Corneal contact lens antibacterial coating, preparation method thereof and corneal contact lens

Abstract

The invention belongs to the technical field of biomedical engineering and optics, and particularly discloses a corneal contact lens antibacterial coating, a preparation method of the corneal contact lens antibacterial coating and a corneal contact lens. The antibacterial coating for the corneal contact lens is prepared from the following raw materials in parts by weight: 20 to 30 parts of phosphorylcholine, 15 to 25 parts of methacryloylethyl betaine, 5 to 8 parts of gallic acid, 3 to 5 parts of dimethylamino styrene, 10 to 15 parts of chitosan quaternary ammonium salt, 0.5 to 3 parts of cross-linking agent and 0.5 to 3 parts of initiator. The antibacterial coating for the corneal contact lens, prepared by the preparation method disclosed by the invention, has good biocompatibility and broad-spectrum antibacterial activity, and is excellent in antibacterial effect; core parameters such as the oxygen permeation amount and the contact angle of the corneal contact lens with the antibacterial coating can be guaranteed.

Description

Technical Field

[0001] This invention relates to the fields of biomedical engineering and optical technology, and in particular to an antibacterial coating for corneal contact lenses, a method for preparing the same, and a corneal contact lens. Background Technology

[0002] In the fields of ophthalmology and vision correction, corneal contact lenses (commonly known as contact lenses) have become the daily choice for hundreds of millions of people worldwide due to their portability and aesthetics. However, the problem of microbial infection caused by long-term wear has always been a major challenge in clinical practice.

[0003] Traditional contact lens materials such as hydroxyethyl methacrylate (HEMA) and silicone hydrogel offer good oxygen permeability and comfort, but their surface properties make them highly susceptible to adsorbing proteins, lipids, and microorganisms from tears, forming biofilms that become breeding grounds for bacteria (such as Pseudomonas aeruginosa and Staphylococcus aureus), fungi (such as Fusarium), and amoebae. Statistics show that approximately 40% of microbial keratitis cases are related to contact lens use, with Pseudomonas aeruginosa infection potentially leading to corneal stroma dissolution within 48 hours, causing irreversible vision damage.

[0004] Current solutions primarily rely on chemical disinfection with contact lens solutions (such as polyhexamethylene biguanide and hydrogen peroxide), but these solutions have two major drawbacks: first, the disinfectants decay rapidly over time, failing to provide long-term protection; second, frequent use may disrupt the ocular surface microenvironment, triggering toxic reactions or allergies. In recent years, antibacterial agents such as nano-silver have been attempted to be incorporated into the lens matrix, but they face challenges such as cytotoxicity caused by metal ion migration (e.g., silver ions leading to corneal epithelial apoptosis) or a narrow antibacterial spectrum. Meanwhile, physical modification techniques such as plasma treatment can introduce hydrophilic groups to the lens surface to reduce protein adhesion, but they cannot actively kill microorganisms. Furthermore, existing technologies often focus on a single antibacterial mechanism, making it difficult to address the multiple microbial threats in the complex ocular environment, and long-term wear and tear on the lens surface further weakens the coating's stability. More importantly, contact lenses must simultaneously meet core parameters such as oxygen permeability and contact angle; the introduction of functional coatings may affect these parameters.

[0005] Therefore, providing an antibacterial coating for corneal contact lenses and its preparation method, as well as a corneal contact lens that achieves spectral sterilization through multiple synergistic mechanisms while maintaining the original optical and mechanical properties of the lens, is a problem that urgently needs to be solved in this field. Summary of the Invention

[0006] In view of this, the present invention provides an antibacterial coating for corneal contact lenses and a method for preparing the same, as well as a corneal contact lens, to solve the problems that existing corneal contact lenses themselves do not have antibacterial or bacteriostatic functions, rely on contact lens solutions for bacteriostatic effects but cannot achieve long-term protection, and the problem that existing bacteriostatic methods have a narrow antibacterial spectrum.

[0007] To achieve the above objectives, the present invention adopts the following technical solution:

[0008] An antibacterial coating for corneal contact lenses, the raw materials for which are prepared comprise the following components in parts by weight:

[0009] 20-30 parts phosphorylcholine, 15-25 parts methacryloyl ethyl betaine, 5-8 parts gallic acid, 3-5 parts dimethylaminostyrene, 10-15 parts chitosan quaternary ammonium salt, 0.5-3 parts crosslinking agent, and 0.5-3 parts initiator.

[0010] Preferably, the degree of substitution of the chitosan quaternary ammonium salt is ≥85%.

[0011] Preferably, the crosslinking agent comprises one or more of ethylene glycol dimethacrylate, polyethylene glycol diglycidyl ether, and N,N'-methylenebisacrylamide.

[0012] Preferably, the initiator includes one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone, phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide, azobisisobutyronitrile, and benzoyl peroxide.

[0013] Another object of the present invention is to provide a method for preparing an antibacterial coating for corneal contact lenses, comprising the following steps:

[0014] 1) Dissolve phosphorycholine and methacrylethyl betaine in a buffer solution to obtain solution A;

[0015] Gallic acid and dimethylaminostyrene were dissolved in ethanol to obtain solution B;

[0016] 2) Mix solution A, solution B and chitosan quaternary ammonium salt, then add crosslinking agent and initiator to obtain antibacterial coating precursor solution;

[0017] 3) The substrate is impregnated and lifted in the antibacterial coating precursor solution, and then cured to obtain the antibacterial coating for corneal contact lenses.

[0018] Preferably, the mass concentration of phosphorycholine in solution A is 10-20%;

[0019] The pH value of the buffer solution is 7.2 to 7.5;

[0020] The mass concentration of dimethylaminostyrene in solution B is 1-5%.

[0021] Preferably, the lifting speed of the immersion-lifting process in step 2) is 0.3 to 0.8 mm / s;

[0022] The curing process includes photocuring and / or thermal curing.

[0023] Another object of the present invention is to provide a corneal contact lens, wherein the method for preparing the corneal contact lens includes the following steps:

[0024] The contact lens substrate is pretreated, then immersed in an antibacterial coating precursor solution for impregnation and lifting, and then cured to obtain a corneal contact lens;

[0025] The antibacterial coating precursor solution is the antibacterial coating precursor solution described above.

[0026] Preferably, the pretreatment is a sequential process of oxygen plasma treatment and dopamine-Tris impregnation treatment;

[0027] The contact lens substrate includes a silicone hydrogel corneal contact lens.

[0028] Preferably, the oxygen plasma treatment has a power of 80-100W and a duration of 4-6 minutes;

[0029] The concentration of the dopamine-Tris impregnation solution used in the dopamine-Tris impregnation treatment is 0.1–0.12 mol / L.

[0030] As can be seen from the above technical solution, compared with the prior art, the present invention has the following beneficial effects:

[0031] 1. This invention discloses the addition of phosphorylcholine and methacryloylethyl betaine. Phosphorylcholine has a cell membrane-mimicking structure, which can improve biocompatibility and permanently provide hydrophilicity, reducing protein adsorption. Methacrylethyl betaine has zwitterionic properties, which can achieve long-lasting antibacterial effect. The two work synergistically to form a zwitterionic surface, significantly reducing protein adsorption. Phosphorylcholine provides hydrophilicity, and methacryloylethyl betaine enhances the antibacterial adhesion ability. The cations of chitosan quaternary ammonium salt can also form a micro-electric field with the anionic region of methacryloylethyl betaine, enhancing the bacterial membrane penetration ability and achieving broad-spectrum and highly efficient antibacterial effect. The phenolic hydroxyl groups in gallic acid can provide antioxidant and broad-spectrum antibacterial activity. The positively charged quaternary ammonium groups in chitosan quaternary ammonium salt can interact with the negatively charged bacterial cell membrane, disrupting membrane integrity. In synergy with phosphorylcholine, it can also improve the biocompatibility of the coating.

[0032] 2. Phosphorylcholine can form a stable network structure with dimethylaminostyrene to fix the active ingredient. The phenolic hydroxyl groups in gallic acid can also form hydrogen bonds with the polymer chain to enhance the stability of the coating. The addition of crosslinking agents can build a three-dimensional network structure, which can improve the stability of the coating while ensuring oxygen permeability. Detailed Implementation

[0033] This invention provides an antibacterial coating for corneal contact lenses, the raw materials of which comprise the following components in parts by weight:

[0034] The formula consists of 20-30 parts phosphorycholine, 15-25 parts methacryloyl ethyl betaine, 5-8 parts gallic acid, 3-5 parts dimethylaminostyrene, 10-15 parts chitosan quaternary ammonium salt, 0.5-3 parts crosslinking agent, and 0.5-3 parts initiator. Under the above ratio, the specific amounts of phosphorycholine added can be 22, 24, 25, 26, or 28 parts; the specific amounts of methacryloyl ethyl betaine added can be 16, 18, 20, 22, or 24 parts; and the specific amounts of gallic acid added can be 5, 5.5, 6, 6.5, 7, 7.5, or 8 parts. The specific amounts of methylaminostyrene added can be 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, and 4.8 parts; the specific amounts of chitosan quaternary ammonium salt added can be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, and 15 parts; the specific amounts of crosslinking agent added can be 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, and 2.8 parts; and the specific amounts of initiator added can be 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, and 2.8 parts.

[0035] In this invention, the degree of substitution of the chitosan quaternary ammonium salt is ≥85%, specifically 86%, 87%, 88%, 89%, 90%, 92%, 94%, or 95%.

[0036] In this invention, the crosslinking agent includes one or more of ethylene glycol dimethacrylate, polyethylene glycol diglycidyl ether, and N,N'-methylenebisacrylamide.

[0037] In this invention, the initiator includes one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone, phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide, azobisisobutyronitrile, and benzoyl peroxide.

[0038] This invention also provides a method for preparing an antibacterial coating for corneal contact lenses, comprising the following steps:

[0039] 1) Dissolve phosphorycholine and methacryloylethyl betaine in buffer solution to obtain solution A; dissolve gallic acid and dimethylaminostyrene in ethanol to obtain solution B;

[0040] 2) Mix solution A, solution B and chitosan quaternary ammonium salt, then add crosslinking agent and initiator to obtain antibacterial coating precursor solution;

[0041] 3) The substrate is impregnated and lifted in the antibacterial coating precursor solution, and then cured to obtain the antibacterial coating for corneal contact lenses.

[0042] In this invention, the mass concentration of phosphorycholine in solution A is 10-20%, specifically 12%, 14%, 15%, 16%, or 18%.

[0043] In this invention, the pH value of the buffer solution is 7.2 to 7.5, specifically 7.2, 7.3, 7.4, or 7.5.

[0044] In this invention, the buffer solution in step 1) is preferably a PBS buffer solution.

[0045] In this invention, the mass concentration of dimethylaminostyrene in solution B is 1-5%, specifically 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, or 4.5%.

[0046] In this invention, the lifting speed of the immersion-lifting process in step 2) is 0.3 to 0.8 mm / s, specifically 0.4 mm / s, 0.5 mm / s, 0.6 mm / s, or 0.7 mm / s.

[0047] In this invention, the curing includes photocuring and / or thermal curing.

[0048] The present invention also provides a corneal contact lens, the preparation method of which includes the following steps:

[0049] The contact lens substrate is pretreated, then immersed in an antibacterial coating precursor solution for impregnation and lifting, and then cured to obtain a corneal contact lens.

[0050] The antibacterial coating precursor solution is the antibacterial coating precursor solution described above.

[0051] In this invention, the pretreatment consists of sequential oxygen plasma treatment and dopamine-Tris impregnation treatment.

[0052] In this invention, the contact lens substrate includes a silicone hydrogel corneal contact lens.

[0053] In this invention, the power of the oxygen plasma treatment is 80-100W, specifically 82W, 85W, 88W, 90W, 92W, 95W, or 98W; the time is 4-6 minutes, specifically 4.2 minutes, 4.5 minutes, 4.8 minutes, 5 minutes, 5.2 minutes, 5.5 minutes, or 5.8 minutes.

[0054] In this invention, the concentration of the dopamine-Tris impregnation solution is 0.1 to 0.12 mol / L, specifically 0.1 mol / L, 0.11 mol / L, or 0.12 mol / L.

[0055] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0056] Example 1

[0057] Preparation of antibacterial coating precursor solution:

[0058] 22 parts of phosphorycholine and 18 parts of methacryloyl ethyl betaine were dissolved in PBS buffer (phosphorycholine mass concentration was 15%) at 40°C and stirred thoroughly for 2 hours to obtain an aqueous solution.

[0059] Six parts gallic acid and four parts dimethylaminostyrene were dissolved in ethanol at 40°C (the mass concentration of dimethylaminostyrene was 3%) to obtain an organic phase solution.

[0060] The aqueous and organic phase solutions were then mixed, and 12 parts of chitosan quaternary ammonium salt (85% substitution degree) were added. Then, 1 part of crosslinking agent ethylene glycol dimethacrylate and 0.8 parts of initiator 2-hydroxy-2-methyl-1-phenyl-1-propanone were added. The mixture was ultrasonically dispersed for 30 min to obtain the antibacterial coating precursor solution.

[0061] Preparation of corneal contact lenses with antibacterial coating:

[0062] Silicone hydrogel corneal contact lenses were treated with oxygen plasma at 100W for 5 minutes, and then immersed in a 0.1mol / L dopamine-Tris solution to form a transition layer.

[0063] The treated silicone hydrogel corneal contact lens was dipped and pulled in the antibacterial coating precursor solution at a speed of 0.5 mm / s using the dip-pull method to form a uniform liquid film on the lens surface. It was then placed under 365 nm ultraviolet light for photoinitiated curing (curing time was 1.5 min). After ultraviolet curing, it was placed at 60 °C for heat curing for 1 hour. After heat curing, unreacted monomers were removed by rinsing with physiological saline. After vacuum drying, a corneal contact lens with a stable antibacterial coating was obtained.

[0064] Example 2

[0065] Preparation of antibacterial coating precursor solution:

[0066] 26 parts of phosphorycholine and 22 parts of methacryloyl ethyl betaine were dissolved in PBS buffer (phosphorycholine mass concentration was 15%) at 40°C and stirred thoroughly for 2 hours to obtain an aqueous solution.

[0067] Eight parts gallic acid and five parts dimethylaminostyrene were dissolved in ethanol at 40°C (the mass concentration of dimethylaminostyrene was 5%) to obtain an organic phase solution.

[0068] The aqueous and organic phase solutions were then mixed, and 12 parts of chitosan quaternary ammonium salt (85% substitution degree) were added. Then, 1.2 parts of crosslinking agent ethylene glycol dimethacrylate and 1.2 parts of initiator 2-hydroxy-2-methyl-1-phenyl-1-propanone were added. The mixture was ultrasonically dispersed for 30 min to obtain the antibacterial coating precursor solution.

[0069] Preparation of corneal contact lenses with antibacterial coating:

[0070] Silicone hydrogel corneal contact lenses were treated with oxygen plasma at 100W for 5 minutes, and then immersed in a 0.1mol / L dopamine-Tris solution to form a transition layer.

[0071] The treated silicone hydrogel corneal contact lens was dipped and pulled in the antibacterial coating precursor solution at a speed of 0.5 mm / s using the dip-pull method to form a uniform liquid film on the lens surface. It was then placed under 365 nm ultraviolet light for photoinitiated curing (curing time was 1.5 min). After ultraviolet curing, it was placed at 60 °C for heat curing for 1 hour. After heat curing, unreacted monomers were removed by rinsing with physiological saline. After vacuum drying, a corneal contact lens with a stable antibacterial coating was obtained.

[0072] Example 3

[0073] Preparation of antibacterial coating precursor solution:

[0074] 30 parts of phosphorycholine and 25 parts of methacryloyl ethyl betaine were dissolved in PBS buffer (phosphorycholine mass concentration was 15%) at 40°C and stirred thoroughly for 2 hours to obtain an aqueous solution.

[0075] Eight parts gallic acid and three parts dimethylaminostyrene were dissolved in ethanol at 40°C (the mass concentration of dimethylaminostyrene was 3%) to obtain an organic phase solution.

[0076] The aqueous and organic phase solutions were then mixed, and 15 parts of chitosan quaternary ammonium salt (88% substitution degree) were added. Then, 2 parts of crosslinking agent polyethylene glycol diglycidyl ether and 1.5 parts of initiator 2-hydroxy-2-methyl-1-phenyl-1-propanone were added. The mixture was ultrasonically dispersed for 30 min to obtain the antibacterial coating precursor solution.

[0077] Preparation of corneal contact lenses with antibacterial coating:

[0078] The silicone hydrogel corneal contact lens was treated with oxygen plasma at 100W for 5 minutes, and then immersed in a dopamine-Tris solution with a concentration of 0.12mol / L to form a transition layer.

[0079] The treated silicone hydrogel corneal contact lens was dipped and pulled in an antibacterial coating precursor solution at a speed of 0.6 mm / s using an immersion-lift method to form a uniform liquid film on the lens surface. It was then subjected to photoinitiated curing under 365 nm ultraviolet light (curing time was 1.5 min). After ultraviolet curing, it was subjected to thermal curing at 60 °C for 1 hour. After thermal curing, unreacted monomers were removed by rinsing with physiological saline. After vacuum drying, a corneal contact lens with a stable antibacterial coating was obtained.

[0080] Example 4

[0081] Preparation of antibacterial coating precursor solution:

[0082] 25 parts of phosphorycholine and 15 parts of methacryloyl ethyl betaine were dissolved in PBS buffer (phosphorycholine mass concentration was 15%) at 40°C and stirred thoroughly for 2 hours to obtain an aqueous solution.

[0083] Six parts gallic acid and three parts dimethylaminostyrene were dissolved in ethanol at 40°C (the mass concentration of dimethylaminostyrene was 2%) to obtain an organic phase solution.

[0084] The aqueous and organic phase solutions were then mixed, and 11 parts of chitosan quaternary ammonium salt (86% substitution degree) were added. Then, 1.5 parts of crosslinking agent ethylene glycol dimethacrylate and 0.5 parts of initiator 2-hydroxy-2-methyl-1-phenyl-1-propanone were added. The mixture was ultrasonically dispersed for 30 min to obtain the antibacterial coating precursor solution.

[0085] Preparation of corneal contact lenses with antibacterial coating:

[0086] Silicone hydrogel corneal contact lenses were treated with oxygen plasma at 80W for 6 minutes, and then immersed in a 0.1mol / L dopamine-Tris solution to form a transition layer.

[0087] The treated silicone hydrogel corneal contact lens was dipped and pulled in the antibacterial coating precursor solution at a speed of 0.5 mm / s using the dip-pull method to form a uniform liquid film on the lens surface. It was then placed under 365 nm ultraviolet light for photoinitiated curing (curing time was 1.5 min). After ultraviolet curing, it was placed at 60 °C for heat curing for 1 hour. After heat curing, unreacted monomers were removed by rinsing with physiological saline. After vacuum drying, a corneal contact lens with a stable antibacterial coating was obtained.

[0088] Experimental Example 1

[0089] The corneal contact lenses obtained in Examples 1-4 and the untreated silicone hydrogel corneal contact lenses were tested for antibacterial coating thickness, antibacterial properties, cytotoxicity, oxygen permeability, and contact angle. The test results are shown in Table 1.

[0090] Test method:

[0091] The coating thickness is based on the standard GB / T 11417.6 (the center thickness is measured by a thickness gauge, and the coating thickness before and after the coating is tested and calculated).

[0092] The antibacterial rate is referenced from the "Disinfection Technical Specifications";

[0093] Cytotoxicity testing was conducted according to standard GB / T 16886.5-2017.

[0094] The oxygen permeability test is based on the standard GB / T 11417.7-2012, section 4.4.3, polarographic method.

[0095] The contact angle test is conducted according to the standard GB / T 11417.7-2012.

[0096] Table 1. Relevant Test Results

[0097]

[0098] As shown in Table 1, the corneal contact lens with an antibacterial coating prepared according to this invention exhibits excellent antibacterial and bacteriostatic properties, demonstrating good antibacterial effects against various types of bacteria and possessing broad-spectrum efficacy. The oxygen permeability of the corneal contact lens prepared according to this invention remains above 90% of that of the original lens, the contact angle also meets relevant requirements, and it is non-cytotoxic, thus fulfilling the relevant requirements for corneal contact lenses.

[0099] To simulate the real human eye environment, the corneal contact lenses obtained in Examples 1-4 were worn for one week and one month, and their antibacterial rate was tested again to verify their long-term antibacterial ability. The test results are shown in Table 2.

[0100] Table 2. Relationship between antibacterial rate and wearing time

[0101]

[0102] As shown in Table 2, the corneal contact lens with antibacterial coating prepared by this invention has a long-lasting antibacterial effect, specifically: initially it exhibits high antibacterial activity, rapidly killing pathogens and preventing infection; in the middle stage, it provides sustained release, balancing antibacterial performance and coating durability; and in the long term, it is effective, ensuring safety for long-term use. Even after one month, the antibacterial rate can still reach more than 90%, which can meet the antibacterial requirements of monthly disposable lenses.

[0103] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0104] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An antibacterial coating for corneal contact lenses, characterized in that, Its preparation raw materials contain the following components in parts by mass: 20-30 parts phosphorylcholine, 15-25 parts methacryloyl ethyl betaine, 5-8 parts gallic acid, 3-5 parts dimethylaminostyrene, 10-15 parts chitosan quaternary ammonium salt, 0.5-3 parts crosslinking agent, and 0.5-3 parts initiator.

2. The antibacterial coating for a corneal contact lens according to claim 1, characterized in that, The degree of substitution of the chitosan quaternary ammonium salt is ≥85%.

3. The antibacterial coating for a corneal contact lens according to claim 2, characterized in that, The crosslinking agent includes one or more of ethylene glycol dimethacrylate, polyethylene glycol diglycidyl ether, and N,N'-methylenebisacrylamide.

4. The antibacterial coating for corneal contact lenses according to any one of claims 1 to 3, characterized in that, The initiator includes one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone, phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide, azobisisobutyronitrile, and benzoyl peroxide.

5. A method for preparing an antibacterial coating for a corneal contact lens according to any one of claims 1 to 4, characterized in that, Includes the following steps: 1) Dissolve phosphorycholine and methacrylethyl betaine in a buffer solution to obtain solution A; Gallic acid and dimethylaminostyrene were dissolved in ethanol to obtain solution B; 2) Mix solution A, solution B and chitosan quaternary ammonium salt, then add crosslinking agent and initiator to obtain antibacterial coating precursor solution; 3) The substrate is impregnated and lifted in the antibacterial coating precursor solution, and then cured to obtain the antibacterial coating for corneal contact lenses.

6. The method for preparing an antibacterial coating for a corneal contact lens according to claim 5, characterized in that, The mass concentration of phosphorycholine in solution A is 10-20%; The pH value of the buffer solution is 7.2 to 7.5; The mass concentration of dimethylaminostyrene in solution B is 1-5%.

7. The method for preparing an antibacterial coating for a corneal contact lens according to claim 6, characterized in that, The lifting speed of the immersion-lifting process described in step 2) is 0.3–0.8 mm / s; The curing process includes photocuring and / or thermal curing.

8. A corneal contact lens, characterized in that, The method for preparing the corneal contact lens includes the following steps: The contact lens substrate is pretreated, then immersed in an antibacterial coating precursor solution for impregnation and lifting, and then cured to obtain a corneal contact lens; The antibacterial coating precursor solution is the antibacterial coating precursor solution according to any one of claims 5 to 7.

9. A corneal contact lens according to claim 8, characterized in that, The pretreatment consists of sequential oxygen plasma treatment and dopamine-Tris impregnation treatment. The contact lens substrate includes a silicone hydrogel corneal contact lens.

10. A corneal contact lens according to claim 9, characterized in that, The oxygen plasma treatment has a power of 80-100W and a duration of 4-6 minutes; The concentration of the dopamine-Tris impregnation solution used in the dopamine-Tris impregnation treatment is 0.1–0.12 mol / L.

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