Chromatograph temperature control method and system, intelligent terminal and storage medium

Abstract

The invention relates to a chromatographic instrument temperature control method and system, an intelligent terminal and a storage medium, and relates to the technical field of chromatographic instrument sample separation.The method comprises the steps that the sample type of a preset sample is obtained; analyzing the sample type to determine a window heating rate and a window target temperature; acquiring a chromatographic column initial temperature of a preset chromatographic column; analyzing the initial temperature of the chromatographic column and the target temperature of the window to determine the temperature of the chromatographic column needing to be increased; analyzing the temperature required to be increased and the window heating rate of the chromatographic column so as to determine the heating time of the chromatographic column; and controlling a preset chromatographic column temperature regulation and control device to perform temperature control on the chromatographic column according to the chromatographic column heating time and the window target temperature. The method has the effect of improving the precision of the temperature retention time.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of sample separation of a chromatograph, and in particular to a chromatograph temperature control method and system, an intelligent terminal and a storage medium. BACKGROUND

[0002] A chromatograph is a precision instrument for separating and quantitatively or qualitatively analyzing complex mixtures by utilizing the difference in distribution coefficients of components in a mixture between a stationary phase and a mobile phase.

[0003] In related technologies, temperature control of a chromatograph is a core link for ensuring chromatographic separation effect, repeatability and accuracy. By regulating the environmental temperature of a chromatographic column, the distribution coefficient of components in a stationary phase and a mobile phase is stabilized, and key analysis indicators such as retention time and separation degree are controlled.

[0004] For the related technologies in the above, the function of separating a mixture is realized by heating a chromatographic column to a target temperature and then stopping heating. However, after heating is stopped, the excess heat generated by the heating element will continue to warm up the chromatographic column, so that the actual temperature range of the chromatographic column after heating is higher than the target temperature, resulting in a temperature fluctuation range between different regions in the column oven being larger than a standard temperature fluctuation range, which further affects the temperature retention time accuracy and causes some components in the mixture to not be normally separated, and there is still room for improvement. SUMMARY

[0005] In order to improve the temperature retention time accuracy, the present application provides a chromatograph temperature control method, system, intelligent terminal and storage medium.

[0006] In a first aspect, the present application provides a chromatograph temperature control method, which adopts the following technical solution:

[0007] A chromatograph temperature control method, comprising:

[0008] Obtaining a sample type of a preset sample;

[0009] Analyzing the sample type to determine a window temperature rising rate and a window target temperature;

[0010] Obtaining a chromatographic column initial temperature of a preset chromatographic column;

[0011] Analyzing the chromatographic column initial temperature and the window target temperature to determine that the chromatographic column needs to be raised in temperature;

[0012] Analyzing the chromatographic column temperature to be raised and the window temperature rising rate to determine a chromatographic column temperature rising time;

[0013] Controlling a preset chromatographic column temperature control device to control the temperature of the chromatographic column according to the chromatographic column temperature rising time and the window target temperature.

[0014] By adopting the technical scheme, the window temperature rising rate and the window target temperature are obtained by analyzing the sample type, the chromatographic column temperature rising time is obtained by analyzing the chromatographic column initial temperature and the window target temperature, the chromatographic column temperature rising time and the window target temperature are analyzed to control the chromatographic column temperature control device to control the temperature of the chromatographic column, so that the temperature fluctuation range between each region in the column oven is controlled within the standard temperature fluctuation range, thereby improving the temperature retention time precision and making the components in the mixture normally elute.

[0015] Optionally, the chromatographic column temperature control device comprises a temperature rising assembly, and the step of controlling the preset chromatographic column temperature control device to control the temperature of the chromatographic column according to the chromatographic column temperature rising time and the window target temperature comprises:

[0016] controlling the temperature rising assembly to heat the chromatographic column according to the window temperature rising rate, and obtaining the real-time temperature rising time of the chromatographic column;

[0017] judging whether the real-time temperature rising time of the chromatographic column is consistent with the chromatographic column temperature rising time;

[0018] if not, the real-time temperature rising time of the chromatographic column is continuously obtained for cyclic judgment;

[0019] if yes, the temperature rising assembly is controlled to stop heating the chromatographic column;

[0020] the window target temperature is analyzed to determine the chromatographic column residual heat influence temperature;

[0021] the chromatographic column temperature control device is controlled to cool down according to the chromatographic column residual heat influence temperature, so that the temperature of the chromatographic column is consistent with the window target temperature.

[0022] By adopting the technical scheme, the chromatographic column is heated by the temperature rising assembly according to the window temperature rising rate, the real-time temperature rising time of the chromatographic column is judged to be consistent with the chromatographic column temperature rising time, if yes, the temperature rising assembly is controlled to stop heating the chromatographic column, the window target temperature is analyzed to obtain the chromatographic column residual heat influence temperature, the chromatographic column temperature control device is controlled to cool down according to the chromatographic column residual heat influence temperature, so that the temperature of the chromatographic column is consistent with the window target temperature, and the actual temperature fluctuation range of the chromatographic column is controlled within the standard temperature fluctuation range.

[0023] Optionally, the step of analyzing the window target temperature to determine the chromatographic column residual heat influence temperature comprises:

[0024] the heat capacity of the chromatographic column and the heating power of the temperature rising assembly are obtained;

[0025] the heating element power and the chromatographic column temperature rising time are analyzed to determine the total heat release;

[0026] analyzing the heat capacity of the chromatographic column and the temperature that the chromatographic column needs to be raised to determine the heat absorbed by the chromatographic column;

[0027] analyzing the total heat released and the heat absorbed by the chromatographic column to determine the heat not absorbed by the chromatographic column;

[0028] analyzing the heat not absorbed by the chromatographic column, the heat capacity of the chromatographic column and the target temperature of the window to determine the residual heat influencing temperature of the chromatographic column.

[0029] By adopting the technical solutions, the total heat released is obtained by analyzing the power of the heating element and the temperature rising time of the chromatographic column, the heat absorbed by the chromatographic column is obtained by analyzing the heat capacity of the chromatographic column and the temperature that the chromatographic column needs to be raised to, the heat not absorbed by the chromatographic column is obtained by analyzing the total heat released and the heat absorbed by the chromatographic column, and the residual heat influencing temperature of the chromatographic column is obtained by analyzing the heat not absorbed by the chromatographic column, the heat capacity of the chromatographic column and the target temperature of the window, so that the chromatographic column temperature regulating device is controlled to cool down according to the residual heat influencing temperature of the chromatographic column, and then the chromatographic column temperature is kept consistent with the target temperature of the window.

[0030] Optionally, the chromatographic column temperature regulating device comprises an air extraction assembly and an air blowing assembly, and the step of controlling the chromatographic column temperature regulating device to cool down according to the residual heat influencing temperature of the chromatographic column and keeping the chromatographic column temperature consistent with the target temperature of the window comprises:

[0031] obtaining the total heat capacity and the heat dissipation surface area of the chromatographic column;

[0032] analyzing the residual heat influencing temperature of the chromatographic column, the total heat capacity and the heat dissipation surface area of the chromatographic column to determine the time required for cooling down;

[0033] controlling the air blowing assembly to blow away the hot air around the chromatographic column according to the time required for cooling down;

[0034] obtaining the top temperature and the bottom temperature of the pre-set column oven;

[0035] controlling the air extraction assembly to extract the hot air according to the top temperature and the bottom temperature.

[0036] By adopting the technical solutions, the time required for cooling down is obtained by analyzing the residual heat influencing temperature of the chromatographic column, the total heat capacity and the heat dissipation surface area of the chromatographic column, so that the air blowing assembly is controlled to blow away the hot air around the chromatographic column according to the time required for cooling down, and the air extraction assembly is controlled to extract the hot air according to the top temperature and the bottom temperature after the time required for cooling down ends and the air blowing assembly stops working, and then the temperature fluctuation range between different areas inside the column oven is controlled within the standard temperature fluctuation range.

[0037] Optionally, the step of analyzing the residual heat influencing temperature of the chromatographic column, the total heat capacity and the heat dissipation surface area of the chromatographic column to determine the time required for cooling down comprises:

[0038] analyzing the preset fan forced convection heat transfer coefficient and the chromatographic column heat dissipation surface area to determine the heat dissipation power per unit time;

[0039] analyzing the total heat capacity and the heat dissipation power per unit time to determine the time required for a unit temperature change;

[0040] analyzing the window target temperature and the chromatographic column residual heat influence temperature to determine the initial temperature difference of the chromatographic column;

[0041] analyzing the initial temperature difference of the chromatographic column and the preset allowable temperature difference of the chromatographic column to determine the temperature difference change time correction coefficient;

[0042] analyzing the time required for a unit temperature change and the temperature difference change correction coefficient to determine the time required for cooling.

[0043] By adopting the above technical solutions, the fan forced convection heat transfer coefficient and the chromatographic column heat dissipation surface area are analyzed to obtain the heat dissipation power per unit time, the total heat capacity and the heat dissipation power per unit time are analyzed to obtain the time required for a unit temperature change, the window target temperature and the chromatographic column residual heat influence temperature are analyzed to obtain the initial temperature difference of the chromatographic column, the initial temperature difference of the chromatographic column and the allowable temperature difference of the chromatographic column are analyzed to obtain the temperature difference change time correction coefficient, and the time required for a unit temperature change and the temperature difference change correction coefficient are analyzed to obtain the time required for cooling. Then, the hot air around the chromatographic column is blown away by the air blowing assembly according to the time required for cooling.

[0044] Optionally, the step of controlling the air extraction assembly to extract hot air according to the top temperature and the bottom temperature comprises:

[0045] analyzing the top temperature and the window target temperature to determine the top temperature difference;

[0046] analyzing the bottom temperature and the window target temperature to determine the bottom temperature difference;

[0047] analyzing the top temperature difference, the bottom temperature difference, and the preset column oven temperature difference to determine the column oven air extraction position;

[0048] controlling the air extraction assembly to extract hot air according to the column oven air extraction position.

[0049] By adopting the above technical solutions, the top temperature and the window target temperature are analyzed to obtain the top temperature difference, the bottom temperature and the window target temperature are analyzed to obtain the bottom temperature difference, and the top temperature difference, the bottom temperature difference, and the column oven temperature difference are analyzed to obtain the column oven air extraction position. Then, the air extraction assembly extracts hot air according to the column oven air extraction position.

[0050] Optionally, the step of controlling the air extraction assembly to extract hot air according to the column oven air extraction position comprises:

[0051] obtaining air density, total volume of the internal column oven and air constant volume specific heat capacity;

[0052] analyzing the air density, total volume of the internal column oven and air constant volume specific heat capacity to determine total air heat capacity;

[0053] obtaining air constant pressure specific heat capacity;

[0054] analyzing preset air fan unit time gas flow, air constant pressure specific heat capacity and air density to determine unit time heat dissipation capacity;

[0055] analyzing the total air heat capacity and unit time heat dissipation capacity to determine basic heat dissipation time;

[0056] obtaining the temperature of the chromatographic column and the external environment temperature of the column oven after the fan stops;

[0057] analyzing the temperature of the chromatographic column and the external environment temperature of the column oven after the fan stops to determine the initial temperature difference of air extraction;

[0058] analyzing the initial temperature difference of air extraction and the temperature difference of the column oven to determine the heat dissipation time correction coefficient;

[0059] analyzing the basic heat dissipation time and the heat dissipation time correction coefficient to determine the air extraction time;

[0060] controlling the air extraction assembly at the position of the column oven requiring air extraction to extract hot air according to the air extraction time.

[0061] By using the above technical scheme, the air density, total volume of the internal column oven and air constant volume specific heat capacity are analyzed to obtain the total air heat capacity, the preset air fan unit time gas flow, air constant pressure specific heat capacity and air density are analyzed to obtain the unit time heat dissipation capacity, the total air heat capacity and unit time heat dissipation capacity are analyzed to obtain the basic heat dissipation time, the temperature of the chromatographic column and the external environment temperature of the column oven after the fan stops are analyzed to obtain the initial temperature difference of air extraction, the initial temperature difference of air extraction and the temperature difference of the column oven are analyzed to obtain the heat dissipation time correction coefficient, thereby the basic heat dissipation time and the heat dissipation time correction coefficient are analyzed to obtain the air extraction time, and then the air extraction assembly at the position of the column oven requiring air extraction is controlled to extract hot air according to the air extraction time.

[0062] In a second aspect, the present application provides a chromatographic instrument temperature control system, which adopts the following technical scheme:

[0063] A chromatographic instrument temperature control system comprises:

[0064] an obtaining module for obtaining sample type and initial temperature of a chromatographic column;

[0065] A memory for storing a program of a chromatograph temperature control method according to any one of the preceding aspects.

[0066] A processor, the program in the memory can be loaded and executed by the processor to implement a chromatograph temperature control method according to any one of the preceding aspects.

[0067] By adopting the technical solution, the processor loads and executes the program of the chromatograph temperature control method stored in the memory, the control acquisition module acquires a series of data related to the sample separation implementation of the chromatograph, so as to analyze the sample type to obtain the window temperature rising rate and the window target temperature, analyze the chromatograph column initial temperature and the window target temperature to obtain the chromatograph column temperature to be raised, analyze the chromatograph column temperature to be raised and the window temperature rising rate to obtain the chromatograph column temperature rising time, and control the chromatograph column temperature control device according to the chromatograph column temperature rising time and the window target temperature, so as to control the temperature fluctuation range between the regions in the column oven within the standard temperature fluctuation range, thereby improving the temperature retention time accuracy and making the components in the mixture normally eluted.

[0068] In a third aspect, the present application provides an intelligent terminal, which adopts the technical solution as follows:

[0069] An intelligent terminal, comprising a memory and a processor, and the memory stores a computer program capable of being loaded and executed by the processor to implement a chromatograph temperature control method according to any one of the preceding aspects.

[0070] By adopting the technical solution, the processor loads and executes the program of the chromatograph temperature control method stored in the memory, the control acquisition module acquires a series of data related to the sample separation implementation of the chromatograph, so as to analyze the sample type to obtain the window temperature rising rate and the window target temperature, analyze the chromatograph column initial temperature and the window target temperature to obtain the chromatograph column temperature to be raised, analyze the chromatograph column temperature to be raised and the window temperature rising rate to obtain the chromatograph column temperature rising time, and control the chromatograph column temperature control device according to the chromatograph column temperature rising time and the window target temperature, so as to control the temperature fluctuation range between the regions in the column oven within the standard temperature fluctuation range, thereby improving the temperature retention time accuracy and making the components in the mixture normally eluted.

[0071] In a fourth aspect, the present application provides a computer storage medium capable of storing a corresponding program, which has the characteristics of facilitating the improvement of the temperature retention time accuracy, and adopts the technical solution as follows:

[0072] A computer readable storage medium, which stores a computer program capable of being loaded and executed by a processor to implement any one of the chromatograph temperature control methods.

[0073] By adopting the technical scheme, the computer readable storage medium stores a computer program of a chromatograph temperature control method, the processor loads and executes the computer program of the chromatograph temperature control method stored in the storage medium, the window temperature rising rate and the window target temperature are obtained by analyzing the sample type, the chromatograph column temperature to be raised is obtained by analyzing the chromatograph column initial temperature and the window target temperature, the chromatograph column temperature rising time is obtained by analyzing the chromatograph column temperature to be raised and the window temperature rising rate, the chromatograph column temperature is controlled by the chromatograph column temperature control device according to the chromatograph column temperature rising time and the window target temperature, the temperature fluctuation range between each region in the column oven is controlled within the standard temperature fluctuation range, the temperature retention time precision is improved, and the components in the mixture are normally eluted.

[0074] In summary, the present application includes at least one of the following beneficial technical effects:

[0075] 1. By analyzing the sample type to obtain the window temperature rising rate and the window target temperature, analyzing the chromatograph column initial temperature and the window target temperature to obtain the chromatograph column temperature to be raised, analyzing the chromatograph column temperature to be raised and the window temperature rising rate to obtain the chromatograph column temperature rising time, and controlling the chromatograph column temperature control device according to the chromatograph column temperature rising time and the window target temperature, the temperature fluctuation range between each region in the column oven is controlled within the standard temperature fluctuation range, the temperature retention time precision is improved, and the components in the mixture are normally eluted;

[0076] 2. By analyzing the heating element power and the chromatograph column temperature rising time to obtain the total heat release, analyzing the chromatograph column heat capacity and the chromatograph column temperature to be raised to obtain the chromatograph column heat absorption, analyzing the total heat release and the chromatograph column heat absorption to obtain the chromatograph column unabsorbed heat, and analyzing the chromatograph column unabsorbed heat, the chromatograph column heat capacity and the window target temperature to obtain the chromatograph column residual heat influence temperature, the chromatograph column temperature control device is controlled according to the chromatograph column residual heat influence temperature to cool down, and the chromatograph column temperature is consistent with the window target temperature;

[0077] 3. By analyzing the chromatograph column residual heat influence temperature, the total heat capacity and the chromatograph column heat dissipation surface area to obtain the cooling time required, the hot air around the chromatograph column is blown away by the blowing assembly according to the cooling time required, and the hot air is extracted by the air extraction assembly according to the top temperature and the bottom temperature after the cooling time required ends and the blowing assembly stops working, and the temperature fluctuation range between each region in the column oven is controlled within the standard temperature fluctuation range. BRIEF DESCRIPTION OF DRAWINGS

[0078] Figure 1 It is a flowchart of a chromatograph temperature control method in the embodiment of the present application.

[0079] Figure 2 is a flow chart of the step of controlling the preset chromatographic column temperature regulating device according to the chromatographic column warming time and the window target temperature to control the temperature of the chromatographic column in the embodiment of the present application.

[0080] Figure 3 is a flow chart of the step of analyzing the window target temperature to determine the chromatographic column residual heat influence temperature in the embodiment of the present application.

[0081] Figure 4 is a flow chart of the step of controlling the chromatographic column temperature regulating device to cool down according to the chromatographic column residual heat influence temperature, so that the temperature of the chromatographic column is consistent with the window target temperature in the embodiment of the present application.

[0082] Figure 5 is a flow chart of the step of analyzing the chromatographic column residual heat influence temperature, the total heat capacity and the chromatographic column heat dissipation surface area to determine the cooling time in the embodiment of the present application.

[0083] Figure 6 is a flow chart of the step of controlling the air extraction assembly to extract hot air according to the top temperature and the bottom temperature in the embodiment of the present application.

[0084] Figure 7 is a flow chart of the step of controlling the air extraction assembly to extract hot air according to the position where the air needs to be extracted in the column oven in the embodiment of the present application. DETAILED DESCRIPTION

[0085] In order to make the purpose, technical scheme and advantages of the present application more clear, the following will combine the drawings of the present application with the embodiments to make further detailed description of the present application. It should be understood that the specific embodiments described herein are only used to explain the present application, and are not used to limit the present application. Figures 1 to 7 The purpose, technical scheme and advantages of the present application will be further described in detail in the embodiments of the present application. It should be understood that the specific embodiments described herein are only used to explain the present application, and are not used to limit the present application.

[0086] The chromatographic instrument temperature control method disclosed in the embodiments of the present application mainly aims at the temperature control problem of the chromatographic instrument, and specifically discloses a column oven, a chromatographic column, a column oven state monitoring device, a chromatographic column temperature regulating device and a processing terminal. The processing terminal is in communication connection with the column oven state monitoring device and the chromatographic column temperature regulating device to realize data interaction and control. After the column oven state monitoring device sends the real-time temperature of the column oven and the real-time temperature of the chromatographic column to the processing terminal, the processing terminal compares the real-time temperature of the column oven and the real-time temperature of the chromatographic column with the normal temperature data. When the real-time temperature of the column oven and the real-time temperature of the chromatographic column are inconsistent with the normal temperature data, the processing terminal controls the chromatographic column temperature regulating device to adjust the internal temperature of the column oven and the temperature of the chromatographic column according to the temperature data difference, so as to rapidly and reasonably control the chromatographic column temperature regulating device to adjust the internal temperature of the column oven and the temperature of the chromatographic column, so that the temperature difference between the column oven and the chromatographic column and the set target temperature is kept within the standard temperature fluctuation range, and the temperature retention time precision is further improved.

[0087] Referring to Figure 1 The embodiment of the present application discloses a chromatograph temperature control method, comprising the following steps:

[0088] Step S100: obtaining the sample type of a preset sample.

[0089] The sample refers to a mixture that needs to be analyzed by a chromatograph.

[0090] The sample type refers to the classification of the sample according to the source, physical and chemical properties of the sample, which is preliminarily judged by an operator according to the source, physical and chemical properties of the sample, such as whether the sample is a gas, solid, liquid or biological sample, and further confirmed by pretreatment methods such as dissolution and extraction, and experiments compared with standard samples.

[0091] The chromatograph refers to a precision instrument for separating and quantitatively or qualitatively analyzing a mixture by utilizing the difference in distribution coefficients between a stationary phase and a mobile phase of each component in the mixture, including a column oven, a chromatographic column and a chromatographic column temperature control device.

[0092] The column oven refers to a device capable of precisely controlling the temperature to heat and keep the chromatographic column, so as to ensure that the chromatographic column maintains constant temperature conditions during the analysis process.

[0093] The chromatographic column refers to a device composed of a column tube and a filler or coating layer, used for separating each component in a mixture in chromatographic analysis, and the chromatographic column is located at the center position in the column oven.

[0094] The chromatographic column temperature control device refers to a device for adjusting the temperature of the chromatographic column and the temperature in the column oven, including a temperature raising assembly, an air extraction assembly and an air blowing assembly. The temperature raising assembly refers to a component for raising the temperature of the chromatographic column to reach a set target temperature, so that the substances in the sample are precipitated, and the temperature raising assembly is composed of a metal heating wire, an insulating support and a protective sleeve. When it is determined that the temperature needs to be raised and the temperature raising rate, the temperature raising assembly can be started to heat the chromatographic column, so that the temperature of the chromatographic column reaches the target temperature.

[0095] The air extraction assembly is a component that extracts hot air from the column oven, maintaining the temperature difference between various locations within the oven within a set range. This ensures more complete sample precipitation and improves sample accuracy. The air extraction assembly consists of two exhaust fans installed at the top and bottom of the column oven, respectively. When the temperature difference between the top or bottom of the column oven and the chromatographic column exceeds the set range, the location requiring air extraction is determined. The corresponding exhaust fan is then activated based on this location, and its operating time is determined according to the temperature difference. After the exhaust fan's operating time ends, it is stopped, thus ensuring that the temperature difference between the top or bottom of the column oven and the chromatographic column remains within the set range.

[0096] The air blowing assembly is a component that achieves uniform heat distribution and efficient heat exchange inside the column oven through forced airflow circulation. The air blowing assembly consists of a built-in fan installed inside the column oven and kept at the same level as the center of the chromatographic column. When the heating assembly stops heating the chromatographic column, the air blowing assembly is activated to blow away the excess heat during the heating process to all parts of the column oven, thereby avoiding the problem of insufficient precipitation caused by the actual temperature of the chromatographic column exceeding the target temperature due to excess heat.

[0097] Step S101: Analyze the sample type to determine the window heating rate and the window target temperature.

[0098] The window heating rate refers to the amount of temperature increase per unit time set for different temperature ranges in chromatographic analysis. In one embodiment, the operator determines the high-boiling-point and low-boiling-point components in the sample according to the sample type. A slower window heating rate is used for low-boiling-point components, with the heating rate in the range of 10-20℃ / min. A faster window heating rate is used for high-boiling-point components, with the heating rate in the range of 1-5℃ / min. If the sample is a low-boiling-point C1-C5 hydrocarbon sample, the window heating rate can be set to 15℃ / min.

[0099] The target window temperature refers to the temperature that needs to be reached each time the chromatographic column is heated in chromatographic analysis. In one embodiment, the operator determines whether the sample contains high-boiling-point and low-boiling-point components based on the sample type. If both components are present, two target window temperatures are set: one for the low-boiling-point component and the other for the high-boiling-point component. The target window temperature for the low-boiling-point component is in the range of 30-80°C, and the target window temperature for the high-boiling-point component is in the range of 150-250°C. If the sample is a low-boiling-point C1-C5 hydrocarbon sample, the target window temperature can be set to 80°C.

[0100] Step S102: Obtain the initial temperature of the preset chromatographic column.

[0101] The chromatographic column in this step is consistent with the chromatographic column in step S100, and will not be described here.

[0102] The initial temperature of the chromatographic column refers to the temperature of the chromatographic column measured after the sample enters the chromatographic column. The temperature near the chromatographic column is detected by the temperature sensor in the column oven state monitoring device at the beginning of chromatographic analysis, and the temperature is transmitted to the processing terminal. The temperature is the initial temperature of the chromatographic column.

[0103] The column oven state monitoring device refers to a device composed of a temperature sensor, a timer module and a communication module, which is used to monitor the working state of the column oven and obtain the internal state data of the column oven in real time.

[0104] Step S103: Analyzing the initial temperature of the chromatographic column and the target temperature of the window to determine the temperature that the chromatographic column needs to be raised.

[0105] The temperature that the chromatographic column needs to be raised refers to the temperature that the chromatographic column needs to be raised by the column oven heating operation. After the initial temperature of the chromatographic column is transmitted to the processing terminal, the temperature that the chromatographic column needs to be raised can be obtained by subtracting the initial temperature of the chromatographic column from the target temperature of the window.

[0106] Step S104: Analyzing the temperature that the chromatographic column needs to be raised and the window heating rate to determine the chromatographic column heating time.

[0107] The chromatographic column heating time refers to the time required to raise the temperature of the chromatographic column from the initial temperature to the target temperature. The chromatographic column heating time can be obtained by dividing the temperature that the chromatographic column needs to be raised by the window heating rate.

[0108] Step S105: Controlling the preset chromatographic column temperature control device to control the temperature of the chromatographic column according to the chromatographic column heating time and the target temperature of the window.

[0109] After the processing terminal determines the chromatographic column heating time and the target temperature of the window, the processing terminal controls the chromatographic column temperature control device to control the temperature of the chromatographic column according to the chromatographic column heating time and the target temperature of the window. For details, refer to the steps of Figure 2 , so as to adjust the temperature of the chromatographic column and the column oven, and keep the temperature difference between the column oven and the chromatographic column within the normal temperature fluctuation range, thereby improving the temperature retention time accuracy.

[0110] The chromatographic column temperature control device in this step is consistent with the chromatographic column temperature control device in step S100, and will not be described here.

[0111] Refer to Figure 2 , the step of controlling the preset chromatographic column temperature control device to control the temperature of the chromatographic column according to the chromatographic column heating time and the target temperature of the window includes:

[0112] Step S200: controlling the heating assembly to heat the chromatographic column according to the window heating rate, and obtaining the real-time heating time of the chromatographic column.

[0113] Wherein, after the processing terminal determines the window heating rate, the processing terminal controls the heating assembly to heat the chromatographic column according to the window heating rate, so that the temperature of the chromatographic column reaches the window target temperature at the end of the chromatographic column heating time.

[0114] The real-time heating time of the chromatographic column refers to the time that the chromatographic column has been heated. The timer in the column oven state monitoring device starts counting from the moment the heating assembly starts heating the chromatographic column. The terminal triggers once, and the time increases by one second, so as to obtain the real-time heating time of the chromatographic column.

[0115] Step S201: determining whether the real-time heating time of the chromatographic column and the chromatographic column heating time are consistent.

[0116] Wherein, the processing terminal determines whether the real-time heating time of the chromatographic column and the chromatographic column heating time are consistent, so as to determine whether the heating of the chromatographic column by the heating assembly is completed.

[0117] Step S2011: if not consistent, continue to obtain the real-time heating time of the chromatographic column for cyclic judgment.

[0118] Wherein, if the processing terminal determines that the real-time heating time of the chromatographic column and the chromatographic column heating time are inconsistent, it means that the heating of the chromatographic column by the heating assembly has not been completed, so the heating process is continued to be timed, so as to continuously monitor the heating process of the chromatographic column.

[0119] Step S2012: if consistent, control the heating assembly to stop heating the chromatographic column.

[0120] Wherein, if the processing terminal determines that the real-time heating time of the chromatographic column and the chromatographic column heating time are consistent, it means that the heating of the chromatographic column by the heating assembly has been completed, so the processing terminal sends a stop signal to the heating assembly to make the heating assembly stop heating the chromatographic column.

[0121] Step S20121: analyzing the window target temperature to determine the residual heat influence temperature of the chromatographic column.

[0122] Wherein, the residual heat influence temperature of the chromatographic column refers to the temperature that the chromatographic column continues to rise due to the residual heat generated by the heating assembly after the heating process of the chromatographic column is completed, and the final temperature reached by the chromatographic column. The specific determination method is referred to the steps of Figure 3 , so as to provide data support for the subsequent control of the chromatographic column temperature regulating device to keep the chromatographic column at the window target temperature.

[0123] Step S20122: According to the temperature control device of the chromatographic column, the temperature of the chromatographic column is controlled to be reduced, so that the temperature of the chromatographic column is consistent with the target temperature of the window.

[0124] In the process terminal, the temperature of the chromatographic column is controlled according to the chromatographic column heat-affected temperature to be reduced, so that the temperature of the chromatographic column is consistent with the target temperature of the window.

[0125] Reference Figure 3 The step of analyzing the target temperature of the window to determine the chromatographic column heat-affected temperature comprises:

[0126] Step S300: Obtain the heat capacity of the chromatographic column and the heating power of the heating assembly.

[0127] The heat capacity of the chromatographic column refers to the ability of the chromatographic column to absorb or release heat, and in an embodiment, the corresponding mass of the chromatographic column and the specific heat capacity of the chromatographic column are obtained by querying the technical manual of the chromatographic column by the operator, and the mass of the chromatographic column and the specific heat capacity of the chromatographic column are transmitted to the processing terminal, and the heat capacity of the chromatographic column is obtained by multiplying the mass of the chromatographic column and the specific heat capacity of the chromatographic column by the processing terminal.

[0128] The heating power refers to the ability of the heating element to convert electrical energy into heat energy per unit time, and in an embodiment, the corresponding heating power of the heating element is determined by querying the technical manual of the heating element by the operator, and the heating power is transmitted to the processing terminal.

[0129] Step S301: Analyze the heating element power and the chromatographic column heating time to determine the total heat release.

[0130] The total heat release refers to the total heat released by the heating element during the chromatographic column heating process, and the total heat release can be obtained by multiplying the heating element power and the chromatographic column heating time by the processing terminal.

[0131] Step S302: Analyze the heat capacity of the chromatographic column and the temperature of the chromatographic column to be raised to determine the heat absorbed by the chromatographic column.

[0132] The heat absorbed by the chromatographic column refers to the heat absorbed by the chromatographic column during the chromatographic column heating process, and the heat absorbed by the chromatographic column can be obtained by multiplying the heat capacity of the chromatographic column and the temperature of the chromatographic column to be raised by the processing terminal.

[0133] Step S303: Analyze the total heat release and the heat absorbed by the chromatographic column to determine the heat not absorbed by the chromatographic column.

[0134] The heat not absorbed by the chromatographic column refers to the heat not absorbed by the chromatographic column among the heat generated by the heating element during the chromatographic column heating process, and the heat not absorbed by the chromatographic column can be obtained by subtracting the heat absorbed by the chromatographic column from the total heat release by the processing terminal.

[0135] Step S304: analyzing the heat not absorbed by the chromatographic column, the heat capacity of the chromatographic column and the window target temperature to determine the chromatographic column residual heat influence temperature.

[0136] In this step, the chromatographic column residual heat influence temperature is consistent with the chromatographic column residual heat influence temperature in the above step S20121, and the chromatographic column residual heat influence temperature is obtained by the processing terminal according to the formula , wherein, is the chromatographic column residual heat influence temperature, is the window target temperature, is the heat not absorbed by the chromatographic column, is the heat capacity of the chromatographic column.

[0137] Referring to Figure 4 , the step of controlling the chromatographic column temperature regulating device to cool down according to the chromatographic column residual heat influence temperature so that the chromatographic column temperature is consistent with the window target temperature comprises:

[0138] Step S400: obtaining the total heat capacity and the chromatographic column heat dissipation surface area.

[0139] In this step, the chromatographic column heat dissipation surface area refers to the total area of the chromatographic column that can exchange heat with the air, in an embodiment, the length of the chromatographic column and the radius of the chromatographic column are determined by the operator querying the technical manual of the chromatographic column, and the length of the chromatographic column and the radius of the chromatographic column are transmitted to the processing terminal, and the chromatographic column heat dissipation surface area is obtained by the processing terminal according to the formula , wherein, is the chromatographic column heat dissipation surface area, is the constant pi, for example, = 3.14, is the radius of the chromatographic column, is the length of the chromatographic column.

[0140] The total heat capacity refers to the ability of the column oven to absorb or release heat, and the total heat capacity can be obtained by adding the heat capacity of the chromatographic column and the heat capacity of the air in the column oven by the processing terminal.

[0141] The air heat capacity refers to the ability of the air around the chromatographic column to absorb or release heat, and the air heat capacity can be obtained by multiplying the air mass and the air constant pressure specific heat capacity by the processing terminal.

[0142] The air mass refers to the air mass directly contacted by the chromatographic column, and the air mass can be obtained by multiplying the air density and the air volume by the processing terminal, in an embodiment, if the air directly contacted by the chromatographic column refers to the annular area wrapped around the chromatographic column, the air volume can be calculated by the processing terminal according to the formula , wherein, is the air volume, Pi refers to the ratio of the circumference of a circle to its diameter, and = 3.14 as an example, R refers to the radius of the chromatographic column, T refers to the effective air layer thickness, which is obtained by capturing the temperature gradient mutation surface of the chromatographic column surface and the air layer by the infrared thermal imager, and combining the spatial resolution of the thermal imager, L refers to the length of the chromatographic column; the air density can be obtained by the processing terminal according to the formula , wherein Cp refers to the air density, P refers to the ambient pressure, and = 101325 Pa as an example, R refers to the air gas constant, and = 287 J / (kg·K) as an example, T refers to the air thermodynamic temperature, which is obtained by detecting the air Celsius temperature by the temperature sensor in the column oven state monitoring device, and transmitting the air Celsius temperature to the processing terminal, and adding 273.15 to the air Celsius temperature by the processing terminal to obtain the air thermodynamic temperature.

[0143] The air constant-pressure specific heat capacity refers to the heat required by unit mass of air to increase by 1℃ at constant pressure. In an embodiment, the air constant-pressure specific heat capacity is obtained by the operator looking up in the air constant-pressure specific heat capacity table according to the window target temperature. For example, when the target temperature is 50℃, the air constant-pressure specific heat capacity is 1.008 kJ / (kg·℃).

[0144] The chromatographic column heat capacity in this step is the same as the chromatographic column heat capacity in step S300 described above, which will not be repeated here.

[0145] Step S401: Analyzing the chromatographic column residual heat influence temperature, total heat capacity and chromatographic column heat dissipation surface area to determine the cooling time required.

[0146] The cooling time required refers to the time required for the air blowing assembly to blow air to the chromatographic column. After the processing terminal determines the total heat capacity and the chromatographic column heat dissipation surface area, the processing terminal determines the cooling time required according to the chromatographic column residual heat influence temperature, the total heat capacity and the chromatographic column heat dissipation surface area. The specific determination method is referred to the step of Figure 5 , thereby providing support for subsequent control of the air blowing assembly to blow air to the chromatographic column to maintain the chromatographic column at the target temperature.

[0147] Step S402: Controlling the air blowing assembly to blow away the hot air around the chromatographic column according to the cooling time required.

[0148] After the processing terminal determines the cooling time required, the processing terminal controls the air blowing assembly to blow away the hot air around the chromatographic column according to the cooling time required, so that the temperature of the chromatographic column is maintained at the window target temperature.

[0149] The air blowing assembly in this step is consistent with the air blowing assembly in step S100, and will not be repeated here.

[0150] Step S403: Obtain the top temperature and the bottom temperature of the preset column oven.

[0151] The column oven in this step is consistent with the column oven in step S100, and will not be repeated here.

[0152] The top temperature refers to the real-time temperature of the top of the column oven, which can be obtained by measuring the top area of the column oven through the temperature sensor in the column oven state monitoring device.

[0153] The bottom temperature refers to the real-time temperature of the bottom of the column oven, which can be obtained by measuring the bottom area of the column oven through the temperature sensor in the column oven state monitoring device.

[0154] Step S404: Control the air extraction assembly to extract hot air according to the top temperature and the bottom temperature.

[0155] After the processing terminal receives the top temperature and the bottom temperature measured by the temperature sensor in the state monitoring device, the processing terminal determines the position where air needs to be extracted according to the top temperature and the bottom temperature. For details, refer to step S404 of Figure 6 , so that the hot air at the corresponding position is extracted according to the position where air needs to be extracted.

[0156] The air extraction assembly in this step is consistent with the air extraction assembly in step S100, and will not be repeated here.

[0157] For details, refer to Figure 5 , the steps of analyzing the temperature affected by the residual heat of the chromatographic column, the total heat capacity, and the heat dissipation surface area of the chromatographic column to determine the cooling time include:

[0158] Step S500: Analyze the fan forced convection heat transfer coefficient and the heat dissipation surface area of the chromatographic column to determine the unit time heat dissipation power.

[0159] The fan forced convection heat transfer coefficient refers to a physical parameter that describes the heat transfer capacity between the forced air flow provided by the air extraction assembly and the solid surface. In an embodiment, the fan forced convection heat transfer coefficient is between 15-25 W / (M 2 ·K).

[0160] The unit time heat dissipation power refers to the heat that the fan can take away from the surface of the chromatographic column per unit time. The unit time heat dissipation power can be obtained by multiplying the fan forced convection heat transfer coefficient and the heat dissipation surface area of the chromatographic column through the processing terminal.

[0161] Step S501: Analyzing the total heat capacity and the heat dissipation power per unit time to determine the time required for a unit temperature change.

[0162] The time required for a unit temperature change refers to the time required for the temperature of the chromatographic column to change by 1℃. The time required for a unit temperature change can be obtained by dividing the total heat capacity by the heat dissipation power per unit time through the processing terminal.

[0163] Step S502: Analyzing the window target temperature and the chromatographic column residual heat influence temperature to determine the initial temperature difference of the chromatographic column.

[0164] The initial temperature difference of the chromatographic column refers to the temperature difference between the chromatographic column and the surrounding air when the air extraction assembly is started. The initial temperature difference of the chromatographic column can be obtained by subtracting the window target temperature from the chromatographic column residual heat influence temperature through the processing terminal.

[0165] Step S503: Analyzing the initial temperature difference of the chromatographic column and the preset allowed temperature difference of the chromatographic column to determine the temperature difference change time correction coefficient.

[0166] The allowed temperature difference of the chromatographic column refers to the maximum allowed fluctuation range of the actual temperature of the chromatographic column relative to the window target temperature. In an embodiment, the allowed temperature difference of the chromatographic column is ±0.3℃.

[0167] The temperature difference change time correction coefficient refers to the correction coefficient for the time required for a unit temperature change when quantifying the rule that "the smaller the temperature difference, the slower the heat dissipation" in a logarithmic form. The temperature difference change time correction coefficient can be obtained through the processing terminal according to the formula wherein, refers to the temperature difference change time correction coefficient, refers to the initial temperature difference of the chromatographic column, refers to the allowed temperature difference of the chromatographic column.

[0168] Step S504: Analyzing the time required for a unit temperature change and the temperature difference change correction coefficient to determine the time required for cooling.

[0169] The time required for cooling in this step is consistent with the time required for cooling in the above step S401. The time required for cooling can be obtained by multiplying the time required for a unit temperature change and the temperature difference change correction coefficient through the processing terminal.

[0170] Referring to Figure 6 the step of controlling the air extraction assembly to extract hot air according to the top temperature and the bottom temperature includes:

[0171] Step S600: Analyzing the top temperature and the window target temperature to determine the top temperature difference.

[0172] The top temperature difference refers to the difference between the top temperature in the column oven and the target temperature of the window, and the top temperature difference can be obtained by subtracting the target temperature of the window from the top temperature through the processing terminal.

[0173] Step S601: Analyzing the bottom temperature and the target temperature of the window to determine the bottom temperature difference.

[0174] The bottom temperature difference refers to the difference between the bottom temperature in the column oven and the target temperature of the window, and the bottom temperature difference can be obtained by subtracting the target temperature of the window from the bottom temperature through the processing terminal.

[0175] Step S602: Analyzing the top temperature difference, the bottom temperature difference, and the preset column oven temperature difference to determine the column oven position requiring air extraction.

[0176] The column oven temperature difference refers to the maximum allowable fluctuation range of the temperature difference between the actual temperatures of the various regions of the column oven. In an embodiment, the column oven temperature difference is ±1℃.

[0177] The column oven position requiring air extraction refers to the region in the column oven that requires air extraction. The processing terminal compares the column oven temperature difference with the top temperature difference and the bottom temperature difference to determine which of the top temperature difference or the bottom temperature difference is greater than the column oven temperature difference. If the processing terminal determines that the top temperature is greater than the column oven temperature difference, the top of the column oven is determined as the column oven position requiring air extraction. If the processing terminal determines that the bottom temperature is greater than the column oven temperature difference, the bottom of the column oven is determined as the column oven position requiring air extraction. If the processing terminal determines that both the top temperature and the bottom temperature are greater than the column oven temperature difference, both the top of the column oven and the bottom of the column oven are determined as the column oven position requiring air extraction.

[0178] Step S603: Controlling the air extraction assembly to extract hot air according to the column oven position requiring air extraction.

[0179] After the processing terminal determines the column oven position requiring air extraction, the processing terminal controls the air extraction assembly to extract hot air according to the column oven position requiring air extraction, so that the difference between the temperatures of the various regions in the column oven is maintained within the column oven temperature difference range.

[0180] With reference to Figure 7 controlling the air extraction assembly to extract hot air according to the column oven position requiring air extraction includes:

[0181] Step S700: Obtaining the air density, the total volume inside the column oven, and the air constant volume specific heat capacity.

[0182] The air density refers to the mass of air per unit volume, and the air density can be obtained through the processing terminal according to the formula wherein is the air density, is referred to as the air pressure in the column oven, taking = 101325 Pa as an example, is referred to as the air molar mass, taking = 0.029 kg / mol as an example, is referred to as the ideal gas constant, taking = 8.314 J / (mol·kg) as an example, is referred to as the absolute temperature of the column oven, the temperature of the position where the column oven needs to be pumped is measured by the temperature sensor in the column oven state monitoring device, and the temperature is transmitted to the processing terminal. The absolute temperature of the column oven can be obtained by adding 273.15 to the temperature through the processing terminal.

[0183] The total internal volume of the column oven refers to the effective space volume that can accommodate air in the column oven. In an embodiment, the volumes of each device and the internal volume of the column oven are obtained by the operator querying the technical manual of each device in the column oven, and the volumes of each device and the internal volume of the column oven are transmitted to the processing terminal. The total internal volume of the column oven can be obtained by subtracting the volume of each device from the internal volume of the column oven through the processing terminal.

[0184] The specific heat capacity of air at constant volume refers to the heat absorbed or released per unit mass when the volume of air is constant and the temperature is raised or lowered by 1°C. In an embodiment, the specific heat capacity of air at constant volume can be obtained by querying the temperature measured by the temperature sensor in the column oven state monitoring device in the thermophysical property data manual.

[0185] Step S701: analyzing the air density, the total internal volume of the column oven, and the specific heat capacity of air at constant volume to determine the total heat capacity of air.

[0186] The total heat capacity of air refers to the total amount of heat released by the air in the column oven when the temperature is lowered from the current temperature to the target temperature of the window. The total heat capacity of air can be determined by multiplying the air density, the total internal volume of the column oven, and the specific heat capacity of air at constant volume through the processing terminal.

[0187] Step S702: obtaining the specific heat capacity of air at constant pressure.

[0188] The specific heat capacity of air at constant pressure refers to the heat absorbed or released per unit mass when the pressure of air is constant and the temperature is raised or lowered by 1°C. In an embodiment, the specific heat capacity of air at constant pressure can be obtained by querying the temperature measured by the temperature sensor in the column oven state monitoring device in the thermophysical property data manual.

[0189] Step S703: analyzing the preset air fan unit time gas flow, the specific heat capacity of air at constant pressure, and the air density to determine the unit time heat dissipation capacity.

[0190] ​​​The air fan unit time gas flow refers to the volume of air discharged per unit time. For example, the air fan unit time gas flow is 200 L / h.

[0191] The unit time heat dissipation capacity refers to the heat that can be taken away by the air exhaust assembly per unit time. The unit time heat dissipation capacity can be determined by multiplying the air fan unit time gas flow, the specific heat capacity of air at constant pressure, and the air density through the processing terminal.

[0192] Step S704: Analyzing the total heat capacity of air and the unit time heat dissipation capacity to determine the basic heat dissipation time.

[0193] The basic heat dissipation time refers to the heat dissipation time before parameter correction. The basic heat dissipation time can be determined by dividing the total heat capacity of air by the unit time heat dissipation capacity through the processing terminal.

[0194] Step S705: Obtaining the column temperature after the fan stops and the column oven external environment temperature.

[0195] The column temperature after the fan stops refers to the temperature of the column when the air blowing assembly stops. The column temperature after the fan stops can be determined by measuring the temperature outside the column through the temperature sensor in the column oven state monitoring device.

[0196] The column oven external environment temperature refers to the temperature of the air drawn into the column oven from the outside. The column oven external environment temperature can be determined by measuring the outside of the column oven through the temperature sensor in the column oven state monitoring device.

[0197] Step S706: Analyzing the column temperature after the fan stops and the column oven external environment temperature to determine the air exhaust initial temperature difference.

[0198] The air exhaust initial temperature difference refers to the temperature difference between the air in the column oven and the outside air when the air exhaust assembly starts working. The air exhaust initial temperature difference can be determined by subtracting the column oven external environment temperature from the column temperature after the fan stops through the processing terminal.

[0199] Step S707: Analyzing the air exhaust initial temperature difference and the column oven temperature difference to determine the heat dissipation time correction coefficient.

[0200] The heat dissipation time correction coefficient refers to the correction coefficient of the time required for unit temperature change when quantifying the law that the cooling rate slows down with the decrease of temperature difference in logarithmic form. The heat dissipation time correction coefficient can be obtained through the processing terminal according to the formula wherein, is the heat dissipation time correction coefficient, is the air exhaust initial temperature difference, is the column oven temperature difference.

[0201] Step S708: analyze the base heat dissipation time and the heat dissipation time correction coefficient to determine the air extraction time.

[0202] The air extraction time refers to the time required by the air extraction assembly to extract air from the air extraction position of the column oven. The air extraction time can be determined by multiplying the base heat dissipation time and the heat dissipation time correction coefficient on the processing terminal.

[0203] Step S709: control the air extraction assembly at the air extraction position of the column oven to extract hot air according to the air extraction time.

[0204] After the processing terminal determines the air extraction time, the processing terminal controls the air extraction assembly at the air extraction position of the column oven to extract air according to the air extraction time, so that the temperature difference between each part of the column oven is within the column oven temperature difference range.

[0205] Based on the same inventive concept, the embodiment of the present application provides a chromatograph temperature control method, comprising:

[0206] The acquisition module is configured to acquire a sample type, a column initial temperature, a column real-time heating time, a column heat capacity, a heating power of a heating assembly, a total heat capacity, a column heat dissipation surface area, a top temperature, a bottom temperature, an air density, a column oven internal total volume, an air constant volume specific heat capacity, an air constant pressure specific heat capacity, a column temperature after the fan stops, and an external environment temperature of the column oven.

[0207] The memory is configured to store a program of a chromatograph temperature control method.

[0208] The processor can load and execute the program in the memory, and implement a chromatograph temperature control method.

[0209] Those skilled in the art can clearly understand that, for the convenience and brevity of description, only the division of the above functional modules is taken as an example for illustration. In actual application, the above functions can be completed by different functional modules according to needs, that is, the internal structure of the device is divided into different functional modules to complete all or part of the functions described above. The specific working process of the above-described system, device and unit can refer to the corresponding process in the foregoing method embodiments, which will not be described here.

[0210] The embodiment of the present application provides a computer readable storage medium, which stores a computer program capable of being loaded and executed by a processor to implement a chromatograph temperature control method.

[0211] The computer storage medium includes, for example, a U disk, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, and various media capable of storing program codes.

[0212] Based on the same inventive concept, the embodiment of the present application provides a kind of intelligent terminal, including memory and processor, memory is stored with the computer program of being capable of being loaded and being executed by processor a kind of chromatograph temperature control method.

[0213] Those skilled in the art can clearly understand that, for the convenience and brevity of description, only the above-mentioned division of each functional module is exemplified, and in actual application, the above-mentioned functions can be completed by different functional modules according to needs, that is, the internal structure of the device is divided into different functional modules to complete all or part of the functions described above.The specific working process of the above-described system, device and unit can refer to the corresponding process in the foregoing method embodiments, which will not be described here.

[0214] The above are preferred embodiments of the present application, and are not intended to limit the protection scope of the present application, any feature disclosed in the specification (including the abstract and drawings) can be replaced by other equivalent or similar purpose alternative features, unless specifically described. That is, unless specifically described, each feature is only an example of a series of equivalent or similar features.

Claims

1. A method for controlling the temperature of a chromatograph, characterized in that, include: Get the sample type of the preset sample; Analyze the sample types to determine the window heating rate and the window target temperature; Obtain the initial temperature of the preset chromatographic column; The initial temperature of the chromatographic column and the target window temperature were analyzed to determine the required temperature increase for the chromatographic column. The column temperature and window heating rate need to be increased for analysis to determine the column heating time. The chromatographic column temperature is controlled by a preset temperature control device based on the column heating time and the target window temperature.

2. The chromatograph temperature control method according to claim 1, characterized in that, The column temperature control device includes a heating component. The steps of controlling the column temperature according to the column heating time and the target window temperature include: The heating component is controlled to heat the chromatographic column according to the window heating rate, and the real-time heating time of the chromatographic column is obtained. Determine whether the real-time temperature rise time of the chromatographic column and the chromatographic column temperature rise time are consistent; If there is a discrepancy, continue to obtain the real-time temperature rise time of the chromatographic column for cyclical judgment; If they match, the heating element will stop heating the column. The target window temperature was analyzed to determine the effect of residual heat on the temperature of the chromatographic column. The column temperature is controlled by a temperature control device based on the residual heat of the column to cool it down, so that the column temperature is consistent with the target window temperature.

3. The chromatograph temperature control method according to claim 2, characterized in that, The steps for analyzing the target window temperature to determine the effect of column residual heat on the temperature include: Obtain the heat capacity of the chromatographic column and the heating power of the heating assembly; The power of the heating element and the heating time of the chromatographic column were analyzed to determine the total heat release; The heat capacity of the chromatographic column and the required temperature for column elevation are analyzed to determine the heat absorbed by the column. The total heat release and the heat absorbed by the chromatographic column were analyzed to determine the heat not absorbed by the chromatographic column. The unabsorbed heat of the chromatographic column, the column heat capacity, and the target window temperature were analyzed to determine the effect of residual heat on the temperature.

4. The chromatograph temperature control method according to claim 2, characterized in that, The column temperature control device includes a vacuum assembly and a purge assembly. The steps of controlling the column temperature control device to cool down the column based on the residual heat effect temperature of the column, so that the column temperature remains consistent with the target window temperature, include: Obtain the total heat capacity and the heat dissipation surface area of ​​the chromatographic column; The effects of residual heat on temperature, total heat capacity, and heat dissipation surface area of ​​the chromatographic column were analyzed to determine the time required for cooling. The air blowing assembly is controlled to disperse the hot air around the chromatographic column according to the time required for cooling. Obtain the top and bottom temperatures of the preset column oven; The exhaust assembly is controlled to extract hot air based on the top and bottom temperatures.

5. The chromatograph temperature control method according to claim 4, characterized in that, The steps for analyzing the effects of residual heat on temperature, total heat capacity, and heat dissipation surface area of ​​the chromatographic column to determine the required cooling time include: The preset fan forced convection heat transfer coefficient and chromatographic column heat dissipation surface area were analyzed to determine the heat dissipation power per unit time. The total heat capacity and heat dissipation power per unit time are analyzed to determine the time required for a unit temperature change. The influence of the target window temperature and residual heat of the column on the temperature was analyzed to determine the initial temperature difference of the column. The initial temperature difference of the chromatographic column and the preset allowable temperature difference of the chromatographic column are analyzed to determine the correction factor for the time of temperature change. The time required for a unit temperature change and the correction factor for the temperature difference change are analyzed to determine the time required for cooling.

6. The chromatograph temperature control method according to claim 4, characterized in that, The steps for controlling the extraction assembly to remove hot air based on the top and bottom temperatures include: Analyze the top temperature and the target window temperature to determine the top temperature difference; Analyze the bottom temperature and the target window temperature to determine the bottom temperature difference; The temperature difference at the top, the temperature difference at the bottom, and the preset temperature difference in the column oven are analyzed to determine the location where the column oven needs to be evacuated. The extraction assembly is controlled to extract hot air according to the location where air needs to be extracted from the column temperature chamber.

7. A chromatograph temperature control method according to claim 6, characterized in that, The steps for controlling the extraction assembly to extract hot air based on the required extraction location of the column temperature chamber include: Obtain the air density, total internal volume of the column oven, and specific heat capacity of air at constant volume; The air density, total internal volume of the column oven, and specific heat capacity of air at constant volume were analyzed to determine the total heat capacity of the air. Obtain the specific heat capacity of air at constant pressure; The pre-defined air flow rate per unit time, specific heat capacity of air at constant pressure, and air density of the exhaust fan are analyzed to determine the heat dissipation capacity per unit time. The total heat capacity of the air and the heat dissipation capacity per unit time are analyzed to determine the basic heat dissipation time; Obtain the column temperature and the ambient temperature outside the column oven after the fan stops; The column temperature and the temperature difference between the column and the external environment after the fan stops are analyzed to determine the initial temperature difference during gas extraction. The initial temperature difference during air extraction and the temperature difference in the column oven were analyzed to determine the heat dissipation time correction factor. The basic heat dissipation time and the heat dissipation time correction factor are analyzed to determine the evacuation time; The hot air is extracted from the extraction components at the required extraction location in the column temperature chamber based on the extraction time.

8. A temperature control system for a chromatograph, characterized in that, include: The acquisition module is used to acquire the sample type and the initial temperature of the chromatographic column; A memory for storing a program for a chromatograph temperature control method as described in any one of claims 1 to 7; The processor and the program in the memory can be loaded and executed by the processor to implement the chromatograph temperature control method as described in any one of claims 1 to 7.

9. A smart terminal, characterized in that, It includes a memory and a processor, wherein the memory stores a computer program that can be loaded by the processor and executed as described in any one of claims 1 to 7.

10. A computer-readable storage medium, characterized in that, The computer program is stored and can be loaded by a processor and executed as described in any one of claims 1 to 7.

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