Cream for massage and preparation method and application thereof

Abstract

The invention relates to the technical field of massage cream, in particular to cream for massage as well as a preparation method and application thereof, and the cream comprises the following components in parts by weight: 50-60 parts of basic matrix and 40-50 parts of traditional Chinese medicine ingredients, wherein the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10-20 parts of flos carthami, 10-20 parts of peach kernels, 5-10 parts of frankincense, 5-10 parts of myrrh, 10-15 parts of salvia chinensis, 10-15 parts of radix angelicae sinensis, 10-15 parts of herba violae, 5-10 parts of costus roots, 5-10 parts of cassia twigs, 3-8 parts of radix aconiti lateralis preparata, 1-3 parts of herba asari, 1-3 parts of semen momordicae, 10-15 parts of spica prunellae, 1-3 parts of camphor and 1-3 parts of borneol. According to the massage cream provided by the invention, the synergistic effect of the efficacy of traditional Chinese medicines and massage manipulation is utilized, so that a'synergist 'and a'targeted drug delivery system' are formed; through transdermal absorption of the medicine, under the help of massage physical stimulation, the medicine accurately acts on a focus part, the core curative effect of a traditional Chinese medicine formula is remarkably enhanced, the massage treatment effect is greatly improved, and the application range is greatly widened.

Description

Technical Field

[0001] This invention belongs to the field of massage cream technology, specifically relating to a massage cream, its preparation method, and its application. Background Technology

[0002] Massage cream is a topical ointment specifically designed for massage and manipulation. It combines various beneficial ingredients to provide lubrication during the massage process while offering certain health and therapeutic benefits. It is widely used in massage and manipulation procedures, suitable for professional massage therapists to perform relaxation and therapeutic massages for clients, and can also be used for personal self-massage. It is commonly found in health massage parlors, rehabilitation centers, and home healthcare settings.

[0003] Massage creams typically contain lubricating and functional ingredients. The lubricating component, also known as the base matrix, generally has good occlusive and lubricating properties, forming a protective film on the skin surface. This reduces friction between the skin and hands during massage, making the massage smoother and preventing moisture loss, keeping the skin soft and smooth. The functional ingredients usually include plant extracts or traditional Chinese medicine components. Different functional ingredients can be formulated according to different massage needs. For example, lavender extract has a soothing and relaxing effect, relieving muscle tension and anxiety; peppermint extract has a cooling sensation, reducing muscle pain and inflammation, and also refreshing the mind; frankincense and myrrh have blood-activating and stasis-removing effects, promoting blood circulation and relieving muscle fatigue and soreness; Panax notoginseng extract can reduce swelling and relieve pain, providing some relief for pain caused by sprains, strains, and other injuries. However, existing massage creams containing traditional Chinese medicine components still rely heavily on massage during use, making it difficult to fully utilize the efficacy of the herbal ingredients and achieve a synergistic effect between the two in treating myofascial pain syndromes. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a massage cream, its preparation method, and its application. The massage cream utilizes the synergistic effect of traditional Chinese medicine efficacy and massage techniques to form a "synergist" and a "targeted drug delivery system." Through transdermal absorption of the drug, aided by the physical stimulation of massage, it precisely targets the affected area, significantly enhancing core therapeutic effects such as promoting blood circulation, removing blood stasis, clearing meridians, relieving pain, clearing heat and toxins, cooling blood and reducing swelling, and dispelling cold pathogens. This greatly improves the effectiveness and applicability of massage therapy. This invention, through the practical application of the theories of "treating internal diseases externally" and "meridian drug delivery" in traditional Chinese medicine, enhances the patient experience and promotes the development of massage therapy, possessing significant clinical value and significance. Furthermore, animal experiments have verified the significant therapeutic effect of the massage cream combined with ointment massage therapy on soft tissue injuries.

[0005] Specifically, the first aspect of the present invention provides a massage cream containing the following components in parts by weight: 50-60 parts of a base matrix and 40-50 parts of traditional Chinese medicine ingredients; wherein the traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition: safflower, peach kernel, frankincense, myrrh, *Heliotropium indicum*, angelica sinensis tail, *Viola yedoensis*, costus root, cinnamon twig, prepared aconite root, asarum, momordica cochinchinensis, prunella vulgaris, camphor, and borneol.

[0006] In Traditional Chinese Medicine (TCM), soft tissue injuries fall under the category of "tendon injury." Damage to tendons, bones, muscles, and blood vessels leads to the accumulation of blood outside the vessels, resulting in hematomas, fever, and limited mobility. The *Nan Jing* (Classic of Difficult Issues) states, "Qi governs warmth, blood governs nourishment." Internal TCM treatments invigorate Yang Qi and promote the circulation of Qi and blood, while external TCM treatments directly relieve local pain and improve blood flow. Acupuncture and massage open the meridians, regulate Qi, remove blood stasis, and promote new tissue regeneration to achieve therapeutic effects. Modern TCM theory often uses the principles of promoting blood circulation, removing blood stasis, regulating Qi, and relieving pain as its basic treatment principles. Furthermore, external "tendon injuries" are often accompanied by external pathogenic factors (such as wind, cold, dampness, heat, dryness, fire, and fire) and constitutional deficiency, manifesting as a mixture of cold and heat, with underlying deficiency and superficial excess. This means there is both heat-related pathogenic factors such as heat toxicity and blood heat, as well as the pathological basis of cold stagnation or insufficient Yang Qi. Therefore, the design principle of the medicinal ingredients in this invention is based on the basic treatment principles of "tendon injury" in traditional Chinese medicine. It also considers symptoms of heat evil caused by blood stasis transforming into heat, external invasion of heat toxins, and blood stasis, thus supplementing treatment with heat-clearing and detoxifying, blood-cooling and swelling-reducing herbs. Furthermore, it considers symptoms of deficiency / cold evil caused by external invasion of cold evil (cold-dampness), deficiency of yang qi, and cold coagulation and blood stasis, thus adding herbs that invigorate yang qi and dispel cold evil, ultimately forming the medicinal massage cream provided by this invention. This medicinal cream, combined with massage techniques, quickly assists the various herbs to penetrate the skin and reach the deep layers of the musculoskeletal membrane directly to the lesion by massaging muscles and tendons. Simultaneously, the traction effect on local muscles can accelerate local blood circulation.

[0007] Specifically, the compatibility significance of the herbal cream provided by this invention is as follows: The principal herbs are safflower and peach kernel, which work synergistically to achieve the effect of promoting blood circulation and removing blood stasis; frankincense, myrrh, *Hemiptera japonica*, and angelica sinensis tail are the assistant herbs. Among them, frankincense and myrrh, when combined, can promote qi circulation, reduce swelling, and relieve pain; *Hemiptera japonica* and angelica sinensis tail, when combined, can enhance the effects of promoting blood circulation, removing blood stasis, detoxifying, and relieving pain; Viola yedoensis, costus root, cinnamon twig, prepared aconite root, and asarum are the adjuvant herbs. Viola yedoensis excels at clearing heat toxins, cooling blood, and reducing swelling; costus root excels at promoting qi circulation, relieving stagnation, and eliminating distension. The combination of these two herbs can clear heat toxins. The combination of cinnamon twig, prepared aconite root, and asarum can help yang qi, warm the meridians, and dispel cold and relieve pain, thereby achieving the effect of invigorating yang qi and dispelling cold pathogens. Momordica cochinchinensis, prunella vulgaris, camphor, and borneol are the guiding herbs. Among them, Momordica cochinchinensis can enhance the effects of clearing heat and detoxifying, reducing swelling and relieving pain in the formula, while prunella vulgaris can further cooperate with Momordica cochinchinensis to disperse nodules. Camphor has a strong penetrating property to guide the medicine through the skin, while borneol can help the medicine penetrate through the skin to the deep layer of the muscle membrane and reach the lesion directly, so as to achieve the purpose of eliminating the root cause from the surface.

[0008] Safflower: Properties: Pungent, warm. Channels entered: Heart and Liver. Safflower is mainly used externally to promote blood circulation, remove blood stasis, reduce swelling, and relieve pain. It is commonly used in the following situations: Traumatic injuries, swelling and pain: Safflower can promote local blood circulation, dissipate blood stasis, and relieve swelling and pain. It can be used alone, ground into powder, mixed with wine or vinegar for application, or combined with Angelica sinensis, Ligusticum chuanxiong, frankincense, etc., to make a decoction for external washing or wet compress, or made into safflower oil, safflower tincture, etc. for external application to the affected area (such as the common "safflower oil" which uses safflower as its main ingredient). Sores, swelling and pain, skin ecchymosis: For sores in their early stages, local redness, swelling, heat and pain (belonging to the category of blood stasis and heat accumulation), or ecchymosis that does not dissipate after trauma, safflower can be used externally to promote blood circulation, reduce swelling, and promote the absorption of ecchymosis. It is often used externally in combination with heat-clearing and detoxifying drugs (such as dandelion and forsythia). For rheumatic pain and meridian contracture: Safflower is pungent and warm, and can dredge the meridians and relieve joint pain and difficulty in bending and stretching caused by rheumatic obstruction and poor blood circulation. It can be decocted for fumigation and washing or used externally with warming and cold-dispersing herbs such as mugwort and ginger.

[0009] Peach kernel: Properties: Bitter, sweet, neutral; slightly toxic. Channels entered: Heart, Liver, Large Intestine. External effects: Peach kernel is mainly used externally to promote blood circulation, remove blood stasis, reduce swelling and relieve pain. It can also disperse nodules and reduce swelling. It is suitable for traumatic swelling and pain, sores and carbuncles caused by blood stasis. For traumatic injuries and swelling due to blood stasis: Peach kernel can be crushed, mixed with rice wine and applied to the affected area, or combined with blood-activating herbs such as safflower, angelica, and red peony root to make powder or ointment for external application to enhance the effect of dispersing blood stasis and reducing swelling (e.g., in "Qianjin Fang" it is used with rhubarb and angelica to treat traumatic injuries with blood stasis). For sores and carbuncles caused by blood stasis and heat toxins (such as early-stage mastitis and lung abscess), peach kernel can be crushed and applied alone, or combined with heat-clearing and detoxifying herbs (such as honeysuckle and forsythia) for external application to help reduce swelling and drain pus by promoting blood circulation and removing blood stasis.

[0010] Frankincense: Properties: Pungent, bitter, warm. Channels entered: Heart, Liver, Spleen. External uses: Frankincense is used externally primarily to promote blood circulation, relieve pain, reduce swelling, and promote tissue regeneration. It is widely used in surgery, traumatology, and dermatology for various conditions: For traumatic injuries, bruises, and fractures: Frankincense's pungent and penetrating properties promote blood circulation, regulate qi, and relieve pain, making it an essential medicine in traumatology. It is often combined with myrrh (e.g., "Hai Fu San"), ground into powder and applied topically or made into plasters for traumatic injuries, bruises, swelling, pain, and fractures, promoting the dissipation of blood stasis and relieving pain. For sores and ulcers that are slow to heal: For initial redness, swelling, heat, and pain in sores and carbuncles, external application can promote blood circulation, reduce swelling, and relieve pain. It is often combined with honeysuckle, forsythia, and angelica to clear heat and detoxify. For ulcers with thin, clear pus that are slow to heal, frankincense can promote tissue regeneration and wound healing. It is often combined with myrrh, dragon's blood, and catechu (e.g., "Sheng Ji San") to promote wound healing. Rheumatic pain and numbness of limbs: Its pungent and warm properties can promote blood circulation, dispel wind and relieve pain. When used externally, it can relieve joint swelling and pain and difficulty in flexion and extension caused by rheumatic obstruction of the meridians. It is often combined with other rheumatic drugs such as Angelica pubescens and Clematis chinensis to make plasters or medicinal wines for external application.

[0011] Myrrh: Properties: pungent, bitter, neutral. Channels entered: Heart, Liver, Spleen. External effects: Myrrh has the effects of promoting blood circulation, relieving pain, reducing swelling, and promoting tissue regeneration. It is often used for the following conditions: Sores and ulcers with swelling and pain, and slow healing after ulceration: Myrrh can promote blood circulation, reduce swelling, and promote tissue regeneration and wound healing. It is suitable for carbuncles and boils with initial redness, swelling, heat, and pain, or ulcers with oozing pus and slow healing. It is often combined with frankincense (such as Hai Fu San in *Surgical Elucidation*), ground into powder and sprinkled externally or mixed into a paste to enhance the effects of reducing swelling and promoting tissue regeneration. Traumatic injuries, bruises, swelling, and pain: External use can promote the dissipation of blood stasis and relieve local swelling and pain. It is often used for sprains, bruises, and muscle and bone injuries. It can be used alone as a powder and mixed into a paste, or combined with blood-activating herbs such as safflower and peach kernel. In modern times, it is also used to treat certain skin diseases (such as eczema and tinea), taking advantage of its effects of promoting blood circulation, reducing swelling, drying dampness, and promoting wound healing, but it needs to be used in combination with other drugs.

[0012] *Hemiberlesia lingua* (Stone-leaved Amaranth): Properties: Bitter, pungent, slightly cold. Channels: Liver and Spleen. External Use: Clears heat and detoxifies, reduces swelling and relieves pain. Primarily used externally for carbuncles, boils, and swelling caused by heat toxins, snake bites, and bruises and pain from falls and injuries. Fresh amaranth can be crushed and applied externally, or decocted for fumigation and washing of the affected area to clear heat toxins, reduce swelling, and relieve pain.

[0013] Angelica sinensis tail: Taste and properties: Sweet and pungent, warm in nature. Meridian tropism: Liver, Heart, and Spleen meridians. External applications: Angelica sinensis tail refers to the tail of the branch root of Angelica sinensis. Its effects are primarily to invigorate blood circulation, remove blood stasis, reduce swelling, and relieve pain. Externally, it is mainly used for local swelling and pain, sores, and other conditions caused by blood stasis. Specific applications are as follows: For traumatic injuries with blood stasis and swelling: Angelica sinensis tail can invigorate blood circulation, remove blood stasis, reduce swelling, and relieve pain. It can be used alone as a decoction for external washing, or combined with blood-activating herbs such as safflower, peach kernel, frankincense, and myrrh, mashed and applied externally to promote the dissipation of blood stasis and relieve pain. For early-stage sores with redness, swelling, heat, and pain: For early-stage sores and carbuncles with local blood stasis and swelling, it can be combined with heat-clearing and detoxifying herbs for a decoction for wet compress, or made into an ointment for external application to invigorate blood circulation, reduce swelling, disperse nodules, and relieve pain. For skin diseases caused by blood stasis: Such as blood stasis type eczema and nodular erythema, it can improve local blood circulation and relieve symptoms of stasis by invigorating blood circulation and removing blood stasis.

[0014] Viola yedoensis: Properties: Bitter, pungent, cold. Channels entered: Heart and Liver channels. External use effects: Viola yedoensis is bitter and cold in nature, clearing heat and purging stagnation. It primarily enters the Heart Meridian (the Heart governs blood vessels, and sores are often related to blood heat and heat toxins) and the Liver Meridian (the Liver governs the free flow of Qi, and the stagnation of heat toxins easily leads to swelling and toxicity). Externally, it has the effects of clearing heat and detoxifying, cooling blood and reducing swelling, and is especially effective in treating sores and toxicities caused by intense heat toxins, making it a "key medicine for treating boils and carbuncles." Specific applications include: boils and carbuncles: For boils caused by the accumulation of heat toxins (manifested as local redness, swelling, heat, pain, and a deep, hard root like a nail), fresh Viola yedoensis can be crushed and applied externally alone, or combined with heat-clearing and detoxifying herbs such as dandelion and honeysuckle to enhance its ability to reduce swelling and dissipate nodules. Early stages of mastitis and appendicitis: For early stages of mastitis (acute mastitis) with redness, swelling, heat, and pain, or early stages of appendicitis with abdominal pain and tenderness upon palpation, and signs of heat toxicity, fresh herbs can be mashed and applied to the affected area (for mastitis, apply to the red and swollen area of ​​the breast; for appendicitis, apply around the navel or the painful area) to help relieve local redness, swelling, heat, and pain. Erysipelas and skin redness, swelling, heat, and pain: For erysipelas (sudden reddening of the skin in patches, resembling cinnabar) caused by heat toxicity, or other heat toxicity skin diseases (such as cellulitis), a decoction of Viola yedoensis can be used for external washing or wet compresses to clear heat, cool the blood, and reduce redness and swelling.

[0015] Costus root (Guangmuxiang): Pungent, bitter, and warm in nature. It enters the spleen, stomach, large intestine, gallbladder, and triple burner meridians. It has the effects of promoting qi circulation, dispelling cold, and relieving pain. It can be used for pain caused by cold stagnation of qi. Externally, it can penetrate the skin and meridians, unblock local qi flow, dispel cold pathogens, and relieve pain caused by cold stagnation of qi. It also has the effects of promoting blood circulation, reducing swelling, and relieving pain. It can be used for traumatic injuries, carbuncles, and boils. Externally, it can promote local blood circulation, dispel stagnation, and thus relieve swelling and pain.

[0016] Cinnamon Twig: Properties: Pungent, sweet, warm. Channels Entered: Heart, Lung, Bladder. External Use: Cinnamon twig, when used externally, warms and unblocks the channels, dispels cold and relieves pain. It is mainly suitable for the following conditions: Wind-cold-dampness arthralgia, joint pain: Cinnamon twig is pungent and warm, dispels cold, warms and unblocks the channels, and removes wind-cold-dampness. Early stage of chilblains, local swelling and pain: For chilblains caused by cold stagnation and blood stasis (without ulceration), cinnamon twig can dispel cold, unblock the channels, and promote local blood circulation. It can be used alone as a decoction for external washing, or combined with other Chinese medicines to enhance the effect of dispelling cold and reduce redness, swelling and pain.

[0017] Prepared Aconite: Pungent and sweet in nature, very hot; toxic. Meridian Tropism: Enters the Heart, Kidney, and Spleen meridians. External Use Efficacy: Disperses cold and relieves pain, warms the meridians and unblocks collaterals: Primarily used for cold-dampness arthralgia (such as rheumatoid arthritis, severe cold pain in joints), carbuncles and boils (such as gangrene, chronic frostbite), and local cold pain caused by Yang deficiency and cold stagnation. It can be ground into powder and applied topically or decocted for fumigation and washing, relieving symptoms by warming Yang, dispersing cold, unblocking meridians, and relieving pain. Resuscitating Yang and Reversing Collapse: For cold extremities and weak pulse caused by Yang deficiency, it can be used in conjunction with internal medications, with the external application of prepared aconite powder absorbed through the skin to assist in resuscitating Yang and reversing collapse.

[0018] Asarum: Properties: Pungent, warm; slightly toxic. Channels entered: Lung, Kidney, Heart. External effects: Dispels wind and cold, clears nasal passages and relieves pain: Headache, toothache: Grind into powder and apply topically or insert into the nose to relieve headache and toothache caused by wind and cold (such as toothache caused by cavities), clearing nasal passages and relieving pain through its pungent and aromatic properties. Nasal congestion and runny nose: Combined with other drugs to make Nasal Congestion Powder, etc., for external use as a nasal plug to improve nasal congestion caused by wind and cold and sinusitis. Warming the lungs and resolving phlegm (external adjunctive use): Used for cough and asthma caused by cold phlegm, it can be combined with fresh ginger, etc., mashed and applied to the Lung Shu acupoint to assist in warming the lungs, dispelling cold and resolving phlegm.

[0019] Momordica cochinchinensis seed: Bitter and slightly sweet in taste, cool in nature. It enters the liver, spleen, and stomach meridians. Momordica cochinchinensis seed has a strong detoxifying effect and can be used to treat various surgical conditions such as sores, boils, scrofula, and mastitis. In some ancient prescriptions for treating sores and boils, Momordica cochinchinensis seed is often used in combination with other heat-clearing, detoxifying, swelling-reducing, and pain-relieving drugs to enhance efficacy and promote the dissipation of sores. It can also reduce swelling and dissipate nodules, and has a certain therapeutic effect on bruises and swelling caused by falls and injuries, as well as phlegm nodules.

[0020] Prunella vulgaris: Properties: pungent, bitter, cold. Channels entered: Liver and Gallbladder channels. External effects: Prunella vulgaris has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules when used externally. It is mainly used for the following conditions: Sores and carbuncles, mastitis: Prunella vulgaris can be decocted alone for external washing, or mashed and applied externally to the affected area. Its bitter and cold properties can clear local heat toxins and relieve redness, swelling, heat and pain. Scrofula, phlegm nodules (such as cervical lymph node tuberculosis, subcutaneous lumps): External application (such as decoction for fumigation or combined with other nodule-dissipating drugs for external application) can promote the dissipation of lumps caused by phlegm and fire stagnation.

[0021] Camphor: Properties: Pungent, hot; toxic. Channels entered: Heart and Spleen channels. External effects: Camphor has the effects of dehumidifying, killing insects, warming and relieving pain, and opening the orifices and dispelling foulness. It is mainly used for the following conditions: Scabies and itching, eczema and ulceration: Camphor is pungent and hot, and can dehumidify, kill insects, and relieve itching. It is a commonly used medicine for treating scabies. It can be mixed with sulfur, alum, etc., ground into powder and applied topically, or made into a tincture for external application, such as "Camphor Powder" in "Orthodox Manual of Surgery". Toothache and traumatic injuries: This product is pungent and hot, and can warm and unblock the meridians, dispel cold and relieve pain. For toothache caused by cavities, it can be used alone or mixed with pepper, asarum, etc., ground into powder and stuffed into the cavity; for traumatic injuries, swelling and pain due to blood stasis, it can be mixed with frankincense, myrrh and other blood-activating and pain-relieving medicines, and applied to the affected area with wine. Abdominal pain due to heatstroke, sudden fainting: Camphor is pungent and aromatic, and has the effects of opening the orifices and waking the mind, and dispelling foulness and turbidity. For external use, it can be used for acute symptoms such as abdominal distension, vomiting, diarrhea, and coma caused by exposure to cold, dampness, and foul air. It is often combined with musk, borneol, etc. to make pills or nasal inhalers. As recorded in "Ben Cao Zheng Yi", it "opens the orifices and relieves stagnation of qi".

[0022] Borneol: Taste and nature: pungent and bitter, slightly cold. Meridian tropism: Enters the heart, spleen, and lung meridians. Efficacy and effects: Borneol has a strong effect of opening the orifices and reviving the mind, mainly used to treat coma caused by obstruction of consciousness. Its pungent and penetrating nature allows it to quickly penetrate the blood-brain barrier, stimulate the central nervous system, and excite the brain, thereby reviving consciousness. Borneol has good heat-clearing and analgesic effects and can be used for various painful and heat-toxin-related conditions. It can also be used to treat sores, boils, and burns. Borneol has a certain antiseptic effect, inhibiting the growth and reproduction of bacteria and fungi, promoting wound healing, and can be used to treat chronic, non-healing sores.

[0023] As a further explanation of the present invention, the traditional Chinese medicine composition comprises the following medicinal materials in parts by weight: 10-20 parts safflower, 10-20 parts peach kernel, 5-10 parts frankincense, 5-10 parts myrrh, 10-15 parts *Hemiberlesia lingua*, 10-15 parts angelica sinensis (tail), 10-15 parts *Viola yedoensis*, 5-10 parts *Saussurea costus*, 5-10 parts cinnamon twig, 3-8 parts prepared aconite root, 1-3 parts asarum, 1-3 parts *Momordica cochinchinensis*, 10-15 parts prunella vulgaris, 1-3 parts camphor, and 1-3 parts borneol.

[0024] As a further explanation of the present invention, the traditional Chinese medicine composition is composed of the following medicinal materials in parts by weight: 15 parts safflower, 15 parts peach kernel, 8 parts frankincense, 8 parts myrrh, 12 parts rockwort, 12 parts angelica tail, 12 parts violet, 8 parts costus root, 8 parts cinnamon twig, 5 parts prepared aconite, 2 parts asarum, 2 parts momordica seed, 12 parts prunella vulgaris, 2 parts camphor, and 2 parts borneol.

[0025] As a further explanation of the present invention, the base matrix is ​​composed of the following components in parts by weight: 50-60 parts of liquid paraffin, white petrolatum, and a mixture of one or more of dimethicone; 30-40 parts of isopropyl palmitate, sweet almond oil, caprylic / capric triglyceride, and dioctyl carbonate; and 10-20 parts of microcrystalline wax, polyethylene wax, Fischer-Tropsch wax, and beeswax.

[0026] Liquid paraffin, white petrolatum, and dimethicone provide strong sealing and lubrication, preventing moisture evaporation and thus lubricating, moisturizing, and reducing massage friction. Isopropyl palmitate, sweet almond oil, caprylic / capric triglyceride, and dioctyl carbonate provide skin-moisturizing and spreading properties, thus serving as carriers for active ingredients and helping drugs penetrate the skin and reach the affected area. Microcrystalline wax, polyethylene wax, Fischer-Tropsch wax, and beeswax thicken the oil phase / paste, increase the melting point / hardness, and stabilize the emulsion structure, thereby increasing the consistency of the paste and making it easier to apply.

[0027] As a further explanation of the present invention, the cream also contains the following functional additives in parts by weight: 1-3 parts of one or more of butylated hydroxytoluene, vitamin E, propyl gallate, and tert-butylhydroquinone; and 0.1-1 parts of one or more of phenoxyethanol, ethylhexylglycerin, and tea tree oil.

[0028] Adding ingredients such as butylated hydroxytoluene, vitamin E, propyl gallate, and tert-butylhydroquinone to creams provides antioxidant (protecting oils / creams from oxidative rancidity and extending shelf life) and protects the skin barrier. Ingredients such as phenoxyethanol, ethylhexylglycerin, and tea tree oil have antibacterial (antimicrobial, antifungal), auxiliary anti-inflammatory, and distinctive odor (tea tree oil has a strong characteristic odor), thereby preventing skin infections.

[0029] As a further explanation of the present invention, the traditional Chinese medicine component is a fluid extract of traditional Chinese medicine obtained by extracting the traditional Chinese medicine composition.

[0030] A second aspect of the present invention provides a method for preparing a massage cream as described in any one of the above-mentioned methods, the method comprising the following steps: S1: Add 8-10 times the total weight of water to the pretreated safflower, peach kernel, rockwort, angelica tail, violet, prepared aconite, asarum, momordica cochinchinensis, and prunella vulgaris, and decoct 1-3 times, 40-60 minutes each time. After each decoction, separate the solid and liquid using a centrifuge and collect the extract. Combine the extracts from each decoction and then concentrate under reduced pressure until the relative density is 1.1-1.2 to obtain the first fluid extract for later use. S2: Add an appropriate amount of ethanol to the pretreated frankincense, myrrh, costus root, and cinnamon twig and soak for 2-4 hours. Then, put the soaked Chinese medicinal materials into a percolation tube, add ethanol and let stand for 24-48 hours to allow the solvent to fully penetrate the Chinese medicinal materials. Collect the percolate and concentrate it under reduced pressure to a relative density of 1.1-1.2 to obtain the second fluid extract for later use. S3: Combine the first fluid extract and the first fluid extract to obtain a traditional Chinese medicine fluid extract. Dissolve camphor and borneol in an appropriate amount of ethanol and add it to the traditional Chinese medicine fluid extract. Mix well. S4: Add the base matrix to the herbal extract obtained in S3, mix well, and you will get a massage cream.

[0031] As a further explanation of the present invention, the pretreatment process of the Chinese medicinal materials is as follows: all medicinal materials are crushed into coarse powder of 24-65 mesh for later use; the prepared aconite root needs to be decocted for 40-60 minutes in advance before being decocted with other medicinal materials to fully remove its toxicity.

[0032] As a further explanation of the present invention, in S4, the functional additive is added to the obtained cream and then mixed evenly.

[0033] The third aspect of the present invention provides the use of the above-described massage cream or the massage cream prepared by the above-described method in the preparation of a medicament for treating soft tissue injuries.

[0034] Compared with the prior art, the present invention has the following beneficial technical effects: The massage cream provided by this invention utilizes the synergistic effect of traditional Chinese medicine efficacy and massage techniques to form an "enhancer" and a "targeted drug delivery system." Through transdermal absorption of the drug, it acts precisely on the lesion site with the help of massage physical stimulation, significantly enhancing the core therapeutic effects such as promoting blood circulation and removing blood stasis, clearing meridians and collaterals, promoting qi circulation and relieving pain, clearing heat and detoxifying, cooling blood and reducing swelling, and dispelling cold pathogens, greatly improving the effectiveness and applicability of massage therapy.

[0035] This invention, through the application of the theories and practices of "treating internal diseases externally" and "meridian-based drug delivery" in Traditional Chinese Medicine, enhances the patient experience and promotes the development of massage therapy, possessing significant clinical value and importance. Furthermore, animal experiments have verified that the massage cream combined with ointment massage therapy provided by this invention has significant therapeutic effects on soft tissue injuries. Attached Figure Description

[0036] Figure 1 The results show the SOD concentration in the serum of rats in each group.

[0037] Figure 2 The results show the concentration of MDA in the serum of rats in each group.

[0038] Figure 3The results of the pathological scores of the muscle tissue of rats in each group are shown. Detailed Implementation

[0039] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0040] Example 1 This embodiment provides a traditional Chinese medicine massage cream, which is composed of the following components in parts by weight: 55 parts base matrix and 45 parts traditional Chinese medicine ingredients. The traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition in parts by weight: 15 parts safflower, 15 parts peach kernel, 8 parts frankincense, 8 parts myrrh, 12 parts *Heliotropium indicum*, 12 parts *Angelica sinensis* (tail), 12 parts *Viola yedoensis*, 8 parts *Saussurea costus*, 8 parts cinnamon twig, 5 parts prepared aconite root, 2 parts asarum, 2 parts *Momordica cochinchinensis*, 12 parts *Prunella vulgaris*, 2 parts camphor, and 2 parts borneol. The base matrix is ​​composed of the following components in parts by weight: 55 parts white petrolatum, 35 parts sweet almond oil, and 10 parts beeswax.

[0041] Example 2 This embodiment provides a traditional Chinese medicine massage cream, which is composed of the following components in parts by weight: 50 parts base matrix and 50 parts traditional Chinese medicine ingredients. The traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition in parts by weight: 10 parts safflower, 10 parts peach kernel, 5 parts frankincense, 5 parts myrrh, 10 parts *Heliotropium indicum*, 10 parts *Angelica sinensis* (tail), 10 parts *Viola yedoensis*, 5 parts *Saussurea costus*, 5 parts cinnamon twig, 3 parts prepared aconite root, 1 part asarum, 1 part *Momordica cochinchinensis*, 10 parts *Prunella vulgaris*, 1 part camphor, and 1 part borneol. The base matrix is ​​composed of the following components in parts by weight: 50 parts liquid paraffin, 30 parts isopropyl palmitate, and 20 parts microcrystalline wax.

[0042] Example 3 This embodiment provides a traditional Chinese medicine massage cream, which is composed of the following components in parts by weight: 60 parts of base matrix and 40 parts of traditional Chinese medicine ingredients; wherein, the traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition in parts by weight: 20 parts of safflower, 20 parts of peach kernel, 10 parts of frankincense, 10 parts of myrrh, 15 parts of *Heliotropium indicum*, 15 parts of angelica sinensis tail, 15 parts of *Viola yedoensis*, 10 parts of *Saussurea costus*, 10 parts of cinnamon twig, 8 parts of prepared aconite root, 3 parts of asarum, 3 parts of *Momordica cochinchinensis*, 15 parts of *Prunella vulgaris*, 3 parts of camphor, and 3 parts of borneol; the base matrix is ​​composed of the following components in parts by weight: 60 parts of dimethicone oil, 40 parts of caprylic / capric triglyceride, and 15 parts of polyethylene wax.

[0043] Example 4 This embodiment provides a traditional Chinese medicine massage cream, which is composed of the following components in parts by weight: 55 parts base matrix, 45 parts traditional Chinese medicine ingredients, and functional additives: 1 part vitamin E and 1 part tea tree oil. The traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition in parts by weight: 15 parts safflower, 15 parts peach kernel, 8 parts frankincense, 8 parts myrrh, 12 parts *Hedysarum heterotropoides*, 12 parts angelica sinensis (tail), 12 parts *Viola yedoensis*, 8 parts *Saussurea costus*, 8 parts cinnamon twig, 5 parts prepared aconite root, 2 parts asarum, 2 parts *Momordica cochinchinensis*, 12 parts *Prunella vulgaris*, 2 parts camphor, and 2 parts borneol. The base matrix is ​​composed of the following components in parts by weight: 55 parts white petrolatum, 35 parts sweet almond oil, and 10 parts beeswax.

[0044] Example 5 This embodiment provides a traditional Chinese medicine massage cream, which is composed of the following components in parts by weight: 55 parts base matrix, 45 parts traditional Chinese medicine ingredients, and functional additives: 3 parts propyl gallate and 0.1 parts ethylhexylglycerin. The traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition in parts by weight: 15 parts safflower, 15 parts peach kernel, 8 parts frankincense, 8 parts myrrh, 12 parts *Heliotropium indicum*, 12 parts *Angelica sinensis* (tail), 12 parts *Viola yedoensis*, 8 parts *Saussurea costus*, 8 parts cinnamon twig, 5 parts prepared aconite root, 2 parts asarum, 2 parts *Momordica cochinchinensis*, 12 parts *Prunella vulgaris*, 2 parts camphor, and 2 parts borneol. The base matrix is ​​composed of the following components in parts by weight: 55 parts white petrolatum, 35 parts sweet almond oil, and 10 parts beeswax.

[0045] Comparative Example 1: A traditional Chinese medicine massage cream, which differs from Example 1 in that it removes *Scutellaria baicalensis* and *Angelica sinensis* tail from the traditional Chinese medicine composition.

[0046] Comparative Example 2: A traditional Chinese medicine massage cream, which differs from Example 1 in that it removes Viola yedoensis and Aucklandia lappa from the traditional Chinese medicine composition.

[0047] Comparative Example 3: A traditional Chinese medicine massage cream, which differs from Example 1 in that it removes cinnamon twig, prepared aconite root, and asarum from the traditional Chinese medicine composition.

[0048] Comparative Example 4: A traditional Chinese medicine massage cream, which differs from Example 1 in that it removes Momordica cochinchinensis and Prunella vulgaris from the traditional Chinese medicine composition.

[0049] Comparative Example 5: A traditional Chinese medicine massage cream, which differs from Example 1 in that the ingredients of the traditional Chinese medicine composition, namely, *Scutellaria baicalensis* and *Angelica sinensis* tail, are replaced with *Paeonia lactiflora* and *Ligusticum chuanxiong*, respectively.

[0050] Comparative Example 6: A traditional Chinese medicine massage cream, which differs from Example 1 in that the Viola yedoensis and Aucklandia lappa in the traditional Chinese medicine composition are replaced with Taraxacum mongolicum and Cyperus rotundus, respectively.

[0051] The preparation process of the traditional Chinese medicine massage cream provided in Examples 1-3 above is as follows (the dosage of each herb and component in the cream is converted according to the corresponding examples during the preparation process): S1: Pre-treatment of Chinese medicine: Grind all medicinal materials into coarse powder of 24 mesh for later use.

[0052] S2: After decocting the coarse powder of prepared aconite root in water for 40 minutes, add the coarse powders of safflower, peach kernel, rock hemp seed, angelica tail, violet, asarum, momordica cochinchinensis, and prunella vulgaris. Then add water equal to 8 times the total weight of the medicinal materials and decoct for 60 minutes. After decoction, separate the solid and liquid components using a centrifuge and collect the extract. Then add 8 times the amount of water to the residue and decoct again for 40 minutes. Then filter twice, combine the two extracts, and then concentrate under reduced pressure to a relative density of 1.10 to obtain the first fluid extract for later use.

[0053] S3: Add an appropriate amount of ethanol to the coarse powders of frankincense, myrrh, costus root, and cinnamon twig. Seal the container and let it soak for 3 hours to allow the herbs to fully and evenly swell. Turn the container 1-2 times during this period. Place absorbent cotton at the bottom of the percolator. Fill the percolator with the soaked herbs in batches, ensuring they are evenly packed. Gently compact each layer to avoid gaps (the filling height of the coarse powder should be about 2 / 3 of the percolator's height). Cover the top of the herbs with absorbent cotton. Slowly open the lower outlet of the percolator to expel air. Then, slowly add ethanol until the liquid level is about 3 cm above the powder. Close the outlet and seal the top of the percolator. Let it stand for 36 hours to allow the solvent to fully penetrate the powder. Slowly collect the percolate, continuously adding ethanol during the collection process to keep the liquid level above the powder. Collect approximately 85% of the initial amount of herbs that flowed out. The concentrated percolate was percolated again, and a dilute percolate of four times the amount of the medicinal material was collected. The collected concentrated and dilute percolates were then combined and concentrated under reduced pressure to a relative density of 1.10 to obtain a second fluid extract for later use.

[0054] S4: Combine the above first fluid extract and the first fluid extract to obtain a traditional Chinese medicine fluid extract. Take an appropriate amount of ethanol to dissolve camphor and borneol, and add it to the traditional Chinese medicine fluid extract. Mix evenly. Then add the corresponding weight parts of each basic matrix component in each embodiment, mix evenly, and the massage cream is obtained.

[0055] The difference between the preparation process of the traditional Chinese medicine massage cream provided in Examples 4-5 and the preparation process in Examples 1-3 is that in S4, after adding each basic matrix component, a corresponding amount of functional additives also needs to be added.

[0056] The difference between the preparation process of the Chinese herbal massage cream provided in Comparative Examples 1-6 and the preparation process of Example 1 is that when a certain Chinese herbal medicine is removed, the herbal medicine is omitted in the corresponding extraction step. When it is necessary to replace it with Paeonia lactiflora, Ligusticum chuanxiong, Taraxacum mongolicum and Cyperus rotundus respectively, Paeonia lactiflora and Taraxacum mongolicum coarse powder are added in S2 for decoction to prepare fluid extract. In S3, Ligusticum chuanxiong and Cyperus rotundus coarse powder are added for soaking and percolation to prepare fluid extract. The remaining steps are the same as in Example 1.

[0057] The following animal experiments verify the efficacy of the traditional Chinese medicine massage cream provided in the embodiments and comparative examples of this invention on rats with acute soft tissue injury.

[0058] 1. Experimental materials and animals: 1.1 Materials: Voltaren ointment, Beijing Novartis Pharmaceutical Co., Ltd.; Traditional Chinese medicine massage cream made from the traditional Chinese medicine formulas provided in Example 1 and Comparative Examples 1-6 above.

[0059] 1.2 Laboratory animals: Male SD rats (weight: 180-220g) were obtained from the Experimental Animal Center of Changchun University of Traditional Chinese Medicine. After the rats were purchased, they were placed under SPF-grade conditions for an acclimatization trial for one week before the experiment.

[0060] 2. Establishment of animal models and drug intervention process: 2.1 Animal grouping: Rats were randomly divided into four groups: the low-dose ointment group of Example 1, the medium-dose ointment group of Example 1, the high-dose ointment group of Example 1, the high-dose ointment groups of Comparative Examples 1-6, the positive ointment group, the high-dose application group of Example 1, the blank group, and the model group, with 10 rats in each group.

[0061] 2.2 Establishment of an acute soft tissue injury model: Modeling was performed on rats in groups other than the control group. Hair was removed from the left hind leg. After hair removal, the rats were anesthetized by injection of sodium pentobarbital (40-50 mg / kg body weight, intraperitoneal injection). The rats' left hind legs were then fixed with the knee extended and the back flexed at a right angle. A 200g weight was used to strike the biceps femoris muscle of the rat's left hind leg by vertical free fall. The strikes were repeated multiple times until swelling, ecchymosis and tissue damage appeared at the strike site, but no fractures or dislocations, no skin breaks and no other abnormalities were found. The model was considered successfully established.

[0062] 2.3 Drug intervention Ointment massage therapy: 24 hours after modeling, rats in all groups except the model group, blank group, and high-dose patch application group of Example 1 were fixed on the operating table with their limbs extended. The above-mentioned Chinese herbal massage creams obtained in the examples and comparative examples were then applied to the soft tissue injury site of the left hind limb of the rats. The massage was performed using the index finger massage method, with a massage frequency of about 120-160 times / minute and a duration of 5 minutes for each massage, twice a day (the massage intensity should be such that the rats do not move around and remain relatively quiet), for a total of 3 days.

[0063] The dosage of ointment applied to each group of rats during each treatment was as follows: Example 1 low-dose ointment group: 2.5 g / kg of the herbal massage ointment obtained in Example 1; Example 1 medium-dose ointment group: 5 g / kg of the herbal massage ointment obtained in Example 1; Example 1 high-dose ointment group: 10 g / kg of the herbal massage ointment obtained in Example 1; Comparative Examples 1-6 high-dose ointment group: 10 g / kg of the massage cream obtained in Comparative Examples 1-6; Positive ointment group: 10 g / kg of diclofenac ointment.

[0064] Application therapy: 24 hours after modeling, rats in the high-dose application group of Example 1 were fixed on the operating table with their limbs extended. The herbal massage cream obtained in Example 1 was then applied to the soft tissue injury site of the left hind limb of the rats. The application dose was 10g / kg, twice a day, for a total of 3 days.

[0065] Note: When applying the massage cream and massaging, ensure that the application area of ​​each group of rats is basically the same and that the application and massage treatment is performed at the same time every day to avoid environmental interference.

[0066] 3. Observation indicators: 3.1 Measurement of serum SOD and MDA levels: After treatment with ointment and plaster, rats in all groups, as well as the model group and blank group, were anesthetized with sodium pentobarbital (40-50 mg / kg body weight, intraperitoneal injection). Blood was collected from the abdominal aorta. The SOD level in rat serum was determined by enzyme activity assay (appropriately diluted rat serum sample, mixed with NBT solution and enzyme substrate solution, incubated at 37°C in the dark for 45 minutes, cooled to room temperature, centrifuged to remove precipitate, and the supernatant was used to measure the absorbance of NBT reduction product using a spectrophotometer, and the SOD activity was calculated according to the standard curve). The MDA level in rat serum was determined by TBA colorimetric assay (appropriately diluted rat serum sample, added with an appropriate amount of TBA reagent, incubated in a boiling water bath for 45 minutes, cooled to room temperature, centrifuged to remove precipitate, and the supernatant was used to measure its absorbance using a spectrophotometer, and the MDA content was calculated according to the standard curve).

[0067] 3.2 Muscle tissue pathological score: HE staining: Rats were sacrificed, and muscle tissue from the injured area was fixed in fixative. The fixed muscle tissue was then placed in a tissue embedding cassette, followed by graded alcohol dehydration, xylene clearing, and paraffin embedding. Sections were then prepared and dewaxed, with a section thickness of approximately 4 μm. Hematoxylin staining and eosin staining were then performed sequentially, and finally, the sections were mounted with neutral resin.

[0068] Pathological scoring: After hematoxylin-eosin staining and mounting with neutral resin, the slides were observed under an optical microscope and scored pathologically. The scoring criteria are as follows: 1. Inflammatory cell infiltration: 0 points: No obvious inflammatory cell infiltration; 1 point: A small number of inflammatory cells (such as neutrophils and macrophages) infiltrate; 2 points: Moderate inflammatory cell infiltration; 3 points: A large number of inflammatory cells infiltrate and are densely distributed.

[0069] 2. Muscle fiber damage: 0 points: Muscle fibers are neatly arranged with no obvious damage; 1 point: Minor muscle fiber damage (such as blurred striations and mild swelling); 2 points: Moderate muscle fiber damage (such as unclear striations and muscle membrane damage); 3 points: Severe muscle fiber damage (such as muscle fiber rupture and necrosis).

[0070] 3. Edema: 0 points: no edema; 1 point: mild edema (slightly widened interstitium); 2 points: moderate edema (significantly widened interstitium); 3 points: severe edema (destruction of tissue structure, significant enlargement of interstitial spaces).

[0071] 4. Vascular changes: 0 points: normal blood vessels, no obvious changes; 1 point: slight vasodilation or congestion; 2 points: moderate vasodilation, congestion or exudation; 3 points: severe vasodilation, exudation or thrombosis.

[0072] 5. Necrotic area: 0 points: no necrosis; 1 point: small amount of necrotic area (such as nuclear condensation and dissolution); 2 points: moderate necrotic area; 3 points: extensive necrotic area (large area of ​​tissue necrosis).

[0073] 6. Overall score: Add up the scores of the above indicators, and the total score is 0-15 points, where 0-3 points: minor injury; 4-7 points: moderate injury; 8-15 points: severe injury.

[0074] 4. Experimental Results 4.1 Statistical Methods: Differences were tested using a two-sample t-test, and all measurement data were analyzed using... It is indicated that SPSS version 22.0 was used for data processing.

[0075] 4.2 Results: 4.2.1 Comparison of SOD and MDA levels in the serum of rats in each group.

[0076] Table 1. Changes in serum SOD and MDA levels in rats of different groups

[0077] Note that compared with the control group, #P<0.05, ##P<0.01; compared with the model group, , Compared with the high-dose ointment group in Example 1, , n=10.

[0078] SOD is an important antioxidant enzyme that can scavenge superoxide anion free radicals. This reduces oxidative damage to cells and tissues caused by free radicals. In acute soft tissue injury, the injury site triggers an oxidative stress response, leading to increased free radical levels. Superoxide dismutase (SOD) activity increases accordingly to scavenge free radicals and alleviate oxidative stress. Drug intervention, with its antioxidant or tissue-repair-promoting effects, stimulates SOD activity or expression, further increasing SOD levels. MDA is one of the end products of lipid peroxidation, and its level reflects the degree of cell membrane lipid peroxidation, indirectly reflecting the intensity of oxidative stress. In acute soft tissue injury, increased free radical levels at the injury site exacerbate lipid peroxidation, resulting in a significant increase in MDA levels. Drug intervention to inhibit free radical generation or enhance antioxidant capacity can reduce lipid peroxidation and lower MDA levels. Therefore, a decrease in MDA levels indicates that the drug can effectively inhibit oxidative stress and reduce tissue damage. (See Table 1...) Figure 1 and Figure 2It can be seen that, compared with the blank group, the serum SOD and MDA levels of the model group rats were significantly increased; while compared with the model group rats, the serum SOD levels of the positive ointment group, the medium and high dose ointment groups of Example 1, and the high dose application group of Example 1 were significantly increased, and the differences were statistically significant (P < 0.05); compared with the model group rats, the serum MDA levels of the positive ointment group, the low, medium, and high dose ointment groups of Example 1, and the high dose application group of Example 1 were significantly decreased, and the differences were statistically significant (P < 0.05). This indicates that the traditional Chinese medicine massage cream provided by the present invention, in combination with ointment massage treatment or simply using the massage cream provided by the present invention for application treatment, can improve the tissue repair function of rats and reduce lipid peroxidation, thereby increasing SOD levels and decreasing MDA levels. Furthermore, compared with the high-dose ointment massage group of Comparative Examples 1-6 and the high-dose patch application group of Example 1, the SOD level of the rats in the high-dose ointment massage group of Example 1 of this application increased more significantly and the MDA level decreased more significantly, and the difference was statistically significant (P<0.05). This indicates that the therapeutic effect of the massage cream provided by this invention combined with ointment massage is significantly better than the therapeutic effect of applying the massage cream provided by this invention alone. It also shows that when any Chinese herbal medicine is missing or replaced in this invention, the effect of the Chinese herbal medicine cream on improving the SOD and MDA levels in rat serum will be weakened. Therefore, the various Chinese herbal medicine components in the Chinese herbal medicine cream provided by this invention are synergistic and indispensable.

[0079] 4.2.2 Pathological scores of rat muscle tissue in each group.

[0080] Table 2. Pathological scores of rat muscle tissue in each group

[0081] Note that compared with the control group, #P<0.05, ##P<0.01; compared with the model group, , Compared with the high-dose ointment group in Example 1, , n=10.

[0082] From Table 2 and Figure 3As can be seen, the muscle tissue pathology scores of the model group rats were significantly higher than those of the blank group rats. However, compared with the model group rats, the muscle tissue pathology scores of the positive ointment massage group, the low, medium and high dose ointment massage groups of Example 1, and the high dose application group of Example 1 were all significantly lower. This indicates that the use of the traditional Chinese medicine ointment provided by the present invention for ointment massage treatment or the use of the massage ointment provided by the present invention for application treatment can significantly improve the muscle tissue damage of rats. Furthermore, compared with the high-dose ointment massage group of Comparative Examples 1-6 and the high-dose patch application group of Example 1, the muscle tissue pathology score of the rats in the high-dose ointment massage group of Example 1 of this application was significantly reduced, and the difference was statistically significant (P<0.05). This indicates that the therapeutic effect of the massage cream provided by this invention combined with ointment massage is significantly better than the therapeutic effect of simply using the massage cream provided by this invention for patch application. It also indicates that the level of improvement of muscle tissue pathology in rats provided by the traditional Chinese medicine cream of this application is better than that provided by Comparative Examples 1-6. It also indicates that the absence or replacement of a certain traditional Chinese medicine in this invention will weaken the effect of the traditional Chinese medicine cream on improving muscle tissue pathology. Therefore, the various traditional Chinese medicine components in the traditional Chinese medicine cream provided by this invention are synergistic and indispensable.

[0083] It should be noted that, in this document, terms such as “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0084] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A massage cream, characterized in that, The cream contains the following components in parts by weight: 50-60 parts of base matrix and 40-50 parts of traditional Chinese medicine ingredients; wherein the traditional Chinese medicine ingredients are extracted from the following traditional Chinese medicine composition: safflower, peach kernel, frankincense, myrrh, rock hemp seed, angelica tail, violet, costus root, cinnamon twig, prepared aconite root, asarum, momordica seed, prunella vulgaris, camphor, and borneol.

2. The massage cream as described in claim 1, characterized in that, The traditional Chinese medicine composition consists of the following medicinal materials in parts by weight: 10-20 parts safflower, 10-20 parts peach kernel, 5-10 parts frankincense, 5-10 parts myrrh, 10-15 parts *Hemiberlesia lingua*, 10-15 parts angelica sinensis (tail), 10-15 parts violet, 5-10 parts costus root, 5-10 parts cinnamon twig, 3-8 parts prepared aconite root, 1-3 parts asarum, 1-3 parts momordica cochinchinensis, 10-15 parts prunella vulgaris, 1-3 parts camphor, and 1-3 parts borneol.

3. The massage cream as described in claim 1, characterized in that, The traditional Chinese medicine composition consists of the following medicinal materials in parts by weight: 15 parts safflower, 15 parts peach kernel, 8 parts frankincense, 8 parts myrrh, 12 parts *Heliotropium indicum*, 12 parts angelica sinensis (tail), 12 parts *Viola yedoensis*, 8 parts costus root, 8 parts cinnamon twig, 5 parts prepared aconite root, 2 parts asarum, 2 parts momordica cochinchinensis, 12 parts prunella vulgaris, 2 parts camphor, and 2 parts borneol.

4. The massage cream as described in claim 1, characterized in that, The base matrix is ​​composed of the following components in parts by weight: 50-60 parts of liquid paraffin, white petrolatum, and a mixture of one or more of dimethicone; 30-40 parts of one or more of isopropyl palmitate, sweet almond oil, caprylic triglyceride, and dioctyl carbonate; 10-20 parts of a mixture of one or more of the following: microcrystalline wax, polyethylene wax, Fischer-Tropsch wax, and beeswax.

5. The massage cream as described in claim 1, characterized in that, The cream also contains the following functional additives in parts by weight: 1-3 parts of one or more of the following: butylated hydroxytoluene, vitamin E, propyl gallate, and tert-butylhydroquinone; 0.1-1 part of phenoxyethanol, ethylhexylglycerin, or a mixture of one or more of tea tree oil.

6. The massage cream as described in claim 1, characterized in that, The herbal ingredients are fluid extracts of traditional Chinese medicine obtained from the herbal composition.

7. A method for preparing a massage cream according to any one of claims 1-6, characterized in that, The method includes the following steps: S1: Add 8-10 times the total weight of water to the pretreated safflower, peach kernel, rockwort, angelica tail, violet, prepared aconite, asarum, momordica cochinchinensis, and prunella vulgaris, and decoct 1-3 times, 40-60 minutes each time. After each decoction, separate the solid and liquid using a centrifuge and collect the extract. Combine the extracts from each decoction and then concentrate under reduced pressure until the relative density is 1.1-1.2 to obtain the first fluid extract for later use. S2: Add an appropriate amount of ethanol to the pretreated frankincense, myrrh, costus root, and cinnamon twig and soak for 2-4 hours. Then, put the soaked Chinese medicinal materials into a percolation tube, add ethanol and let stand for 24-48 hours to allow the solvent to fully penetrate the Chinese medicinal materials. Collect the percolate and concentrate it under reduced pressure to a relative density of 1.1-1.2 to obtain the second fluid extract for later use. S3: Combine the first fluid extract and the first fluid extract to obtain a traditional Chinese medicine fluid extract. Dissolve camphor and borneol in an appropriate amount of ethanol and add it to the traditional Chinese medicine fluid extract. Mix well. S4: Add the base matrix to the herbal extract obtained in S3, mix well, and you will get a massage cream.

8. The method for preparing a massage cream as described in claim 7, characterized in that, The pretreatment process of the Chinese medicinal materials is as follows: all medicinal materials are crushed into coarse powder of 24-65 mesh for later use; the prepared aconite root needs to be decocted for 40-60 minutes in advance before being decocted together with other medicinal materials.

9. The method for preparing the massage cream as described in claim 7, characterized in that, In S4, functional additives are added to the resulting cream and then mixed thoroughly.

10. The use of the massage cream according to any one of claims 1 to 6 or the massage cream prepared by any one of claims 7 to 9 in the preparation of a medicament for treating soft tissue injuries.

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