Blumea oil gel as well as preparation method and application thereof

Abstract

The invention provides blumea oil gel as well as a preparation method and application thereof, and relates to the technical field of daily chemicals. The blumea oil gel provided by the invention comprises the following components in percentage by mass: 45-65% of vegetable fat, 25-40% of polyol and 10-15% of an emulsifier, the vegetable fat comprises the following components in percentage by mass: 5-10% of folium artemisiae argyi essential oil, 30-40% of meadowfoam seed oil and 50-65% of caprylic / capric triglyceride. The meadowfoam seed oil and the caprylic / capric triglyceride are added into the vegetable fat component, so that volatilization of the folium artemisiae argyi essential oil can be reduced, and stabilization of effective components is facilitated; according to the blumea oil gel disclosed by the invention, the blumea oil gel is jointly formed by a proper amount of polyhydric alcohol, an emulsifier and vegetable fat containing the blumea oil, an oil gel system with a three-dimensional network structure can be formed, and a continuous oil phase in the system is fixed in a gel network, so that the stability of effective components is improved, and meanwhile, percutaneous absorption can be better promoted.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products technology, specifically relating to an artemisia argyi oil gel, its preparation method, and its application. Background Technology

[0002] Artemisia argyi essential oil is one of the main functional components of Artemisia argyi and is also one of the most widely used Artemisia argyi cosmetic raw materials. It has antibacterial, anti-inflammatory, anti-allergic, whitening, and antioxidant effects, and has broad application prospects in skin care products targeting skin inflammations such as acne, sensitivity, redness, and itching.

[0003] However, Artemisia argyi essential oil mainly contains volatile monoterpenes and sesquiterpenes, such as eucalyptol, camphor, and thujone. These components have small molecular weights and low boiling points, making them easily released into the air from the essential oil under the influence of heat and light, leading to a decrease in the concentration and content of active ingredients. Furthermore, the active ingredients in Artemisia argyi essential oil are heat-sensitive; high temperatures accelerate their chemical reaction rates, causing oxidation, decomposition, and the formation of other substances, thereby reducing their original pharmacological activity. Summary of the Invention

[0004] The purpose of this invention is to provide an artemisia argyi oil gel, its preparation method, and its application. The artemisia argyi oil gel provided by this invention exhibits good stability of the effective components of artemisia argyi essential oil and excellent skin-soothing effects.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a mugwort oil gel, which, by mass content, comprises: 45-65% plant oil, 25-40% polyol and 10-15% emulsifier; the plant oil, by mass content, comprises: 5-10% mugwort essential oil, 30-40% meadowfoam seed oil and 50-65% caprylic / capric triglycerides.

[0006] Preferably, the mugwort oil gel comprises: 55-65% vegetable oil, 25-40% polyol, and 10-15% emulsifier.

[0007] Preferably, the plant oil comprises: 8-10% Artemisia argyi essential oil, 30-40% meadowfoam seed oil, and 50-60% caprylic / capric triglycerides.

[0008] Preferably, the polyol is one or more of 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, and glycerol.

[0009] Preferably, the emulsifier comprises stearyl alcohol polyether with EO=2 and stearyl alcohol polyether with EO=21.

[0010] Preferably, the mass ratio of the stearyl alcohol polyether with EO=2 to the stearyl alcohol polyether with EO=21 is 1.5:3.4~3.6.

[0011] This invention also provides a method for preparing the Artemisia argyi oleogloss described in the above technical solution, comprising the following steps: The polyol and emulsifier are first mixed and then heated to obtain a mixed component. Artemisia argyi essential oil, meadowfoam seed oil and caprylic / capric triglyceride were mixed and then heated to obtain vegetable oil. The plant oil is mixed with the third component of the mixture and then homogenized to obtain Artemisia argyi oil gel.

[0012] Preferably, the temperature of the first heating is 70~85℃; the temperature of the second heating is 40~60℃.

[0013] Preferably, the rotation speed of the homogenization process is 4000~5000 rpm.

[0014] The present invention also provides the application of the Artemisia argyi essential oil gel described in the above technical solution or the Artemisia argyi essential oil gel prepared according to the preparation method described in the above technical solution in the preparation of skin care products.

[0015] This invention provides an artemisia oil gel, comprising, by mass content: 45-65% plant oil, 25-40% polyol, and 10-15% emulsifier; the plant oil comprises, by mass content: 5-10% artemisia essential oil, 30-40% meadowfoam seed oil, and 50-65% caprylic / capric triglycerides. In the plant oil components of the artemisia oil gel provided by this invention, artemisia essential oil is a volatile oil, while meadowfoam seed oil is a non-volatile oil. Meadowfoam seed oil, as a base oil, is miscible with artemisia essential oil, which reduces the volatilization of artemisia essential oil and contributes to the stability of the active ingredients. Caprylic / capric triglycerides, as a high-quality oil, have good moisturizing properties and excellent stability, which can further enhance the stability of the active ingredients. Plant oils, along with appropriate proportions of polyols and emulsifiers, can form an oleogel system. This oleogel system is a three-dimensional network structure material system in which the continuous oil phase is fixed within the gel network, possessing the dual advantages of both oil and gel. While improving the stability of the active ingredients, it can better promote transdermal absorption. Experimental results show that after basic care of patients with skin discomfort, the Artemisia argyi oleogel prepared in this invention significantly reduced discomfort and improved their quality of life. Attached Figure Description

[0016] Figure 1 This is a graph showing the change in oil retention rate of the Artemisia argyi oleogel prepared in Example 1 of the present invention over storage time. Figure 2Ultraviolet absorption spectrum of Artemisia argyi essential oil; Figure 3 Artemisia argyi essential oil standard curve; Figure 4 The graph shows the change in the release rate of Artemisia argyi essential oil over time between the Artemisia argyi oil gel prepared in Example 1 of the present invention and the Artemisia argyi compound oil prepared in Comparative Example 1. Figure 5 This is an age distribution diagram of the experimental subjects in an application example of the present invention; Figure 6 This is a graph showing the change in the average score of skin discomfort severity of the experimental subjects in the application example of the present invention before and after using Artemisia argyi oil gel for 28 days; Figure 7 This is a graph showing the distribution of skin discomfort severity scores in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 8 This is a graph showing the average percentage change in the area affected by skin inflammation in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 9 This is a graph showing the distribution of the skin area affected by skin inflammation before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 10 This is a graph showing the change in the average skin dryness score of the experimental subjects in the application example of this invention before and after using Artemisia argyi oil gel for 28 days. Figure 11 This is a graph showing the distribution of skin dryness scores of experimental subjects in an application example of the present invention before and 28 days after using Artemisia argyi oil gel. Figure 12 This is a graph showing the change in the average skin peeling / scabbing degree of experimental subjects in the application example of this invention before and 28 days after using Artemisia argyi oil gel. Figure 13 This is a graph showing the distribution of skin peeling / scabbing severity scores in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 14 This is a graph showing the change in the average skin erythema / redness score of the experimental subjects in the application example of this invention before and after using Artemisia argyi oil gel for 28 days. Figure 15 This is a graph showing the distribution of skin erythema / redness severity scores in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 16This is a graph showing the change in the average skin pain score of the experimental subjects in the application example of this invention before and after using Artemisia argyi oil gel for 28 days. Figure 17 This is a graph showing the distribution of skin pain intensity scores in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 18 This is a graph showing the change in the average skin burning sensation score of the experimental subjects in the application example of this invention before and after using Artemisia argyi oil gel for 28 days. Figure 19 This is a graph showing the distribution of skin burning sensation scores in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 20 This is a graph showing the change in the average score of skin itching in the experimental subjects of the present invention before and after using Artemisia argyi oil gel for 28 days. Figure 21 This is a graph showing the distribution of skin itching scores in experimental subjects before and 28 days after using Artemisia argyi oil gel in an application example of the present invention. Figure 22 This is a distribution chart showing the average tolerance scores of physicians and experimental subjects to the product after 28 days of use of Artemisia argyi oil gel in an application example of the present invention. Detailed Implementation

[0017] This invention provides a mugwort oil gel, which, by mass content, comprises: 45-65% plant oil, 25-40% polyol and 10-15% emulsifier; the plant oil, by mass content, comprises: 5-10% mugwort essential oil, 30-40% meadowfoam seed oil and 50-65% caprylic / capric triglycerides.

[0018] The Artemisia argyi olegel provided by this invention comprises 45-65% plant oil, preferably 55-65%, by weight. By controlling the content of plant oil within the above range, this invention helps to form an olegel system with a three-dimensional network structure.

[0019] In this invention, the plant oil comprises, by mass content: 5-10% Artemisia argyi essential oil, 30-40% meadowfoam seed oil, and 50-65% caprylic / capric triglycerides.

[0020] In this invention, the plant oil comprises, by mass content, 5-10% mugwort essential oil, preferably 8-10%, and more preferably 10%. Mugwort essential oil has a skin-soothing effect and can relieve symptoms such as skin inflammation, sensitivity, and itching. By controlling the content of mugwort essential oil within the above-mentioned range, this invention ensures that the active ingredients can function effectively and facilitates good stability.

[0021] In this invention, the plant oil comprises, by mass content, 30-40% meadowfoam seed oil, preferably 35-40%. Meadowfoam seed oil has a skin-soothing effect, is a non-volatile oil, and is miscible with artemisia essential oil. By controlling the content of meadowfoam seed oil within the above range, this invention helps to reduce the volatilization of artemisia essential oil and improve the stability of the active ingredients.

[0022] In this invention, the plant oil comprises, by weight, 50-65% caprylic / capric triglyceride, preferably 50-60%. Caprylic / capric triglyceride, as a high-quality oil, possesses excellent moisturizing properties; furthermore, it enhances the stability of the system. By controlling the content of caprylic / capric triglyceride within the aforementioned range, this invention ensures that the Artemisia argyi oil gel has a gentle, easily spreadable, and non-sticky texture.

[0023] The Artemisia argyi olegel provided by this invention comprises 25-40% polyol by mass content. As one embodiment of this invention, the mass content of polyol in the Artemisia argyi olegel can be 25%, 30%, or 40%. By controlling the polyol content within the above range, this invention helps to form an olegel system with a three-dimensional network structure.

[0024] In this invention, the polyol is preferably one or more of 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, and glycerol. As one embodiment of this invention, the polyol may be 1,2-propanediol, 1,3-butanediol, or a mixture of 1,3-propanediol and glycerol in a mass ratio of 1:1.

[0025] The Artemisia argyi olegel provided by this invention comprises 10-15% emulsifier by mass content. In one embodiment of this invention, the mass content of the emulsifier in the Artemisia argyi olegel can be 10%, 12%, or 15%. By controlling the emulsifier content within the above range, this invention helps to form an olegel system with a three-dimensional network structure.

[0026] In this invention, the emulsifier preferably comprises stearyl alcohol polyether with EO=2 and stearyl alcohol polyether with EO=21; the mass ratio of the stearyl alcohol polyether with EO=2 to the stearyl alcohol polyether with EO=2 is preferably 1.5:3.4~3.6, more preferably 1.5:3.5. The use of the above-mentioned emulsifier in this invention helps to form an oleogel system with a three-dimensional network structure.

[0027] The Artemisia argyi oil gel provided by this invention can improve the stability of the drug and enhance the adhesion and spreadability of the gel to the skin, thereby better promoting transdermal absorption.

[0028] This invention also provides a method for preparing the Artemisia argyi oleogloss described in the above technical solution, comprising the following steps: The polyol and emulsifier are first mixed and then heated to obtain a mixed component. Artemisia argyi essential oil, meadowfoam seed oil and caprylic / capric triglyceride were mixed and then heated to obtain vegetable oil. The plant oil is mixed with the third component of the mixture and then homogenized to obtain Artemisia argyi oil gel.

[0029] In this invention, polyols and emulsifiers are first mixed and then heated to obtain a mixed component.

[0030] The present invention does not have any special limitations on the operation of the first mixing of the polyol and the emulsifier; a uniform dispersion can be achieved by using a technical solution known to those skilled in the art.

[0031] In this invention, the preferred temperature for the first heating is 70-85°C. As one embodiment of the invention, the temperature for the first heating can be 70°C, 80°C, or 85°C. These heating conditions can reduce the viscosity of the polyol, increasing its fluidity and making it easier to mix evenly with the emulsifier, which helps to form a stable system.

[0032] This invention involves mixing Artemisia argyi essential oil, meadowfoam seed oil, and caprylic / capric triglycerides, followed by a second heating process to obtain a plant oil.

[0033] The present invention does not have any special limitations on the operation of the second mixture of Artemisia argyi essential oil, meadowfoam seed oil and caprylic / capric triglyceride, and can be dispersed evenly using a technical solution known to those skilled in the art.

[0034] In this invention, the preferred heating temperature is 40-60°C. As one embodiment of the invention, the heating temperature can be 40°C, 45°C, 50°C, 55°C, or 60°C. Since the plant oil contains the volatile essential oil Artemisia argyi, heating to 40-60°C is sufficient to achieve uniform mixing.

[0035] After obtaining the mixed components and plant oils, the present invention further homogenizes the plant oils and the mixed components to obtain Artemisia argyi oil gel.

[0036] This invention does not impose any particular limitations on the third mixing operation of the plant oil and the mixed components; any technique well-known to those skilled in the art can be used to disperse the oil evenly. Preferably, the plant oil is added to the mixed components under stirring conditions; the stirring speed is preferably 500-800 rpm, more preferably 600-800 rpm. In this invention, the plant oil at 40-60°C is enveloped by the mixed components at 70-85°C, providing a temperature buffer and preventing the volatilization of the mugwort essential oil.

[0037] In this invention, the homogenization process is preferably performed using a high-speed homogenizer. The homogenization speed is preferably 4000-5000 rpm, more preferably 4500-5000 rpm; the homogenization time is preferably 3-10 min, more preferably 6-10 min. The above homogenization conditions facilitate the formation of an oleogel system with a three-dimensional network structure.

[0038] The method for preparing the above-mentioned mugwort oil gel provided by the present invention can obtain mugwort essential oil with good stability of effective ingredients and excellent skin soothing effect.

[0039] The present invention also provides the application of the Artemisia argyi oil gel described in the above technical solution or the Artemisia argyi oil gel prepared according to the preparation method described in the above technical solution in the preparation of skin care products.

[0040] The technical solutions of this invention will be clearly and completely described below with reference to the embodiments thereof. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0041] Example 1 The Artemisia argyi oil gel, by mass content, comprises: 58% vegetable oil, 30% polyol, and 12% emulsifier; the vegetable oil comprises: 10% Artemisia argyi essential oil, 40% meadowfoam seed oil, and 50% caprylic / capric triglyceride; the polyol is 1,2-propylene glycol, and the emulsifier is stearyl alcohol polyether with EO=2 and stearyl alcohol polyether with EO=21 in a mass ratio of 1.5:3.5.

[0042] The preparation method of Artemisia argyi oil gel is as follows: First, a polyol and an emulsifier are mixed and heated to 80°C to obtain a mixed component; second, Artemisia argyi essential oil, meadowfoam seed oil, and caprylic / capric triglycerides are mixed and heated to 60°C to obtain a plant oil; third, the plant oil is mixed with the mixed component (stirring at 600 rpm while stirring the mixed component, and slowly adding the plant oil simultaneously), and then homogenized in a high-speed homogenizer at 4500 rpm for 6 minutes to obtain Artemisia argyi oil gel.

[0043] Example 2 The Artemisia argyi oil gel, by mass content, comprises: 65% vegetable oil, 25% polyol, and 10% emulsifier; the vegetable oil comprises: 10% Artemisia argyi essential oil, 35% meadowfoam seed oil, and 55% caprylic / capric triglycerides; the polyol is 1,3-butanediol, and the emulsifier is stearyl alcohol polyether with EO=2 and stearyl alcohol polyether with EO=21 in a mass ratio of 1.5:3.5.

[0044] The preparation method of Artemisia argyi oil gel is as follows: First, a polyol and an emulsifier are mixed and heated to 85°C to obtain a mixed component; second, Artemisia argyi essential oil, meadowfoam seed oil, and caprylic / capric triglycerides are mixed and heated to 60°C to obtain a plant oil; third, the plant oil is mixed with the mixed component (stirring at 800 rpm while slowly adding the plant oil), and then homogenized in a high-speed homogenizer at 5000 rpm for 3 minutes to obtain Artemisia argyi oil gel.

[0045] Example 3 The Artemisia argyi oil gel, by mass content, comprises: 55% vegetable oil, 40% polyol, and 15% emulsifier; the vegetable oil, by mass content, comprises: 10% Artemisia argyi essential oil, 30% meadowfoam seed oil, and 60% caprylic / capric triglyceride; the polyol is 1,3-propanediol and glycerol in a mass ratio of 1:1, and the emulsifier is stearyl alcohol polyether with EO=2 and stearyl alcohol polyether with EO=21 in a mass ratio of 1.5:3.5.

[0046] The preparation method of Artemisia argyi oil gel is as follows: First, a polyol and an emulsifier are mixed and heated to 70°C to obtain a mixed component; second, Artemisia argyi essential oil, meadowfoam seed oil, and caprylic / capric triglycerides are mixed and heated to 60°C to obtain a plant oil; third, the plant oil is mixed with the mixed component (stirring at 400 rpm while stirring the mixed component, and then slowly adding the plant oil), and then homogenized in a high-speed homogenizer at 4000 rpm for 10 minutes to obtain Artemisia argyi oil gel.

[0047] Comparative Example 1 The components of the Artemisia argyi compound oil are: 10% Artemisia argyi essential oil, 40% meadowfoam seed oil and 50% caprylic / capric triglycerides.

[0048] The preparation method of Artemisia argyi compound oil is as follows: Artemisia argyi essential oil, meadowfoam seed oil and caprylic / capric triglyceride are mixed.

[0049] The oil holding capacity of the Artemisia argyi olegel prepared in Example 1 was determined. The specific method for determining the oil holding capacity was as follows: 1 mL of Artemisia argyi olegel was placed in a 2 mL centrifuge tube and left at room temperature for 1 day. After centrifugation at 10000 r / min for 15 min, the sample was inverted for 15 min and the drained oil was absorbed with filter paper.

[0050] The formula for calculating oil retention ratio (H) is: , In the formula: m1 is the mass of the centrifuge tube / g; m2 is the total mass of the centrifuge tube and Artemisia argyi oil gel before centrifugation / g; m3 is the total mass of the centrifuge tube and Artemisia argyi oil gel after centrifugation to remove the precipitated oil / g.

[0051] The calculated oil retention rate of Artemisia argyi olegel as a function of storage time is as follows: Figure 1 As shown.

[0052] from Figure 1 It can be seen that as the storage time is extended, the oil retention rate of Artemisia argyi olegel is over 99%, indicating that Artemisia argyi olegel has good stability.

[0053] The release rate of Artemisia argyi essential oil was determined for the Artemisia argyi oleogel prepared in Example 1 and the Artemisia argyi compound oil prepared in Comparative Example 1. Artemisia argyi oil solutions of various concentrations were precisely prepared using anhydrous ethanol as the solvent. The absorbance curves were measured using a UV-Vis spectrophotometer, and the resulting UV absorption spectra of Artemisia argyi essential oil are shown below. Figure 2 As shown, from Figure 2 An absorption peak can be observed at a wavelength of 320 nm. Using the maximum absorption peak (at a wavelength of 320 nm) as a reference, a standard working curve of "absorbance-concentration" was established by fitting a linear equation. The resulting standard curve for Artemisia argyi essential oil is shown below. Figure 3 As shown, the standard equation is y = 0.0653x + 0.0263; R 2 =0.9967; Using a silicone mold, the mugwort oil gel prepared in Example 1 was made into spherical gel particles (0.15g / particle) with a particle size of 5mm (each oil gel particle contains 0.0087g of mugwort essential oil). 0.087g of the mugwort compound oil prepared in Comparative Example 1 (containing 0.0087g of mugwort essential oil) was also taken. During the assay, one gel particle or Artemisia argyi compound oil was dissolved in 3 mL of anhydrous ethanol and left exposed at room temperature. The absorbance was measured every 2 days to determine the amount of remaining Artemisia argyi essential oil in the gel particle or Artemisia argyi compound oil. Three particles were measured in parallel each time, and the average value was taken. The calculated changes in the release rate of Artemisia argyi essential oil over time for the Artemisia argyi oil gel prepared in Example 1 and the Artemisia argyi compound oil prepared in Comparative Example 1 are shown below. Figure 4 As shown.

[0054] from Figure 4 It can be seen that after 6 days under the test conditions, the Artemisia argyi essential oil in the Artemisia argyi compound oil prepared in Comparative Example 1 almost completely evaporated, while for the Artemisia argyi oleogel particles prepared in Example 1 with the same amount, the maximum release of Artemisia argyi essential oil was less than 30%. This indicates that Artemisia argyi oleogel can effectively slow down the evaporation rate of Artemisia argyi essential oil. On the other hand, the release of Artemisia argyi essential oil in Artemisia argyi oleogel showed a non-linear relationship with time, exhibiting a faster release rate in the early stage and a slower release rate in the later stage (approximately after day 16), which is consistent with the release behavior of oleogel. It is speculated that in the initial stage, the concentration gradient of Artemisia argyi essential oil between the surface area of ​​Artemisia argyi oleogel particles and the external environment is relatively large, resulting in a faster release of Artemisia argyi essential oil in the initial stage. In the later stage, the release of Artemisia argyi essential oil is mainly affected by the diffusion of Artemisia argyi essential oil molecules inside the Artemisia argyi oleogel particles in the oleogel matrix.

[0055] Application Example 1 1. Experimental subjects and methods 1.1 Test Subjects The study recruited 92 individuals over the age of 18 who experienced skin discomfort.

[0056] Artemisia argyi oil gel prepared in Example 1 was packaged in a tube and used as a skin care product.

[0057] 1.2 Collection Standards Individuals with mild to severe dry, sensitive skin, or occasional rashes; those with good treatment adherence; participants must be over 18 years of age; and participants must voluntarily join and sign an informed consent form.

[0058] 1.3 Exclusion Criteria Those with advanced cancer, abnormal blood clotting function, other skin diseases, those who refuse to participate in experimental investigations, those with legally notifiable infectious diseases, and those with poor treatment compliance were excluded.

[0059] 1.4 Experimental Design This study consisted of two consultations. Initial consultation (Day 0): Participant enrollment and baseline assessment: ① Informed consent was provided; both the physician and the participant had to read and sign it. ② The physician and participant jointly completed a skin condition assessment. ③ A questionnaire was completed. ④ Artemisia argyi oil gel was prescribed as a topical product.

[0060] Follow-up appointment four weeks later (Day 28): ① Face-to-face assessment. ② Skin condition assessment completed jointly by the physician and participant. ③ Questionnaire completed.

[0061] 1.5 Observation Indicators and Evaluation Criteria (1) Physician clinical assessment The physician quantitatively assessed the skin-related symptoms before and after treatment, with 0 indicating mild; 1 indicating mild; 2 indicating moderate; 3 indicating severe; and 4 indicating very severe. The specific scoring dimensions are as follows: ① Severity of skin inflammation; ② Degree of skin dryness (outside the lesion); ③ Skin desquamation / shedding / scaling (outside the lesion); ④ Erythema / redness (outside the lesion); ⑤ Inflammatory response (affected skin area).

[0062] 0 points: None; 1 point: (S represents the percentage of skin area affected) S<10%; 2 points: 10%≤S<30%; 3 points: 30%≤S<50%; 4 points: 50%≤S<75%; 5 points: S≥75%.

[0063] (2) Self-assessment of discomfort by the participants Participants quantitatively assessed skin discomfort and related symptoms before and after the treatment, using a scale of 0: not serious; 1: mild; 2: moderate; 3: severe; 4: very severe / unbearable. The specific scoring dimensions are as follows: ①Current level of skin pain; ②Do you currently experience a burning sensation on your skin? ③Is your skin currently itchy?

[0064] (3) Product tolerance assessment Physicians and trial participants quantitatively assessed the tolerability of the product after use, with the following scoring criteria: 1 point: poor; 2 points: fair; 3 points: good; 4 points: excellent.

[0065] 1.6 Statistical Methods Data analysis was performed using SPSS 22.0 statistical software. Quantitative data were expressed as (x±s). Paired t-tests were used for comparisons within groups before and after. A p-value < 0.05 was considered statistically significant.

[0066] 2. Experimental Results 2.1. General Information In this application example, a total of 92 experimental subjects were recruited, including 50 males and 42 females. The age distribution is shown in the figure below. Figure 5 As shown.

[0067] from Figure 5 The average age is 38.

[0068] The graph showing the change in the average skin discomfort severity score of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 6 As shown in the figure; the distribution of skin discomfort severity scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 7 As shown.

[0069] from Figure 6 and Figure 7 It can be seen that after using Artemisia argyi oil gel for 28 days, the average score of the severity of skin discomfort decreased from 1.74 to 1.40, showing significant improvement (P<0.01), with an improvement rate of 19.5%.

[0070] In this application example, the average percentage change in the area of ​​skin affected by skin inflammation before and 28 days after using Artemisia argyi oil gel is shown in the graph. Figure 8 As shown in the figure; the distribution of the area affected by skin inflammation in the experimental subjects before and 28 days after using Artemisia argyi oil gel in this application example is as follows. Figure 9 As shown.

[0071] from Figure 8 and Figure 9 It can be seen that after 28 days of using Artemisia argyi oil gel, the area of ​​skin affected by skin inflammation decreased from 17.8% to 14.3%, showing significant improvement (P<0.01), with an improvement rate of 19.7%.

[0072] The average skin dryness score of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is shown in the graph below. Figure 10 As shown in the figure; the distribution of skin dryness scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 11 As shown.

[0073] from Figure 10 and Figure 11 It can be seen that after using Artemisia argyi oil gel for 28 days, the average score of skin dryness decreased from 1.63 to 1.15, showing significant improvement (P<0.01), with an improvement rate of 29.4%.

[0074] In this application example, the average score changes in the degree of skin peeling / scalying in the experimental subjects before and 28 days after using Artemisia argyi oil gel are shown in the graph. Figure 12 As shown in the figure; the distribution of skin peeling / scalying severity scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 13As shown.

[0075] from Figure 12 and Figure 13 It can be seen that after 28 days of using Artemisia argyi oil gel, the average score of skin peeling / scalyness decreased from 1.39 to 0.93, showing significant improvement (P<0.01), with an improvement rate of 33.1%.

[0076] The average skin erythema / redness score changes of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel are shown in the graph. Figure 14 As shown in the figure; the distribution of skin erythema / redness severity scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is shown in the figure. Figure 15 As shown.

[0077] from Figure 14 and Figure 15 It can be seen that after 28 days of using Artemisia argyi oil gel, the average score of skin erythema / redness decreased from 1.36 to 0.95, showing significant improvement (P<0.01), with an improvement rate of 30.1%.

[0078] The graph showing the change in average skin pain scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 16 As shown in the figure; the distribution of skin pain scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 17 As shown.

[0079] from Figure 16 and Figure 17 It can be seen that after 28 days of using Artemisia argyi oil gel, the average score of skin pain decreased from 1.48 to 1.13, showing significant improvement (P<0.01), with an improvement rate of 23.6%.

[0080] The average skin burning sensation scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel are shown in the graph below. Figure 18 As shown in the figure; the distribution of skin burning sensation scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 19 As shown.

[0081] from Figure 18 and Figure 19 It can be seen that after 28 days of using Artemisia argyi oil gel, the average score of skin burning sensation decreased from 1.24 to 1.0, showing significant improvement (P<0.01), with an improvement rate of 24.0%.

[0082] The graph showing the change in the average score of skin itching in the experimental subjects before and 28 days after using Artemisia argyi oil gel in this application example is as follows. Figure 20 As shown in the figure; the distribution of skin itching scores of the experimental subjects in this application example before and 28 days after using Artemisia argyi oil gel is as follows. Figure 21 As shown.

[0083] from Figure 20 and Figure 21 It can be seen that after 28 days of using Artemisia argyi oil gel, the average score of skin itching decreased from 2.30 to 1.22, showing significant improvement (P<0.01), with an improvement rate of 47.0%.

[0084] In this application example, the distribution of average tolerance scores for the product to physicians and subjects after 28 days of use of Artemisia argyi oil gel is shown in the following graph. Figure 22 As shown.

[0085] from Figure 22 It can be seen that after 28 days of using Artemisia argyi oil gel, the average tolerance score of the product given by physicians was 3.21 points, and the average tolerance score of the product given by test subjects was 3.39 points. 88% of the test subjects considered the tolerance after using the product to be "good".

[0086] As can be seen from the above examples and applications, after using the prepared Artemisia argyi oil gel for 28 days, the test subjects' skin dryness and peeling problems were significantly improved; skin itching was significantly improved; inflammatory reactions such as skin redness were also significantly improved; pain and burning sensations were reduced, and the product had high tolerability. After using Artemisia argyi oil gel for basic care of patients with skin discomfort, the test subjects' discomfort was significantly reduced, and their quality of life was improved.

[0087] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. An oil gel of Artemisia leaves comprising, by mass content: Plant oil 45~65%, polyol 25~40% and emulsifier 10~15%. The plant oil comprises, by mass content: essential oil of folium artemisiae argyi 5~10%, white pool flower seed oil 30~40% and caprylic / capric triglyceride 50~65%.

2. The Artemisia argyi oil gel of claim 1, characterized in that, Comprise: Plant oil 55~65%, polyol 25~40% and emulsifier 10~15%.

3. The folium artemisiae argyi oil gel of claim 1 or 2, characterized in that, The plant oil comprises: essential oil of folium artemisiae argyi 8~10%, white pool flower seed oil 30~40% and caprylic / capric triglyceride 50~60%.

4. The artemisia oil gel as claimed in claim 1, wherein, The polyol is one or more of 1,2-propanediol, 1,3-propanediol, 1,3-butanediol and glycerol.

5. The artemisia oil gel as claimed in claim 1, wherein, The emulsifier comprises stearyl alcohol polyether with EO=2 and stearyl alcohol polyether with EO=21.

6. The artemisia oil gel as claimed in claim 5, wherein, The mass ratio of the stearyl alcohol polyether with EO=2 and the stearyl alcohol polyether with EO=21 is 1.5:3.4~3.

6.

7. The preparation method of the folium artemisiae argyi oil gel according to any one of claims 1~6, comprising the following steps: The polyol and the emulsifier are first mixed and then first heated to obtain a mixed component; The essential oil of folium artemisiae argyi, the white pool flower seed oil and the caprylic / capric triglyceride are second mixed and then second heated to obtain a plant oil; The plant oil and the mixed component are third mixed and then homogenized to obtain the folium artemisiae argyi oil gel.

8. The preparation method according to claim 7, characterized in that, The first heating temperature is 70~85℃; the second heating temperature is 40~60℃.

9. The production method according to claim 7 or 8, characterized by, The homogenization rotation speed is 4000~5000rpm.

10. The use of the folium artemisiae argyi oil gel according to any one of claims 1~6 or the folium artemisiae argyi oil gel prepared according to any one of claims 7~9 in the preparation of skin care products.

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