Dendrobium officinale paste capable of improving stomach yin deficiency function and preparation method of dendrobium officinale paste

Abstract

The invention discloses a dendrobium officinale paste capable of improving stomach yin deficiency and a preparation method thereof, and particularly relates to the technical field of dendrobium officinale paste formulae, the dendrobium officinale paste comprises the following components by weight: 100-200 g of wolfberry, 80-150 g of coix seed, 70-120 g of polygonatum odoratum, 100-200 g of Chinese yam, 50-100 g of ginseng, 100-200 g of poria cocos, 50-150 g of polygonatum kingianum, and 10-80 g of dendrobium officinale. And 100 to 200 g of mulberry. The dendrobium officinale paste aims at the symptoms of body fluid insufficiency such as dry mouth, dry throat, dry skin, dry stool and the like, and can improve the symptoms of hunger, poor appetite and stomach noisy and discomfort caused by deficiency of stomach yin.

Description

Technical Field

[0001] This application relates to the technical field of Dendrobium officinale paste, and in particular to a Dendrobium officinale paste that can improve the function of stomach yin deficiency and its preparation method. Background Technology

[0002] Stomach Yin Deficiency, also known as Stomach Yin Insufficiency, is a common clinical syndrome, often caused by factors such as the later stages of febrile diseases, emotional distress, or excessive consumption of spicy and warming foods, leading to depletion of stomach Yin fluids and internal disturbance of deficiency heat. Its main clinical manifestations include dry mouth and tongue, dull or burning pain in the stomach, loss of appetite, dry retching and hiccups, constipation, and a red tongue with little coating. In modern society, due to fast-paced lifestyles, irregular eating habits, and mental stress, the incidence of Stomach Yin Deficiency is showing a significant upward trend, seriously affecting people's quality of life.

[0003] Dendrobium officinale Kimura et Migo, a traditional and precious Chinese medicinal herb, is hailed as a "sacred tonic for nourishing Yin," particularly renowned for its stomach-strengthening, fluid-generating, Yin-nourishing, and heat-clearing effects. It is a core ingredient in treating stomach Yin deficiency. Currently, products utilizing Dendrobium officinale to improve stomach function take various forms, primarily including: 1. Traditional decoctions: This is the most commonly used dosage form. However, decoctions require daily preparation, are cumbersome, difficult to preserve, and have an unpleasant taste, failing to meet modern consumers' demands for convenience and compliance. 2. Single Dendrobium powder or extract: Products on the market are made by grinding or extracting Dendrobium officinale alone. While convenient to take, these products have limited efficacy and fail to adhere to the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide" in drug formulation. Stomach Yin deficiency is often accompanied by complex pathogenesis such as Qi and Yin deficiency and spleen dysfunction; single-drug therapy is often insufficient for comprehensive treatment, resulting in limited efficacy. 3. Common compound preparations: Although some existing compound products contain multiple medicinal materials, their formulations often remain at the level of simple combinations of traditional prescriptions. In terms of preparation processes, simple mixing and decoction are often used, resulting in low extraction rates of the effective components of some medicinal materials (such as those rich in polysaccharides and saponins), or damage during high-temperature and long-term decoction, affecting the bioavailability and efficacy stability of the final product.

[0004] Therefore, there is an urgent need in this field for a Dendrobium officinale paste product specifically designed to improve stomach yin deficiency, which has a scientific formulation, optimized preparation process, definite efficacy, convenient administration and stable quality, in order to overcome the above-mentioned defects of the prior art. Summary of the Invention

[0005] This invention provides a Dendrobium officinale paste that can improve the function of stomach yin deficiency and its preparation method. The Dendrobium officinale paste is effective for symptoms of insufficient body fluid such as dry mouth, dry throat, dry skin, and constipation, and can improve loss of appetite and stomach discomfort caused by stomach yin deficiency.

[0006] The objective of this invention is achieved through the following technical solution: A Dendrobium officinale paste that can improve the function of stomach yin deficiency, comprising the following components by weight: 100-200g of wolfberry, 80-150g of coix seed, 70-120g of Solomon's seal rhizome, 100-200g of yam, 50-100g of ginseng, 100-200g of poria cocos, 50-150g of polygonatum rhizome, 10-80g of Dendrobium officinale, 100-200g of mulberry, and 100-200g of raspberry.

[0007] As a preferred embodiment, the Dendrobium officinale extract, by weight, comprises the following components: 80-120g of wolfberry, 90-120g of coix seed, 80-110g of Solomon's seal rhizome, 120-160g of yam, 70-80g of ginseng, 120-170g of poria cocos, 90-120g of polygonatum rhizome, 30-60g of Dendrobium officinale, 80-160g of mulberry, and 80-160g of raspberry.

[0008] As a preferred embodiment, the Dendrobium officinale extract, by weight, comprises the following components: 150g of wolfberry, 100g of coix seed, 100g of Solomon's seal rhizome, 150g of yam, 75g of ginseng, 150g of poria cocos, 100g of polygonatum rhizome, 50g of Dendrobium officinale, 150g of mulberry, and 150g of raspberry.

[0009] As a preferred option, Dendrobium officinale extract may also include honey or maltose.

[0010] This invention also provides a method for preparing Dendrobium officinale extract that can improve the function of stomach yin deficiency, the method comprising the following steps: S01, Processing of medicinal materials Wash all the medicinal herbs and place them in a well-ventilated place to dry thoroughly; S02, Grinding and sieving The dried medicinal materials are pulverized separately using a grinder and passed through a 60-80 mesh sieve to make coarse powder for later use. S03, decoction extraction First decoction: Put all the prepared herbal powder into a clean stainless steel pot or earthenware pot, add water, the amount of water should be enough to completely submerge the herbs and about 3 finger joints above their surface, bring to a boil over high heat, then simmer over low heat for at least 2 hours. Second decoction: Filter the first decoction using a strainer or gauze, pour the dregs back into the pot, add an appropriate amount of water, and simmer over low heat for 1-1.5 hours; after filtering, you will get the second decoction. Combine the medicinal liquid: Combine the first and second juices, filter once with 100-mesh gauze to ensure the medicinal liquid is clear and free of impurities; S04, Concentrated Paste Settling: Let the combined filtered medicinal liquid stand for several hours to allow the very fine medicinal residue to settle naturally; Concentration over a low flame: Pour the supernatant into a clean pot and heat it slowly over a low flame to concentrate it, stirring constantly during the process; Add excipients: When the medicinal liquid is concentrated to the point where it drips in beads when dipped with chopsticks, add maltose or honey, and continue to stir and simmer until the sugar is completely dissolved and thoroughly mixed with the medicinal liquid; To determine if a paste has formed: continue heating until the paste does not immediately disperse when dropped into cold water; this indicates that a paste has formed.

[0011] Preferably, in step S02, the sieve aperture is 70 mesh.

[0012] Preferably, in step S03, the weight ratio of material to liquid is approximately 1:20.

[0013] As a preferred option, the storage conditions for this herbal paste are: Sterilize containers: Prepare one or more clean glass jars, sterilize them by boiling in water or drying in an oven, ensuring they are free of water and oil; Pour the hot paste into sterilized glass jars while it is still hot, and store it in a cool, dry place or in the refrigerator.

[0014] Compared with the prior art, the advantages or beneficial effects of the technical solution of this application include: 1. Synergistic Effect, Significant and Targeted Therapy. This invention does not simply pile up Dendrobium officinale with other medicinal materials, but rather uses a scientific combination based on the traditional Chinese medicine theory of "principal, assistant, adjuvant, and guide." Dendrobium officinale is used as the principal herb, directly addressing the pathogenesis and powerfully nourishing stomach yin; Polygonatum odoratum, Polygonatum sibiricum, and mulberry are used as assistant herbs to enhance the effects of nourishing yin and generating fluids; Dioscorea opposita, Poria cocos, and Coix lacryma-jobi are used as adjuvant herbs to strengthen the spleen, replenish qi, and eliminate dampness, preventing the stagnation of yin-nourishing herbs and aiding in the generation of qi, blood, and body fluids; Ginseng is used as the guide herb to greatly replenish vital energy and generate fluids. The combined effects of these herbs nourish yin and stomach, replenish qi and generate fluids, and strengthen the spleen and aid digestion. It systematically regulates the root cause of stomach yin deficiency and its common concurrent symptoms (such as qi and yin deficiency, spleen deficiency and dampness), overcoming the limitations of single-herb therapy and achieving multi-target, synergistic therapeutic effects, which are significantly superior to the simple combination of traditional prescriptions.

[0015] 2. Optimized Process for High Extraction Rate and Stable Quality of Active Ingredients. This invention features key optimizations to the preparation process. First, by pulverizing and sieving the medicinal materials, the specific surface area of ​​the materials is greatly increased, making it easier for the active ingredients to dissolve during subsequent decoction. Second, an extraction method involving two separate decoctions and combined filtrates maximizes the extraction of water-soluble active ingredients (such as Dendrobium polysaccharides, Polygonatum polysaccharides, and Poria cocos polysaccharides), avoiding the component losses caused by traditional single-stage decoction. Finally, in the concentration and paste-forming stage, precise control is achieved through specific physical indicators (such as "hanging flag" and "water droplets forming beads"), ensuring the consistency of the paste's consistency and the stability of the active ingredients. This standardized process significantly improves the extraction and transfer rates of active ingredients, reduces losses caused by excessive pyrolysis or insufficient extraction, thereby guaranteeing high batch-to-batch uniformity of the final product and the reliability and repeatability of its therapeutic effects.

[0016] 3. Convenient product form, wide applicability, and excellent user experience. This invention transforms compound traditional Chinese medicine into a paste, overcoming the drawbacks of cumbersome decoction preparation and poor preservation. It achieves the goals of immediate use, easy portability, and long-term storage, greatly improving patient medication adherence. Furthermore, it offers multiple flavoring options, such as rock sugar or honey, allowing for flexible adjustments based on the needs of different groups (e.g., those with normal blood sugar or those needing to control sugar intake), resulting in a mild and palatable product suitable for a wider range of people. In addition, the concentrated paste is small in volume, accurately dosed, and convenient to take, making it more suitable for health maintenance and chronic disease management in today's fast-paced lifestyle, providing a significantly superior user experience compared to traditional dosage forms. Detailed Implementation

[0017] The following detailed description of the implementation methods of this application, in conjunction with specific embodiments, will provide a thorough understanding of how this application uses technical means to solve technical problems and achieve corresponding technical effects, enabling its implementation accordingly. The embodiments of this application and the various features within them can be combined with each other without conflict, and all resulting technical solutions are within the protection scope of this application.

[0018] It should be clearly stated that the embodiments described below are merely some embodiments of this application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0019] Example 1: Preparation of the basic formula Ingredients: 150g wolfberry, 100g coix seed, 100g Solomon's seal rhizome, 150g yam, 75g ginseng, 150g poria cocos, 100g polygonatum rhizome, 50g dendrobium officinale, 150g mulberry, 150g raspberry.

[0020] Herbal processing: Rinse the above-mentioned herbs quickly with clean water to remove surface dust, and place them in a well-ventilated, dark place to dry.

[0021] Grinding and sieving: Use a Chinese medicine grinding machine to grind each medicinal material separately, pass them through a 70-mesh sieve, and make them into uniform coarse powder. Mix them evenly.

[0022] Decoction extraction: First decoction: Place the mixed medicinal powder in a stainless steel extraction pot and add 6 liters of purified water (material-to-liquid ratio approximately 1:20). Bring to a boil over high heat, then reduce to a simmer and cook for 2 hours, stirring occasionally.

[0023] Second decoction: Filter through 100-mesh gauze and collect the first decoction. Return the dregs to the pot, add 4 liters of purified water, and simmer again for 1.5 hours. Filter and combine the two filtrates (first and second decoctions).

[0024] Concentrate the paste: Let the combined medicinal liquids stand for 3 hours, then pour the supernatant into a clean concentrator. Heat over low heat, stirring constantly to prevent scorching. Concentrate until the liquid forms a "flag" (drops fall slowly in beads) when lifted. Add 150 grams of honey and continue stirring and simmering until well mixed. Take a small amount of the paste and drop it into cold water; if it forms a round bead that doesn't disperse ("drops form beads"), remove it from the heat.

[0025] Filling and storage: While still hot, fill the paste into sterilized and dried brown glass bottles and seal. After cooling, store in a cool, dry place or refrigerate.

[0026] Example 2: Preparation of Optimized Formulation Ingredients: 120g wolfberry, 120g coix seed, 110g Solomon's seal rhizome, 160g yam, 80g ginseng, 170g poria cocos, 120g polygonatum rhizome, 60g dendrobium officinale, 160g mulberry, 160g raspberry.

[0027] Preparation method: Same as in Example 1. This example uses the upper limit of the formulation range to demonstrate the feasibility of preparing the paste under different dosage ratios, resulting in a thicker paste.

[0028] Example 3: Preparation of Maltose-Containing Paste Ingredients: 100g wolfberry, 90g coix seed, 80g Solomon's seal rhizome, 120g yam, 70g ginseng, 120g poria cocos, 90g polygonatum rhizome, 30g dendrobium officinale, 80g mulberry, 80g raspberry.

[0029] Preparation method: The preparation process is the same as in Example 1, except that in the final stage, honey is replaced with an equal amount of maltose. This example demonstrates the feasibility of using different flavoring agents (suitable for people who are intolerant to honey or prefer different tastes), resulting in a paste with a darker color and a richer flavor.

[0030] Test Example 1: Sensory Evaluation and Physical Property Testing Objective: To evaluate the appearance, taste, and physical stability of the herbal paste product of this invention.

[0031] Methods: The finished pastes prepared in Examples 1, 2, and 3 were subjected to sensory evaluation by 10 trained evaluators. Simultaneously, the relative density (20°C) and moisture content of the pastes were measured.

[0032] result: Sensory evaluation: The pastes prepared in all examples were dark brown in color, with a rich medicinal aroma and honey / maltose aroma, a delicate taste, sweet but not cloying, and no off-flavors or burnt taste. The overall evaluation was "excellent".

[0033] Physical properties: The paste is semi-fluid at room temperature and does not flow easily; it becomes solid after refrigeration and is easy to scoop. The relative density is between 1.25 and 1.35, and the moisture content is below 25%. This indicates that the product is stable and easy to store and consume.

[0034] Test Example 2: Observation on the improvement effect on typical symptoms of stomach yin deficiency Objective: To preliminarily observe the effect of the herbal paste of the present invention on improving related symptoms in people with stomach yin deficiency.

[0035] Methods: Sixty volunteers meeting the diagnostic criteria for stomach yin deficiency (mainly manifested as dry mouth and throat, loss of appetite, stomach discomfort, and constipation) were recruited and randomly divided into two groups. The experimental group (30 people) took 15 grams of Dendrobium officinale paste prepared in Example 1 twice daily with warm water; the control group (30 people) took a placebo paste with a similar appearance (mainly composed of caramel and dextrin). The trial lasted for 4 weeks. Before and after the trial, a symptom scoring method (0, 1, 2, and 3 points for each symptom, respectively, indicating none, mild, moderate, and severe symptoms) was used for evaluation.

[0036] Results: Before the trial, there was no significant difference in the total symptom scores between the two groups (P>0.05). After 4 weeks of the trial, the scores of symptoms such as dry mouth and throat, loss of appetite, and stomach upset in the experimental group decreased significantly, and the improvement rate of the total score was significantly higher than that in the control group (P<0.01). The improvement was particularly significant in terms of "dry mouth and throat" and "constipation".

[0037] Conclusion: The Dendrobium officinale extract of the present invention can effectively improve the typical clinical symptoms of stomach yin deficiency, and no obvious adverse reactions were found during the period of use, indicating good safety.

Claims

1. A Dendrobium officinale paste capable of improving the function of stomach yin deficiency, characterized in that, By weight, including the following components: 100-200 grams of medlar, 80-150 grams of yam, 70-120 grams of polygonatum, 100-200 grams of ginseng, 50-100 grams of poria, 100-200 grams of 50-150 grams of turmeric, 10-80 grams of dendrobium, 100-200 grams of mulberry, 100-200 grams of raspberry.

2. The Dendrobium officinale paste for improving the function of stomach yin deficiency according to claim 1, characterized in that, By weight, including the following components: 80-120 grams of medlar, 90-120 grams of yam, 80-110 grams of polygonatum, 120-160 grams of ginseng, 70-80 grams of poria, 90-120 grams of 90-120 grams of turmeric, 30-60 grams of dendrobium, 80-160 grams of mulberry, 80-160 grams of raspberry.

3. The Dendrobium officinale paste for improving the function of stomach yin deficiency according to claim 1, characterized in that, By weight, including the following components: 150 grams of medlar, 100 grams of yam, 100 grams of polygonatum, 150 grams of ginseng, 75 grams of poria, 100 grams of turmeric, 50 grams of dendrobium, 150 grams of mulberry, 150 grams of raspberry.

4. The Dendrobium officinale paste for improving the function of stomach yin deficiency according to any one of claims 1-3, characterized in that, Also including honey or malt sugar.

5. A preparation method of a Dendrobium officinale paste capable of improving the function of stomach yin deficiency, characterized in that, Including the following steps: S01, processing of medicinal materials Wash all medicinal materials and dry thoroughly in a well-ventilated place; S02, crushing and sieving Dry the medicinal materials and crush them with a powder machine, then sieve them through a 60-80 mesh sieve to make coarse powder for later use; S03, decocting and extracting First decoction: Put all the processed medicinal material powder into a clean stainless steel pot or sand pot, add water, and the water level should be enough to immerse the medicinal materials and be about 3 knuckles higher than the surface. Boil with strong fire, then turn to low heat and decoct for at least 2 hours; Second decoction: Filter with a filter screen or gauze, take out the first medicinal liquid, and put the medicinal residue back into the pot, add appropriate amount of water, and decoct again with low heat for 1-1.5 hours. Filter to get the second medicinal liquid; Combine the medicinal liquids: Combine the first and second medicinal liquids and filter once with 100 mesh gauze to ensure the medicinal liquid is clear and free of impurities; S04, concentration and collection of paste Static sedimentation: Let the filtered medicinal liquid stand for several hours to allow the very fine residue to settle naturally; Low heat concentration: Pour the supernatant into a clean pot and heat slowly with low heat. Stir constantly during the process; Add auxiliary materials: When the medicinal liquid is concentrated to the point where it forms beads when dropped with a chopstick, add malt sugar or honey and continue to stir until the sugar is completely melted and evenly mixed with the medicinal liquid; Determine the paste: Continue heating until the paste does not immediately disperse when dropped into cold water, indicating that the paste is complete.

6. The production method according to claim 5, wherein In step S02, the mesh size of the sieve is 70 mesh.

7. The preparation method according to claim 5, characterized in that, In step S03, the weight ratio of the material to the liquid is about 1:

20.

8. The preparation method according to claim 5, characterized in that, Storage conditions are: Sterilized containers: Prepare one or more clean glass jars and sterilize them by boiling or drying in an oven to ensure they are free of water and oil; Hot filling: While the paste is still hot, pour it into the sterilized glass jars and store them in a cool, dry place or in the refrigerator.