Fat-reducing slimming composition formula and preparation method thereof
By combining traditional Chinese medicine ingredients with proteases to form a solid preparation, which can be applied to the skin or taken orally, the problem of poor efficacy and significant side effects of existing weight loss methods is solved, achieving a safe and effective fat reduction effect, suitable for the weight loss needs of teenage girls.
Patent Information
- Application Number
- CN202511287495.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-10
- Publication Date
- 2025-12-05
AI Technical Summary
Existing weight loss methods are ineffective, have significant side effects, and are difficult to maintain, especially for young women. Exercise is too tiring, tea-based weight loss methods are costly and difficult to stick to, and dieting is unscientific and harmful to health.
This product combines Chinese medicinal herbs such as Phoenix Grass, Smilax glabra, Tian Shan Snow Lotus, Angelica sinensis, Saffron, Hawthorn, Cassia Seed, Lotus Leaf, Alisma plantago-aquatica, Poria cocos, Atractylodes macrocephala, Ophiopogon japonicus, Lilium brownii, and Polygonum multiflorum with protease to form a solid preparation that can be applied to the skin or taken orally. The ingredients are then introduced into the skin through an iontophoresis device or an ultrasonic transdermal delivery device, and the combined internal and external effects achieve a fat-reducing effect.
By working synergistically from both internal and external sources, we enhance fat-burning effects, reduce the difficulty of the process, increase adherence to the regimen, and provide a scientific and safe way to lose weight.
Abstract
Description
TECHNICAL FIELD
[0001] The present application belongs to the technical field of composition formula, and particularly relates to a fat-reducing and slimming composition formula and a preparation method thereof. BACKGROUND
[0002] Obesity is the most common and oldest metabolic disease. Obesity has existed since ancient times. Chinese medicine understands obesity from the aspects of constitution, diet, mental state, and imbalance of work and rest, and discusses the relationship between obesity and spleen and stomach, qi deficiency, and phlegm-dampness. It is pointed out that during the process of obesity, various changes occur, causing many other diseases. Obesity not only affects body shape and appearance, but more importantly, it increases the incidence of cardiovascular, cerebrovascular, diabetes, hyperlipidemia, infertility, and tumor diseases, seriously affecting human physical and mental health, weakening the body's resistance, and increasing the mortality rate. According to the statistics of WHO, there are more than 300 million obese people in the world, and 1.1 billion people are overweight. The number of people who die from eating is higher than that of people who die from hunger.
[0003] At present, common weight loss methods include enema weight loss, osmotic pressure weight loss, sauna weight loss, milk powder weight loss, rope skipping weight loss, Pu'er tea weight loss, surgical weight loss, and drug weight loss. However, for most young women, exercise weight loss is too tiring and generally cannot be sustained. Tea weight loss is too expensive and most people do not have the habit of drinking tea. Diet weight loss is very painful and unscientific, and is very harmful to the body. Drug weight loss has obvious toxic side effects and poor weight loss effect. SUMMARY
[0004] The present application aims to provide a fat-reducing and slimming composition formula and a preparation method thereof, to solve the technical problems of poor weight loss effect, large toxic side effects, and difficulty in persistence of traditional weight loss methods.
[0005] To solve the above technical problems, the specific technical solutions of the present application are as follows:
[0006] In some embodiments of the present application, a fat-reducing and slimming composition formula and a preparation method thereof are provided, comprising: component A and component B.
[0007] The component A is composed of the following components: phoenix grass, milk vetch root, Saussurea involucrata, angelica, saffron, hawthorn, cassia seed, lotus leaf, alisma, poria, atractylodes, ophiopogon, lily, and prepared rehmannia.
[0008] The component B is a protease, wherein the addition amount of the protease is 0.5-2 parts of the dry matter weight of the component A.
[0009] In some embodiments of the present application, the protease is selected from at least one of bromelain, trypsin, and papain, and the enzyme activity is greater than or equal to 500,000 U / g.
[0010] In some embodiments of the present application, a method for preparing the fat-reducing and slimming composition of any one of claims 1-2, comprising the following steps:
[0011] 1) Component A raw material is subjected to ethanol-water fractionation extraction to obtain an extract infusion;
[0012] 2) A protease is added to the infusion under the condition of inert gas protection and a temperature ≤ 45°C;
[0013] 3) Spray drying to obtain a solid preparation.
[0014] In some embodiments of the present application, the fractionation extraction is specifically: first extracting for 2-3 hours at 30-40°C with 50-70% ethanol, and then extracting for 1-2 hours at 90-100°C with water.
[0015] In some embodiments of the present application, a method for preparing the fat-reducing and slimming composition of any one of claims 1-2, comprising the following steps:
[0016] 1) Each traditional Chinese medicine ingredient is subjected to low-temperature ultrafine grinding at -15°C to obtain a traditional Chinese medicine powder with a particle size ≤ 50 μm;
[0017] 2) The traditional Chinese medicine powder and microcrystalline cellulose are mixed in a mass ratio of 1:1-1:3 under an environment with a relative humidity ≤ 45%;
[0018] 3) Hydroxypropyl methyl cellulose ethanol solution is added as a binder, and high-speed shearing granulation is performed to form wet granules;
[0019] 4) Fluidized bed drying is performed at 50±5°C until the moisture content is ≤ 3.5%;
[0020] 5) Tabletting or capsule filling is performed;
[0021] 6) The prepared tablets or capsules are used orally, and the protease is coated on the surface of the human skin and introduced into the skin by an ion introduction instrument or an ultrasonic introduction instrument, so that the protease penetrates into the skin.
[0022] In some embodiments of the present application, step 1) comprises: the low-temperature ultrafine grinding is performed under nitrogen protection; and after grinding, Co 60 irradiation sterilization is performed at a dose of 8-10 kGy.
[0023] In some embodiments of the present application, in step 2), the microcrystalline cellulose is PH-102 type with a particle size of 90-150 μm; and the mixing device is a three-dimensional motion mixer, and the mixing time is ≥ 45 minutes.
[0024] In some embodiments of the present application, in step 3), the hydroxypropyl methyl cellulose is E5 grade, the concentration is 5wt%, the binder is added in an amount of 20-35% of the total powder weight, and the shearing paddle of the granulator rotates at a speed of 800-1200rpm.
[0025] In some embodiments of the present application, the granules obtained after step 4) satisfy the following conditions: the bulk density is 0.45-0.60g / cm 3 ; the Carr index is 15-20%; and the disintegration time is ≤30 minutes.
[0026] In some embodiments of the present application, the tabletting parameters of step 5) are as follows: 0.5-1% magnesium stearate is added as a lubricant; the tabletting pressure is 8-12kN; and the tablet hardness is 50-80N.
[0027] Compared with the prior art, the present application has the following beneficial effects: by coating the solid preparation of traditional Chinese medicine and protease on the surface of human skin, and directly introducing the components in the preparation into the skin through an ion introduction instrument or an ultrasonic wave introduction instrument, the effect of fat reduction is achieved; by preparing the traditional Chinese medicine into a powder, and then into a cellulose capsule or a tablet for oral use, the effect of internal fat reduction is achieved; by coating the protease directly on the surface of human skin, and directly introducing the components in the preparation into the skin through an ion introduction instrument or an ultrasonic wave introduction instrument, the effect of fat reduction is further improved; by adopting the internal and external synergistic effect, the effect of fat reduction is improved, and the operation of the user is reduced, so that the user can better adhere to the use. DETAILED DESCRIPTION
[0028] The specific embodiments of the present application will be further described in detail below with reference to the examples. The following examples are used to illustrate the present application, but are not used to limit the scope of the present application.
[0029] In order to better understand the purpose, structure and function of the present application, the present application will be further described in detail below with reference to the examples.
[0030] Example 1
[0031] According to the embodiments of the present application, it comprises component A and component B.
[0032] The component A is composed of the following components: phoenix grass, milk vetch, Tibetan snow lotus, angelica, saffron, hawthorn, cassia seed, lotus leaf, alisma, poria, atractylodes, ophiopogon, lily, prepared rehmannia;
[0033] The component B is protease, wherein the amount of protease added is 0.5-2 parts of the dry matter weight of component A.
[0034] In the embodiments of the present application, the protease is selected from at least one of the following: bromelain, trypsin, and papain, and the enzyme activity is ≥500,000U / g.
[0035] The preparation method comprises the following steps:
[0036] 1) The raw materials of component A are subjected to ethanol-water segmented extraction to obtain an extract infusion;
[0037] 2) A protease is added to the infusion under the condition of inert gas protection and a temperature ≤ 45°C;
[0038] 3) Spray drying is performed to obtain a solid preparation.
[0039] The segmented extraction is specifically as follows: 50-70% ethanol is used to extract at 30-40°C for 2-3 hours, and then water is used to extract at 90-100°C for 1-2 hours.
[0040] After the solid preparation is prepared, the components in the solid preparation are directly introduced into the skin by coating the surface of the human skin, and then the components are introduced into the skin by an ion introduction instrument, an ultrasonic introduction instrument, an infrared introduction instrument, and the like, and penetrate into the human body, thereby achieving the effect of fat reduction.
[0041] Example 2
[0042] In the embodiments of the present application, some of the technical features in the above examples are adopted, wherein the preparation method comprises the following steps:
[0043] 1) Each traditional Chinese medicine ingredient is subjected to low-temperature ultrafine pulverization at -15°C to obtain a traditional Chinese medicine powder with a particle size ≤ 50 μm;
[0044] 2) The traditional Chinese medicine powder and microcrystalline cellulose are mixed in a mass ratio of 1:1-1:3 under an environment with a relative humidity ≤ 45%;
[0045] 3) Hydroxypropyl methyl cellulose ethanol solution is added as a binder, and high-speed shearing granulation is performed to form wet granules;
[0046] 4) Fluidized bed drying is performed at 50±5°C until the moisture content is ≤ 3.5%;
[0047] 5) Tabletting or capsule filling is performed for molding;
[0048] 6) The prepared tablets or capsules are used orally, and the protease is coated on the surface of the human skin and introduced into the skin by an ion introduction instrument or an ultrasonic introduction instrument.
[0049] In step 1), the low-temperature ultrafine pulverization is performed under nitrogen protection, and Co 60 irradiation sterilization is performed at a dose of 8-10 kGy.
[0050] In step 2), the microcrystalline cellulose is PH-102 type with a particle size of 90-150 μm, and the mixing device is a three-dimensional motion mixer with a mixing time ≥ 45 minutes.
[0051] In step 3), the hydroxypropyl methyl cellulose is E5 grade, and the concentration is 5 wt%; the binder is added in an amount of 20-35% of the total powder weight; and the shearing paddle of the granulator rotates at 800-1200 rpm.
[0052] After step 4), the obtained granules have a bulk density of 0.45-0.60 g / cm 3 , a Carr index of 15-20%, and a disintegration time of ≤30 minutes.
[0053] In step 5), the tabletting parameters are as follows: 0.5-1% magnesium stearate is added as a lubricant; the tabletting pressure is 8-12 kN; and the tablet hardness is 50-80 N.
[0054] In addition, the traditional Chinese medicine is made into a powder, and then made into a cellulose capsule or a tablet for oral use, so as to enhance the feeling of satiety and achieve the effect of internal fat reduction. The protease is directly applied to the surface of the human skin, and the components in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, so as to further improve the effect of fat reduction. The internal and external synergistic effects are adopted to improve the effect of fat reduction, and the operation of the user is reduced, so as to better adhere to the use.
[0055] In the description of the present application, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the examples, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.
[0056] The terms "first", "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, unless otherwise specified and limited, the meaning of "a plurality of" is two or more.
[0057] In the description of the present application, it should be noted that, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood in a broad sense, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through an intermediate medium; it can be the communication between the two elements inside. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.
[0058] The various embodiments described in this specification are intended to be illustrative only and in no way limit the scope of the application. One skilled in the art will readily devise many variations and modifications of the methods and apparatuses as set forth herein without departing from the spirit or scope of the application. Accordingly, the disclosure is intended to be illustrative only and in no way limiting of the scope of the application as it is defined by the appended claims.
[0059] The foregoing description of the disclosed embodiments enables a person skilled in the art to implement or use the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein can be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the claims, the principles and the practical equivalents thereof.
[0060] The widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A fat loss lean composition formulation, characterized in that, Comprise: Component A and component B; Wherein, component A is composed of the following components: red clover, milk vetch, Saussurea involucrata, angelica, saffron, hawthorn, cassia seed, lotus leaf, alisma, poria, atractylodes, ophiopogon, lily, prepared rehmannia; Component B is protease, wherein the addition amount of protease is 0.5-2 parts of the dry matter weight of component A.
2. The fat loss slimming composition formulation according to claim 1, wherein, The protease is selected from at least one of bromelain, trypsin, and papain, and the enzyme activity is ≥500,000 U / g.
3. A method of preparing the fat-reducing slimming composition according to any one of claims 1-2, characterized by, Comprise the following steps: 1) Component A raw materials are extracted by ethanol-water in stages to obtain extract infusion; 2) Protease is added to the infusion under the condition of inert gas protection and temperature ≤45℃; 3) Spray drying to obtain a solid preparation.
4. The method of claim 3, wherein the fat-reducing slimming composition is prepared by mixing the fat-reducing slimming composition with water in a ratio of 1: 1 to 1:
10. The segmented extraction is specifically: first extract for 2-3 hours at 30-40℃ with 50-70% ethanol, and then extract for 1-2 hours at 90-100℃ with water.
5. A method of preparing the fat-reducing slimming composition according to any one of claims 1 to 2, characterized by, Comprise the following steps: 1) Each traditional Chinese medicine ingredient is separately subjected to low-temperature ultrafine grinding at-15℃ to obtain a traditional Chinese medicine powder with a particle size ≤50μm; 2) The traditional Chinese medicine powder is mixed with microcrystalline cellulose at a mass ratio of 1:1-1:3 in an environment with a relative humidity ≤45%; 3) Hydroxypropyl methyl cellulose ethanol solution is added as a binder, and high-speed shearing granulation is performed to form wet granules; 4) Fluidized bed drying at 50±5℃ to a moisture content ≤3.5%; 5) Tabletting or capsule filling and molding; 6) The prepared tablets or capsules are used orally, and the protease is coated on the surface of the human skin and introduced by ion or ultrasonic introduction instrument, so that the protease penetrates into the skin.
6. The method of claim 5, wherein the fat-reducing slimming composition is prepared by mixing the fat-reducing slimming composition with water in a ratio of 1: 1 to 1:
10. Step 1) comprises: the low-temperature ultrafine grinding is carried out under nitrogen protection; Co 60 Irradiation sterilization, dose 8-10 kGy.
7. The method for preparing the fat-reducing and slimming composition according to claim 1, characterized in that, In step 2), the microcrystalline cellulose is PH-102 type with a particle size of 90-150μm, and the mixing equipment is a three-dimensional motion mixer with a mixing time ≥45 minutes.
8. The method of claim 1, wherein, In step 3), the hydroxypropyl methyl cellulose is E5 grade with a concentration of 5wt%, and the binder addition amount is 20-35% of the total powder weight; the shearing paddle rotation speed of the granulator is 800-1200rpm.
9. The method of claim 1, wherein, The granules obtained after step 4) satisfy: bulk density 0.45-0.60 g / cm3 3 ; Carr index 15-20%; disintegration time < 30 minutes.
10. The method of claim 1, wherein, The tabletting parameters of step 5) are: 0.5-1% magnesium stearate is added as a lubricant; the tabletting pressure is 8-12kN; The tablet hardness is 50-80N.