SerpinB3 inhibitor and application thereof

By using phloretin as a Serpin B3 inhibitor, the treatment challenges of rosacea and psoriasis have been addressed. By inhibiting the expression of Serpin B3 and inflammatory factors, inflammatory symptoms have been significantly reduced, providing a new approach for the development of related products.

CN121102184APending Publication Date: 2025-12-12XIANGYA HOSPITAL CENT SOUTH UNIV
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Patent Information

Application Number
CN202511314786.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-15
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

There is a lack of effective treatments for rosacea and psoriasis in the current technology, and the application of phloretin in these skin diseases has not been reported.

Method used

Phloretin is used as a Serpin B3 inhibitor to prepare products for the treatment and prevention of inflammatory skin diseases, including skin care products, pharmaceuticals and functional foods. It alleviates inflammatory symptoms by inhibiting the expression of Serpin B3 and reducing the expression of inflammatory factors such as TNF-α, IL-6, CCL2 and CCL20.

Benefits of technology

Phloretin significantly alleviated the symptoms of rosacea and psoriasis, providing a new treatment strategy and a theoretical basis for the development of related products.

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Abstract

The invention discloses a SerpinB3 inhibitor and an application of the SerpinB3 inhibitor. The phloretin can be used as the SerpinB3 inhibitor for the first time, can effectively relieve the symptoms of the rosacea and the psoriasis at the same time, and is used for preparing related drugs for treating inflammatory skin diseases such as the rosacea and the psoriasis. The invention provides a certain theoretical basis for research and development of related treatment products for inflammatory skin diseases such as rosacea or psoriasis.
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