Liver and gall specimen processing equipment

Abstract

A liver and gall specimen processing device disclosed by the present invention comprises a shell, a detection mechanism and a sorting control module, the circumference of the upper end of the shell is provided with a plurality of placing grooves used for placing specimen storage tools composed of cup bodies and self-sealing cover bodies, the upper part of the shell is rotatably connected with a first cover body through motor driving, and the detection mechanism is installed on the first cover body. The sample liquid detection module comprises a sharp piercing pipe capable of being controlled to pierce through the cover body and a detection head with the interior capable of stretching into sample liquid, detection signals are transmitted to the integrated display controller through the signal processing mechanism, and the sequencing control module dynamically optimizes the detection sequence and displays results in real time on the basis of detection data. High-activity or critical specimens can be preferentially detected, the specimen failure risk is remarkably reduced, the detection efficiency and accuracy are improved, and the diagnosis and treatment timeliness is guaranteed.

Description

Technical Field

[0001] This invention relates to the field of liver and gallbladder specimen processing technology, specifically to a liver and gallbladder specimen processing device. Background Technology

[0002] In the biomedical field, the processing and testing of liver and gallbladder specimens is an important task. Traditional processing methods typically follow the order in which specimens are entered to ensure that each specimen is managed in an orderly and effective manner.

[0003] Current clinical specimen processing generally adopts a first-come, first-served (FROM) model. Determining whether a specimen is suitable for testing relies heavily on indirect parameters such as time spent outside the body or subjective experience, which is difficult to reflect real-time activity. For example, some specimens, although having been outside the body for a short time, may have significantly reduced activity due to tissue type, patient's preoperative condition, and post-extraction preservation conditions. Therefore, relying solely on time spent outside the body cannot guarantee that the specimen meets the testing requirements.

[0004] In other words, current processing procedures are often inflexible in such situations, lacking a priority scheduling mechanism for specific specimens. This frequently leads to missed optimal testing windows, failure to obtain suitable processing conditions, and potential deviations in test results, thus affecting the pathological classification and treatment evaluation of hepatobiliary diseases. Sometimes, resampling is even necessary, especially for critically ill patients such as those with acute cholangitis and liver failure, which can delay treatment. This not only increases the cost and time of medical services but also causes unnecessary trouble and inconvenience for doctors and patients. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this invention is to provide a liver and gallbladder specimen processing device to solve the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: This invention provides a liver and gallbladder specimen processing device, comprising a housing, multiple detection mechanisms, and a sorting control module. Multiple placement slots are arranged circumferentially on the upper surface of the housing. These slots hold specimen storage containers containing liver and gallbladder specimens. Each specimen storage container includes a cup and a self-sealing lid, the self-sealing lid being mounted on the cup. A first lid, matching the placement slot, is rotatably connected to the housing. The detection mechanisms detect liver and gallbladder specimens located within the specimen storage containers. Each detection mechanism includes a first mounting base and a second mounting base, with a second electric push rod fixedly connected between the first and second mounting bases. An outer shell is fixedly connected to the first mounting base, and a spiked tube is slidably connected within the outer shell. The spiked tube is used to pierce the self-sealing cover. A first electric push rod for driving the spiked tube to slide is fixedly connected inside the spiked tube. An inner tube is slidably connected inside the spiked tube. A first wire is fixedly connected inside the inner tube. A detection head is fixedly connected to the lower end of the first wire. A signal processing mechanism matching the first wire is fixedly connected to the second mounting base. An integrated display controller is fixedly connected to the middle of the first cover. A second wire is installed between the signal processing mechanism and the integrated display controller. The sorting control module is used to receive the detection data from the detection mechanism and sort the detection order of the specimen storage device according to the detection data. The sorting result is displayed through the integrated display controller.

[0007] In one or more embodiments of the present invention, the self-sealing cover includes a second cover, the cup body has an external thread, the second cover is threadedly connected to a first internal thread, the cup body and the second cover are threadedly connected, a baffle plate matching the cup body is fixedly connected inside the second cover, the baffle plate has a second through hole in the middle, an external threaded ring is fixedly connected to the upper end of the second cover, a third cover matching the external threaded ring is threadedly connected to the second cover, a pressure ring is fixedly connected inside the third cover, the pressure ring has a third through hole matching the second through hole, and a sealing rubber is installed between the baffle plate and the pressure ring.

[0008] In one or more embodiments of the present invention, an airbag is fixedly connected to the second cover, a first air supply pipe is fixedly connected to one end of the airbag, a first quick connector is fixedly connected to the end of the first air supply pipe away from the airbag, a first air supply assembly matching the airbag is installed on the housing, the first air supply assembly includes a first branch pipe installed outside the housing, a first branch pipe is fixedly connected to the first branch pipe, a second air supply pipe matching the first branch pipe is installed on the housing, a first solenoid valve is fixedly connected to the second air supply pipe, a second quick connector is fixedly connected to the end of the second air supply pipe away from the first branch pipe, and the second quick connector is fixedly connected inside the placement slot.

[0009] In one or more embodiments of the present invention, a fourth electric push rod matching the placement groove is installed on the housing, and a sealing plate is fixedly connected to the protruding end of the fourth electric push rod. The sealing plate is located at the bottom of the placement groove, and a sealing plate is slidably connected inside the placement groove. The sealing plate is fixedly connected to the protruding end of the fourth electric push rod. At least two third electric push rods are fixedly connected to the housing, and the third electric push rods are symmetrically arranged along the circumference of the placement groove. An arc-shaped plate is fixedly connected to the protruding end of the placement groove.

[0010] In one or more embodiments of the present invention, a cleaning tank matching the detection mechanism is provided on the housing, a first connecting pipe and a second connecting pipe matching the cleaning tank are installed on the housing, a second liquid supply mechanism matching the first connecting pipe and the second connecting pipe is installed on the housing, the second liquid supply mechanism includes a third diversion pipe, a first liquid supply pipe matching the first connecting pipe is fixedly connected to the third diversion pipe, a third solenoid valve is fixedly connected to the first liquid supply pipe, the second liquid supply mechanism also includes a sixth diversion pipe, a first liquid outlet pipe matching the second connecting pipe is fixedly connected to the sixth diversion pipe, and a fourth solenoid valve is fixedly connected to the first liquid outlet pipe.

[0011] In one or more embodiments of the present invention, a plurality of transducers matching the cleaning tank are fixedly connected to the housing.

[0012] In one or more embodiments of the present invention, a first air supply mechanism is included, the first air supply mechanism including a fourth branch pipe and a fifth branch pipe, a third air supply pipe matching the first connecting pipe is fixedly connected to the fourth branch pipe, a ninth solenoid valve is fixedly connected to the third air supply pipe, a third air inlet pipe matching the second connecting pipe is fixedly connected to the fifth branch pipe, and a tenth solenoid valve is fixedly connected to the third air inlet pipe.

[0013] In one or more embodiments of the present invention, the first air supply mechanism includes an air pump, the air inlet end of the first air supply mechanism is fixedly connected to a fourth air inlet pipe that matches the third air inlet pipe, the fourth air inlet pipe is fixedly connected to an eighth solenoid valve, the air outlet end of the air pump is fixedly connected to a first air supply pipe, the end of the first air supply pipe away from the air pump is fixedly connected to a filter, and the filter is equipped with a second air supply pipe that matches the fourth diverter pipe.

[0014] In one or more embodiments of the present invention, a heat dissipation hole is provided at the bottom of the housing, and a motor matching the heat dissipation hole is fixedly connected to the housing, and the output end of the motor is connected to the first cover.

[0015] In one or more embodiments of the present invention, the first cover has a retrieval opening, and a sealing cover matching the retrieval opening is installed on the first cover.

[0016] The beneficial effects of this invention are as follows: through the coordinated work of the detection mechanism, the sorting control module and the integrated display controller, the traditional fixed mode of first-come, first-served is changed. The liver and gallbladder specimen processing equipment can automatically detect key indicators reflecting specimen activity and intelligently sort them based on the activity decay rate and clinical urgency. This ensures that specimens with high activity, rapid decay or clinical urgency can be tested first, significantly reducing the risk of specimen failure due to queuing and saving valuable time for the diagnosis and treatment of patients with acute liver failure and other critical illnesses. The first liquid supply mechanism injects a temperature-controlled insulating liquid into the placement tank, providing a stable preservation environment for the specimens and reducing specimen deterioration caused by temperature fluctuations. Secondly, after the test is completed, the equipment can automatically move the testing unit to the cleaning tank for thorough cleaning and drying through soaking in cleaning solution and purging with drying gas, which greatly reduces the risk of cross-contamination between different specimens and ensures the accuracy and repeatability of subsequent test results. The liver and gallbladder specimen processing equipment is highly integrated. After the specimen is placed in the equipment, the entire process, from piercing the self-sealing cap, signal detection, data transmission to sorting and display, is basically automated. This reduces tedious manual operation steps, lowers the labor intensity and skill dependence of operators, and increases the specimen processing throughput per unit time. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the structure of a liver and gallbladder specimen processing device according to an embodiment of the present invention. Figure 1 ; Figure 2 This is a schematic diagram of the structure of a liver and gallbladder specimen processing device according to an embodiment of the present invention. Figure 2 ; Figure 3 This is a partial structural schematic diagram of a liver and gallbladder specimen processing device according to an embodiment of the present invention; Figure 4 This is a partial cross-section of a liver and gallbladder specimen processing device according to an embodiment of the present invention. Figure 1 ; Figure 5 This is a partial cross-section of a liver and gallbladder specimen processing device according to an embodiment of the present invention. Figure 2 ; Figure 6 for Figure 5Schematic diagram of the structure at point A in the middle; Figure 7 for Figure 5 Schematic diagram of the structure at point B; Figure 8 for Figure 5 Schematic diagram of the structure at point C; Figure 9 for Figure 5 Schematic diagram of the structure at point D; Figure 10 This is a partial cross-section of a liver and gallbladder specimen processing device according to an embodiment of the present invention. Figure 3 ; Figure 11 for Figure 5 Schematic diagram of the structure at point E in the middle; Figure 12 This is a partial cross-section of a liver and gallbladder specimen processing device according to an embodiment of the present invention. Figure 4 ; Figure 13 This is a cross-sectional view of a specimen storage device according to an embodiment of the present invention; Figure 14 This is an exploded view of a specimen storage device according to an embodiment of the present invention; Figure 15 This is a schematic diagram of the structure of the second cover in one embodiment of the present invention; Figure 16 This is a schematic diagram of the detection mechanism in one embodiment of the present invention; Figure 17 This is a cross-sectional view of the detection mechanism in one embodiment of the present invention; Figure 18 This is a cross-sectional view of the detection head in one embodiment of the present invention.

[0019] Explanation of reference numerals in the attached figures: 1. Shell; 101. Heat dissipation hole; 102. Mounting groove; 103. First through hole; 104. Cleaning groove; 105. Placement groove; 2. First cover; 201. Connecting post; 2011. Connecting groove; 202. Sequence mark; 203. Sealing cover; 3. Motor; 301. Output shaft; 4. First bearing; 5. Second bearing; 6. Specimen storage container; 7. Cup body; 701. External thread; 8. Second cover; 801. First internal thread; 802. Baffle plate; 8021. Second through hole; 803. External threaded ring; 9. Third cover; 901. Third internal thread; 10. Lower pressure ring; 10 01. Third through hole; 11. First electric push rod; 12. Sealing rubber; 13. Airbag; 14. First air supply pipe; 1401. First quick connector; 15. Detection mechanism; 16. First mounting base; 1601. Fourth through hole; 17. Second electric push rod; 18. Second mounting base; 19. Outer shell; 20. Spiked tube; 2001. Lower pressure plate; 2002. First limiting ring; 21. Inner tube; 2101. Second limiting ring; 22. Signal processing; 23. First wire; 2301. Wire body; 2302. Protective tube; 24. Detection head; 2401. Detection head body; 2402. 25. Protective layer; 26. Second wire; 27. Integrated display controller; 28. First gas supply assembly; 29. ​​First branch pipe; 30. Second gas supply pipe; 31. Second quick connector; 32. First solenoid valve; 33. Fixing mechanism; 34. Third electric push rod; 35. Arc plate; 36. Fourth electric push rod; 37. Sealing plate; 38. First liquid supply mechanism; 39. Second branch pipe; 40. Second solenoid valve; 41. First connecting pipe; 42. Second connecting pipe; 43. Second liquid supply mechanism; 44. Third branch pipe; 45. Sixth branch pipe; 46. 6. First liquid supply pipe; 47. Third solenoid valve; 48. First liquid outlet pipe; 49. Fourth solenoid valve; 50. Eighth solenoid valve; 51. First air supply mechanism; 52. Air inlet plate; 53. First air inlet pipe; 54. Fifth solenoid valve; 55. Second air inlet pipe; 56. Sixth solenoid valve; 57. Air pump; 58. First air supply pipe; 59. Filter; 60. Second air supply pipe; 61. Seventh solenoid valve; 62. Fourth diversion pipe; 63. Third air supply pipe; 64. Ninth solenoid valve; 65. Fifth diversion pipe; 66. Third air inlet pipe; 67. Tenth solenoid valve; 68. Fourth air inlet pipe; 69. Transducer. Detailed Implementation

[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] like Figures 1-4 As shown, a liver and gallbladder specimen processing device according to one embodiment of the present invention includes a housing 1, on which a plurality of placement slots 105 are provided, arranged circumferentially on the upper end surface of the housing 1. The placement slots 105 are used to place specimen storage containers 6, which are used to store liver and gallbladder specimens and other solutions such as formalin for fixing the liver and gallbladder specimens. A first cover 2 is rotatably connected to the housing 1, which completely covers the placement slots 105 and can achieve a seal.

[0022] like Figures 1-6 As shown, a mounting groove 102 is provided at the bottom of the housing 1, and a motor 3 is fixedly connected to the top wall of the mounting groove 102. A first through hole 103 matching the motor 3 is provided on the housing 1, and the output shaft 301 of the motor 3 is located in the first through hole 103. A first bearing 4 is fixedly connected between the first through hole 103 and the output shaft 301. A connecting post 201 matching the first through hole 103 is fixedly connected to the lower end of the first cover 2. A second bearing 5 is installed between the connecting post 201 and the first through hole 103. A connecting groove 2011 matching the output shaft 301 is provided on the connecting post 201. The output shaft 301 is inserted into the connecting groove 2011. During the rotation of the output shaft 301, the first cover 2 can rotate on the housing 1.

[0023] like Figures 1-5 As shown, the first cover 2 has multiple retrieval openings that match the housing 1. A sealing cap 203 that matches the retrieval opening is installed on the first cover 2. When the sealing cap 203 is installed on the retrieval opening, it completely seals the retrieval opening. The first cover 2 is provided with a sequence mark 202 that matches the retrieval opening. The sequence mark 202 is used to indicate the specimen storage device 6 located in the corresponding placement slot 105.

[0024] like Figures 12-15As shown, the specimen storage device 6 includes a cup body 7 and a second cover body 8. The outer wall of the cup body 7 has an external thread 701, and the inner wall of the second cover body 8 has a first internal thread 801 that matches the external thread 701. The cup body 7 and the second cover body 8 are threadedly connected. A baffle plate 802 is fixedly connected to the middle of the second cover body 8, and the baffle plate 802 has a second through hole 8021 in its middle. An external threaded ring 803 is fixedly connected to the upper end of the baffle plate 802, and a third cover body 9 is threadedly connected to the external threaded ring 803. Specifically, the third cover body 9 has a third internal thread 901 that matches the external threaded ring 803, and the third internal thread 901 and the external threaded ring 803 are threadedly connected.

[0025] In addition, such as Figures 12-15 As shown, a lower pressure ring 10 is fixedly connected to the middle of the third cover 9. The lower pressure ring 10 has a third through hole 1001 that matches the second through hole 8021. A sealing rubber 12 is placed on the baffle plate 802. When the third cover 9 is screwed tightly with the external threaded ring 803, the lower end face of the third through hole 1001 presses against the sealing rubber 12 to achieve the sealing of the second cover 8.

[0026] like Figures 1-3 As shown, multiple detection mechanisms 15 are detachably mounted on the first cover 2. The detection mechanisms 15 are located between two sealing covers 203. The detection mechanisms 15 rotate with the first cover 2, eventually aligning with the placement slot 105 at the same center. The detection mechanisms 15 pierce the self-sealing cover, extending their detection ends into the specimen storage container 6 and contacting the solution inside. The detection mechanisms 15 detect the characteristic signals of the specimen in the solution, using these signals to provide a basis for subsequent testing sequence ranking.

[0027] Specifically, such as Figures 12-15 As shown, an airbag 13 matching the sealing rubber 12 is fixedly connected to the second cover 8. When the detection mechanism 15 pierces the sealing rubber 12 and the detection mechanism 15 separates from the sealing rubber 12, the airbag 13 expands and the sealing rubber 12 deforms on its own, so that the opening created by the detection mechanism 15 is sealed, thus preventing the liver and gallbladder specimens in the specimen storage device 6 from being exposed to the outside air for a long time.

[0028] like Figures 5-15As shown, a first air supply tube 14 is fixedly connected to the airbag 13, and a first quick connector 1401 is fixedly connected to the end of the first air supply tube 14 away from the airbag 13. The liver and gallbladder specimen processing device includes a first air supply assembly 27 for supplying air to the airbag 13. The first air supply assembly 27 controls the air intake to control the expansion and contraction of the airbag 13. The first air supply assembly 27 includes a first branch tube 28, a plurality of first branch tubes 29 are fixedly connected to the first branch tube 28, a second air supply tube 30 matching the first branch tubes 29 is installed on the housing 1, a first solenoid valve 32 is fixedly connected to the second air supply tube 30, and a second quick connector 31 is fixedly connected to the end of the second air supply tube 30 away from the first branch tubes 29. The second quick connector 31 and the first quick connector 1401 can be quickly connected. An air source system is installed on the first air supply assembly 27, which can supply or depress air according to the needs of the airbag 13.

[0029] like Figures 16-17 As shown, the detection mechanism 15 includes a first mounting base 16 and a second mounting base 18. A second electric push rod 17 is fixedly connected between the first mounting base 16 and the second mounting base 18, and the distance between the first mounting base 16 and the second mounting base 18 is controlled by the second electric push rod 17. A housing 19 is fixedly connected to the first mounting base 16, and a spike tube 20 is slidably connected inside the housing 19. The lower end of the spike tube 20 is a spike that can pierce the self-sealing cover.

[0030] like Figures 16-17 As shown, a lower pressure plate 2001 is fixedly connected to the upper end of the spike tube 20. A fourth through hole 1601 is provided on the first mounting base 16 for the spike tube 20 to pass through. The outer diameter of the lower pressure plate 2001 is greater than or equal to the diameter of the fourth through hole 1601 to prevent the spike tube 20 from detaching from the first mounting base 16.

[0031] like Figures 16-17 As shown, an inner tube 21 is slidably connected inside the spiked tube 20. A second limiting ring 2101 is fixedly connected to the lower end of the inner tube 21. Two first limiting rings 2002 are fixedly connected inside the spiked tube 20. The inner diameter of the two second limiting rings 2101 is equal to the outer diameter of the inner tube 21, and the second limiting rings 2101 are located between the two first limiting rings 2002. The first limiting rings 2002 serve a limiting function to prevent the inner tube 21 from detaching from the spiked tube 20 and to ensure that the inner tube 21 slides within the spiked tube 20. A first electric push rod 11 is fixedly connected inside the spiked tube 20, and the first electric push rod 11 controls the spiked tube 20 to slide within the outer casing 19.

[0032] like Figures 16-17As shown, a first wire 23 is fixedly connected inside the inner tube 21. A detection head 24 is fixedly connected to the lower end of the first wire 23. A signal processing mechanism 22 matching the first wire 23 is fixedly connected to the second mounting base 18. A second wire 25 is connected to the signal processing mechanism 22. An integrated display controller 26 is installed at the end of the second wire 25 away from the signal processing mechanism 22. The integrated display controller 26 is used to display sorting and other information, and can realize simple control of the detection mechanism 15 such as stopping, closing, and starting through the integrated display controller 26.

[0033] In its initial state, the detection mechanism 15 is located between the two placement slots 105. When the detection mechanism 15 needs to detect the liver and gallbladder specimens in the specimen storage container 6, the motor 3 drives the first cover 2 to rotate, positioning the detection mechanism 15 directly above the placement slot 105. The first electric push rod 11 pulls the spike tube 20 downward, allowing its lower end to pierce the sealing rubber 12. Then, the second electric push rod 17 is activated, causing the second mounting base 18 to move downward along with the signal processing mechanism 22. Based on the model of the detection head 24, it is selected whether the detection head 24 needs to be inserted into the fixative. The detection of the specimen characteristic signals is completed according to the actual model of the detection head 24. The integrated display controller 26 displays the intelligent sorting results generated by the sorting control module, and the staff performs sequential detection based on this sorting information.

[0034] Intelligent sorting is performed by the sorting control module, and the results are displayed through the integrated display controller 26 after sorting. Of course, the sorting control module does not only consider the specimen characteristic signals, although these are an important part of the sorting of liver and gallbladder specimens. In the process of intelligent sorting, the patient's specific condition also needs to be taken into account, that is, the patient's physical parameters are also one of the sorting considerations.

[0035] Specifically, the sorting control module, as the core of the system's intelligent decision-making, operates as follows: First, the module synchronously acquires real-time specimen characteristic signals and their time-series data from various testing institutions 15, and associates these with patient clinical parameters via the integrated display controller 26. Then, the core algorithm prioritizes calculating the signal change rate of each hepatobiliary specimen, and, considering its current signal intensity and clinical severity, dynamically calculates a priority score using a weighted scoring model with configurable weights. Finally, the sorting control module generates a real-time updated testing order based on this score and drives the integrated display controller 26 to output the sorting list. This process, by quantifying the activity decay trend and clinical urgency, achieves a shift from passive sequential processing to predictive priority scheduling, ensuring that high-value specimens are tested within their optimal activity window, thus effectively solving the specimen failure and testing delay problems caused by fixed procedures in the background technology.

[0036] In order to ensure that the specimen storage device 6 remains stable in the placement slot 105, and to allow the placement slot 105 to accommodate specimen storage devices 6 of different sizes, such as Figures 3 to 12 As shown, a fourth electric push rod 36 is fixedly connected inside the housing 1. The fourth electric push rod 36 is located at the lower end of the placement slot 105, and its extended end is fixedly connected to the sealing plate 37. The fourth electric push rod 36 can change the position of the sealing plate 37 in the placement slot 105, and the sealing plate 37 and the inner wall of the arc-shaped plate 35 are sealed. During the upward movement, the height of the placement slot 105 decreases, making it suitable for smaller specimen storage devices 6. A fixing mechanism 33 is also fixedly connected to the housing 1. This fixing mechanism 33 is used to fix the upper end of the specimen storage device 6, preventing the specimen storage device 6 from swaying left and right in the placement slot 105.

[0037] Specifically, such as Figure 12 As shown, the fixing mechanism 33 includes at least one pair of third electric push rods 34. The third electric push rods 34 are symmetrically arranged around the circumference of the placement groove 105 and are symmetrically arranged at the left and right ends of the placement groove 105. An arc-shaped plate 35 is fixed to the extended end of the third electric push rod 34. The end face of the arc-shaped plate 35 near the specimen storage device 6 is arc-shaped. The third electric push rod 34 pushes the arc-shaped plate 35 to squeeze the upper part of the specimen storage device 6, thereby fixing the specimen storage device 6 with the arc-shaped plate 35 and maintaining the stability of the specimen storage device 6 during the signal detection process performed by the detection mechanism 15.

[0038] like Figures 1-12 As shown, the housing 1 is also equipped with a first liquid supply mechanism 38 that matches the placement tank 105. The first liquid supply mechanism 38 can supply heat preservation liquid into the placement tank 105. The heat preservation liquid can change the temperature of the specimen storage device 6 located in the placement tank 105, so that the temperature can match the liver and gallbladder specimens located in the specimen storage device 6. Moreover, the temperature of the heat preservation liquid in each placement tank 105 can be different.

[0039] like Figure 12 As shown, the first liquid supply mechanism 38 includes a second diversion pipe 39, to which a second branch pipe 40 is fixedly connected. The end of the second branch pipe 40 furthest from the second diversion pipe 39 is fixedly connected to a sealing plate 37. A second solenoid valve 41 is installed on the second branch pipe 40. The second diversion pipe 39 is connected to a liquid supply system (not shown in the figure), which can be external or integrated into the liver and gallbladder specimen processing equipment. During liquid inlet, the liquid supply system delivers a heat-preserving liquid of the corresponding temperature based on the specimen characteristic signal detected by the detection mechanism 15. The second solenoid valve 41 precisely controls the placement tank 105 into which the heat-preserving liquid needs to enter. Furthermore, the heat-preserving liquid can be discharged via the second branch pipe 40 and the second diversion pipe 39.

[0040] like Figures 1 to 11 As shown, a cleaning tank 104 is provided on the housing 1, and a first connecting pipe 42 and a second connecting pipe 43 matching the cleaning tank 104 are installed on the housing 1. A second liquid supply mechanism 44 is installed on the housing 1, which can input and output cleaning liquid into the cleaning tank 104 through the first connecting pipe 42 and the second connecting pipe 43. After the detection mechanism 15 completes one cleaning, a simple cleaning is performed on the detection mechanism 15 to avoid cross-contamination and improve the accuracy of the detection.

[0041] Specifically. For example... Figures 1 to 11 As shown, the second liquid supply mechanism 44 includes a third diversion pipe 45 and a sixth diversion pipe 4501. The third diversion pipe 45 serves as the liquid inlet diversion pipe, and a first liquid supply pipe 46 is fixedly connected to the third diversion pipe 45. The first liquid supply pipe 46 is connected to the first connecting pipe 42, and a third solenoid valve 47 is fixedly connected to the first liquid supply pipe 46. The sixth diversion pipe 4501 serves as the liquid outlet diversion pipe, and a first liquid outlet pipe 48 is fixedly connected to the sixth diversion pipe 4501. The first liquid outlet pipe 48 is connected to the second connecting pipe 43, and a fourth solenoid valve 49 is fixedly connected to the first liquid outlet pipe 48. During liquid inlet, the fourth solenoid valve 49 is closed, and the liquid in the third diversion pipe 45 enters the first connecting pipe 42 through the first liquid supply pipe 46, and finally enters the cleaning tank 104. When liquid is discharged, the third solenoid valve 47 closes, and the liquid in the cleaning tank 104, under negative pressure, enters the first outlet pipe 48 through the second connecting pipe 43, and then enters the sixth diversion pipe 4501 through the first outlet pipe 48, from which the liquid is discharged. It is worth noting that both the third diversion pipe 4501 and the sixth diversion pipe 4501 are connected to the liquid supply system.

[0042] The cleaning solution in the cleaning tank 104 is mainly used to clean the solution residue on the detection head 24. During cleaning, the motor 3 drives the first cover 2 to rotate, so that the detection mechanism 15 is above the cleaning tank 104. The second electric push rod 17 is activated, and the second electric push rod 17 moves the second mounting base 18 downward, allowing the detection head 24 to be immersed in the cleaning solution.

[0043] like Figure 11 As shown, for some detection heads 24 that can be cleaned using ultrasonic waves, a transducer 69 is provided on the cleaning tank 104. The transducer 69 vibrates the cleaning fluid in the cleaning tank 104 to achieve deep cleaning of the detection head 24.

[0044] After cleaning, the detection head 24 is dried by blowing air. For example... Figures 1-9As shown, gas is supplied to the cleaning tank 104 using the first air supply mechanism 51, and this gas is used to dry the residual cleaning liquid on the detection head 24. Specifically, the first air supply mechanism 51 includes an air pump 57. The air inlet end of the air pump 57 is fixedly connected to a fourth air inlet pipe 68. An eighth solenoid valve 50 is installed on the fourth air inlet pipe 68. The end of the fourth air inlet pipe 68 away from the air pump 57 is fixedly connected to a fifth diverter pipe 65. A third air inlet pipe 66, which matches the first connecting pipe 42, is installed on the fifth diverter pipe 65. A tenth solenoid valve 67 is installed on the third air inlet pipe 66. The air outlet end of the air pump 57 is fixedly connected to a first air supply pipe 58. The end of the first air supply pipe 58 away from the air pump 57 is fixedly connected to a filter 59, which filters the air and reduces impurities in the air. A second air supply duct 60 is installed on the filter 59, and a seventh solenoid valve 61 is installed on the second air supply duct 60. A fourth diversion duct 62 is fixedly connected to the end of the second air supply duct 60 away from the filter 59. Multiple third air supply ducts 63, which are matched with the first connecting duct 42, are installed on the fourth diversion duct 62. A ninth solenoid valve 64 is installed on the third air supply duct 63. The first air supply mechanism 51 described above can be used to clean the cleaning tank 104 by blowing dry gas into the cleaning tank 104 to slowly dry the detection head 24 and avoid damaging the detection head 24.

[0045] like Figure 1 As shown, the air pump 57 is also fixedly connected to a second air inlet pipe 55, which is connected to the fourth air inlet pipe 68. A sixth solenoid valve 56 is fixedly connected to the second air inlet pipe 55.

[0046] like Figure 1 As shown, a heat dissipation hole 101 for dissipating heat from the motor 3 is provided on one side of the housing 1. An air inlet plate 52 is fixedly connected to the side of the housing 1 away from the heat dissipation hole 101. A first air inlet pipe 53 matching the air inlet end of the air pump 57 is installed on the air inlet plate 52. A fifth solenoid valve 54 is fixedly connected to the first air inlet pipe 53. By using the air inlet plate 52, the first air inlet pipe 53 and the fifth solenoid valve 54, heat dissipation can be provided for the motor 3 inside the housing 1 to prevent the motor 3 from overheating.

[0047] In use, first place the specimen storage container 6 containing the liver and gallbladder specimens into the placement tank 105, and then cover the corresponding retrieval port with the sealing cap 203. At this time, the environment in which the specimen storage container 6 is located is a sealed environment. The operator sets the parameters according to the condition of the liver and gallbladder specimens in the specimen storage container 6, and uses the liquid supply system to deliver an appropriate amount of heat-preserving liquid into the placement tank 105 to preserve the liver and gallbladder specimens at a suitable temperature.

[0048] The testing mechanism 15 periodically tests the liver and gallbladder specimens in the specimen storage container 6 according to a set time. During testing, the motor 3 drives the first cover 2 to rotate, positioning the testing mechanism 15 directly above the placement slot 105. The first electric push rod 11 is activated, moving the spike tube 20 downwards. The lower end of the spike tube 20 first pierces the sealing rubber 12. The second electric push rod 17 is then activated, causing the inner tube 21 to slide downwards inside the spike tube 20. The inner tube 21 moves downwards together until the detection head 24 enters the cup body 7. Depending on the model of the detection head 24, either a contact or non-contact testing method is selected to detect the specimen characteristic signals of the liver and gallbladder specimens. After the test is completed, the second electric push rod 17 lifts the second mounting base 18, the spike tube 20 returns to its original position, and the detection head 24 is located inside the spike tube 20. Simultaneously, the outer casing 19 lifts the lower pressure plate 2001. After the spike tube 20 returns to its original position, the motor 3 drives the first cover 2 to rotate, aligning the detection mechanism 15 with the nearest cleaning tank 104. The second electric push rod 17 then activates, pulling down the second mounting base 18 to position the detection head 24 in the cleaning tank 104. Cleaning solution for cleaning the detection head 24 is then added to the cleaning tank 104 via the liquid supply system. Immersion is generally used, which minimizes the risk of damage to the detection head 24.

[0049] After the detection head 24 is soaked and cleaned, the cleaning solution is discharged through the second connecting pipe 43, and dry gas is blown into the cleaning tank 104 through the first air supply mechanism 51 to dry the detection head 24. Under normal circumstances, the dry gas is blown in slowly to avoid damage to the detection head 24 due to excessive air pressure.

[0050] like Figure 18 As shown, the first conductor 23 includes a conductor body 2301 and a protective tube 2302. The protective tube 2302 is mainly used to protect the conductor body 2301 from damage during sliding. The detection head 24 includes a detection head body 2401 and a protective layer 2402. Similarly, the protective layer 2402 is used to protect the detection head body 2401 from damage. For scenarios where the detection head body 2401 needs to be immersed in the protective layer 2402, the protective layer 2402 protects the detection head body 2401 to the greatest extent and ensures that it does not affect the detection head body 2401 from completing the detection operation.

[0051] In another embodiment, the difference from the above embodiments is: In molecular pathology studies such as gene mutation detection, FISH, and PCR, alcohol-based fixatives are often used. To achieve high sensitivity, specificity, and reliability, the activity of liver and biliary specimens needs to be monitored. In this embodiment, the characteristic signal detected is cathepsin B. Cathepsin B reflects the degree of cell apoptosis. Utilizing the enzyme's specific cleavage ability and the luminescence properties of fluorescent substances, the concentration of cathepsin B is converted into a measurable optical signal, and the activity level of the liver and biliary specimen is then determined based on the optical signal. In other words, the detection mechanism 15 utilizes the characteristic that liver and biliary specimens with low activity release more cathepsin B, converting this invisible enzyme concentration into visible fluorescence intensity, and determining the activity level of the liver and biliary specimens stored in the specimen storage container 6 based on the fluorescence intensity.

[0052] Specifically, the detection head body 2401 is a fluorescent probe, and the protective layer 2402 is a transparent protective structure. After the fluorescent probe reacts, it releases fluorescence. The detection head body 2401 has a built-in micro-fluorescence detector that detects the fluorescence intensity in real time and converts it into cathepsin B concentration. Multiple liver and gallbladder specimens are tested simultaneously, and based on the test results, the liver and gallbladder specimens are sorted using a sorting control module. Subsequent testing steps are completed according to the order provided by the sorting control module.

[0053] In another embodiment, the difference from the above embodiments is: The detection mechanism 15 is fixedly connected to the first cover 2 via a snap-fit ​​mechanism and is a detachable structure. The detection head body 2401 is a fiber optic probe, the protective layer 2402 is a lactic acid-sensitive fluorescent dye film, and the lead wire body 2301 is an optical fiber. The fiber optic probe has strong corrosion resistance. A lactic acid-sensitive fluorescent dye film is fixed to the tip of the fiber optic probe. Since the detection mechanism 15 is detachable, it can be removed after the test is completed, and the fluorescent dye film can be replaced manually. Alternatively, before replacement, the detection head 24 can be immersed in the cleaning tank 104 for cleaning. During immersion, the lactic acid-sensitive fluorescent dye film detaches from the lead wire body 2301. After the detection mechanism 15 is removed, only the fluorescent dye film needs to be fixed in place.

[0054] When lactic acid diffuses into the membrane, it causes changes in the fluorescence intensity or lifetime of the dye. The signal processing unit 22 contains an excitation beam and a detector. The excitation beam is transmitted to the tip via an optical fiber, and the excited fluorescence signal is then transmitted back to the detector via another optical fiber. The lactic acid concentration is calculated by analyzing the changes in the fluorescence signal, and the lactic acid concentration change curve is recorded. The sorting control module uses this curve to determine the sorting priority.

[0055] If sorted solely by current lactate levels, liver and gallbladder specimens A and B would be grouped with the same priority. This could lead to specimen B's lactate level exceeding the threshold during the queuing process, rendering the test results invalid. However, by identifying the decay rate through the curve slope, specimen B can be elevated to an urgent priority, thus securing testing resources and preventing invalid tests.

[0056] For clinicians, the ultimate goal of testing prioritization is to complete the testing of each specimen within its optimal activity window. Lactate concentration change curves are the core tool for achieving this goal: they not only provide the basis for prioritization, but also answer the key questions of why priority should be given and when testing is necessary, transforming prioritization from experience-based judgment to data-driven, precise decision-making, perfectly adapting to the entire process of pathological specimen transportation and testing.

[0057] In another embodiment, the difference from the above embodiments is: The main body of the detection head, 2401, is specifically an enzyme-free electrochemical sensor. The core advantage of an enzyme-free electrochemical sensor is that it does not rely on specific biological enzymes. It typically uses electrodes modified with nanomaterials such as noble metal nanoparticles, carbon nanotubes, and graphene. These materials can directly catalyze the oxidation or reduction reactions of certain electroactive substances in solution. When it is inserted into the formalin-fixed liver and gallbladder specimen soaking solution, it detects the sum of electrochemically active small molecules that have leaked from damaged cells into the soaking solution. In other words, the enzyme-free sensor measures a macroscopic electrochemical signal that is proportional to the degree of cell damage and necrosis.

[0058] Enzyme-free electrochemical sensors indirectly but rapidly reflect the cellular integrity and freshness of liver and gallbladder specimens by detecting the total amount of electroactive small molecules from damaged cells in formalin immersion solution. A stronger electrical signal indicates greater cellular leakage and poorer specimen quality. Clinical sequencing only needs to differentiate quality levels, without requiring precise detection of a specific small molecule. While the macroscopic signal from enzyme-free sensors does not distinguish specific substances, it can more comprehensively reflect the overall degree of damage to the specimen. For example, if lactic acid and adenosine are leaked simultaneously, the superposition of signals can better indicate the severity. The sequencing control module sorts the liver and biliary specimens to be tested based on multiple characteristic signals, ensuring that each specimen is tested within its optimal activity window.

[0059] The core value of enzyme-free electrochemical sensors lies in solving the problem of rapid, stable, and low-cost specimen quality assessment in a formalin environment with extremely simple detection logic. Its advantages are perfectly suited to the clinical needs of efficient, interference-resistant, and easy-to-implement detection sequencing.

[0060] Obviously, the above-described embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention also intends to include these modifications and variations.

Claims

1. A liver and gallbladder specimen processing device, characterized in that, include: The shell (1) has a plurality of placement slots (105) arranged around its upper end surface. The placement slots (105) are used to place a specimen storage device (6) containing liver and gallbladder specimens. The specimen storage device (6) includes a cup body (7) and a self-sealing cover. The self-sealing cover is installed on the cup body (7). A first cover (2) that matches the placement slots (105) is rotatably connected to the shell (1). Multiple testing mechanisms (15) are used to test liver and gallbladder specimens located in specimen storage containers (6). Each testing mechanism (15) includes a first mounting base (16) and a second mounting base (18). A second electric push rod (17) is fixedly connected between the first mounting base (16) and the second mounting base (18). An outer shell (19) is fixedly connected to the first mounting base (16). A spike tube (20) is slidably connected inside the outer shell (19). The spike tube (20) is used to pierce a self-sealing cover. A first electric push rod (11) for driving the spike tube (20) to slide is fixedly connected inside the spike tube (20). An inner tube (21) is slidably connected inside the spike tube (20). A first wire (23) is fixedly connected inside the inner tube (21). A detection head (24) is fixedly connected to the lower end of the first wire (23). A signal processing mechanism (22) matching the first wire (23) is fixedly connected to the second mounting base (18). An integrated display controller (26) is fixedly connected to the middle of the first cover (2), and a second wire (25) is installed between the signal processing mechanism (22) and the integrated display controller (26). The sorting control module is used to receive the detection data from the detection agency (15), sort the detection order of the specimen storage device (6) according to the detection data, and display the sorting result through the integrated display controller (26).

2. The liver and gallbladder specimen processing device as described in claim 1, characterized in that, The self-sealing cover includes a second cover (8), the cup body (7) is provided with an external thread (701), the second cover (8) is threaded with a first internal thread (801), and the cup body (7) and the second cover (8) are threaded together. The second cover (8) is fixedly connected to a baffle plate (802) that matches the cup body (7). The baffle plate (802) has a second through hole (8021) in the middle. The upper end of the second cover (8) is fixedly connected to an external threaded ring (803). The second cover (8) is threadedly connected to a third cover (9) that matches the external threaded ring (803). The third cover (9) is fixedly connected to a lower pressure ring (10). The lower pressure ring (10) has a third through hole (1001) that matches the second through hole (8021). A sealing rubber (12) is installed between the baffle plate (802) and the lower pressure ring (10).

3. The liver and gallbladder specimen processing device as described in claim 2, characterized in that, An airbag (13) is fixedly connected to the second cover (8). One end of the airbag (13) is fixedly connected to a first air supply pipe (14), and the end of the first air supply pipe (14) away from the airbag (13) is fixedly connected to a first quick connector (1401). The housing (1) is equipped with a first air supply assembly (27) that matches the airbag (13). The first air supply assembly (27) includes a first diversion pipe (28) installed outside the housing (1). A first branch pipe (29) is fixedly connected to the first diversion pipe (28). The housing (1) is equipped with a second air supply pipe (30) that matches the first branch pipe (29). A first solenoid valve (32) is fixedly connected to the second air supply pipe (30). A second quick connector (31) is fixedly connected to one end of the second air supply pipe (30) away from the first branch pipe (29). The second quick connector (31) is fixedly connected inside the placement slot (105).

4. A liver and gallbladder specimen processing device as described in any one of claims 1 to 3, characterized in that, The housing (1) is equipped with a fourth electric push rod (36) that matches the placement groove (105). The extended end of the fourth electric push rod (36) is fixedly connected to a sealing plate (37). The sealing plate (37) is located at the bottom of the placement groove (105). The sealing plate (37) is slidably connected in the placement groove (105). The sealing plate (37) is fixedly connected to the extended end of the fourth electric push rod (36). At least two third electric push rods (34) are fixedly connected to the housing (1). The third electric push rods (34) are symmetrically arranged around the placement groove (105). An arc plate (35) is fixedly connected to the protruding end of the placement groove (105).

5. The liver and gallbladder specimen processing device as described in claim 1, characterized in that, The housing (1) is provided with a cleaning tank (104) that matches the detection mechanism (15), and the housing (1) is provided with a first connecting pipe (42) and a second connecting pipe (43) that match the cleaning tank (104). The housing (1) is equipped with a second liquid supply mechanism (44) that matches the first connecting pipe (42) and the second connecting pipe (43). The second liquid supply mechanism (44) includes a third diversion pipe (45). A first liquid supply pipe (46) that matches the first connecting pipe (42) is fixedly connected to the third diversion pipe (45). A third solenoid valve (47) is fixedly connected to the first liquid supply pipe (46). The second liquid supply mechanism (44) also includes a sixth diversion pipe (4501), on which a first liquid outlet pipe (48) matching the second connecting pipe (43) is fixedly connected, and a fourth solenoid valve (49) is fixedly connected to the first liquid outlet pipe (48).

6. The liver and gallbladder specimen processing device as described in claim 5, characterized in that, Multiple transducers (69) that match the cleaning tank (104) are fixedly connected to the housing (1).

7. A liver and gallbladder specimen processing device as described in claim 5 or 6, characterized in that, It includes a first gas supply mechanism (51), which includes a fourth branch pipe (62) and a fifth branch pipe (65). A third air supply pipe (63) matching the first connecting pipe (42) is fixedly connected to the fourth branch pipe (62). A ninth solenoid valve (64) is fixedly connected to the third air supply pipe (63). A third air inlet pipe (66) matching the second connecting pipe (43) is fixedly connected to the fifth branch pipe (65). A tenth solenoid valve (67) is fixedly connected to the third air inlet pipe (66).

8. The liver and gallbladder specimen processing device as described in claim 7, characterized in that, The first air supply mechanism (51) includes an air pump (57), and the air inlet end of the first air supply mechanism (51) is fixedly connected to a fourth air inlet pipe (68) that matches the third air inlet pipe (66), and an eighth solenoid valve (50) is fixedly connected to the fourth air inlet pipe (68). The air pump (57) is fixedly connected to a first air supply pipe (58) at its outlet end. A filter (59) is fixedly connected to the end of the first air supply pipe (58) away from the air pump (57). A second air supply pipe (60) matching the fourth diversion pipe (62) is installed on the filter (59).

9. The liver and gallbladder specimen processing device as described in claim 1, characterized in that, The bottom of the housing (1) is provided with a heat dissipation hole (101), and a motor (3) matching the heat dissipation hole (101) is fixedly connected to the housing (1). The output end of the motor (3) is connected to the first cover (2).

10. A liver and gallbladder specimen processing device as described in claim 1 or 9, characterized in that, The first cover (2) has a retrieval opening, and a sealing cover (203) matching the retrieval opening is installed on the first cover (2).

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