Traditional Chinese medicine mask for treating cyst nodule type acne and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine mask for treating cyst nodule type acne and a preparation method thereof. The traditional Chinese medicine mask is prepared from the following components in percentage by mass: 10% of traditional Chinese medicine potato powder and 90% of mask matrix. Wherein the traditional Chinese medicine powder comprises potatoes, radix ranunculi ternati, radix angelicae, spina gleditsiae, raw radix astragali, raw liquorice and borneol, and the mask matrix comprises kaolin, glycerol, bentonite and the like. The preparation method comprises the following steps: drying the traditional Chinese medicinal materials at low temperature, crushing, sieving, mixing with the borneol by adopting an equivalent incremental method, performing Co-60 irradiation disinfection, and mixing with the mask matrix to prepare a finished product. Animal experiments prove that the mask has a remarkable treatment effect on an experimental acne model and can effectively relieve local inflammation and promote skin lesion healing, acute toxicity and skin irritation tests show that the mask is good in safety, and a natural, safe and effective external treatment choice is provided for cyst nodule type acne.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine mask for treating cyst nodule type acne and a preparation method thereof. BACKGROUND

[0002] Acne vulgaris is one of common diseases in dermatology, is a chronic inflammation occurring in hair follicle sebaceous glands with damage to beauty, is prone to occur on the face, neck and back, and has various manifestations, and is commonly manifested as acne, papules, cysts, pustules and scars.

[0003] At present, external drug treatment is the basic treatment for acne, and mild and mild-to-moderate acne can be mainly treated by external drug treatment, and moderate-to-severe and severe acne is treated by external drug treatment while being treated by system treatment. For cyst nodule type acne, the clinical system treatment is mainly to use antibiotics, retinoids, hormone preparations and intralesional injection of glucocorticoids, but the above-mentioned methods have common adverse reactions, and have obvious side effects after long-term use. In addition, photodynamic therapy, red and blue light, laser and photon therapy are expensive, and the treatment scheme of cyst nodule type acne should be formulated according to the pathogenesis and severity of the disease as far as possible.

[0004] Based on the above reasons, it is particularly important to explore a treatment drug with small side effects, non-systemic use of antibiotics and hormone therapy, and reduction of sequelae such as scar formation. SUMMARY

[0005] The present application aims to provide a traditional Chinese medicine mask for treating cyst nodule type acne and a preparation method thereof, so as to solve the problems of large side effects and high cost of existing drug treatment of acne.

[0006] In order to achieve the above-mentioned purpose, the present application provides the following technical scheme:

[0007] A traditional Chinese medicine mask for treating cyst nodule type acne comprises a traditional Chinese medicine potato powder and a mask component, the mass percentage of the traditional Chinese medicine potato powder is 10%, the mass percentage of the mask component is 90%, the traditional Chinese medicine potato powder comprises potato, cat's claw, baizhi, soapstick, raw radix astragali, raw licorice and borneol, and the mask component comprises kaolin, glycerol, bentonite, dead sea mud, Tween-80, hydroxyethyl cellulose, preservative and deionized water.

[0008] Further, the proportion of each component of the traditional Chinese medicine potato powder is as follows: potato 30%, cat's claw 15%, baizhi 8%, soapstick 15%, raw radix astragali 10%, raw licorice 10% and borneol 2%.

[0009] Further, kaolin 30%, glycerol 20%, bentonite 10%, Dead Sea mud 10%, traditional Chinese medicine potato powder 10%, Tween-80 2%, hydroxyethyl cellulose 2%, preservative 0.5% and deionized water 15.5%.

[0010] A preparation method of a traditional Chinese medicine mask for treating cystic nodular acne treatment, comprising the following steps:

[0011] S1, mix potato, cat's paw, Bai Zhi, soapstick, raw radix astragali, raw licorice and borneol according to the proportion uniformly, low temperature drying, crushing through 200 mesh sieve for standby;

[0012] S2, the ice piece is finely ground with a mortar, and is mixed uniformly with the powder in step S1 by using the equal increment method, and is sterilized by Co-60 irradiation for standby;

[0013] S3, the powder obtained in step S2 is added to kaolin, glycerol, bentonite, Dead Sea mud, Tween-80, hydroxyethyl cellulose, preservative and deionized water according to the proportion, and is filled in a bottle to obtain the mask.

[0014] The principle and beneficial effects of the technical solution are as follows: the traditional Chinese medicine compound potato mask can effectively treat acne, and the mask preparation process is simple, low in cost and convenient to use; basically no side effects during use, can effectively reduce adverse reactions, reduce the pain of patients, increase the compliance of patients; the drug is not an antibiotic hormone therapy, but is prepared from natural crops, which can effectively reduce side effects and reduce the production of scars. DETAILED DESCRIPTION

[0015] The application will be further described in detail in combination with specific implementation manners as follows:

[0016] In this embodiment, acute toxicity experiment, irritation experiment and pharmacodynamics experiment are selected to evaluate the toxicity, irritation intensity and drug efficacy of the traditional Chinese medicine mask.

[0017] Firstly, the traditional Chinese medicine mask is prepared, and the following components are mixed uniformly: potato 30%, cat's paw 15%, Bai Zhi 8%, soapstick 15%, raw radix astragali 10% and raw licorice 10%. Then, low temperature drying, crushing through 200 mesh sieve for standby, obtaining traditional Chinese medicine potato powder; then, 2% borneol is finely ground with a mortar, and is mixed uniformly with the traditional Chinese medicine potato powder by using the equal increment method, and is sterilized by Co-60 irradiation for standby. The components are filled into a bottle according to the following proportion: kaolin 30%, glycerol 20%, bentonite 10%, Dead Sea mud 10%, traditional Chinese medicine potato powder 10%, Tween-80 2%, hydroxyethyl cellulose 2%, preservative 0.5% and deionized water 15.5%, to obtain the traditional Chinese medicine component mask.

[0018] Example 1

[0019] Acute toxicity test of Chinese medicine compound potato mask

[0020] Twenty SPF grade white rabbits with large ears were selected and randomly divided into four groups (A, B, C, D), five rabbits in each group, divided into Chinese medicine compound potato mask normal skin group (A), Chinese medicine compound potato mask damaged skin group (B), excipient normal skin group (C), and excipient damaged skin group (D). The fur on the right side of the spine of each rabbit was cut, and the fur area was 4x4 cm. After depilation, B and D groups were scratched with a needle on the skin of the depilation area to make a " " scratch, with a diameter of 3 cm, to scratch the epidermis without damaging the dermis, with mild bleeding. The Chinese medicine compound potato mask and the same dose of excipient were applied to the right depilation area, covered with one layer of oil paper and two layers of gauze, and fixed with non-irritating gauze. After 24 hours, the remaining drug was washed off with warm water, and the local congestion, edema, and systemic reactions such as urticaria, respiration, sneezing, etc. of the rabbits were observed at 0, 12, 24, 48, and 72 hours. The Chinese medicine compound potato mask and excipient were replaced every day, and the above experiment was repeated. The rabbits were routinely fed for one week, and the changes in body weight, skin, hair, eyes and mucous membranes, diet, respiration, behavior, appearance, excrement, secretion, toxic reactions and death were observed throughout the period. The results of each observation after drug administration were listed and evaluated.

[0021] Experimental results

[0022] Local skin reaction observation results, as shown in Table 1 below, the local skin reaction observation results of the right depilation area on the back of the rabbit were observed in detail and scored at multiple time points of 0, 12, 24, 48, and 72 hours.

[0023] Table 1 Local skin reaction observation and scoring of the right depilation area on the back of the rabbit

[0024]

[0025] From the above results, it can be seen that A group and C group did not appear any skin irritation reaction during the entire observation period, indicating that the Chinese medicine compound potato mask and its excipient had no irritation to the intact normal skin. The mild congestion and edema in B group and D group in the early stage were caused by artificial skin damage, which belonged to normal wound reaction. There was no significant difference in healing speed and reaction degree between the two groups, indicating that the Chinese medicine compound potato mask did not produce additional irritation or delay the healing process of the damaged skin, and did not cause allergic reactions (such as urticaria).

[0026] Systemic reaction observation results, during the entire experiment, all four groups of rabbits did not appear any systemic abnormal reaction.

[0027] The results above show that the herbal compound potato mask of the present invention contains no acutely toxic substances and exhibits good skin safety.

[0028] Example 2

[0029] Stimulation experiment of compound potato facial mask made of traditional Chinese medicine

[0030] Ten SPF-grade white rabbits were randomly divided into two groups of five each: a herbal compound potato mask group and an excipient group. A 4x4cm area of ​​skin was selected from the right side of the rabbit's spine. After shaving, a normal skin stimulation test was performed. The herbal compound potato mask and an equal amount of excipient were applied to each group, covered with a layer of oil paper and two layers of gauze, and then fixed with non-irritating gauze. After 24 hours, residual medication was washed off with warm water. Skin reactions, such as erythema, congestion, edema, bleeding, erosion, and ulceration, were carefully observed at 0, 1, 12, 24, 48, and 72 hours. The intensity of irritation was evaluated according to the skin irritation response scoring criteria in the Technical Guidelines for Research on the Irritation of Traditional Chinese Medicine Natural Drugs. 72 hours later, a 4x4cm patch of skin on the left side of the rabbit's spine was removed for a skin irritation test. Before drug administration, a 3cm diameter "#" puncture was made on the skin in the removed area with a needle, designed to puncture the epidermis without damaging the dermis, resulting in slight bleeding. The drug application method was the same as before. Skin reactions were observed at 0, 1, 12, 24, 48, and 72 hours after drug administration, as described above. The intensity of irritation was evaluated according to the skin irritation response scoring criteria in the Technical Guidelines for Research on the Irritation of Traditional Chinese Medicine Natural Drugs, and the results were tabulated and statistically analyzed.

[0031] Experimental results

[0032] In the complete skin irritation test, during the entire 72-hour observation period, none of the rabbits in the herbal compound potato mask group or the excipient group showed any irritation reactions such as erythema, edema, hemorrhage, erosion, or ulceration on their intact skin. The irritation response scores for both groups were 0 at all time points.

[0033] After creating a "#"-shaped abrasion in the hairless area of ​​the left spine of the rabbit, the test substance was applied for 24 hours, and observations were made at the same time points. The results are shown in Table 2.

[0034] Table 2. Skin Irritation Response Scores in Rabbits

[0035]

[0036] The results show that at 0 and 1 hour after application, both groups of animals exhibited mild erythema (score approximately 0.6 points). This reaction was normal traumatic hyperemia following skin abrasion and not caused by the drug. Over time, the skin reaction in both groups rapidly subsided, with the erythema essentially disappearing by 12 and 24 hours. By 48 and 72 hours, the skin reaction had completely disappeared in all animals, with scores of 0. Therefore, the compound potato mask of this invention is non-irritating to damaged rabbit skin, exhibiting the same reaction as the excipient group, and did not delay the natural healing process of the wound.

[0037] Example 3

[0038] Pharmacodynamic Experiment of Compound Potato Facial Mask

[0039] Thirty-two SPF-grade male white rabbits were randomly divided into four groups of eight each: a blank control group, a model group, a positive control group, and a traditional Chinese medicine mask group. The acne model was established by local chemical stimulation of the rabbit ears combined with intradermal injection of Staphylococcus epidermidis. The dressing was changed continuously for four weeks, and the recovery of acne was observed. The rabbits were then sacrificed, and their serum and ear tissue were preserved as experimental specimens for further analysis.

[0040] Model establishment: Acne-like lesions were successfully induced in the targeted ears of rabbits in all model groups, positive control groups, and traditional Chinese medicine mask groups using a combination of chemical stimulation and intradermal injection of Staphylococcus epidermidis. These lesions manifested as prominent local erythema, papules, and pustules, similar to the clinical presentation of human acne. The skin of the ears of rabbits in the control group was normal, showing no abnormalities.

[0041] During the four-week treatment period, the rabbit ear acne lesions were macroscopically scored weekly (quantified based on the number, size, and degree of redness and swelling of the lesions). The results are shown below:

[0042] Week 0: No skin lesions were observed in the blank group; there were no statistically significant differences in skin lesion scores among the other three groups (model group, positive control group, and traditional Chinese medicine mask group), indicating that the model was successfully replicated and the groups were balanced.

[0043] Model group: Throughout the experiment, the skin lesion score decreased slowly and remained at a high level until week 4, indicating that the natural healing process was slow and the model was stable.

[0044] Positive control group: The skin lesion score decreased significantly from week 1, indicating that the positive drug used was effective and verifying the reliability of the experimental system.

[0045] Traditional Chinese medicine facial mask group: From week 2, the skin lesion score showed a significant decrease, and the decreasing trend was significantly better than that of the model group. By week 4, the score was close to that of the positive control group and significantly lower than that of the model group.

[0046] At the end of the experiment, all rabbits were euthanized after blood was drawn from the marginal ear vein. Serum samples from all 32 rabbits were successfully isolated and cryopreserved. Simultaneously, target areas and corresponding normal ear tissues were precisely excised from each group of rabbits. Some samples were cryopreserved at -80°C, while others were fixed in 4% paraformaldehyde for subsequent testing.

[0047] This experiment successfully replicated a rabbit ear acne model. Macroscopic scoring results confirmed that the traditional Chinese medicine compound potato mask could significantly improve acne-like lesions, reduce local inflammatory response, and promote lesion healing. Its efficacy was superior to the naturally recovering model group and approached that of the positive control drug.

[0048] The above descriptions are merely embodiments of the present invention, and common knowledge regarding specific technical solutions or characteristics is not elaborated upon here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the technical solutions of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A traditional Chinese medicine facial mask for treating cystic nodular acne, characterized in that: The product comprises a traditional Chinese medicine potato powder and a facial mask component. The traditional Chinese medicine potato powder accounts for 10% by mass, and the facial mask component accounts for 90% by mass. The traditional Chinese medicine potato powder includes potato, cat's claw herb, angelica dahurica, soapberry thorn, raw astragalus, raw licorice, and borneol. The facial mask component includes kaolin, glycerin, bentonite, Dead Sea mud, Tween-80, hydroxyethyl cellulose, preservatives, and deionized water.

2. The traditional Chinese medicine facial mask for treating cystic nodular acne according to claim 1, characterized in that, The proportions of each component in the Chinese herbal potato powder are as follows: potato 30%, cat's claw grass 15%, angelica dahurica 8%, soapberry thorn 15%, raw astragalus 10%, raw licorice 10%, and borneol 2%.

3. The traditional Chinese medicine facial mask for treating cystic nodular acne according to claim 1, characterized in that, The proportions of the ingredients in this face mask are as follows: 30% kaolin, 20% glycerin, 10% bentonite, 10% Dead Sea mud, 10% Chinese herbal potato powder, 2% Tween-80, 2% hydroxyethyl cellulose, 0.5% preservative, and 15.5% deionized water.

4. A method for preparing a traditional Chinese medicine facial mask for treating cystic nodular acne according to any one of claims 1-3, comprising the following steps: S1. Mix potatoes, cat's claw grass, angelica dahurica, soapberry thorns, raw astragalus, raw licorice and borneol evenly in proportion, dry at low temperature, pulverize and pass through a 200-mesh sieve for later use. S2. Grind the borneol into a fine powder using a mortar and pestle, pass it through a 200-mesh sieve, and mix it evenly with the powder from step S1 using an equal-incremental method. Sterilize the mixture by Co-60 irradiation and set it aside for later use. S3. Add the powder obtained in step S2 to kaolin, glycerin, bentonite, Dead Sea mud, Tween-80, hydroxyethyl cellulose, preservative and deionized water in proportion, and fill the bottle to obtain the final product.

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