Traditional Chinese medicine composition for improving survival rate of piglets as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for improving the survival rate of piglets and a preparation method and application thereof, and belongs to the technical field of feed additives. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6 to 10 parts of fructus forsythiae, 15 to 22 parts of radix isatidis, 15 to 22 parts of radix scutellariae, 8 to 12 parts of honeysuckle flower, 5 to 8 parts of herba taraxaci, 10 to 15 parts of rhizoma atractylodis macrocephalae, 8 to 12 parts of poria cocos, 6 to 10 parts of rhizoma dioscoreae, 12 to 18 parts of radix astragali seu hedysari, 8 to 12 parts of radix bupleuri, 5 to 8 parts of liquorice root and 3 to 6 parts of semen ziziphi spinosae. Based on the traditional Chinese medicine theory of supporting healthy energy and giving consideration to both symptoms and root causes, a three-dimensional synergistic system of clearing heat, resisting bacteria, invigorating spleen, benefiting intestines, tonifying qi and resisting stress is constructed to adapt to the physiological characteristics of weaned piglets, so that the problems of low survival rate, slow growth and substandard quality in weaned piglet breeding are solved, and the survival rate of the weaned piglets is remarkably improved.

Description

Technical Field

[0001] This invention belongs to the field of feed additive technology, and in particular relates to a traditional Chinese medicine composition for improving the survival rate of piglets, its preparation method and application. Background Technology

[0002] In intensive pig farming, piglets are generally weaned at 3 weeks old, which improves sow reproductive efficiency. However, the series of physiological disorders caused by weaning stress have become a key bottleneck restricting farming efficiency: 1) Immune function defects: Piglets' immune organs are not fully developed, and the supply of maternal antibodies is interrupted and rapidly reduced after weaning, resulting in a significant decrease in resistance to pathogens such as E. coli and Salmonella, making them susceptible to infectious diseases; 2) Digestive function disorders: After weaning, the activity of digestive enzymes in piglets drops sharply, the intestinal flora is imbalanced, high-protein basic feed is difficult to digest, inducing nutritional diarrhea, and in severe cases, dehydration and death; 3) Strong stress response: Multiple stresses such as environmental changes, nutritional transitions, and separation of mother and piglets lead to activation of the hypothalamus-pituitary-adrenal axis in piglets, increasing cortisol levels, further inhibiting immune function and appetite; 4) Infection and vertical transmission of some viral diseases, such as porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus, cause piglets to be in an immunosuppressed state. The superposition of multiple factors easily leads to a sub-healthy state and decreased survival rate of piglets. Current technologies often employ antibiotics or chemical inhibitors, which may lead to drug resistance in pathogens. The use of single-herb additives results in limited functionality, failing to address multiple needs simultaneously. Traditional direct addition methods lead to low levels of effective components and poor palatability, resulting in decreased feed intake in piglets. Furthermore, feeding programs may not be designed to meet the different physiological needs of piglets at different post-weaning stages, resulting in limited survival rate improvements and failing to meet the practical needs of large-scale farming. Therefore, developing a multi-functional, synergistic, and easily applicable traditional Chinese medicine composition feed additive tailored to the physiological characteristics of post-weaning piglets has become an urgent problem for the industry. Summary of the Invention

[0003] In view of this, the purpose of this invention is to provide a traditional Chinese medicine composition for improving the survival rate of piglets, its preparation method, and its application. Based on the traditional Chinese medicine theory of "strengthening the body's resistance and addressing both the root cause and symptoms," this invention constructs a three-dimensional synergistic system of "clearing heat and fighting bacteria, strengthening the spleen and intestines, and replenishing qi and resisting stress," which is adapted to the physiological characteristics of piglets after weaning, thus significantly improving the survival rate of piglets after weaning.

[0004] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a traditional Chinese medicine composition for improving the survival rate of piglets, comprising the following raw materials in parts by weight: 6-10 parts of Forsythia suspensa, 15-22 parts of Isatis indigotica, 15-22 parts of Scutellaria baicalensis, 8-12 parts of Lonicera japonica, 5-8 parts of Taraxacum mongolicum, 10-15 parts of Atractylodes macrocephala, 8-12 parts of Poria cocos, 6-10 parts of Dioscorea opposita, 12-18 parts of Astragalus membranaceus, 8-12 parts of Bupleurum chinense, 5-8 parts of Glycyrrhiza uralensis, and 3-6 parts of Ziziphus jujuba var. spinosa.

[0005] As a preferred option, the raw materials include the following parts by weight: 7-9 parts forsythia, 17-20 parts isatis root, 17-20 parts scutellaria, 9-11 parts honeysuckle, 5.5-7 parts dandelion, 11-14 parts atractylodes macrocephala, 9-11 parts poria cocos, 7-9 parts yam, 14-16 parts astragalus, 9-11 parts bupleurum, 5.5-7 parts licorice, and 3.5-5 parts jujube seed.

[0006] As a preferred option, the raw materials include the following parts by weight: 8 parts forsythia, 18 parts isatis root, 18 parts scutellaria, 10 parts honeysuckle, 6 parts dandelion, 12 parts atractylodes macrocephala, 10 parts poria cocos, 8 parts yam, 15 parts astragalus, 10 parts bupleurum, 6 parts licorice, and 4 parts jujube seed.

[0007] This invention provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps: (1) Mix the raw materials to obtain a mixture; (2) Mix the mixture with water, decoct 1 to 3 times, filter, collect and combine the filtrates, concentrate and dry to obtain the traditional Chinese medicine composition.

[0008] Preferably, the mass ratio of the mixture to water is 1:7~10, the boiling time is 20~40 minutes each time, and the mesh size of the sieve used for filtration is 80~120 mesh.

[0009] The present invention also provides the application of the traditional Chinese medicine composition described herein or the traditional Chinese medicine composition obtained according to the preparation method in the preparation of feed to improve the survival rate of piglets.

[0010] Preferably, the amount of the traditional Chinese medicine composition added is 0.5% to 10% of the total feed mass.

[0011] The present invention also provides the application of the traditional Chinese medicine composition described herein or the traditional Chinese medicine composition obtained according to the preparation method in the preparation of formulations that improve the survival rate of piglets.

[0012] Preferably, the method of using the preparation is as follows: the traditional Chinese medicine composition is added to the drinking water of piglets, and the final concentration of the preparation is 50~80mg / L.

[0013] Compared with existing technologies, the present invention has the following beneficial effects: The present invention provides a traditional Chinese medicine composition for improving the survival rate of piglets, its preparation method, and its application. Using the traditional Chinese medicine composition of the present invention as a feed additive can significantly improve the survival rate and growth rate of piglets after weaning. Based on the traditional Chinese medicine theory of "strengthening the body's resistance and addressing both the root cause and symptoms," the present invention constructs a three-dimensional synergistic system of "clearing heat and antibacterial properties, strengthening the spleen and intestines, and replenishing qi and resisting stress," which is adapted to the physiological characteristics of piglets after weaning. This solves the problems of "low survival rate, slow growth, and substandard quality" in weaned piglet farming, significantly improving the survival rate of piglets after weaning. Detailed Implementation

[0014] This invention provides a traditional Chinese medicine composition for improving the survival rate of piglets, comprising the following raw materials in parts by weight: 6-10 parts of Forsythia suspensa, preferably 7-9 parts, and more preferably 8 parts; 15-22 parts of Isatis root, preferably 17-20 parts, and more preferably 18 parts; Scutellaria baicalensis 15-22 parts, preferably 17-20 parts, more preferably 18 parts; 8-12 parts of honeysuckle, preferably 9-11 parts, and even more preferably 10 parts; Dandelion 5-8 parts, preferably 5.5-7 parts, more preferably 6 parts; 10-15 parts of Atractylodes macrocephala, preferably 11-14 parts, and more preferably 12 parts; 8-12 parts of Poria cocos, preferably 9-11 parts, and even more preferably 10 parts; The amount of yam is 6 to 10 parts, preferably 7 to 9 parts, and even more preferably 8 parts; Astragalus membranaceus: 12-18 parts, preferably 14-16 parts, and even more preferably 15 parts; Bupleurum chinense: 8-12 parts, preferably 9-11 parts, and even more preferably 10 parts; Licorice 5-8 parts, preferably 5.5-7 parts, more preferably 6 parts; The amount of jujube seed is 3 to 6 parts, preferably 3.5 to 5 parts, and even more preferably 4 parts.

[0015] In this invention, Forsythia is bitter and slightly cold in nature, and enters the lung, heart and small intestine meridians. It has the functions of clearing heat and detoxifying, reducing swelling and dissipating nodules, and dispersing wind-heat. It is often used for carbuncles, scrofula, mastitis, erysipelas, wind-heat cold, the initial stage of febrile disease, febrile disease entering the nutritive level, high fever and thirst, delirium and rashes, and painful urination. Isatis root is bitter and cold in nature, and enters the heart and stomach meridians. It has the functions of clearing heat and detoxifying, cooling blood and relieving sore throat. It is often used for febrile diseases, fever and sore throat, febrile rashes, mumps, erysipelas, epidemic parotitis, erysipelas, and carbuncles. Scutellaria baicalensis is bitter and cold in nature, and enters the lung, gallbladder, spleen, large intestine and small intestine meridians. It has the functions of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding and calming the fetus. It is often used for damp-heat syndrome, summer-heat syndrome, chest tightness and nausea, damp-heat fullness, diarrhea, jaundice, lung-heat cough, high fever and thirst, blood-heat vomiting and nosebleeds, carbuncles and boils, and threatened abortion. Honeysuckle is sweet and cold in nature, and enters the lung, heart and stomach meridians. It has the functions of clearing heat and detoxifying, and dispersing wind-heat. It is often used for carbuncles, boils, sore throat, erysipelas, dysentery caused by heat toxins, wind-heat colds, and febrile diseases. Dandelion is bitter, sweet, and cold in nature, and enters the liver and stomach meridians. It has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules, and promoting diuresis and relieving strangury. It is often used for boils and carbuncles, mastitis, scrofula, red eyes, sore throat, lung abscess, intestinal abscess, damp-heat jaundice, and painful urination due to heat. Atractylodes macrocephala is bitter, sweet, and warm in nature. It enters the spleen and stomach meridians and has the functions of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It is often used for spleen deficiency with poor appetite, abdominal distension and diarrhea, phlegm retention, dizziness and palpitations, edema, spontaneous sweating, and threatened abortion. Poria cocos is sweet, bland, and neutral in nature. It enters the heart, lung, spleen, and kidney meridians. It has the functions of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind. It is often used for edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia. Yam is sweet and neutral in nature, and enters the spleen, lung, and kidney meridians. It has the functions of tonifying the spleen and stomach, promoting body fluid and benefiting the lungs, and tonifying the kidneys and astringing essence. It is often used for spleen deficiency with poor appetite, chronic diarrhea, lung deficiency with cough and wheezing, kidney deficiency with seminal emission, leukorrhea, frequent urination, and thirst due to deficiency heat. Astragalus is sweet and slightly warm in nature, and enters the lung and spleen meridians. It has the functions of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting circulation and relieving pain, promoting the elimination of toxins and pus, and promoting wound healing and tissue regeneration. It is often used for qi deficiency and fatigue, poor appetite and loose stools, sinking of middle qi, chronic diarrhea and rectal prolapse, hematochezia and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, internal heat and thirst, blood deficiency and chlorosis, hemiplegia, numbness and pain, carbuncles and boils that are difficult to ulcerate, and chronic ulcers that do not heal. Bupleurum has a pungent, bitter, and slightly cold nature. It enters the liver, gallbladder, and lung meridians. It has the functions of dispersing and reducing fever, soothing the liver and relieving depression, and raising yang qi. It is often used for colds with fever, alternating chills and fever, chest and rib pain, irregular menstruation, uterine prolapse, and rectal prolapse. Licorice is sweet and neutral in nature, and enters the heart, lung, spleen and stomach meridians. It has the functions of tonifying the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasms and pain, and harmonizing various medicines. It is often used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with phlegm, abdominal and limb spasms and pain, carbuncles and boils, and to alleviate the toxicity and harshness of drugs. Sour jujube seed is sweet, sour, and neutral in nature. It enters the liver, gallbladder, and heart meridians. It has the functions of nourishing the heart and liver, calming the mind and soothing the nerves, astringing sweat, and promoting body fluid production. It is often used for insomnia due to deficiency and restlessness, palpitations and excessive dreaming, excessive sweating due to physical weakness, and thirst due to fluid depletion.

[0016] In this invention, forsythia, isatis root, honeysuckle, and dandelion are combined to achieve the effect of clearing heat and antibacterial properties; scutellaria, atractylodes, poria, and yam are combined to achieve the effect of strengthening the spleen and benefiting the intestines; and astragalus, bupleurum, licorice, and jujube seed are combined to achieve the effect of invigorating qi and resisting stress. This invention constructs a three-dimensional synergistic system of "clearing heat and antibacterial properties - strengthening the spleen and benefiting the intestines - invigorating qi and resisting stress," so that each herb can perform its function to jointly improve the survival rate of piglets after weaning.

[0017] This invention provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps: (1) Mix the raw materials to obtain a mixture; (2) Mix the mixture with water, decoct 1 to 3 times, filter, collect and combine the filtrates, concentrate and dry to obtain the traditional Chinese medicine composition.

[0018] In this invention, the mass ratio of the mixture to water is 1:7~10, preferably 1:7.5~9, and more preferably 1:8; the boiling time is 20~40 min, preferably 25~35 min, and more preferably 30 min; the mesh size of the filtration sieve is 80~120 mesh, preferably 90~110 mesh, and more preferably 100 mesh; the concentration temperature is 40~60℃, preferably 45~55℃, and more preferably 50℃; the concentrated volume is 40%~60% of the original volume, preferably 45%~55%, and more preferably 50%; and the drying method is freeze drying.

[0019] The present invention also provides the application of the traditional Chinese medicine composition described herein or the traditional Chinese medicine composition obtained according to the preparation method in the preparation of feed to improve the survival rate of piglets.

[0020] In this invention, the amount of the traditional Chinese medicine composition added is 0.5% to 10% of the total mass of the feed, preferably 2% to 7%, and more preferably 5%.

[0021] The present invention also provides the application of the traditional Chinese medicine composition described herein or the traditional Chinese medicine composition obtained according to the preparation method in the preparation of formulations that improve the survival rate of piglets.

[0022] In this invention, the method of using the preparation is as follows: the traditional Chinese medicine composition is added to the drinking water of piglets, and the final concentration of the preparation is 50~80mg / L, preferably 60~75mg / L, and more preferably 70mg / L.

[0023] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0024] Example 1

[0025] Weigh out 0.8 kg of Forsythia suspensa, 1.8 kg of Isatis indigotica, 1.8 kg of Scutellaria baicalensis, 1.0 kg of Lonicera japonica, 0.6 kg of Taraxacum mongolicum, 1.2 kg of Atractylodes macrocephala, 1.0 kg of Poria cocos, 0.8 kg of Dioscorea opposita, 1.5 kg of Astragalus membranaceus, 1.0 kg of Bupleurum chinense, 0.6 kg of Glycyrrhiza uralensis, and 0.4 kg of Ziziphus jujuba var. spinosa. Add 100 kg of water, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter through a 100-mesh sieve and collect the liquid. Add 87.5 kg of water again for a second decoction, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter through a 100-mesh sieve and collect the liquid. Combine the two filtrates and place them in a vacuum concentration apparatus. Set the temperature to 50°C and concentrate the liquid to half the original volume. The concentrated liquid is then freeze-dried to obtain a traditional Chinese medicine composition for improving the survival rate of piglets.

[0026] Example 2

[0027] Weigh out 0.6 kg of Forsythia suspensa, 1.5 kg of Isatis indigotica, 1.5 kg of Scutellaria baicalensis, 0.8 kg of Lonicera japonica, 0.5 kg of Taraxacum mongolicum, 1.0 kg of Atractylodes macrocephala, 0.8 kg of Poria cocos, 0.6 kg of Dioscorea opposita, 1.2 kg of Astragalus membranaceus, 0.8 kg of Bupleurum chinense, 0.5 kg of Glycyrrhiza uralensis, and 0.3 kg of Ziziphus jujuba var. spinosa. Add 70.7 kg of water, bring to a boil over high heat, then simmer over low heat for 20 minutes. Filter through a 100-mesh sieve and collect the liquid. Add another 70.7 kg of water and boil a second time. Bring to a boil over high heat, then simmer over low heat for 20 minutes. Filter through a 100-mesh sieve and collect the liquid. Combine the two filtrates and place them in a vacuum concentration apparatus. Set the temperature to 50°C and concentrate the liquid to 2 / 5 of the original volume. Obtain the concentrated liquid, freeze-dry it, and obtain a traditional Chinese medicine composition for improving the survival rate of piglets.

[0028] Example 3

[0029] Weigh out 1.0 kg of Forsythia suspensa, 2.2 kg of Isatis indigotica, 2.2 kg of Scutellaria baicalensis, 1.2 kg of Lonicera japonica, 0.8 kg of Taraxacum mongolicum, 1.5 kg of Atractylodes macrocephala, 1.2 kg of Poria cocos, 1.0 kg of Dioscorea opposita, 1.8 kg of Astragalus membranaceus, 1.2 kg of Bupleurum chinense, 0.8 kg of Glycyrrhiza uralensis, and 0.6 kg of Ziziphus jujuba var. spinosa. Add 155 kg of water, bring to a boil over high heat, then simmer over low heat for 40 minutes. Filter through a 100-mesh sieve and collect the liquid. Add 124 kg of water again and decoct a second time. Bring to a boil over high heat, then simmer over low heat for 40 minutes. Filter through a 100-mesh sieve and collect the liquid. Combine the two filtrates and place them in a vacuum concentration apparatus. Set the temperature to 50°C and concentrate the liquid to 3 / 5 of the original volume. Obtain the concentrated liquid, freeze-dry it, and obtain a traditional Chinese medicine composition for improving the survival rate of piglets.

[0030] Comparative Example 1

[0031] Weigh out 0.4 kg of Forsythia suspensa, 1.0 kg of Isatis indigotica, 1.0 kg of Scutellaria baicalensis, 0.5 kg of Lonicera japonica, 0.3 kg of Taraxacum mongolicum, 0.5 kg of Atractylodes macrocephala, 0.5 kg of Poria cocos, 0.4 kg of Dioscorea opposita, 0.8 kg of Astragalus membranaceus, 0.5 kg of Bupleurum chinense, 0.3 kg of Glycyrrhiza uralensis, and 0.1 kg of Ziziphus jujuba var. spinosa. Add 50.4 kg of water, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter through a 100-mesh sieve and collect the liquid. Add 44.1 kg of water again for a second decoction, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter through a 100-mesh sieve and collect the liquid. Combine the two filtrates and place them in a vacuum concentration apparatus. Set the temperature to 50°C and concentrate the liquid to half the original volume. The concentrated liquid is then freeze-dried to obtain a traditional Chinese medicine composition for improving the survival rate of piglets.

[0032] Comparative Example 2

[0033] Weigh out 1.5 kg of Forsythia suspensa, 2.5 kg of Isatis indigotica, 2.5 kg of Scutellaria baicalensis, 1.5 kg of Lonicera japonica, 1.0 kg of Taraxacum mongolicum, 1.8 kg of Atractylodes macrocephala, 1.5 kg of Poria cocos, 1.3 kg of Dioscorea opposita, 2.0 kg of Astragalus membranaceus, 1.5 kg of Bupleurum chinense, 1.0 kg of Glycyrrhiza uralensis, and 1 kg of Ziziphus jujuba var. spinosa. Add 152.8 kg of water, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter through a 100-mesh sieve and collect the liquid. Add 133.7 kg of water again and decoct for a second time. Bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter through a 100-mesh sieve and collect the liquid. Combine the two filtrates and place them in a vacuum concentration apparatus. Set the temperature to 50°C and concentrate the liquid to half the original volume. The concentrated liquid is then freeze-dried to obtain a traditional Chinese medicine composition for improving the survival rate of piglets.

[0034] Comparative Example 3

[0035] The traditional Chinese medicine composition for improving the survival rate of piglets was prepared according to Example 1, except that Scutellaria baicalensis was replaced with Coptis chinensis.

[0036] Comparative Example 4

[0037] The traditional Chinese medicine composition for improving the survival rate of piglets was prepared according to the method of Example 1, except that Scutellaria baicalensis, Atractylodes macrocephala, Poria cocos, and Dioscorea opposita were not used.

[0038] Comparative Example 5

[0039] The traditional Chinese medicine composition for improving the survival rate of piglets was prepared according to the method of Example 1, except that Astragalus membranaceus, Bupleurum chinense, Glycyrrhiza uralensis and Ziziphus jujuba var. spinosa were not used.

[0040] Comparative Example 6

[0041] The traditional Chinese medicine composition for improving the survival rate of piglets was prepared according to Example 1, except that 0.6 kg of Coptis chinensis was added to the traditional Chinese medicine composition.

[0042] Experimental Example 1

[0043] The traditional Chinese medicine composition obtained using the method in Example 1 was used as a feed additive. Healthy SPF-grade mice (half male, half female, weighing 18-22g) were selected and, after 3 days of acclimatization, randomly divided into four groups of 10 mice each: high-dose, medium-dose, and low-dose groups, and a blank control group. The high-dose group received a diet supplemented with 10% feed additive by weight of the total feed weight; the medium-dose group received a diet supplemented with 5% feed additive by weight of the total feed ...

[0044] Table 1. Records of mouse status in different groups

[0045] As shown in Table 1, no animal deaths occurred within 4 weeks of continuous administration. Mice in different feeding groups exhibited normal behavior, mental state, and bowel movements, and showed good growth and development. No other significant behavioral changes or signs of poisoning were observed, indicating that this product has no toxic side effects on animals.

[0046] Experiment Example 2

[0047] The traditional Chinese medicine composition obtained using the method in Example 1 was used as a feed additive. The low-dose group had 0.5% of the total feed weight of the feed additive mixed into the basal diet (purchased from Binzhou Huijia Biotechnology Co., Ltd.); the medium-dose group had 5% of the total feed weight of the feed additive mixed into the basal diet; and the high-dose group had 10% of the total feed weight of the feed additive mixed into the basal diet. This experiment was conducted at Qingdao Hebang Agricultural Group Co., Ltd. Forty healthy piglets weaned at 21 days old were randomly selected and randomly divided into four groups. Groups 1-3 were fed the low, medium, and high-dose groups respectively, while the other four groups were fed only the basal diet. After six weeks of feeding, the piglets' condition was observed, and the results are shown in Table 2.

[0048] Table 2 Feeding conditions for piglets in different groups

[0049] As shown in Table 2, the feed additives of this application can effectively reduce the diarrhea rate of piglets and improve the survival rate of piglets. When the addition amount is 5%, it can significantly improve the growth and development of piglets and increase the weight of piglets.

[0050] Experimental Example 3

[0051] This experiment was conducted at Qingdao Hebang Agricultural Group Co., Ltd. Forty healthy piglets, weaned at 21 days old, were randomly selected and randomly divided into four groups. Group 1 piglets drank a 50 mg / L solution prepared using the herbal composition obtained in Example 1; Group 2 piglets drank a 70 mg / L solution prepared using the herbal composition obtained in Example 1; Group 3 piglets drank a 80 mg / L solution prepared using the herbal composition obtained in Example 1; and Group 4 piglets drank water without any additives. All piglets were fed a normal basal diet (purchased from Binzhou Huijia Biotechnology Co., Ltd.) and had free access to water. After 6 weeks of feeding, the results are shown in Table 3.

[0052] Table 3. Piglets in different drinking solutions groups

[0053] As shown in Table 3, the traditional Chinese medicine composition of this application can effectively reduce the diarrhea rate of piglets and improve the survival rate of piglets. Moreover, when the solution concentration is 70 mg / L, it has the best effect on improving the growth and development of piglets and increasing the weight of piglets.

[0054] Experiment Example 4

[0055] This experiment was conducted at Qingdao Hebang Agricultural Group Co., Ltd. One hundred healthy piglets, weaned at 21 days old, were randomly selected and divided into 10 groups. They were fed using routine management methods, with the difference being that groups 1-9 were fed feed containing the traditional Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-6, respectively, with the traditional Chinese medicine composition added at 5% of the total feed mass. Group 10 was fed only a basal diet. After 6 weeks of feeding, the piglets' condition was observed, and the results are shown in Table 4.

[0056] Table 4. Effects of different treatment groups on piglets

[0057] As shown in Table 4, the traditional Chinese medicine composition of this invention can significantly improve the survival rate of piglets, promote their growth and development, and reduce their diarrhea and mortality rates. Analysis of Example 1 and Comparative Examples 1-6 shows that the component ratio and selection of the traditional Chinese medicine composition all affect the survival rate, diarrhea rate, and feed conversion ratio of piglets. Furthermore, comparison of the results of Example 1 and Comparative Examples 4 and 5 shows that when the traditional Chinese medicine composition does not contain the spleen-strengthening and intestinal-benefiting formula, it reduces the growth and development of piglets; when the traditional Chinese medicine composition does not contain the qi-tonifying and stress-resistant formula, it cannot reduce the diarrhea rate of piglets or increase their survival rate. Therefore, this invention constructs a three-dimensional synergistic system of "heat-clearing and antibacterial, spleen-strengthening and intestinal-qi-tonifying and stress-resistant," allowing each herb to perform its specific function to jointly achieve the goal of improving the survival rate of piglets after weaning and promoting their growth and development.

[0058] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for improving the survival rate of piglets, characterized in that, The ingredients include the following parts by weight: Forsythia suspensa 6-10 parts, Isatis indigotica 15-22 parts, Scutellaria baicalensis 15-22 parts, Lonicera japonica 8-12 parts, Taraxacum mongolicum 5-8 parts, Atractylodes macrocephala 10-15 parts, Poria cocos 8-12 parts, Dioscorea opposita 6-10 parts, Astragalus membranaceus 12-18 parts, Bupleurum chinense 8-12 parts, Glycyrrhiza uralensis 5-8 parts, and Ziziphus jujuba var. spinosa 3-6 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The ingredients include the following parts by weight: Forsythia 7-9 parts, Isatis root 17-20 parts, Scutellaria baicalensis 17-20 parts, Honeysuckle 9-11 parts, Dandelion 5.5-7 parts, Atractylodes macrocephala 11-14 parts, Poria cocos 9-11 parts, Dioscorea opposita 7-9 parts, Astragalus membranaceus 14-16 parts, Bupleurum chinense 9-11 parts, Licorice 5.5-7 parts, and Ziziphus jujuba var. spinosa 3.5-5 parts.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The ingredients include the following parts by weight: Forsythia 8 parts, Isatis root 18 parts, Scutellaria baicalensis 18 parts, Honeysuckle 10 parts, Dandelion 6 parts, Atractylodes macrocephala 12 parts, Poria cocos 10 parts, Dioscorea opposita 8 parts, Astragalus membranaceus 15 parts, Bupleurum chinense 10 parts, Glycyrrhiza uralensis 6 parts, and Ziziphus jujuba var. spinosa 4 parts.

4. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: (1) Mix the raw materials to obtain a mixture; (2) Mix the mixture with water, decoct 1 to 3 times, filter, collect and combine the filtrates, concentrate and dry to obtain the traditional Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that, The mass ratio of the mixture to water is 1:7~10, the boiling time is 20~40 minutes each time, and the sieve used for filtration has a mesh size of 80~120 mesh.

6. The use of the traditional Chinese medicine composition according to any one of claims 1 to 3 or the traditional Chinese medicine composition obtained by the preparation method according to claim 4 or 5 in the preparation of feed to improve the survival rate of piglets.

7. The application according to claim 6, characterized in that, The amount of the traditional Chinese medicine composition added is 0.5% to 10% of the total feed mass.

8. The use of the traditional Chinese medicine composition according to any one of claims 1 to 3 or the traditional Chinese medicine composition obtained by the preparation method according to claim 4 or 5 in the preparation of a formulation to improve the survival rate of piglets.

9. The application according to claim 8, characterized in that, The method of using the preparation is as follows: add the traditional Chinese medicine composition to the drinking water of piglets, and the final concentration of the preparation is 50~80mg / L.

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