Traditional Chinese medicine composition for preventing and treating postoperation enteroparalysis of puerpera after cesarean section

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating postcesarean enteroparalysis of lying-in women, which relates to the technical field of traditional Chinese medicine formulae and is technically characterized in that ten traditional Chinese medicines including fructus aurantii, rhizoma anemarrhenae, perilla stem and the like are decocted into 150ml with water and then are heated for oral administration; during decoction, soaking for 30 minutes, boiling with big fire, decocting for 40 minutes with small fire, repeating once, and concentrating the liquid medicine; a puerpera takes 150ml of the traditional Chinese medicine twice a day for 3-4 days continuously, and the traditional Chinese medicine is stored in a clean and dry place at the temperature of 5-10 DEG C; the composition is specially designed for qi stagnation and damp obstruction type intestinal paralysis, and can effectively regulate qi activity, remove damp obstruction and reduce the occurrence of intestinal paralysis; the components are natural and free of side effects; the traditional Chinese medicine composition is more easily absorbed by human bodies, has obvious curative effects and can promote postoperative rehabilitation of puerperae.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine formulation technology, and in particular to a traditional Chinese medicine composition for preventing and treating postpartum ileus after cesarean section. Background Technology

[0002] Currently, a wide variety of drugs are used in the clinical treatment of postoperative ileus (POI). Prokinetic drugs play a crucial role, commonly including metoclopramide, cisapride, cholecystokinin, and dopamine antagonists. In addition, opioid antagonists, ghrelin agonists, and some new therapies still under investigation are also being used to treat this condition. Extensive clinical practice has shown that most of these drugs are significantly effective in shortening the duration of POI, providing some support for patient recovery.

[0003] While Western medicine has achieved some success in treating POI (Potential Inflammatory Disease), the significant side effects it brings cannot be ignored. For example, mosapride is not recommended for breastfeeding patients, limiting its use in this specific population. Other prokinetic drugs also carry numerous adverse reactions, such as diarrhea, abdominal pain, rash, dizziness, and abnormal liver function. These side effects make it difficult for some patients to tolerate treatment, affecting not only the therapeutic effect but also potentially causing further harm to their health, posing a challenge to clinical treatment.

[0004] In the field of Traditional Chinese Medicine (TCM), some herbal decoctions, such as Chengqi Decoction and Simo Decoction, are used to treat postoperative post-injury injuries (POIs). However, these traditional formulas are mainly for patients with excess patterns. Postpartum patients, however, have unique physical conditions, often exhibiting pathological characteristics of deficiency and blood stasis, along with often impaired spleen and stomach function. In such cases, using herbal decoctions primarily targeting excess patterns, with excessive purgation, may further damage the patient's spleen and stomach function, hindering postoperative recovery and potentially leading to other complications. This limits the widespread application of TCM in treating POIs. Summary of the Invention

[0005] In order to at least solve one of the above-mentioned technical problems, the present invention aims to provide a traditional Chinese medicine composition for preventing and treating postpartum ileus after cesarean section, which is specifically designed for ileus after cesarean section caused by qi stagnation and dampness obstruction, and helps to reduce its occurrence; it has no side effects on the human body and can be taken by breastfeeding women; the ingredients are natural and hormone-free, making it easier for the human body to absorb and with significant therapeutic effects.

[0006] To achieve the above objectives, the present invention provides the following technical solution: A traditional Chinese medicine composition for preventing and treating paralytic ileus after cesarean section in parturients, comprising the following components: 12 grams of Fructus Aurantii, 9 grams of Anemarrhena Rhizome, 9 grams of Perilla Stem, 12 to 18 grams of Magnolia Officinalis, 12 to 18 grams of Tsaoko Fruit, 9 to 40 grams of Scutellaria Baicalensis, 6 grams of Honey-Fried Licorice Root, 12 grams of White Peony Root, 30 grams of Astragalus Root, 15 grams of Angelica Sinensis; decoct the above components into 150 ml, and the usage method is to take orally after heating.

[0007] Preferably, the decocting method of the traditional Chinese medicine composition is as follows: put the medicine into a decocting pot, add clear water 2 - 3 cm above the medicine, soak for 30 minutes, first quickly boil with high heat, then decoct with low heat for 40 minutes, and filter out the medicinal liquid; then add clear water 2 - 3 cm above the medicine residue again, repeat the above decocting process, combine the medicinal liquids filtered out twice, and continue to decoct and concentrate to 150 ml.

[0008] Preferably, the taking method of the traditional Chinese medicine composition is as follows: the parturient drinks it 2 times a day, takes it for 3 - 4 days in total, takes 150 ml each time, and takes it orally after heating to 50 to 80 °C when taking the medicine.

[0009] Preferably, the storage conditions of the traditional Chinese medicine composition are: clean, dry, cool and dark, and the storage temperature is controlled at 5 - 10 °C.

[0010] The present invention has the following beneficial effects: Reduce the occurrence of paralytic ileus after cesarean section of qi stagnation and damp obstruction type: The present invention is specifically formulated for paralytic ileus after cesarean section of qi stagnation and damp obstruction type. Fructus Aurantii can promote qi circulation and relieve distension; Perilla Stem can regulate qi and relieve distension; Magnolia Officinalis can dry dampness and resolve phlegm, lower qi and relieve fullness. The synergistic effect of these medicines can effectively regulate qi movement and remove damp obstruction. Through reasonable drug compatibility, it can improve the pathological state of qi stagnation and damp obstruction after parturient's operation, reduce the occurrence probability of paralytic ileus after cesarean section of qi stagnation and damp obstruction type from the root, help the smooth recovery of the parturient's intestinal function after operation, and ensure the health of the parturient.

[0011] It has no side effects on the human body and can be taken by lactating women: Compared with the existing western medicine for treating POI, the present invention has significant advantages. Western medicines such as Mosapride are not recommended for use during lactation, and other prokinetic drugs also have risks of side effects such as diarrhea, abdominal pain, rash, dizziness, and abnormal liver function. All components of the present invention are natural Chinese medicinal materials, and after scientific compatibility, they will not produce the above side effects on the human body under normal dosage. Especially for lactating parturients, there is no need to worry about the adverse effects of the medicine on the baby and they can take it with confidence, providing a safe and effective choice for treating paralytic ileus after cesarean section in lactating parturients.

[0012] The ingredients are natural and hormone-free, making them easier for the body to absorb and resulting in significant therapeutic effects: This invention uses only natural Chinese herbal ingredients and contains no hormones. Compared to drugs containing hormones, natural ingredients are more compatible with the human body's physiological environment and are more easily recognized and absorbed. For example, Astragalus membranaceus has the effects of tonifying Qi and raising Yang, and strengthening the body's defenses; Angelica sinensis can nourish blood and promote blood circulation. These natural medicinal materials, through reasonable combination, synergistically enhance the therapeutic effect. Clinical practice shows that after taking this invention, postpartum women experience earlier flatulence and bowel movements, and a lower incidence of postpartum ileus (POI), fully demonstrating its significant therapeutic effect and effectively promoting postpartum recovery after cesarean section. Detailed Implementation

[0013] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0014] This traditional Chinese medicine composition for preventing and treating postoperative ileus in women undergoing cesarean section, through the combination of different drug components and corresponding preparation and administration methods, can effectively improve the postoperative ileus condition and reduce the incidence of POI (postoperative ileus). The following are the specific operating methods and clinical effects of four different embodiments.

[0015] Example 1: Preparation and administration under normal circumstances Drug composition This traditional Chinese medicine composition contains the following components in parts by weight: 12g of Citrus aurantium, 9g of Anemarrhena asphodeloides, 9g of Perilla frutescens stem, 12g of Magnolia officinalis, 12g of Amomum tsao-ko, 9g of Scutellaria baicalensis, 6g of Glycyrrhiza uralensis (processed), 12g of Paeonia lactiflora, 30g of Astragalus membranaceus, and 15g of Angelica sinensis.

[0016] In addition, 3-6 grams of roasted malt can be added to enhance the overall efficacy of the medicine.

[0017] Method of decocting medicine Soaking: Prepare a clean decoction pot and place the weighed herbs one by one into the pot. Use a measuring cup to add water to the pot, ensuring that the water level is 2-3 cm above the herbs. Record the initial soaking time and soak for 30 minutes. During this period, the herbs will gradually absorb water, and the herbal tissues will become looser, which is conducive to the subsequent extraction of active ingredients.

[0018] First decoction: After soaking, place the decoction pot on a stable heat source, such as a gas stove. First, turn on high heat and quickly bring the water in the pot to a boil. When the water begins to boil vigorously, immediately reduce the heat to low and maintain a gentle simmer for 40 minutes. During the decoction process, observe the pot from time to time. After 40 minutes of decoction, prepare a clean gauze or filter and filter the liquid through it into a clean, sterilized glass or ceramic container for later use.

[0019] The water added for the first decoction is mineral water, because mineral water contains a variety of minerals, which may promote the extraction of the active ingredients of the medicine.

[0020] Second decoction: Add fresh water to the dregs again, enough to cover them by 2-3 cm. Then repeat the first decoction process: first bring to a boil over high heat, then reduce to a simmer and cook for 40 minutes. After decoction, filter the liquid again using clean gauze or a strainer.

[0021] The water added during the second decoction is purified water, which has fewer impurities and can avoid the influence of other impurities on the medicinal liquid.

[0022] Combining and Concentrating: Combine the two filtered decoctions into a single clean and sterilized container. Place the container over a low flame and continue simmering, monitoring the temperature with a thermometer while constantly stirring the decoction with a clean glass rod or wooden spoon to prevent localized overheating and scorching, ensuring a uniform concentration. Stop simmering when the decoction has concentrated to 150ml.

[0023] Dosage The mother should take the medicine twice a day, approximately one hour after breakfast and dinner, for a total of three days. Each time, place 150ml of the concentrated medicine in a suitable container and heat it to 50-80℃ using either a water bath (placing the container in a pot of warm water to indirectly heat the medicine) or a microwave (selecting medium-low power; the heating time depends on the volume of medicine and the microwave's wattage, generally 1-2 minutes). After heating, the mother should take the medicine orally while it is still warm.

[0024] Storage conditions Transfer the prepared herbal composition to a clean, dry, and sterilized brown glass bottle (brown glass effectively protects against light) and tighten the cap. Place a layer of dry cotton wool inside the brown glass bottle before pouring in the herbal composition. The cotton wool provides cushioning and protection, reducing impact between the herbal composition and the bottle walls. Store the brown glass bottle containing the herbal composition in a clean, dry, cool, and dark environment, such as a refrigerator, at a temperature controlled between 5 and 10°C.

[0025] Clinical efficacy Thirty postpartum women undergoing cesarean section with qi stagnation and dampness obstruction were selected as the study subjects. After surgery, the women were treated with this traditional Chinese medicine composition according to the above method. During the treatment, the time of first flatus and defecation for each woman was recorded in detail. Clinical observation showed that after taking this medicine, the average time for first flatus was 18-24 hours post-surgery, and the average time for defecation was 24-30 hours post-surgery. A control group that did not receive this medicine was also included. The comparison revealed that the incidence of postpartum irritation (POI) in the postpartum group was 30% lower than that in the control group.

[0026] Example 2: Preparation and administration of ginger, magnolia bark, and cardamom under adjusted dosages Drug composition This traditional Chinese medicine composition contains the following components in parts by weight: 12g of Citrus aurantium, 9g of Anemarrhena asphodeloides, 9g of Perilla frutescens stem, 15g of Magnolia officinalis, 15g of Amomum tsao-ko, 20g of Scutellaria baicalensis, 6g of Glycyrrhiza uralensis (processed), 12g of Paeonia lactiflora, 30g of Astragalus membranaceus, and 15g of Angelica sinensis.

[0027] If the postpartum woman has mild anemia, the dosage of Angelica sinensis should be increased to 20 grams and the dosage of Astragalus membranaceus should be increased to 35 grams to enhance the effects of replenishing blood and qi.

[0028] Method of decocting medicine The decoction method is the same as in Example 1. First, place the herbs in a clean decoction pot, add water to cover the herbs by 2-3 cm, and soak for 30 minutes. After soaking, perform the first decoction: first bring to a boil over high heat, then reduce to low heat and simmer for 40 minutes, then filter the liquid. Next, add water again to the dregs to cover them by 2-3 cm, and perform the second decoction: again, first bring to a boil over high heat, then simmer for 40 minutes, then filter the liquid. Finally, combine the two decoctions and concentrate them over low heat to 150 ml, stirring constantly.

[0029] Dosage The mother should take the medicine twice a day for a total of 4 days, 150ml each time. When taking the medicine, heat the liquid to 50-80℃, which can be done by water bath or microwave heating. Take it approximately one hour after breakfast and dinner.

[0030] Storage conditions The storage conditions are consistent with those in Example 1. The prepared medicine solution is placed in a clean, dry, sterilized brown glass bottle and stored in a clean, dry, cool and dark place with the temperature controlled at 5-10°C. It can be stored in the refrigerator.

[0031] Clinical efficacy Twenty-five women who underwent cesarean section with qi stagnation and dampness obstruction were treated with the traditional Chinese medicine composition described in this example. The medication was administered according to the above method after surgery. During the treatment, the time of first flatus and defecation for each woman was recorded in detail. Results showed that the average time to first flatus was 16-22 hours post-surgery, and the average time to defecation was 22-28 hours post-surgery. Compared with the control group who did not receive this medication, the incidence of postpartum irritation (POI) in this group was reduced by 35%.

[0032] Example 3: Preparation and administration of Scutellaria baicalensis under adjusted dosage Drug composition This traditional Chinese medicine composition contains the following components in parts by weight: 12g of Citrus aurantium, 9g of Anemarrhena asphodeloides, 9g of Perilla frutescens stem, 18g of Magnolia officinalis, 18g of Amomum tsao-ko, 40g of Scutellaria baicalensis, 6g of Glycyrrhiza uralensis (processed), 12g of Paeonia lactiflora, 30g of Astragalus membranaceus, and 15g of Angelica sinensis.

[0033] Method of decocting medicine The decoction process continues as described in Example 1. First, place the herbs in a clean decoction pot, add water to cover the herbs by 2-3 cm, and soak for 30 minutes. After soaking, perform the first decoction: bring to a boil over high heat, then reduce to low heat and simmer for 40 minutes. Filter the liquid. Then, add water again to the dregs to cover them by 2-3 cm, and perform the second decoction: similarly, bring to a boil over high heat, then simmer for 40 minutes. Filter the liquid. Finally, combine the two decoctions and concentrate them over low heat to 150 ml, stirring constantly during the concentration process.

[0034] Dosage The mother should take 150ml twice a day for 3 days. Heat the liquid to 50-80℃ using a water bath or microwave. Take orally about one hour after breakfast and dinner.

[0035] Storage conditions Similar to the previous two embodiments, the prepared medicine solution is placed in a clean, dry, sterilized brown glass bottle and stored in a clean, dry, cool and light-proof environment at a temperature of 5-10°C. It can be placed in the refrigerator.

[0036] Clinical efficacy The traditional Chinese medicine composition described in this example was used to treat 20 women who underwent cesarean section with qi stagnation and dampness obstruction. The medication was administered according to the above method after surgery. During the treatment, the time of first flatus and defecation for each woman was recorded in detail. The average time to first flatus was 15-20 hours post-surgery, and the average time to defecation was 20-26 hours post-surgery. Compared with the control group that did not receive this medication, the incidence of postpartum irritation (POI) in this group was reduced by 40%.

[0037] Example 4: Preparation and Consumption with Added Roasted Malt Drug composition This traditional Chinese medicine composition contains the following components in parts by weight: 12g of Citrus aurantium, 9g of Anemarrhena asphodeloides, 9g of Perilla frutescens stem, 12g of Magnolia officinalis, 12g of Amomum tsao-ko, 9g of Scutellaria baicalensis, 6g of Glycyrrhiza uralensis (processed), 12g of Paeonia lactiflora, 30g of Astragalus membranaceus, 15g of Angelica sinensis, and 4g of Hordeum vulgare (processed Hordeum vulgare is selected in the range of 3-6g).

[0038] Method of decocting medicine Soaking: Place the weighed herbs into a clean decoction pot, add water to cover the herbs by 2-3 cm, and soak for 30 minutes to allow the herbs to fully absorb the water.

[0039] First decoction: After soaking, place the medicine on a heat source, bring to a boil over high heat, then simmer over low heat for 40 minutes, and filter out the liquid. Use mineral water for the first decoction.

[0040] Second decoction: Add purified water to the dregs again, covering them by 2-3 cm, and repeat the first decoction process, that is, first bring to a boil over high heat, then simmer over low heat for 40 minutes, and filter out the liquid.

[0041] Combining and Concentrating: Combine the two liquids and concentrate them over low heat to 150ml, stirring constantly.

[0042] Dosage The mother should take the medicine twice a day, about one hour after breakfast and dinner, for a total of 3 days, 150ml each time. The liquid should be heated to 50-80℃ before administration, using a water bath or microwave.

[0043] Storage conditions Transfer the prepared medicine solution to a clean, dry, sterilized brown glass bottle. First, place a layer of dry cotton in the bottle, then pour in the medicine solution and tighten the cap. Store in a clean, dry, cool, and dark refrigerator compartment at a temperature of 5-10℃.

[0044] Clinical efficacy Twenty postpartum women with qi stagnation and dampness obstruction after cesarean section were selected and treated with the traditional Chinese medicine composition described in this embodiment. During the treatment, the time of first flatus and defecation for each woman was recorded in detail. Results showed that the average time to first flatus was 17-23 hours post-surgery, and the average time to defecation was 23-29 hours post-surgery. Compared with the control group who did not receive this medication, the incidence of postpartum irritation (POI) in this group was reduced by 28%.

[0045] As can be seen from the above four examples, this traditional Chinese medicine composition can effectively shorten the time for flatus and defecation after cesarean section and reduce the incidence of postpartum POI under different drug dosage combinations and the addition of roasted malt. Furthermore, the clinical effect is improved to a certain extent with the adjustment of the dosage of some drugs or the addition of new ingredients.

[0046] The above are merely specific embodiments of the present invention, but the technical features of the present invention are not limited thereto. Any simple changes, equivalent substitutions, or modifications made based on the present invention to solve essentially the same technical problems and achieve essentially the same technical effects are all covered within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for preventing and treating postpartum ileus after cesarean section, characterized in that: The formula includes the following ingredients: 12g of Citrus aurantium, 9g of Anemarrhena asphodeloides, 9g of Perilla frutescens stem, 12-18g of Magnolia officinalis, 12-18g of Amomum tsao-ko, 9-40g of Scutellaria baicalensis, 6g of Glycyrrhiza uralensis (processed), 12g of Paeonia lactiflora, 30g of Astragalus membranaceus, and 15g of Angelica sinensis. The above ingredients are decocted in water to make 150ml. The formula is to be heated and taken orally.

2. The traditional Chinese medicine composition for preventing and treating postpartum ileus after cesarean section according to claim 1, characterized in that, The decoction method of the Chinese herbal medicine composition is as follows: put the medicine into a decoction pot, add water to cover the medicine by 2-3 cm, soak for 30 minutes, bring to a boil quickly over high heat, then simmer over low heat for 40 minutes, and filter out the liquid; then add water to the dregs again to cover them by 2-3 cm, repeat the above decoction process, combine the two filtered liquids, and continue to decoct and concentrate to 150 ml.

3. The traditional Chinese medicine composition for preventing and treating postpartum ileus paralysis according to claim 2, characterized in that, The method of administration for the Chinese herbal composition is as follows: the postpartum woman should drink it twice a day for a total of 3-4 days, each time taking 150ml, and heating it to 50 to 80℃ before oral administration.

4. The traditional Chinese medicine composition for preventing and treating postpartum ileus after cesarean section according to claim 3, characterized in that, The storage conditions for the traditional Chinese medicine composition are: clean, dry, cool and protected from light, with the storage temperature controlled at 5-10℃.

5. The traditional Chinese medicine composition for preventing and treating postpartum ileus after cesarean section according to claim 1, characterized in that, The herbal composition also contains 3-6 grams of roasted malt.

6. The traditional Chinese medicine composition for preventing and treating postpartum ileus paralysis according to claim 4, characterized in that, When decocting the traditional Chinese medicine composition, mineral water is added for the first decoction and purified water is added for the second decoction.

7. The traditional Chinese medicine composition for preventing and treating postpartum ileus paralysis according to claim 4, characterized in that, When storing the traditional Chinese medicine composition, first place a layer of dry cotton in a brown glass bottle, and then pour in the medicinal liquid.

8. The traditional Chinese medicine composition for preventing and treating postpartum ileus paralysis according to claim 1, characterized in that, In the aforementioned traditional Chinese medicine composition, when the postpartum woman has mild anemia symptoms, the dosage of Angelica sinensis is increased to 20 grams and the dosage of Astragalus membranaceus is increased to 35 grams.