Base for stereotactic injection of newborn mouse and dynamic monitoring system

Abstract

The invention relates to the technical field of basic medicine, and discloses a base and dynamic monitoring system for newborn mouse stereotactic injection, the base comprises a stereotactic instrument, the stereotactic instrument also comprises a test platform, the upper surface of the test platform is provided with a base, the contact surface of the base and the test platform is provided with a connecting mechanism, and the connecting mechanism is connected with the stereotactic instrument. The base is used for detachably fixing the base to the upper surface of a test platform, an anesthesia module is arranged at the front end of the base, and a monitoring module is arranged in the base. Through cooperative work of the base and a dynamic monitoring system, the stability and the operation precision of the injection process are remarkably improved, the injury risk of experimental animals is effectively reduced, and the safety of the experimental animals is improved. Reliable technical support is provided for development of stereotactic intervention research of early brain development, and a solid experimental foundation is laid for deep exploration of pathological mechanisms of neurodevelopment-related diseases.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of basic medicine, more particularly to a new mouse stereotactic injection base and dynamic monitoring system. BACKGROUND

[0002] Brain stereotactic injection technology is a key means in basic medical research. By integrating a brain stereotactic instrument with a standard brain atlas, it can accurately deliver experimental materials such as drugs, viral vectors, stem cells or probes to specific brain regions, thereby achieving high spatial resolution and clear targeting intervention. This technology has good repeatability and strong reliability, and is not only used for conventional drug injection, but also widely used in gene modification, neural circuit tracing, and cutting-edge research directions such as optogenetics and chemogenetics. Compared with traditional whole brain drug delivery or large area perfusion methods, the brain tissue damage caused by stereotactic injection is more localized and controllable, and the animal recovers faster after surgery, which facilitates multiple interventions at different stages of the disease and is conducive to dynamic observation of pathological processes and treatment effects. However, the currently marketed stereotactic instrument is mainly designed based on the anatomical structure of adult mice, and its head fixation relies on a support system composed of ear bars and tooth bars. Newborn mice have not yet fully developed skull, soft bone and small size, which makes it difficult to provide stable and reliable fixation points, so they cannot be effectively fixed on conventional stereotactic platforms. This limitation not only significantly increases the risk of animal injury during the experiment, but also seriously restricts the accurate intervention and dynamic tracking of specific brain regions during early development. In particular, in the research fields of neurodevelopmental disorders and early mechanisms of mental diseases, precise brain intervention in newborn mice has important scientific value, but the design flaws of existing equipment make it difficult to effectively carry out related experiments. Therefore, there is an urgent need for a new mouse stereotactic injection base to solve the above technical problems. SUMMARY

[0003] In order to overcome the above-mentioned defects of the prior art, the present application provides a new mouse stereotactic injection base and a dynamic monitoring system to solve the problems existing in the background art.

[0004] To achieve the above-mentioned purpose, the present application provides the following technical solution: a new mouse stereotactic injection base, comprising a stereotactic instrument, the stereotactic instrument further comprising a test platform, the upper surface of the test platform being provided with a base, wherein the contact surface of the base and the test platform is provided with a connecting mechanism for detachably fixing the base to the upper surface of the test platform, the front end of the base is provided with an anesthesia module, and the inside of the base is provided with a monitoring module for monitoring the real-time body temperature and respiratory physiological signals of the newborn mouse inside the base. The inside of the base is provided with a body accommodating cavity for supporting the body of the newborn mouse, wherein the inside of the base near the position of the body accommodating cavity is provided with a semi-closed support groove, and a flexible lining is detachably installed in the semi-closed support groove for wrapping and fixing the head of the newborn mouse.

[0005] Preferably, the shape of the body accommodating cavity and the semi-closed support groove is adapted to the average profile of the standardized head and neck anatomical model of the target age group of newborn mice, and the base is formed by 3D printing of a medical-grade biocompatible material.

[0006] Preferably, the medical-grade biocompatible material is photosensitive resin or polyamide powder, and the surface of the base is treated with an epoxy resin coating; The flexible lining is made of a medical-grade silicone material and has flexibility and biocompatibility. The connecting structure includes a standardized interface plate and a standardized adapter plate.

[0007] Preferably, the standardized interface plate is arranged in the middle region of the bottom end of the base, and the standardized adapter plate is arranged at the rear end of the base.

[0008] Preferably, the upper surface of the test platform is sequentially provided with a clamping groove structure adapted to the standardized interface plate and the standardized adapter plate, for detachably fixing the base to the upper surface of the test platform. The anesthesia module includes an adjustable sealed nose mask, an anesthesia delivery pipeline, an anesthesia connecting end, and a small animal anesthesia machine.

[0009] Preferably, the adjustable sealed nose mask is fixedly installed on the upper surface of the front end of the base, and its installation position is close to the flexible lining. The small animal anesthesia machine is independently arranged outside the stereotactic instrument.

[0010] Preferably, the anesthesia connecting end is arranged in the inside of the front end of the base and matches the interface of the small animal anesthesia machine, one end of the anesthesia delivery pipeline is in communication with the inside of the adjustable sealed nose mask, and the other end is in communication with the inside of the anesthesia connecting end, so that the anesthesia gas generated by the small animal anesthesia machine flows into the inside of the adjustable sealed nose mask. The adjustable sealed nose mask is made of a flexible high polymer material.

[0011] Preferably, the flexible high polymer material is silicone or polyurethane. The monitoring module includes a micro temperature sensor and a piezoresistive breathing monitoring sheet.

[0012] Preferably, the miniature temperature sensor and the piezoresistive respiratory monitoring chip are both integrated inside the base. The miniature temperature sensor is configured to monitor the real-time body temperature of newborn mice, and the piezoresistive respiratory monitoring chip is configured to monitor the respiratory physiological signals of newborn mice. A control device is installed on the upper surface of one side of the front end of the test platform. The control device integrates a dynamic monitoring system. The miniature temperature sensor and the piezoresistive respiratory monitoring chip are electrically connected to the control device through a flexible circuit to transmit real-time body temperature and respiratory physiological signals to the dynamic monitoring system. The base is equipped with a temperature control module, which includes a flexible heating film. The flexible heating film is fixedly installed inside the base and is positioned close to the body cavity. The flexible heating film is electrically connected to the control device via a data transmission device.

[0013] The technical effects and advantages of this invention are as follows: This invention combines a customized 3D-printed base based on a standardized age-appropriate skull anatomy model of newborn mice with a removable medical-grade flexible silicone liner, perfectly adapting to the soft and tiny skull shape of newborn mice. This contour-following, wrap-around fixation method completely eliminates the reliance on traditional ear rods and dental rods, providing extremely high fixation stability while maximizing pressure cushioning, significantly reducing the risk of skull injury and brain tissue compression, and laying the foundation for precise injection positioning.

[0014] This invention integrates a miniature temperature sensor and a piezoresistive respiratory monitoring pad to monitor the core vital signs (body temperature and respiration) of newborn mice in real time and non-invasively. The system has a built-in intelligent algorithm that can automatically determine whether the vital sign data exceeds the preset safety threshold and immediately trigger a response: either drive the flexible heating film to automatically maintain a constant body temperature, or prompt the operator to intervene through an alarm. This automatic closed-loop control mechanism of "monitoring-analysis-execution" greatly improves the life safety of animals during experiments and ensures the reliability and consistency of experimental data.

[0015] This invention significantly improves the stability and operational precision of the injection process through the coordinated work of the base and the dynamic monitoring system, effectively reduces the risk of injury to experimental animals, provides reliable technical support for conducting stereotactic intervention research on early brain development, and lays a solid experimental foundation for in-depth exploration of the pathological mechanisms of neurodevelopment-related diseases. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the stereo positioning device shown in this invention; Figure 2 for Figure 1 The diagram shows the front-end structure of the stereo positioning device. Figure 3 For Figure 2 the structure of A shown in the enlarged view of the schematic diagram; Figure 4 For Figure 1 the overall structure of the base shown in the schematic diagram; Figure 5 For Figure 4 the side structure of the base shown in the schematic diagram; Figure 6 For Figure 4 the partial structure of the base shown in the side view; Figure 7 The overall flowchart of the dynamic monitoring system shown in the present application.

[0017] The reference signs are: 1, stereotactic instrument; 101, test platform; 2, control device; 3, base; 301, anesthesia connection end; 302, anesthesia delivery pipeline; 303, body accommodating cavity; 304, flexible inner liner; 305, standardized adapter plate; 306, standardized interface plate; 4, adjustable sealed nasal mask; 5, micro temperature sensor; 6, piezoresistive breath monitoring sheet; 7, flexible heating film. DETAILED DESCRIPTION

[0018] The technical solutions in the present application will be described clearly and completely below in combination with the drawings in the present application, and in addition, the forms of each structure described in the following embodiments are only examples, and the new-born mouse stereotactic injection base and dynamic monitoring system involved in the present application are not limited to each structure described in the following embodiments, and all other embodiments obtained by those skilled in the art without making creative efforts belong to the scope of protection of the present application.

[0019] Referring to Figures 1 to 6 , the present application provides a new-born mouse stereotactic injection base, which comprises a stereotactic instrument 1, and the stereotactic instrument 1 further comprises a test platform 101; The upper surface of the test platform 101 is provided with a base 3, wherein the contact surface of the base 3 and the test platform 101 is provided with a connecting mechanism for detachably fixing the base 3 to the upper surface of the test platform 101, the front end of the base 3 is provided with an anesthesia module, and the inside of the base 3 is provided with a monitoring module for monitoring the real-time body temperature and respiratory physiological signals of the new-born mouse inside the base 3; The inside of the base 3 is provided with a body accommodating cavity 303 for supporting the body of the new-born mouse, wherein the inside of the base 3 near the body accommodating cavity 303 is provided with a semi-closed support groove, and a flexible inner liner 304 is detachably installed in the semi-closed support groove for wrapping and fixing the head of the new-born mouse.

[0020] In the embodiment of the present application, the shape of the body accommodating cavity 303 and the semi-closed support groove is adapted to the average profile of the standardized skull dissection model of the target age group of newborn mice, and the base 3 is formed by 3D printing with medical-grade biocompatible materials. The medical-grade biocompatible material is photosensitive resin or polyamide powder, and the surface is treated with an epoxy coating to improve strength and sterilizability. The flexible lining 304 is made of medical-grade silicone material and has flexibility and biocompatibility.

[0021] The flexible lining 304 is detachably installed inside the semi-closed support groove, which facilitates the later disassembly, cleaning, sterilization and replacement of the flexible lining 304.

[0022] The design process of the shape of the body accommodating cavity 303 and the semi-closed support groove is to obtain the skull structure parameters of newborn mice by 3D scanning, establish an average anatomical model, and design by age group. In the embodiment of the present application, the shape of the body accommodating cavity 303 and the semi-closed support groove is adapted to the average profile of the standardized skull dissection model of the target age group of newborn mice, and the base 3 is formed by 3D printing with medical-grade biocompatible materials, which facilitates the stable fixation of the head of newborn mice while reducing the risk of compression and damage to the skull.

[0023] Referring to Figures 1 to 5 The present application provides a base for stereotactic injection of newborn mice, and the connecting structure includes a standardized interface plate 306 and a standardized adapter plate 305, wherein the standardized interface plate 306 is arranged at the middle region of the bottom end of the base 3, and the standardized adapter plate 305 is arranged at the rear end of the base 3. The upper surface of the test platform 101 is provided with a clamping groove structure adapted to the standardized interface plate 306 and the standardized adapter plate 305, for detachably fixing the base 3 to the upper surface of the test platform 101.

[0024] In the embodiment of the present application, the standardized adapter plate 305 and the standardized interface plate 306 are adapted to the clamping groove structure on the upper surface of the test platform 101, which facilitates the quick docking and position fine adjustment of the base 3 and the stereotactic instrument 1; and further ensures the stability and accuracy of the injection process without relying on traditional ear rods and tooth rods. The specific working process of this part of the application embodiment is: the standardized adapter plate 305 and the standardized interface plate 306 are moved to the inside of the corresponding clamping groove by artificial operation, so that the base 3 can be fixed and installed on the upper surface of the test platform 101.

[0025] Referring to Figures 1 to 3As shown, the present application provides a new mouse stereotactic injection base, the anesthesia module includes adjustable sealed nose cover 4, anesthesia delivery pipeline 302, anesthesia connection end 301 and small animal anesthesia machine; The adjustable sealed nose cover 4 is fixedly installed on the upper surface of the front end of the base 3, and the installation position is close to the flexible lining 304; The small animal anesthesia machine is independently arranged outside the stereotactic instrument 1; The anesthesia connection end 301 is arranged inside the front end of the base 3 and matched with the interface of the small animal anesthesia machine, one end of the anesthesia delivery pipeline 302 is communicated with the inside of the adjustable sealed nose cover 4, and the other end is communicated with the inside of the anesthesia connection end 301, so that the anesthesia gas generated by the small animal anesthesia machine flows to the inside of the adjustable sealed nose cover 4; The adjustable sealed nose cover 4 is made of flexible high polymer material; The flexible high polymer material is silica gel or polyurethane.

[0026] In the embodiment of the application, the adjustable sealed nose cover 4 is made of silica gel or polyurethane material, which is conducive to ensuring the air tightness and softness of the adjustable sealed nose cover 4 as a whole and reducing the facial compression of the new mouse.

[0027] The specific working process of the part of the application embodiment is as follows: first, the interface of the small animal anesthesia machine is installed in the inside of the anesthesia connection end 301, the head of the new mouse is fixed in the inside of the flexible lining 304, and then the position of the adjustable sealed nose cover 4 is adjusted by hand to make it tightly fit the nose of the new mouse; the small animal anesthesia machine is started, the anesthesia gas is delivered to the inside space of the adjustable sealed nose cover 4 through the anesthesia delivery pipeline 302, so that the experimental new mouse is inhaled anesthesia, and the stable supply of anesthesia gas in the whole experimental process is ensured.

[0028] Referring to Figure 1 and Figures 6 to 7 As shown, the present application provides a new mouse stereotactic injection base, the monitoring module includes micro temperature sensor 5 and piezoresistive breathing monitoring sheet 6, and the micro temperature sensor 5 and the piezoresistive breathing monitoring sheet 6 are integrated in the inside of the base 3, the micro temperature sensor 5 is configured to monitor the real-time body temperature of the new mouse, and the piezoresistive breathing monitoring sheet 6 is configured to monitor the breathing physiological signal of the new mouse; The upper surface of the front end of the test platform 101 is provided with a control device 2, the inside of the control device 2 is integrated with a dynamic monitoring system, the micro temperature sensor 5 and the piezoresistive breathing monitoring sheet 6 are electrically connected with the control device 2 through a flexible circuit, and are used to transmit the real-time body temperature and the breathing physiological signal to the dynamic monitoring system; The inside of the base 3 is provided with a temperature control module, wherein the temperature control module comprises a flexible heating film 7, the flexible heating film 7 is fixedly installed in the inside of the base 3, and the installation position of the flexible heating film 7 is close to the body accommodating cavity 303, and the flexible heating film 7 is electrically connected with the control device 2 through a data transmission device.

[0029] In the embodiment of the application, the data transmission device adopts two modes of wired transmission or wireless transmission for corresponding control signal transmission.

[0030] Referring to Figure 7 The application provides a dynamic monitoring system for stereotactic injection of a newborn mouse, and is applied to a base for stereotactic injection of a newborn mouse, and the dynamic monitoring system comprises a data acquisition end, a data analysis end and an execution end; The data acquisition end is configured to receive real-time body temperature and respiratory physiological signals monitored by the micro temperature sensor 5 and the piezoresistive respiratory monitoring sheet 6; The data analysis end is configured to analyze the real-time body temperature and the respiratory physiological signals, and is internally provided with a body temperature threshold range and a vital sign threshold range; If the real-time body temperature is not in the body temperature threshold range, a temperature adjustment instruction is generated, and if the real-time respiratory physiological signal is not in the vital sign threshold range, a warning instruction is generated; The execution end is configured to execute the instructions, when the temperature adjustment instruction is received, the constant temperature control circuit is controlled to drive the flexible heating film 7 to work, so that the temperature inside the body accommodating cavity 303 reaches the body temperature threshold range, and when the warning instruction is received, the display of the control device 2 is triggered to issue an alarm; The execution end is internally integrated with a constant temperature control circuit, and the constant temperature control circuit is used to drive the flexible heating film 7 to work according to the feedback signal of the micro temperature sensor 5.

[0031] In the embodiment of the application, the body temperature threshold range and the vital sign threshold range are set by manual setting; the body temperature threshold range set by manual setting is that when the vital sign of the newborn mouse is in a stable state, the real-time body temperature data group generated by the micro temperature sensor 5, and the vital sign threshold range set by manual setting is that when the vital sign of the newborn mouse is in a stable state, the respiratory physiological signal data group generated by the piezoresistive respiratory monitoring sheet 6; Preferably, the body temperature threshold range is 36-37 DEG C. The execution end sends a secondary monitoring signal feedback to the monitoring module, for controlling the adjusting device inside the body accommodating cavity 303 of the monitoring module to perform real-time monitoring; The monitoring module receives the secondary monitoring information feedback, performs secondary monitoring on the adjusted experimental environment of the newborn mouse, collects the adjusted real-time body temperature and respiratory physiological signals through the micro temperature sensor 5 and the piezoresistive respiratory monitoring sheet 6, and then performs secondary monitoring analysis through the dynamic monitoring system; The test case process of the application examples in this part is as follows: Preparation: The researcher fixes the anesthetized mouse on the base, and the data acquisition end starts to work. A smooth breathing waveform and a body temperature reading of 37.1℃ are displayed on the display in real time; Intraoperative monitoring: During the fine operation of skull drilling and injection, the body temperature of the mouse begins to lose due to anesthesia and surgical stress; Automatic intervention: When the body temperature drops to 35.8℃, the dynamic monitoring system detects this phenomenon and automatically starts the heating film silently. While the researcher is fully focused on the operation under the microscope, the body temperature of the mouse is maintained stably, avoiding the potential impact of low body temperature on the experimental results; Crisis warning: Suddenly, the mouse appears respiratory depression due to drug reaction, and the breathing waveform appears a significant trough. The system immediately captures this change and triggers the display of control device 2 to issue an audible and visual alarm; Manual intervention: The researcher hears the alarm and quickly pauses the injection, performs emergency inspection and treatment on the mouse, and successfully alleviates the crisis; Experiment completion: Under the escort of the whole system, the researcher successfully completes the injection, and the vital signs of the mouse are always maintained within an acceptable stable range.

[0032] The specific work flow of the application is as follows: Installation process: By manually moving the standardized adapter plate 305 and the standardized interface plate 306 into the corresponding card slots, the base 3 can be fixedly installed on the upper surface of the test platform 101; Test process: Step one, install the interface of the small animal anesthetizing machine in the inside of the anesthesia connection end 301, and place the body of the newborn mouse in the body containing cavity 303, and the head in the flexible inner liner 304; Step two, after completing step one, adjust the position of the adjustable sealing nose mask 4 by hand so that it tightly fits the nose of the newborn mouse; start the small animal anesthetizing machine, and deliver the anesthetic gas to the inside space of the adjustable sealing nose mask 4 through the anesthesia delivery pipeline 302, so as to implement inhalation anesthesia on the experimental newborn mouse, to ensure stable supply of anesthetic gas during the whole experiment; Step three, adjust the head posture of the newborn mouse by the fine adjustment mechanism in the stereotaxic apparatus 1, fix the target coordinate point, operate the injection to complete the virus micro-injection, and after the injection is completed, turn off the small animal anesthetizing machine, quickly remove the animal and perform postoperative care; Monitoring and adjusting process: During the experiment, the data acquisition end first receives real-time physiological signals from the miniature temperature sensor 5 and the piezoresistive breath monitoring sheet 6; then the data analysis end compares the collected body temperature and breath data with the built-in threshold range, and generates a temperature adjustment instruction if the body temperature is abnormal, or generates a warning instruction if the breath is abnormal; finally, the execution end responds to the instruction, adjusts the temperature through the flexible heating film 7, or triggers the display of the control device 2 to issue an alarm, thereby constituting a complete "monitoring-analysis-execution" automatic closed-loop regulation and control.

[0033] The above merely describes the preferred embodiments of the present application and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A stereotactic injection base for newborn mice, comprising a stereotactic instrument (1), wherein the stereotactic instrument (1) further comprises an experimental platform (101), characterized in that, The upper surface of the test platform (101) is provided with a base (3), wherein the contact surface between the base (3) and the test platform (101) is provided with a connecting mechanism for detachably fixing the base (3) to the upper surface of the test platform (101). The front end of the base (3) is provided with an anesthesia module, and the inside of the base (3) is provided with a monitoring module for monitoring the real-time body temperature and respiratory physiological signals of the newborn mice inside the base (3). The base (3) has a body receiving cavity (303) inside for supporting the body of the newborn mouse. The base (3) has a semi-enclosed support groove inside near the body receiving cavity (303). A flexible liner (304) is detachably installed in the semi-enclosed support groove to wrap and fix the head of the newborn mouse.

2. The injection base for neonatal mouse stereotactic positioning according to claim 1, characterized in that: The shape of the body cavity (303) and the semi-enclosed support groove is adapted to the average contour of the standardized skull anatomy model of the target newborn mouse age group, wherein the base (3) is 3D printed using medical-grade biocompatible material.

3. The injection base for neonatal mouse stereotactic positioning according to claim 2, characterized in that: The medical-grade biocompatible material is photosensitive resin or polyamide powder, and the surface of the base (3) is treated with epoxy resin coating. The flexible liner (304) is made of medical-grade silicone material, which has flexibility and biocompatibility; The connection structure includes a standardized interface board (306) and a standardized adapter board (305).

4. The injection base for neonatal mouse stereotactic positioning according to claim 3, characterized in that: The standardized interface board (306) is located in the middle area at the bottom of the base (3), and the standardized adapter board (305) is located at the rear end of the base (3).

5. The injection base for neonatal mouse stereotactic positioning according to claim 4, characterized in that: The upper surface of the test platform (101) is provided with slot structures that are compatible with the standardized interface plate (306) and the standardized adapter plate (305) in sequence, which are used to detachably fix the base (3) to the upper surface of the test platform (101); The anesthesia module includes an adjustable sealed nose mask (4), an anesthesia delivery tube (302), an anesthesia connection end (301), and a small animal anesthesia machine.

6. The injection base for neonatal mouse stereotactic positioning according to claim 5, characterized in that: The adjustable sealing nasal mask (4) is fixedly installed on the upper surface of the front end of the base (3), and its installation position is close to the flexible inner liner (304). The small animal anesthesia machine is independently installed outside the stereo positioning device (1).

7. The injection base for neonatal mouse stereotactic positioning according to claim 6, characterized in that: The anesthesia connection end (301) is located inside the front end of the base (3) and matches the interface of the small animal anesthesia machine. One end of the anesthesia delivery pipe (302) is connected to the interior of the adjustable sealing nose mask (4), and the other end is connected to the interior of the anesthesia connection end (301), so that the anesthetic gas generated by the small animal anesthesia machine flows into the interior of the adjustable sealing nose mask (4). The adjustable sealing nasal mask (4) is made of flexible polymer material.

8. The injection base for neonatal mouse stereotactic positioning according to claim 7, characterized in that: The flexible polymer material is silicone or polyurethane; The monitoring module includes a miniature temperature sensor (5) and a piezoresistive respiratory monitoring chip (6).

9. The injection base for neonatal mouse stereotactic positioning according to claim 8, characterized in that: The miniature temperature sensor (5) and the piezoresistive respiratory monitoring chip (6) are both integrated inside the base (3). The miniature temperature sensor (5) is configured to monitor the real-time body temperature of newborn mice, and the piezoresistive respiratory monitoring chip (6) is configured to monitor the respiratory physiological signals of newborn mice. A control device (2) is installed on the upper surface of one side of the front end of the test platform (101). The control device (2) integrates a dynamic monitoring system. The miniature temperature sensor (5) and the piezoresistive respiratory monitoring chip (6) are electrically connected to the control device (2) through a flexible circuit to transmit real-time body temperature and respiratory physiological signals to the dynamic monitoring system. The base (3) is equipped with a temperature control module, which includes a flexible heating film (7). The flexible heating film (7) is fixedly installed inside the base (3), and the installation position of the flexible heating film (7) is close to the body cavity (303). The flexible heating film (7) is electrically connected to the control device (2) through a data transmission device.

10. A dynamic monitoring system for stereotactic injection in newborn mice, applied to the stereotactic injection base for newborn mice as described in any one of claims 1-9, characterized in that: The dynamic monitoring system includes a data acquisition terminal, a data analysis terminal, and an execution terminal; The data acquisition end is configured to receive real-time body temperature and respiratory physiological signals monitored by the miniature temperature sensor (5) and the piezoresistive respiratory monitoring chip (6); The data analysis terminal is configured to analyze real-time body temperature and respiratory physiological signals, and has built-in body temperature threshold range and vital sign threshold range. If the real-time body temperature is not within the body temperature threshold range, a temperature regulation command is generated; if the real-time respiratory physiological signal is not within the vital signs threshold range, an early warning command is generated. The execution end is configured to execute the instructions. When a temperature adjustment instruction is received, the constant temperature control circuit is controlled to drive the flexible heating film (7) to work and adjust the internal temperature of the body cavity (303) to reach the body temperature threshold range. When a warning instruction is received, the display of the control device (2) is triggered to issue an alarm. The actuator has an integrated temperature control circuit, which is used to drive the flexible heating film (7) to work based on the feedback signal from the micro temperature sensor (5).

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