Sugar-free decocted extract as well as preparation method and application thereof

Abstract

The invention provides a sugar-free decocted extract as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. Radix asparagi, radix ophiopogonis, prepared rehmannia root, Chinese yam, radix achyranthis bidentatae, rehmannia root, folium cortex eucommiae, prepared polygonum multiflorum, poria cocos, ginseng, radix aucklandiae, semen boitae, schisandra chinensis, rhizoma cibotii, pepper, rhizoma alismatis, rhizoma acori graminei, polygala tenuifolia, semen cuscutae, fructus rosae laevigatae, fructus lycii, raspberry and cortex lycii radicis are decocted with water for three times; combining the decoction, and filtering; concentrating the filtrate, standing for 24 hours, taking supernate, concentrating to obtain clear paste, adding beta-cyclodextrin which is 5%-10% of the weight of the clear paste, and stirring the clear paste and the beta-cyclodextrin at 50-60 DEG C for 1-2 hours at the temperature of 50-60 DEG C; the weight of the xylitol is 2-3 times that of the clear paste, the weight of the sodium carboxymethyl cellulose is 1-3% that of the clear paste, the mixture is stirred at the temperature of 50-60 DEG C until the oral thick paste is uniform in texture, then the paste is collected at the temperature of 80 + / -5 DEG C, and the sugar-free decocted paste is obtained and is sweet in taste, free of other peculiar smells, uniform in state and free of layering and caking.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a sugar-free decocted paste and a preparation method and application thereof. BACKGROUND

[0002] Changyishougao is a decocted paste with the functions of tonifying five internal organs, regulating yin and yang, benefiting qi and blood, and strengthening bones and muscles, and is suitable for physical weakness, premature senility, amnesia, palpitation, insomnia, dizziness, and soreness of waist and knees. The traditional preparation process of the decocted paste uses refined sugar or refined honey, and patients with diabetes should not take the decocted paste for a long time. For patients with diabetes or abnormal glucose tolerance, a sugar-free or low-sugar paste should be selected.

[0003] Xylitol is a natural sweetener with a sweetness equivalent to that of sucrose. At present, it has been confirmed that xylitol has many functions, such as stabilizing blood glucose, stimulating insulin secretion, improving lipid metabolism, improving oxidative stress, and improving kidney function. Xylitol is very similar to sucrose in appearance and taste, and has only 2.4 calories per gram. Due to its low energy value and blood glucose index, xylitol is a sweetener very popular among patients with diabetes. SUMMARY

[0004] The application solves the problems in the prior art, such as the use of refined sugar or refined honey, and the long-term use of the decocted paste by patients with diabetes.

[0005] The application provides a sugar-free decocted paste and a preparation method and application thereof. In the process of preparing the decocted paste, a sugar-free auxiliary material is innovatively selected instead of traditional auxiliary materials such as refined sugar and refined honey, so as to reduce the sugar content, expand the applicable population, and provide more choices for patients with diabetes while ensuring the curative effect.

[0006] To solve the problems in the prior art, the technical scheme adopted by the application is as follows. A preparation method of a sugar-free decocted paste, specifically comprising the following steps: Step 1: 10-30 parts of asparagus, 5-15 parts of ophiopogon, 30-50 parts of prepared rehmannia, 30-50 parts of Chinese yam, 10-30 parts of milkvetch root, 30-50 parts of raw rehmannia, 5-15 parts of eucommia leaf, 30-50 parts of prepared fleece-flower root, 30-50 parts of poria, 30-50 parts of ginseng, 30-50 parts of costus, 10-30 parts of plum seed, 10-30 parts of schisandra, 30-50 parts of dog spine, 30-50 parts of zanthoxylum, 30-50 parts of alisma, 30-50 parts of acorus, 30-50 parts of polygala, 15-20 parts of dodder, 15-20 parts of cherokee rose, 40-50 parts of medlar, 50-60 parts of raspberry, and 10-30 parts of psoralea are weighed according to the mass fraction. Second step: Asparagus, Ophiopogon, Rehmannia, Chinese yam, Cyathula, Rehmannia, Eucommia leaf, prepared Radix Polygoni Multiflori, Poria cocos, ginseng, costus, Platycladus branchlet and seed, dog spine, pepper, Alisma, Acorus, milkvetch, rose hips, wolfberry, raspberry and Colla Corii Asini are decocted three times, and the decoction is combined and filtered; Third step: The filtrate is concentrated to 60℃ relative density of 1.05~1.10, and is placed at 2-8℃ for 24 hours. The supernatant is taken and concentrated to 60℃ relative density of 1.31~1.40 clear paste; Fourth step: β-cyclodextrin is added at 5%-10% of the weight of the clear paste, and the clear paste and β-cyclodextrin are stirred at 50-60℃ for 1-2 hours. Then, 2-3 times the amount of xylitol and 1-3% of sodium carboxymethyl cellulose of the weight of the clear paste are added, and the paste is stirred at 50-60℃ until the paste is uniform in texture. Then, the paste is collected at 80±5℃ to obtain a sugar-free decoction paste.

[0007] Preferably, the Polygala is fried Polygala.

[0008] Preferably, the Asparagus, Ophiopogon, Rehmannia, Chinese yam, Cyathula, Rehmannia, Eucommia leaf, prepared Radix Polygoni Multiflori, Poria cocos, ginseng, costus, Platycladus branchlet and seed, dog spine, pepper, Alisma, Acorus, milkvetch, rose hips, wolfberry, raspberry and Colla Corii Asini are all traditional Chinese medicine decoction pieces.

[0009] Preferably, the three times of decoction are as follows: 8-10 times the amount of water is added, and the mixture is boiled with a large fire, then is kept boiling with a small fire, and is decocted for 40-60 min. The decocted liquid is filtered out, 6-8 times the amount of hot water is added to the residue, and the mixture is decocted for 20-30 min. The decocted liquid is filtered out, 6-8 times the amount of hot water is added to the residue, and the mixture is decocted for 15-25 min.

[0010] Preferably, the paste is collected to a relative density of 1.312~1.425.

[0011] Preferably, the amount of β-cyclodextrin is 5% of the weight of the clear paste, the amount of xylitol is 2 times the weight of the clear paste, and the amount of sodium carboxymethyl cellulose is 1% of the weight of the clear paste.

[0012] Preferably, the amount of β-cyclodextrin is 7% of the weight of the clear paste, the amount of xylitol is 2.5 times the weight of the clear paste, and the amount of sodium carboxymethyl cellulose is 2% of the weight of the clear paste.

[0013] Preferably, the amount of β-cyclodextrin is 10% of the weight of the clear paste, the amount of xylitol is 3 times the weight of the clear paste, and the amount of sodium carboxymethyl cellulose is 3% of the weight of the clear paste.

[0014] A sugar-free decoction paste prepared by any of the above preparation methods.

[0015] The application also discloses application of the sugar-free decoction paste prepared by any of the above preparation methods in preparation of a health care product for benefiting qi and tonifying blood.

[0016] The original explanation: As the inclusion agent, beta-cyclodextrin can include the bitter components and volatile oil in traditional Chinese medicine; The sweetener xylitol not only meets the sugar control requirement, but also neutralizes the slight medicine taste that is not completely covered by the inclusion agent, so that the decoction paste is sweet and easy to take; As the excipient, sodium carboxymethyl cellulose enhances the viscosity, avoids the stratification of the decoction paste after standing, and facilitates the sub-packaging and taking.

[0017] Compared with the prior art, the sugar-free decoction paste and the preparation method and application thereof have the following beneficial effects: 1. The decoction paste obtained by the application is sweet and has no other odor, and is brownish yellow; 2. The preparation process is simple and the quality is controllable, and it can nourish five internal organs, regulate yin and yang, benefit qi and blood, and strengthen bones and muscles; 3. It does not contain sucrose, is suitable for patients with high blood sugar and high blood fat, expands the applicable population, and is suitable for people with physical weakness, palpitation, insomnia, dizziness and dizziness, and soreness of the waist and knees.

[0018] BRIEF DESCRIPTION OF DRAWINGS Figure 1 It is the preparation method flow chart of the sugar-free decoction paste of the application. DETAILED DESCRIPTION

[0019] The application will be further described in detail through specific examples, but it is not limited thereto.

[0020] Example 1, a preparation method of a sugar-free decoction paste, specifically comprising the following steps: First step: according to the mass fraction, take 10 parts of asparagus, 5 parts of ophiopogon, 30 parts of prepared rehmannia, 30 parts of yam, 10 parts of cow's knee, 30 parts of raw rehmannia, 5 parts of eucommia leaf, 30 parts of prepared radix polygoni multiflori, 30 parts of poria cocos, 30 parts of ginseng, 30 parts of costus, 10 parts of cypress seed, 10 parts of schisandra chinensis, 30 parts of dog spine, 30 parts of zedoary, 30 parts of aconite, 30 parts of aconite, 30 parts of aconite, 15 parts of pharbitis, 15 parts of cherokee rose, 40 parts of medlar, 50 parts of raspberry and 10 parts of psoralea; Second step: add 8-10 times the amount of water to asparagus, ophiopogon, prepared rehmannia, yam, cow's knee, raw rehmannia, eucommia leaf, prepared radix polygoni multiflori, poria cocos, ginseng, costus, cypress seed, schisandra chinensis, dog spine, zedoary, aconite, aconite, aconite, pharbitis, cherokee rose, medlar and psoralea, first boil with a large fire, then keep boiling with a small fire, decoct for 40-60 min, filter the decocted liquid, add 6-8 times the amount of hot water to the dregs, decoct for 20-30 min again, filter the decocted liquid, add 6-8 times the amount of hot water to the dregs, decoct for 15-25 min again, and combine the decocted liquid and filter it; Third step: concentrate the filtrate to 60 DEG C relative density 1.05~1.10, stand for 24 hours at 2-8 DEG C, take the supernatant, and concentrate to 60 DEG C relative density 1.31~1.40 clear paste; Fourth step: add β-cyclodextrin according to 5% of the weight of the clear paste, and keep the clear paste and β-cyclodextrin at 50-60°C and stir for 1-2 hours; then add 2 times the amount of xylitol of the weight of the clear paste, and 1% sodium carboxymethyl cellulose of the weight of the clear paste, and stir at 50-60°C until the paste is uniform in texture, and then collect the paste at 80±5°C to a relative density of 1.312-1.425, to obtain the sugar-free decocted paste.

[0021] Shanzhai is fried Shanzhai, and the asparagus, ophiopogon, prepared rehmannia, Chinese yam, cow knee, radix rehmanniae, eucommia leaf, prepared fo-ti-tung, tuckahoe, ginseng, costus, cypress seed, schisandra, dog spine, zanthoxylum, alisma, acorus, shanzhai, dodder, cherry, medlar and psoralea are all traditional Chinese medicine decoction pieces, and the sugar-free decocted paste can be used for preparing health-care products for benefiting qi and tonifying blood.

[0022] Example 2, a method for preparing a sugar-free decocted paste, specifically comprising the following steps: First step: take asparagus 30 parts, ophiopogon 15 parts, prepared rehmannia 50 parts, Chinese yam 50 parts, cow knee 30 parts, radix rehmanniae 50 parts, eucommia leaf 15 parts, prepared fo-ti-tung 50 parts, tuckahoe 50 parts, ginseng 50 parts, costus 50 parts, cypress seed 30 parts, schisandra 30 parts, dog spine 50 parts, zanthoxylum 50 parts, alisma 50 parts, acorus 50 parts, shanzhai 50 parts, dodder 20 parts, cherry 20 parts, medlar 50 parts, and psoralea 60 parts and psoralea 30 parts according to the mass fraction; Second step: add 8-10 times the amount of water to the asparagus, ophiopogon, prepared rehmannia, Chinese yam, cow knee, radix rehmanniae, eucommia leaf, prepared fo-ti-tung, tuckahoe, ginseng, costus, cypress seed, schisandra, dog spine, zanthoxylum, alisma, acorus, shanzhai, dodder, cherry, medlar, and psoralea, boil with a large fire first, and then maintain a slight boil with a small fire, decoct for 40-60 min, filter out the decocted liquid, add 6-8 times the amount of hot water to the dregs, decoct for 20-30 min again, filter out the decocted liquid, add 6-8 times the amount of hot water to the dregs, decoct for 15-25 min again, and combine the decocted liquids and filter them; Third step: concentrate the filtrate to a relative density of 1.05-1.10 at 60°C, stand still at 2-8°C for 24 hours, take the supernatant, and concentrate to a clear paste with a relative density of 1.31-1.40 at 60°C; Fourth step: add β-cyclodextrin according to 5% of the weight of the clear paste, and keep the clear paste and β-cyclodextrin at 50-60°C and stir for 1-2 hours; then add 2 times the amount of xylitol of the weight of the clear paste, and 1% sodium carboxymethyl cellulose of the weight of the clear paste, and stir at 50-60°C until the paste is uniform in texture, and then collect the paste at 80±5°C to a relative density of 1.312-1.425, to obtain the sugar-free decocted paste.

[0023] Radix Polygalae is Radix Polygalae Praeparata, and the asparagus, the ophiopogon, the prepared rehmannia, the Chinese yam, the cow kneecap, the rehmannia, the eucommia leaf, the prepared fleece-flower root, the poria, the ginseng, the costus, the bark of the cypress tree, the schisandra, the dog spine, the pepper, the alisma, the acorus, the Radix Polygalae, the dodder seed, the gold cherry, the medlar seed, the raspberry and the periploca are all pieces of traditional Chinese medicine.

[0024] Embodiment 3, a preparation method of a sugar-free decoction, specifically comprising the following steps: The first step: according to the mass fraction, asparagus 20 parts, ophiopogon 10 parts, prepared rehmannia 40 parts, Chinese yam 40 parts, cow kneecap 20 parts, raw rehmannia 40 parts, eucommia leaf 10 parts, prepared fleece-flower root 40 parts, poria 40 parts, ginseng 40 parts, costus 40 parts, bark of the cypress tree 20 parts, schisandra 20 parts, dog spine 40 parts, pepper 40 parts, alisma 40 parts, aconite 40 parts, Radix Polygalae 40 parts, dodder seed 17 parts, gold cherry 17 parts, medlar seed 44 parts, raspberry 54 parts and periploca 20 parts are weighed; The second step: asparagus, ophiopogon, prepared rehmannia, Chinese yam, cow kneecap, raw rehmannia, eucommia leaf, prepared fleece-flower root, poria, ginseng, costus, bark of the cypress tree, schisandra, dog spine, pepper, alisma, aconite, Radix Polygalae, dodder seed, gold cherry, medlar seed, raspberry and periploca are added with 8-10 times the amount of water, first boiled with a large fire, then kept boiling with a small fire, decocted for 40-60 min, the decocted liquid is filtered out, 6-8 times the amount of hot water is added to the dregs, decocted for 20-30 min again, the decocted liquid is filtered out, 6-8 times the amount of hot water is added to the dregs, decocted for 15-25 min again, and the decocted liquids are combined and filtered. The third step: the filtrate is concentrated to 60℃ relative density 1.05~1.10, 2-8℃ for 24 hours, the supernatant is taken, and the clear paste is concentrated to 60℃ relative density 1.31~1.40. The fourth step: 10% of the weight of the clear paste is added with β-cyclodextrin, and the clear paste and β-cyclodextrin are stirred at 50-60℃ for 1-2 hours; then 3 times the weight of the clear paste is added with xylitol, and 3% of the weight of the clear paste is added with carboxymethyl cellulose sodium, and the paste is stirred at 50-60℃ until the paste is uniform in texture, and then the paste is collected at 80±5℃ to relative density 1.312~1.425, to obtain a sugar-free decoction.

[0025] Radix Polygalae is Radix Polygalae Praeparata, and the asparagus, the ophiopogon, the prepared rehmannia, the Chinese yam, the cow kneecap, the rehmannia, the eucommia leaf, the prepared fleece-flower root, the poria, the ginseng, the costus, the bark of the cypress tree, the schisandra, the dog spine, the pepper, the alisma, the aconite, the Radix Polygalae, the dodder seed, the gold cherry, the medlar seed, the raspberry and the periploca are all pieces of traditional Chinese medicine.

[0026] The decoction prepared according to the above embodiment is sweet and has no other odor, and is uniform in state without stratification and caking, and meets the requirements, and the detection data are shown in Table 1.

[0027] .

[0028] The embodiments described above are only part of the embodiments of the present application, rather than all the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but only to represent selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor are within the scope of protection of the present application.

Claims

1. A process for the preparation of a sugarless electuary, characterized in that, Specifically comprising the following steps: The first step: according to the mass fraction of the proportion of asparagus 10-30 parts, ophiopogon 5-15 parts, prepared rehmannia 30-50 parts, Chinese yam 30-50 parts, radix paeoniae 10-30 parts, raw rehmannia 30-50 parts, eucommia leaf 5-15 parts, prepared rehmannia 30-50 parts, poria cocos 30-50 parts, ginseng 30-50 parts, costus 30-50 parts, platycladus seed 10-30 parts, schisandra 10-30 parts, dog spine 30-50 parts, zanthoxylum 30-50 parts, alisma 30-50 parts, acorus 30-50 parts, polygala 30-50 parts, semen astragali 15-20 parts, cherokee cherry 15-20 parts, medlar 40-50 parts, raspberry 50-60 parts and periploca 10-30 parts; The second step: asparagus, ophiopogon, prepared rehmannia, Chinese yam, radix paeoniae, raw rehmannia, eucommia leaf, prepared rehmannia, poria cocos, ginseng, costus, platycladus seed, schisandra, dog spine, zanthoxylum, alisma, acorus, polygala, semen astragali, cherokee cherry, medlar, raspberry and periploca were added with water and decocted three times, the decoction was combined and filtered; The third step: the filtrate was concentrated to 60℃ relative density 1.05~1.10, 2-8℃ for 24 hours, the supernatant was taken, and the clear paste was concentrated to 60℃ relative density 1.31~1.40; The fourth step: according to the weight of the clear paste 5%-10% added β-cyclodextrin, the clear paste and β-cyclodextrin were heated and stirred at 50-60℃ for 1-2 hours; then 2-3 times the amount of xylitol and 1-3% carboxymethyl cellulose sodium were added, and the paste was stirred at 50-60℃ until the paste was uniform in texture, then the paste was collected at 80±5℃, and the sugar-free decoction was obtained.

2. A process for the preparation of a sugarless decoction according to claim 1, characterized in that, The polygala is fried polygala.

3. The process for the preparation of sugar-free decoction as claimed in claim 1 wherein, The asparagus, ophiopogon, prepared rehmannia, Chinese yam, radix paeoniae, raw rehmannia, eucommia leaf, prepared rehmannia, poria cocos, ginseng, costus, platycladus seed, schisandra, dog spine, zanthoxylum, alisma, acorus, polygala, semen astragali, cherokee cherry, medlar, raspberry and periploca are all traditional Chinese medicine decoction pieces.

4. The process as claimed in claim 1, wherein the sugarless decoction is prepared by, The three times of decoction is specifically adding 8-10 times the amount of water, boiling with large fire first, then keeping boiling with small fire, decocting for 40-60min, filtering out the decoction, adding 6-8 times the amount of hot water to the dregs, decocting for 20-30min again, filtering out the decoction, adding 6-8 times the amount of hot water to the dregs, decocting for 15-25min again.

5. The process as claimed in claim 1, wherein the sugarless decoction is prepared by, The paste is collected to relative density 1.312~1.

425.

6. The process as claimed in claim 1, wherein the sugarless decoction is prepared by, The β-cyclodextrin is used in an amount of 5% of the weight of the clear paste, xylitol is 2 times the weight of the clear paste, and carboxymethyl cellulose sodium is 1% of the weight of the clear paste.

7. The process as claimed in claim 1, wherein the sugarless decoction is prepared by, The β-cyclodextrin is used in an amount of 7% of the weight of the clear paste, xylitol is 2.5 times the weight of the clear paste, and carboxymethyl cellulose sodium is 2% of the weight of the clear paste.

8. The process as claimed in claim 1, wherein the sugarless decoction is prepared by, The β-cyclodextrin is used in an amount of 10% of the weight of the clear paste, xylitol is 3 times the weight of the clear paste, and carboxymethyl cellulose sodium is 3% of the weight of the clear paste.

9. A sugar-free decoction prepared by the preparation method of any one of claims 1-8.

10. The use of a sugar-free decoction prepared by the preparation method of any one of claims 1-8 in the preparation of a health care product for tonifying qi and blood.

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