content of ≤0.5%.

[0071] Preparation of Chinese medicine promoters: Step 1: Weigh each component according to the following weight parts: 19 parts modified Astragalus polysaccharide extract, 10 parts compound flavonoid nanoparticles, 7.5 parts Vaccaria selengensis extract, 6.2 parts Tetrapanax papyrifer extract, 4.0 parts plant-derived prebiotic complex, 0.9 parts xylooligosaccharide, 0.15 parts nano selenium microcapsules, and 2.5 parts trehalose stabilizer.

[0072] Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 11 minutes at 32°C and 1600 r / min until the material is uniform and free of lumps.

[0073] Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing at 32℃ and 1600r / min for 9min until uniform and free of lumps.

[0074] Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill with a grinding pressure of 0.65 MPa and a feeding rate of 13 kg / h. The particle size of the material after grinding is controlled to be ≤5 μm, thus obtaining the traditional Chinese medicine promoter for increasing the milk production of sows. Example 5

[0075] Preparation of modified Astragalus polysaccharide extract: Astragalus polysaccharide was mixed with a 14% citric acid solution at a solid-liquid ratio of 1:13 and stirred at 64℃ for 2.8 h. Then, 0.9 wt% of a compound enzyme (a mixture of cellulase and pectinase at a mass ratio of 1:1) was added for enzymatic hydrolysis for 1.4 h. Finally, the mixture was freeze-dried under vacuum at 0.095 MPa and -32℃ to obtain the modified Astragalus polysaccharide extract.

[0076] Preparation of composite flavonoid nanoparticles: Pueraria lobata flavonoids and Ginkgo biloba flavonoids were mixed at a mass ratio of 4:2.8, and a 7% polyvinylpyrrolidone solution was added at a solid-liquid ratio of 1:14. The mixture was then processed by high-pressure homogenizer at a pressure of 95 MPa for 4 cycles. After filtration through a nanomembrane to remove a molecular weight cutoff of 7500, the nanoparticles were freeze-dried at a temperature of -46℃ and a vacuum degree of 0.098 MPa to obtain composite flavonoid nanoparticles.

[0077] Preparation of Vaccaria segetalis extract: Vaccaria segetalis seeds were subjected to microwave-assisted extraction at a power of 800 W, a temperature of 50℃, and a time of 20 min. The extract was purified using macroporous resin-8 at a loading volume ratio of 1:7, an elution flow rate of 2.8 BV / h, and 70% ethanol as the eluent. The purified extract was then spray-dried at low temperature with an inlet air temperature of 80℃ and an outlet air temperature of 44℃ to prepare Vaccaria segetalis extract powder with a particle size ≤10 μm.

[0078] Preparation of Tetrapanax papyrifer extract: Tetrapanax papyrifer was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 and extracted for 4 hours. After filtration, the filtered extract was spray-dried to obtain Tetrapanax papyrifer extract.

[0079] Preparation of plant-derived prebiotic complex: Konjac oligosaccharide, kudzu root powder and chicory inulin were mixed in a mass ratio of 2.8:1:1, and 7% of the total mass of deionized water was added. The mixture was stirred at 68℃ for 19 min, and then vacuum dried at 58℃ and 0.085 MPa until the moisture content was ≤3%. After pulverizing, the mixture was passed through an 80-mesh sieve to obtain the plant-derived prebiotic complex.

[0080] Preparation of nano-selenium microcapsules: A sodium selenite solution with a concentration of 0.18 mol / L and a chitosan solution with a mass concentration of 1.8% were mixed at a volume ratio of 1:4.8. 0.09% vitamin C was added as a reducing agent, and the mixture was stirred at 38°C for 1.8 h. The nano-selenium microcapsules were then obtained by spray drying.

[0081] Preparation of trehalose stabilizer: Anhydrous trehalose was irradiated with γ-rays at a dose of 5.8 kGy for 2.8 h to obtain a trehalose stabilizer with a moisture content of ≤0.5%.

[0082] Preparation of Chinese medicine promoters: Step 1: Weigh each component according to the following weight parts: 21 parts modified Astragalus polysaccharide extract, 11 parts compound flavonoid nanoparticles, 8.5 parts Vaccaria selengensis extract, 6.8 parts Tetrapanax papyrifer extract, 4.3 parts plant-derived prebiotic complex, 1.1 parts xylooligosaccharide, 0.22 parts nano selenium microcapsules, and 3.2 parts trehalose stabilizer.

[0083] Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 14 minutes at 38°C and 1900 r / min until the material is uniform and free of lumps.

[0084] Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing at 38℃ and 1900 r / min for 11 min until uniform and free of lumps.

[0085] Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill with a grinding pressure of 0.75 MPa and a feeding rate of 14 kg / h. The particle size of the material after grinding is controlled to be ≤5 μm, thus obtaining the traditional Chinese medicine promoter for increasing the milk production of sows.

[0086] Comparative Example 1 The preparation method of the Chinese medicine promoter provided in Example 1 was adopted, except that: no composite flavonoid nanoparticles and nano-selenium microcapsules were added, and the weight parts of each component were adjusted to 25 parts of modified Astragalus polysaccharide extract, 10 parts of Vaccaria selengensis extract, 8 parts of Tetrapanax papyrifer extract, 5 parts of plant-derived prebiotic complex, 1.5 parts of xylooligosaccharide, and 3.5 parts of trehalose stabilizer. The remaining preparation steps (including the preparation process parameters of each raw material, mixing temperature and speed, ultrafine grinding parameters, etc.) were the same as in Example 1.

[0087] Comparative Example 2 The preparation method of the Chinese medicine promoter provided in Example 1 is adopted, except that the modified Astragalus polysaccharide extract is replaced with unmodified ordinary Astragalus polysaccharide, and the composite flavonoid nanoparticles are replaced with ordinary Pueraria lobata flavonoids (not compounded with Ginkgo biloba flavonoids and not made into nanoparticles). The remaining preparation steps (including the preparation process parameters of each raw material, the weight parts of each component, the mixing temperature and speed, the ultrafine grinding parameters, etc.) are the same as in Example 1.

[0088] test Experiment 1: Determination of Daily Milk Yield in Sows Test methods Following the principle of the "manual milking and weighing method" in GB / T35962-2023 "Methods for Determining Milk Yield in Dairy Cows" (adapting to the adjustment of sow lactation characteristics), 70 healthy two-way crossbred sows of similar parity, age, and weight (2-3 parities, 3 days postpartum, weight 180-200 kg) were randomly divided into 7 groups of 10 sows each, corresponding to Examples 1-5 and Comparative Examples 1-2, respectively. Starting from the 3rd day postpartum, the experimental group sows received 50g / sow of the herbal promoter of this invention added to their basal diet daily. The control group (without additional addition) received the same basal diet as the experimental group. The experimental period was 21 days (the critical period for sow lactation). Manual milking was performed daily at fixed times (8:00 AM, 2:00 PM, and 8:00 PM). The milk yield was weighed using an electronic scale (accuracy 0.01 kg) and recorded each time. The total daily milk yield was calculated, and the average daily milk yield over 21 days was taken as the final data. The results are as follows: Table 1

[0089] As shown in Table 1, the average daily milk production of Examples 1-5 was in the range of 7.5-8.5 kg / head, and the overall performance was stable. Among them, the milk production of Examples 3 and 5 was slightly higher, while the milk production of Example 2 was slightly lower. This indicates that within the range of component content, the reasonable increase of component content has a positive promoting effect on milk production, and the synergistic effect of each component is stable.

[0090] The milk yield of Comparative Example 1 was significantly lower than that of Example 1 because it lacked compound flavonoid nanoparticles and nano-selenium microcapsules. Compound flavonoid nanoparticles can regulate the levels of prolactin and estrogen in sows, promote mammary gland development and milk synthesis; nano-selenium microcapsules can supplement selenium, enhance the antioxidant capacity of sows, and reduce stress response during lactation. The absence of both directly disrupted the synergistic lactation mechanism of the formula, resulting in a significant decrease in milk yield.

[0091] The milk production of Comparative Example 2 was lower than that of Example 1 because the raw material form and modification treatment did not meet the standards: the water solubility and bioavailability of unmodified ordinary Astragalus polysaccharide were low, and it could not effectively enhance the immunity and nutrient absorption efficiency of sows; ordinary Pueraria lobata flavonoids were not combined with Ginkgo biloba flavonoids (lacking flavonoid synergistic effect) and were not made into nanoparticles (large particle size, poor absorption), which could not effectively regulate hormone levels. Both of these factors combined led to a weakening of the formula's lactation efficacy and a decrease in milk production.

[0092] Experiment 2: Association between total milk production during lactation and piglet weight gain Test methods Total milk production determination: Continuing the sow grouping and feeding conditions of Experiment 1, the total milk production of each group of sows during the 21-day lactation period was recorded (daily milk production was accumulated).

[0093] Piglet weight gain measurement: Piglets born to each sow (the number of piglets per litter is controlled at 10-12, with a birth weight of 1.3-1.5kg) are weighed at a fixed time every day from birth to weaning at 21 days of age. The birth weight and weaning weight are recorded, and the total weight gain of each piglet in 21 days is calculated. The average weight gain data of each group of piglets is taken.

[0094] Referring to the piglet weight gain determination method in "NY / T822-2021 Standard for Testing the Production Performance of Breeding Pigs", ensuring weighing accuracy (electronic scale accuracy 0.001kg) and data recording standardization, the results are as follows: Table 2

[0095] As shown in Table 2, the total milk production of sows in Examples 1-5 over 21 days is positively correlated with the average weight gain of piglets over 21 days: Example 3 had the highest total milk production, corresponding to the highest weight gain of piglets; Example 2 had the lowest total milk production, corresponding to the lowest weight gain of piglets. This indicates that the herbal promoter of the present invention directly provides sufficient milk to piglets by increasing the milk production of sows, thus promoting piglet growth and verifying the practical application value of the formula.

[0096] In Comparative Example 1, the sows had the lowest total milk production and piglet weight gain. The reason was the same as in Experiment 1: the absence of compound flavonoid nanoparticles and nano-selenium microcapsules led to insufficient milk production in sows, resulting in less milk intake for piglets. Furthermore, the synthesis of nutrients in milk (such as protein and lactose) was affected, further limiting piglet weight gain.

[0097] The total milk production and piglet weight gain of the sows in Comparative Example 2 were lower than those in the Example Group because the modification and morphology of the raw materials did not meet the standards: the efficacy of ordinary Astragalus polysaccharide and ordinary Pueraria lobata flavonoids was limited, the milk production of sows did not reach the optimal level, and the content of immune active substances (such as immunoglobulin promoting components derived from Astragalus polysaccharide) in milk was reduced, the immunity and growth vitality of piglets were weakened, and the weight gain rate was slowed down.

[0098] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine promoter for increasing milk production in sows, characterized in that, The components, by weight, are as follows: 18-22 parts modified Astragalus polysaccharide extract, 9-12 parts compound flavonoid nanoparticles, 7-9 parts Vaccaria selengensis extract, 6-7 parts Tetrapanax papyrifer extract, 3.8-4.5 parts plant-derived prebiotic complex, 0.8-1.2 parts xylooligosaccharides, 0.12-0.25 parts nano-selenium microcapsules, and 2.2-3.5 parts trehalose stabilizer.

2. The herbal medicine promoter according to claim 1, characterized in that, The modified Astragalus polysaccharide extract is prepared by mixing Astragalus polysaccharide with a 10%-15% citric acid solution at a solid-liquid ratio of 1:8-14, stirring and reacting at 58℃-65℃ for 2-3 hours, then adding 0.7wt%-1wt% of a compound enzyme for enzymatic hydrolysis for 1-1.5 hours, and finally obtaining the extract by vacuum freeze-drying. The compound enzyme is composed of cellulase and pectinase mixed in a 1:1 mass ratio; The vacuum freeze-drying parameters are a vacuum degree of 0.08MPa-0.1MPa and a temperature of -40℃ to -30℃.

3. The herbal medicine promoter according to claim 1, characterized in that, The preparation method of the composite flavonoid nanoparticles is as follows: kudzu root flavonoids and ginkgo leaf flavonoids are mixed at a mass ratio of 4:2-3, and a polyvinylpyrrolidone solution with a mass concentration of 5%-8% is added at a solid-liquid ratio of 1:10-1:

15. After being treated by a high-pressure homogenizer, the mixture is filtered through a nanomembrane to retain a molecular weight cutoff of 5000-8000, and then freeze-dried to obtain nanoparticles. The parameters for the high-pressure homogenizer are: pressure 80MPA-100MPA, cycle 3-5 times; The freeze-drying parameters are: temperature -50℃ to -45℃, vacuum degree 0.09MPA-0.1MPA.

4. The herbal medicine promoter according to claim 1, characterized in that, The preparation method of the Wangbuliuxing extract includes: Vaccaria seeds were extracted with microwave assistance, and the extract was purified by macroporous resin-8 with 70% ethanol as the eluent. Micro powder with a particle size ≤10μm was prepared by low-temperature spray drying; The microwave-assisted extraction parameters were 800W power, 50℃ temperature, and 20min time. The extraction solution was purified by macroporous resin-8 with the following parameters: sample volume ratio 1:5-8, elution flow rate 2 BV / h-3 BV / h; The parameters for low-temperature spray drying are: inlet air temperature 80℃ and outlet air temperature 40℃-45℃.

5. The herbal medicine promoter according to claim 1, characterized in that, The preparation method of the Tetrapanax papyrifer extract includes: The pith of Tetrapanax papyriferus was pulverized to 80 mesh, then mixed with 70% ethanol solution at a mass ratio of 1:10 for extraction. After filtration and spray drying, the product was obtained.

6. The herbal medicine promoter according to claim 1, characterized in that, The preparation method of the plant-derived prebiotic complex is as follows: Konjac oligosaccharide, kudzu powder and chicory inulin are mixed in a mass ratio of 2-3:1:1, and then 5%-8% of the total mass of deionized water is added. The mixture is stirred at 60℃-70℃ for 15-20 minutes, and then vacuum dried until the moisture content is ≤3%. The mixture is then pulverized and passed through an 80-mesh sieve to obtain the final product. Vacuum drying temperature: 50℃-60℃, vacuum degree: 0.07MPA-0.09MPA.

7. The herbal medicine promoter according to claim 1, characterized in that, The method for preparing the nano-selenium microcapsules is as follows: a sodium selenite solution with a concentration of 0.1 mol / L to 0.2 mol / L is mixed with a chitosan solution with a mass concentration of 1% to 2% at a volume ratio of 1:4 to 5, and 0.07% to 0.1% vitamin C is added as a reducing agent. The mixture is stirred and reacted at 30℃ to 40℃ for 1 to 2 hours, and then spray-dried to obtain microcapsules.

8. The herbal medicine promoter according to claim 1, characterized in that, The trehalose stabilizer is prepared by irradiating anhydrous trehalose with gamma rays, and the moisture content of the irradiated trehalose is ≤0.5%. The dose of gamma ray irradiation is 5 kGy-6 kGy, and the irradiation time is 2-3 hours.

9. A method for preparing a traditional Chinese medicine promoter for increasing milk production in sows as described in any one of claims 1-8, characterized in that, Includes the following steps: Step 1: Weigh each component according to the stated weight proportions; Step 2: Add the modified Astragalus polysaccharide extract, compound flavonoid nanoparticles, Vaccaria segetalis extract, and Tetrapanax papyrifer extract to a high-speed mixer and mix for 10-15 minutes at a temperature of 30℃-40℃ and a speed of 1500r / min-2000r / min until the material is uniform and free of lumps. Step 3: Add plant-derived prebiotic complex, xylooligosaccharide, nano-selenium microcapsules and trehalose stabilizer to the mixture obtained in Step 2, and continue mixing for 8 min-12 min at the above temperature and speed, until uniform and free of lumps; Step 4: The mixture obtained in Step 3 is subjected to ultrafine grinding using an air jet mill. The particle size of the material after grinding is controlled to be ≤5μm, thus obtaining the traditional Chinese medicine promoter.

10. The preparation method according to claim 8, characterized in that, In step 4, the ultrafine grinding pressure is 0.6MPA-0.8MPA, and the feeding rate is 12kg / h-15kg / h.

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