Bone setting pill and preparation method thereof

The formula and preparation process of Jieguwan (a traditional Chinese medicine formula for bone setting pills) have solved the problem of slow efficacy of existing fracture drugs, and achieved the effects of promoting blood circulation, removing blood stasis, relieving pain, and promoting bone and tendon healing, thus meeting the needs of modern fracture treatment.

CN121102347APending Publication Date: 2025-12-12HARBIN XIAS ORTHOPEDICS HOSPITAL CO LTD
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Patent Information

Application Number
CN202511069843.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-31
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

Existing fracture treatment drugs have limited efficacy, slow treatment time, and unsatisfactory results, failing to meet the application requirements of modern fracture cases.

Method used

The formula for Jieguwan (接骨丸) includes Chinese medicinal herbs such as Dipsacus asperoides, Angelica sinensis, and Drynaria fortunei. These herbs are mixed, pulverized, and bound into pills using a specific process. Temperature and drying processes are controlled to ensure that the medicinal components are not lost.

Benefits of technology

It provides the effects of promoting blood circulation, removing blood stasis, relieving pain, and promoting bone and tendon healing, thus improving the effectiveness and efficiency of fracture treatment.

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Abstract

The invention relates to a bone setting pill and a preparation method thereof. Various traditional Chinese medicinal materials are selected, radix angelicae sinensis, radix saposhnikoviae, pericarpium citri reticulatae and cassia twigs contain volatile components and are preferentially mixed and smashed in the smashing process, and the situation that the volatile components of the traditional Chinese medicinal materials are affected due to the fact that the temperature of the traditional Chinese medicinal materials is too high can be avoided; the fried frankincense, the fried myrrh and the catechu are resinous medicinal materials and are easy to soften and adhere to the interior of the pulverizer in the pulverizing process, so that the softening and adhering phenomena of the resinous medicinal materials in the pulverizing process can be effectively reduced by firstly mixing and pulverizing other medicinal materials, mixing the resinous medicinal materials with fine powder of other medicinal materials and then pulverizing the resinous medicinal materials, and the pulverizing effect is improved. In the drying process, low-temperature drying is adopted to avoid loss of volatile components, and the safety and effectiveness of the medicine can be fully guaranteed. The obtained traditional Chinese medicine pill has the effects of promoting blood circulation to remove blood stasis, stimulating menstrual flow to relieve pain, reunion of fractured bones and tendons and the like, and is used for treating fractured tendons, blood stasis swelling, pain and other symptoms.
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Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a bone-setting pill and its preparation method. Background Technology

[0002] Bone injuries are common and frequently occurring in daily life, including fractures, bone fissures, femoral head necrosis, sprains, strains, and other injuries, which seriously affect people's health and quality of life. Among these, fractures are the most common type of injury in orthopedics, and the prevalence of sports in today's society has led to a significant increase in fracture cases.

[0003] For patients with sprains and fractures, orthopedic surgeons typically apply splints and plaster casts for immobilization, followed by the administration of various pills and powders to promote blood circulation, reduce swelling and pain, and aid in tendon and bone healing. Currently, there are numerous and varied types of such medications, but they generally suffer from drawbacks such as limited efficacy, slow treatment, and unsatisfactory results, failing to meet current application requirements. Summary of the Invention

[0004] In view of the problems existing in the prior art, the present invention discloses a bone-setting pill, the main components and their weight ratios being as follows: 100-120 parts of Dipsacus asper, 80-85 parts of Angelica sinensis, 80-85 parts of Drynaria fortunei, 80-85 parts of Eucommia ulmoides, 80-85 parts of Citrus reticulata peel, 50-60 parts of Saposhnikovia divaricata, 50-60 parts of Achyranthes bidentata, 50-60 parts of Carthamus tinctorius, 50-60 parts of Stephania tetrandra, 50-60 parts of Pheretima aspergillum, 50-60 parts of stir-fried Boswellia carterii, 38-42 parts of stir-fried Commiphora myrrha, 50-60 parts of Zaocys dhumnades, 25-30 parts of Rheum palmatum, 25-30 parts of Cinnamomum cassia, 25-30 parts of Catechu, 25-30 parts of Panax notoginseng, and an appropriate amount of starch paste as a binder.

[0005] A method for preparing a bone-setting pill includes the following steps: Step 1: Select Angelica sinensis, Saposhnikovia divaricata, Citrus reticulata peel, and Cinnamomum cassia according to the weight ratio, and mix and grind them into fine powder using a grinder. Remove the fine powder from the grinder to obtain the first medicinal powder component. Step 2: Select Dipsacus asper, Drynaria fortunei, Eucommia ulmoides, Achyranthes bidentata, Carthamus tinctorius, Stephania tetrandra, Pheretima aspergillum, Zaocys dhumnades, Rheum palmatum, and Panax notoginseng according to the weight ratio, and put them into the pulverizer used in Step 1 for mixing and pulverizing to obtain the second medicinal powder component; Step 3: Mix the first and second powder components to obtain the third powder component, and set aside for later use; Step 4: Select the roasted frankincense, roasted myrrh, and catechu according to the weight ratio, mix them with the third medicinal powder component, and grind them again with a grinder to obtain the mixed medicinal powder component. After moist heat sterilization, it is ready for use. Step 5: Use starch paste as a binder to bind the mixed powder components, and process them into pills using a molding method; Step 6: Dry the pills obtained in Step 5 to obtain bone-setting pills.

[0006] As a preferred embodiment of the present invention, the crushing process in step one is intermittent, and the temperature is controlled not to exceed 60°C.

[0007] As a preferred embodiment of the present invention, the mixed powder components obtained in step four are sieved using a 100-mesh sieve.

[0008] As a preferred embodiment of the present invention, in step five, starch is selected at a weight of 2.8% of the total amount of the mixed powder components, and a starch paste with a starch content of 10% is prepared.

[0009] As a preferred embodiment of the present invention, the drying process in step six adopts a low-temperature drying method, and the drying temperature does not exceed 60°C.

[0010] The beneficial effects of this invention are as follows: This invention selects a variety of traditional Chinese medicinal materials, among which Angelica sinensis, Saposhnikovia divaricata, Citrus reticulata peel, and Cinnamomum cassia twig contain volatile components. Prioritizing their mixing and pulverization during the grinding process avoids excessively high temperatures that could affect the volatile components. Stir-fried frankincense, stir-fried myrrh, and catechu are resinous medicinal materials, which tend to soften and adhere to the pulverizer during grinding. Therefore, the other medicinal materials are mixed and pulverized first, and then the resinous medicinal materials are mixed with the fine powder of the other medicinal materials before grinding. This effectively reduces the softening and adhesion of the resinous medicinal materials during grinding, improving the grinding effect. Low-temperature drying is used in the drying process to avoid loss of volatile components, ensuring the safety and efficacy of the medicine. The resulting traditional Chinese medicine pills have the effects of promoting blood circulation, removing blood stasis, relieving pain, and promoting bone and tendon healing. They are used for symptoms such as fractures, tendon ruptures, swelling due to blood stasis, and pain. Detailed Implementation

[0011] Example 1

[0012] The present invention provides a bone-setting pill, the main components and their weight ratios as follows: 100 parts of Dipsacus asper, 80 parts of Angelica sinensis, 80 parts of Drynaria fortunei, 80 parts of Eucommia ulmoides, 80 parts of Citrus reticulata peel, 50 parts of Saposhnikovia divaricata, 50 parts of Achyranthes bidentata, 50 parts of Carthamus tinctorius, 50 parts of Stephania tetrandra, 50 parts of Pheretima aspergillum, 50 parts of stir-fried Boswellia carterii, 38 parts of stir-fried Commiphora myrrha, 50 parts of Zaocys dhumnades, 25 parts of Rheum palmatum, 25 parts of Cinnamomum cassia, 25 parts of Catechu, 25 parts of Panax notoginseng, and an appropriate amount of starch paste as a binder.

[0013] A method for preparing a bone-setting pill includes the following steps: Step 1: Select Angelica sinensis, Saposhnikovia divaricata, Citrus reticulata peel, and Cinnamomum cassia according to the weight ratio, and mix and grind them into fine powder using a grinder. During the grinding process, grind intermittently and control the temperature to not exceed 60℃. Remove the fine powder from the grinder to obtain the first medicinal powder component. Step 2: Select Dipsacus asper, Drynaria fortunei, Eucommia ulmoides, Achyranthes bidentata, Carthamus tinctorius, Stephania tetrandra, Pheretima aspergillum, Zaocys dhumnades, Rheum palmatum, and Panax notoginseng according to the weight ratio, and put them into the pulverizer used in Step 1 for mixing and pulverizing to obtain the second medicinal powder component; Step 3: Mix the first and second powder components to obtain the third powder component, and set aside for later use; Step 4: Select the roasted frankincense, roasted myrrh, and catechu according to the weight ratio, mix them with the third medicinal powder component, and grind them again with a pulverizer to obtain the mixed medicinal powder component. Sieve it through a 100-mesh sieve, and then perform moist heat sterilization before use. Step 5: Select starch at a weight of 2.8% of the total weight of the mixed powder components and prepare a starch paste with a starch content of 10%. Use the starch paste as a binder to bind the mixed powder components and process them into pills using a molding method. Step 6: Dry the pills obtained in Step 5 at a low temperature, not exceeding 60℃, to obtain the bone-setting pills.

[0014] Example 2

[0015] The present invention provides a bone-setting pill, the main components and their weight ratios being as follows: 120 parts of Dipsacus asper, 85 parts of Angelica sinensis, 85 parts of Drynaria fortunei, 85 parts of Eucommia ulmoides, 85 parts of Citrus reticulata peel, 60 parts of Saposhnikovia divaricata, 60 parts of Achyranthes bidentata, 60 parts of Carthamus tinctorius, 60 parts of Stephania tetrandra, 60 parts of Pheretima aspergillum, 60 parts of stir-fried Boswellia carterii, 42 parts of stir-fried Commiphora myrrha, 60 parts of Zaocys dhumnades, 30 parts of Rheum palmatum, 30 parts of Cinnamomum cassia, 30 parts of Catechu, 30 parts of Panax notoginseng, and an appropriate amount of starch paste as a binder.

[0016] A method for preparing a bone-setting pill includes the following steps: Step 1: Select Angelica sinensis, Saposhnikovia divaricata, Citrus reticulata peel, and Cinnamomum cassia according to the weight ratio, and mix and grind them into fine powder using a grinder. During the grinding process, grind intermittently and control the temperature to not exceed 60℃. Remove the fine powder from the grinder to obtain the first medicinal powder component. Step 2: Select Dipsacus asper, Drynaria fortunei, Eucommia ulmoides, Achyranthes bidentata, Carthamus tinctorius, Stephania tetrandra, Pheretima aspergillum, Zaocys dhumnades, Rheum palmatum, and Panax notoginseng according to the weight ratio, and put them into the pulverizer used in Step 1 for mixing and pulverizing to obtain the second medicinal powder component; Step 3: Mix the first and second powder components to obtain the third powder component, and set aside for later use; Step 4: Select the roasted frankincense, roasted myrrh, and catechu according to the weight ratio, mix them with the third medicinal powder component, and grind them again with a pulverizer to obtain the mixed medicinal powder component. Sieve it through a 100-mesh sieve, and then perform moist heat sterilization before use. Step 5: Select starch at a weight of 2.8% of the total weight of the mixed powder components and prepare a starch paste with a starch content of 10%. Use the starch paste as a binder to bind the mixed powder components and process them into pills using a molding method. Step 6: Dry the pills obtained in Step 5 at a low temperature, not exceeding 60℃, to obtain the bone-setting pills.

[0017] Example 3

[0018] The present invention provides a bone-setting pill, the main components and their weight ratios of which are as follows: 112 parts of Dipsacus asper, 83 parts of Angelica sinensis, 83 parts of Drynaria fortunei, 83 parts of Eucommia ulmoides, 83 parts of Citrus reticulata peel, 56 parts of Saposhnikovia divaricata, 56 parts of Achyranthes bidentata, 56 parts of Carthamus tinctorius, 56 parts of Stephania tetrandra, 56 parts of Pheretima aspergillum, 56 parts of stir-fried Boswellia carterii, 40 parts of stir-fried Commiphora myrrha, 56 parts of Zaocys dhumnades, 27 parts of Rheum palmatum, 27 parts of Cinnamomum cassia, 27 parts of Catechu, 27 parts of Panax notoginseng, and an appropriate amount of starch paste as a binder.

[0019] A method for preparing a bone-setting pill includes the following steps: Step 1: Select Angelica sinensis, Saposhnikovia divaricata, Citrus reticulata peel, and Cinnamomum cassia according to the weight ratio, and mix and grind them into fine powder using a grinder. During the grinding process, grind intermittently and control the temperature to not exceed 60℃. Remove the fine powder from the grinder to obtain the first medicinal powder component. Step 2: Select Dipsacus asper, Drynaria fortunei, Eucommia ulmoides, Achyranthes bidentata, Carthamus tinctorius, Stephania tetrandra, Pheretima aspergillum, Zaocys dhumnades, Rheum palmatum, and Panax notoginseng according to the weight ratio, and put them into the pulverizer used in Step 1 for mixing and pulverizing to obtain the second medicinal powder component; Step 3: Mix the first and second powder components to obtain the third powder component, and set aside for later use; Step 4: Select the roasted frankincense, roasted myrrh, and catechu according to the weight ratio, mix them with the third medicinal powder component, and grind them again with a pulverizer to obtain the mixed medicinal powder component. Sieve it through a 100-mesh sieve, and then perform moist heat sterilization before use. Step 5: Select starch at a weight of 2.8% of the total weight of the mixed powder components and prepare a starch paste with a starch content of 10%. Use the starch paste as a binder to bind the mixed powder components and process them into pills using a molding method. Step 6: Dry the pills obtained in Step 5 at a low temperature, not exceeding 60℃, to obtain the bone-setting pills.

[0020] Components not described in detail in this article are existing technologies.

[0021] While the specific embodiments of the present invention have been described in detail above, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention, and modifications or variations without creative effort are still within the protection scope of the present invention.

Claims

1. A bone-setting pill, characterized in that, Its main components and weight ratio are: Gastrodia 100-120 parts, Angelica 80-85 parts, Radix Dipsaci 80-85 parts, Eucommia 80-85 parts, dried tangerine or orange peel 80-85 parts, Saposhnikovia 50-60 parts, Radix Hedysari 50-60 parts, Red Flowers 50-60 parts, Stephania 50-60 parts, Earthworm 50-60 parts, Fried Olibanum 50-60 parts, Fried Myrrh 38-42 parts, Rhabdophis 50-60 parts, Rhubarb 25-30 parts, Cinnamon Twig 25-30 parts, Uncaria 25-30 parts, Sanchi 25-30 parts. Including Gastrodia 112 parts, Angelica 83 parts, Radix Dipsaci 83 parts, Eucommia 83 parts, dried tangerine or orange peel 83 parts, Saposhnikovia 56 parts, Radix Hedysari 56 parts, Red Flowers 56 parts, Stephania 56 parts, Earthworm 56 parts, Fried Olibanum 56 parts, Fried Myrrh 40 parts, Rhabdophis 56 parts, Rhubarb 27 parts, Cinnamon Twig 27 parts, Uncaria 27 parts, Sanchi 27 parts, and the binder is starch paste.

2. The bone-setting pill according to claim 1, characterized in that: Including the following steps:

3. A method of preparing a bone-setting pill as claimed in claim 1, wherein, Step one, select Angelica, Saposhnikovia, dried tangerine or orange peel, and Cinnamon Twig according to weight ratio, and mix and crush into fine powder with a pulverizer, take out the fine powder from the pulverizer, and get the first medicinal powder component; Step two, select Gastrodia, Radix Dipsaci, Eucommia, Radix Hedysari, Rhubarb, Stephania, Earthworm, Rhabdophis, and Sanchi according to weight ratio, and put them into the pulverizer used in step one for mixing and crushing, to get the second medicinal powder component; Step three, mix the first medicinal powder component and the second medicinal powder component to get the third medicinal powder component, for standby use; Step four, select Fried Olibanum, Fried Myrrh, and Uncaria according to weight ratio, mix them with the third medicinal powder component, and crush them again with a pulverizer to get the mixed medicinal powder component, which is standby used after wet heat sterilization; Step five, use starch paste as the binder to bond the mixed medicinal powder component, and process it into pills by molding method; Step six, dry the pills obtained in step five to get Jiegu Pills. The crushing process in step one is intermittent, and the temperature is controlled not to exceed 60℃.

4. A method of preparing a bone-setting pill as claimed in claim 3, wherein: The mixed medicinal powder component obtained in step four is sieved with a 100 mesh screen.

5. A method of preparing a bone-setting pill as claimed in claim 3, wherein: The starch used in step five is 2.8% of the total amount of the mixed medicinal powder component, and is configured into a starch paste with a starch content of 10%.

6. A method of preparing a bone-setting pill as claimed in claim 3, wherein: The drying treatment in step six adopts low-temperature drying method, and the drying temperature is not higher than 60℃.

7. A method of preparing a bone-setting pill as claimed in claim 3, wherein: ​