Analysis method of ultra-fast electromagnetic pulse on epilepsy suppression and interruption effects

Abstract

The invention discloses a method for analyzing an epilepsy suppression and interruption effect of an ultrafast electromagnetic pulse, and belongs to the technical field of bioelectromagnetism. The method comprises the following steps: S1, irradiating a brain model by adopting ultrafast electromagnetic pulses; s2, pulse parameters are adjusted, and the electric field distribution, the energy absorption amount and the temperature change of the temporal lobe area in the brain are changed; s3, detecting and analyzing the electric field intensity variation, the specific absorption rate (SAR), the temperature and the neural electrical activity response of the temporal lobe area, and determining optimal action parameters; and S4, evaluating inhibition and interruption effects of the ultrafast electromagnetic pulse on abnormal discharge of the temporal lobe epilepsy. According to the method, the action mechanism of the ultrafast electromagnetic pulse on the temporal lobe is researched, and technical support is provided for application research of the ultrafast electromagnetic pulse in the epilepsy replacement therapy.

Description

Technical Field

[0001] This invention relates to an analytical method for the inhibitory and interruptive effects of ultrafast electromagnetic pulses on epilepsy, belonging to the field of bioelectromagnetics technology. Background Technology

[0002] Epilepsy is the most common serious brain disorder, a chronic disease caused by sudden abnormal electrical discharges in the brain, leading to transient brain dysfunction. In patients with refractory focal epilepsy, approximately one-quarter show negative results on MRI (Magnetic Resonance Imaging), with temporal lobe epilepsy (TLE) being the most common. The epileptogenic focus in TLE primarily originates from the medial temporal lobe structures, and the electroencephalogram (EEG) shows abnormal discharges in the temporal region. TLE accounts for about 40% of adult epilepsy cases. Patients with TLE experience epileptiform discharges near or during a seizure, producing distinctive EEG waveforms such as spikes, sharp waves, slow-wave spike-slow-wave complexes, and sharp-slow-wave complexes. The mechanism is not fully understood, and the etiology is complex. Common symptomatic causes include temporal lobe hippocampal sclerosis, infectious lesions, temporal cortical malformations, and temporal region tumors.

[0003] Over the past few decades, a series of cutting-edge neurostimulation technologies have emerged in the field of neuroscience, including deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS). These technologies, with their unique neuromodulation mechanisms, have been widely applied in both clinical practice and laboratory research to explore the treatment of epilepsy.

[0004] It is worth noting that among these emerging technologies, non-invasive transcranial electromagnetic stimulation (TMS), represented by transcranial magnetic stimulation (TMS), has emerged as a leading force in epilepsy treatment research due to its significant advantages such as non-invasiveness and high safety, increasingly attracting high attention from researchers and clinicians both domestically and internationally. Related research has made significant progress, from exploring basic neurophysiological mechanisms to evaluating the efficacy of clinical trials, and is expected to open up entirely new pathways for epilepsy treatment, propelling the field's diagnostic and treatment levels to new heights.

[0005] Studies have shown that epilepsy patients may experience epileptiform discharges before or during a seizure. Among these, spikes are the most typical feature of epileptiform discharges in EEG signals. They can be characterized by a negative surface skew caused by cortical surface orientation, steep ascending and descending branches, and an overall shape resembling the sharp points of thorns. The period is usually 20-70 ms, and the amplitude is greater than 100 μV. Summary of the Invention

[0006] This invention proposes an analytical method for the inhibitory and disruptive effects of ultrafast electromagnetic pulses on epilepsy. By studying the mechanism of action of ultrafast electromagnetic pulses on the temporal lobe, this method provides technical support for the application of ultrafast electromagnetic pulses in epilepsy replacement therapy.

[0007] The technical solution adopted in this invention is as follows:

[0008] A method for analyzing the inhibitory and interruptive effects of ultrafast electromagnetic pulses on epilepsy, characterized by comprising the following steps:

[0009] S1. A nanosecond-level pulse is generated using an ultrafast electromagnetic pulse device to irradiate a pre-set brain model;

[0010] S2. Adjust pulse parameters, including electric field strength, irradiation frequency, pulse bandwidth, irradiation direction and polarization mode, to change the electric field distribution, energy absorption and temperature changes in the temporal lobe region of the brain;

[0011] S3. Detect and analyze the changes in electric field intensity, specific absorptivity (SAR), temperature, and neural electrical activity response in the temporal lobe region to determine the optimal action parameters;

[0012] S4. Evaluate the effect of ultrafast electromagnetic pulses on the inhibition and interruption of abnormal discharges in temporal lobe epilepsy based on optimal parameters.

[0013] Preferably, the ultrafast electromagnetic pulse device includes a pulse generation module and a parameter adjustment module; the pulse generation module generates nanosecond-level pulses through active or passive pulse compression technology; the parameter adjustment module can adjust the electric field strength, irradiation time, frequency, bandwidth, direction and polarization mode of the pulse, so that the pulse can be precisely applied to the temporal lobe region of the brain.

[0014] Preferably, the polarization mode of the ultrafast electromagnetic pulse is linear polarization.

[0015] Preferably, the parameters of the ultrafast electromagnetic pulse include: an electric field strength range of 1V / m to 100V / m, an irradiation frequency range of 1GHz to 10GHz, an irradiation direction of the left and right sides of the brain model, and a pulse bandwidth range of 1ns to 1000ns.

[0016] The beneficial effects of this invention are as follows:

[0017] This invention proposes a systematic method for analyzing the effects of ultrafast electromagnetic pulses on temporal lobe epilepsy, in order to study the key parameters and mechanisms of action of electromagnetic pulse-induced epilepsy.

[0018] This invention uses non-invasive methods to regulate neural activity, which can effectively inhibit and interrupt abnormal discharges in temporal lobe epilepsy while minimizing interference with the patient's physiological functions.

[0019] The pulse parameters used in this invention (such as SAR values ​​within a safe range and irradiation time shorter than the seizure cycle) ensure the safety and effectiveness of the technology application, providing a solid theoretical and experimental basis for the application of ultrafast electromagnetic pulses in epilepsy replacement therapy. Attached Figure Description

[0020] Figure 1 This is a front view of a human head model.

[0021] Figure 2 This is a cross-sectional schematic diagram of an ultrafast electromagnetic pulse acting on a human head model, where 1 represents the temporal lobe.

[0022] Figure 3 This is an electric field diagram of the temporal lobe region after an ultrafast electromagnetic pulse is applied to a human head model, with the darker areas representing regions with higher electric field intensity.

[0023] Figure 4 This is a power loss density map of the temporal lobe region after an ultrafast electromagnetic pulse is applied to a human head model, with the darker areas representing regions with higher power loss densities. Detailed Implementation

[0024] To more clearly illustrate the purpose, features, and advantages of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0025] This invention provides a method for analyzing the inhibitory and disruptive effects of ultrafast electromagnetic pulses on epilepsy, comprising the following steps:

[0026] S1. A nanosecond-level pulse is generated using an ultrafast electromagnetic pulse device to irradiate a pre-defined brain model. This embodiment references the article "Realistic human head voxel model for brain mIcrowave Imaging," an open-source human head model constructed using simulation software based on human brain magnetic resonance imaging (MRI) images. This voxel set includes all geometric information of the major tissue types of the human head (skin, fat, bone (skull), bone marrow, cerebrospinal fluid, dura mater, cerebellum, nerves, muscles, tongue, eyes (lens and vitreous humor), blood, cartilage, gray matter, white matter, and adrenal glands, salivary glands, and thyroid gland).

[0027] S2. Adjust pulse parameters, including electric field strength, irradiation frequency, pulse bandwidth, irradiation direction and polarization mode, to change the electric field distribution, energy absorption and temperature changes in the temporal lobe region of the brain;

[0028] Among them, the irradiation electric field strength is 1-100V / m; the irradiation frequency is 1-10GHz; the irradiation direction is the upper and lower sides, left and right sides, and front and back sides of the brain model respectively; the pulse bandwidth is nanosecond level; and the polarization mode is linear polarization, elliptical polarization, and circular polarization.

[0029] S3. Detect and analyze the changes in electric field intensity, specific absorptivity (SAR), temperature, and neural electrical activity response in the temporal lobe region to determine the optimal action parameters;

[0030] S4. Evaluate the effect of ultrafast electromagnetic pulses on the inhibition and interruption of abnormal discharges in temporal lobe epilepsy based on optimal parameters.

[0031] Multiple control experiments revealed that as the irradiation frequency increased, the concentration of the electric field intensity in the temporal lobe decreased in space, the directionality weakened, and the energy diffused from a concentrated small area to a wider space, exhibiting a "more dispersed" characteristic, making it difficult to target a specific tissue inside the brain.

[0032] As the intensity of the irradiated electric field increases, the intensity of the electric field and the amount absorbed by the brain also increase. If this exceeds a certain standard, it can damage human health.

[0033] The advantage of using nanosecond-level pulses is that the irradiation time is very short, and the amount of electromagnetic waves absorbed by the brain and the temperature are within a certain range, thus ensuring safety.

[0034] Experimental results show that when the electric field strength is around 50 V / m, the irradiation frequency is around 1 GHz, the irradiation direction is on the left side of the brain model, the pulse bandwidth is around 10 ns, and the polarization mode is linear polarization, the electric field strength in most of the left side of the head reaches 10 V / m, with the highest reaching 30 V / m in the temporal lobe, while the electric field strength in most of the right side of the head is 5 V / m. The power-loss density (LPD) in most of the left side of the head reaches 50 W / m^3, with the highest reaching 70 W / m^3 in the temporal lobe, while most of the right side of the head is below 10 W / m^3. The highest specific absorption ratio (SAR) of the head is 0.08 W / kg, which is lower than the internationally recognized standard. The temperature change of the head is basically around 0.7 degrees Celsius, which is within a relatively safe range.

[0035] When the brain is irradiated with ultrafast electromagnetic pulses of appropriate electric field strength, frequency, pulse bandwidth, irradiation direction, and polarization mode, the electric field and absorption of the temporal lobe can be altered, effectively stimulating the temporal lobe and potentially inhibiting or interrupting abnormal discharges in temporal lobe epilepsy.

Claims

1. A method for analyzing the inhibitory and interruptive effects of ultrafast electromagnetic pulses on epilepsy, characterized in that, Includes the following steps: S1. A nanosecond-level pulse is generated using an ultrafast electromagnetic pulse device to irradiate a pre-set brain model; S2. Adjust pulse parameters, including electric field strength, irradiation frequency, pulse bandwidth, irradiation direction and polarization mode, to change the electric field distribution, energy absorption and temperature changes in the temporal lobe region of the brain; S3. Detect and analyze the changes in electric field intensity, specific absorptivity (SAR), temperature, and neural electrical activity response in the temporal lobe region to determine the optimal action parameters; S4. Evaluate the effect of ultrafast electromagnetic pulses on the inhibition and interruption of abnormal discharges in temporal lobe epilepsy based on optimal parameters.

2. The method for analyzing the inhibitory and interruptive effects of ultrafast electromagnetic pulses on epilepsy as described in claim 1, characterized in that, The ultrafast electromagnetic pulse device includes a pulse generation module and a parameter adjustment module; the pulse generation module generates nanosecond-level pulses through active or passive pulse compression technology; the parameter adjustment module can adjust the electric field strength, irradiation time, frequency, bandwidth, direction and polarization mode of the pulse, so that the pulse can be precisely applied to the temporal lobe region of the brain.

3. The method for analyzing the inhibitory and interruptive effects of ultrafast electromagnetic pulses on epilepsy as described in claim 2, characterized in that, The polarization mode of ultrafast electromagnetic pulses is linear polarization.

4. The method for analyzing the inhibitory and interruptive effects of ultrafast electromagnetic pulses on epilepsy as described in claim 3, characterized in that, The parameters of the ultrafast electromagnetic pulse include: electric field strength ranging from 1V / m to 100V / m, irradiation frequency ranging from 1GHz to 10GHz, irradiation direction being the left and right sides of the brain model, and pulse bandwidth ranging from 1ns to 1000ns.

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