Polyurethane pressure-sensitive adhesive and preparation method thereof

Abstract

The invention discloses a polyurethane pressure-sensitive adhesive and a preparation method thereof. The polyurethane pressure-sensitive adhesive comprises the following raw materials in percentage by weight: a) 10-40% of polyisocyanate, b) 45-85% of polyether polyol, c) 0-20% of a chain extender, d) 2-20% of glycolipid, e) 0.5-4% of a curing agent, f) 0.02-0.2% of a catalyst and g) 0-20% of a functional component. The polyurethane pressure-sensitive adhesive is modified by utilizing glycolipid, the initial viscosity, the adhesive force and the cohesive force of the polyurethane pressure-sensitive adhesive are regulated and controlled by regulating and controlling the content and the structure of the glycolipid, and meanwhile, the existence of the glycolipid can regulate and control the drug loading property of the pressure-sensitive adhesive, regulate and control the drug absorption of an organism, and promote drug permeation and wound healing.

Description

Technical Field

[0001] This invention belongs to the field of polymer material preparation technology and application, specifically relating to a polyurethane pressure-sensitive adhesive and its preparation method. Background Technology

[0002] Transdermal drug delivery systems are an emerging field in pharmaceutics, utilizing the skin as a drug delivery route to allow drugs to enter the systemic circulation at a constant rate and duration. Transdermal drug delivery systems can avoid the first-pass effect of the liver and the influence of gastrointestinal factors, reduce individual differences in drug administration, require fewer dosing sessions, maintain a constant effective blood drug concentration, and reduce toxic side effects.

[0003] Pressure-sensitive adhesive (PSA) is a type of adhesive that bonds firmly to substrates without the need for solvents or heating, requiring only the application of light pressure. PSA is easy to apply, easy to remove, and does not damage the substrate. Medical PSA is an ideal transdermal release adhesive for transdermal drug delivery systems and plays an important role in the efficacy of transdermal drug delivery formulations.

[0004] Currently, polyisopropyl, silicone rubber, and polyacrylate-based pressure-sensitive adhesives are traditionally used for transdermal drug delivery. However, these three types of pressure-sensitive adhesives suffer from poor water vapor permeability, low adhesive strength, poor hydrophilicity, and low drug loading capacity. Compared with traditional medical pressure-sensitive adhesives, polyurethane pressure-sensitive adhesives have advantages such as strong hydrophilicity, good air permeability, and low sensitization, making them the preferred pressure-sensitive adhesive material.

[0005] The initial tack of polyurethane pressure-sensitive adhesives (PPAs) is related to the structure and content of soft segments in the polyurethane structure, while cohesion is closely related to its hard segment structure. However, existing PAs achieve better initial tack by increasing the molecular weight or content of the soft segments, but this increase leads to a decrease in the proportion of hard segments, resulting in less significant phase separation and poor elasticity. Conversely, increasing cohesion often reduces initial tack. Therefore, the balance between initial tack, adhesion, and cohesion limits its application in transdermal drug delivery systems. Furthermore, to promote drug release, penetration enhancers are often added to PAs, which further affects their adhesion.

[0006] Therefore, how to create a polyurethane pressure-sensitive adhesive with good initial tack and strong adhesion is a problem that urgently needs to be solved in the industry. Summary of the Invention

[0007] To address the problems existing in the prior art, this invention provides a polyurethane pressure-sensitive adhesive and its preparation method.

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] A polyurethane pressure-sensitive adhesive, comprising the following raw materials in weight percentages:

[0010] a) 10-40% polyisocyanate, preferably 15-30%;

[0011] b) 45%–85% polyether polyol, preferably 55%–78%;

[0012] c) Chain extender 0-20%, preferably 0-10%;

[0013] d) Glycolipids 2%–20%, preferably 4%–15%;

[0014] e) 0.5% to 4% curing agent, preferably 0.5% to 2%;

[0015] f) Catalyst 0.02% to 0.2%, preferably 0.05% to 1.8%;

[0016] g) Functional components: 0%–20%, preferably 0.5%–10%.

[0017] In this invention, the polyisocyanate includes one or more of toluene diisocyanate, isophorone diisocyanate, diphenylmethane diisocyanate, 4,4'-dicyclohexylmethane diisocyanate, hexamethylene diisocyanate, terephthalic diisocyanate, naphthalene diisocyanate, 1,4-cyclohexane diisocyanate, phenylenediamine diisocyanate, cyclohexanediamine diisocyanate, trimethyl-1,6-hexamethylene diisocyanate, tetramethyl-isophthalic acid diisocyanate, and dimethyl diphenylmethane diisocyanate; the polyether polyol includes one or more of polyethylene glycol and polypropylene glycol.

[0018] In this invention, the chain extender comprises a small molecule diol, preferably one or more of propylene glycol, butanediol, and pentanediol; the catalyst is one or more of an organic bismuth catalyst, an amine catalyst, or a triazine trimer catalyst, preferably one or more combinations of bismuth isooctanoate, dimethylaminoethyl ether, pentamethyldiethylenetriamine, bismuth neodecanoate (DY-20), and triazine trimer catalysts; and the curing agent comprises one or more of isocyanate trimers and amino resins, preferably one or more of hexamethylene diisocyanate trimers, toluene diisocyanate trimers, and amino resins.

[0019] In this invention, the solvent includes one or more of ethyl acetate, acetone, 1,4-butanediol, and 1,3-butanediol, and the functional components include one or more of collagen, polypeptides, and amino acids.

[0020] In this invention, the glycolipid is a glycolipid that has not been neutralized by alkaline substances (such as KOH, NaOH, arginine).

[0021] In this invention, the glycolipid is selected from one or more of rhamnolipid, sophorolipid, and mannosyl erythritol lipolipid, with rhamnolipid being preferred.

[0022] This invention also provides a method for preparing the polyurethane pressure-sensitive adhesive, comprising the following steps:

[0023] 1) Isocyanate, polyether polyol and catalyst are mixed and reacted to obtain polyurethane prepolymer;

[0024] 2) Add glycolipids and optional chain extenders to the polyurethane prepolymer and react to obtain glycolipid-modified polyurethane pressure-sensitive adhesive raw material A.

[0025] 3) Add curing agent and optional functional components to raw material A of glycerol-modified polyurethane pressure-sensitive adhesive, mix evenly, apply to release film, and cool to room temperature to obtain glycerol-modified polyurethane pressure-sensitive adhesive;

[0026] Preferably, the reaction temperature in step 1) is 70-90℃.

[0027] Preferably, the reaction temperature in step 2) is 45-65℃ and the reaction time is 2-5h.

[0028] In this invention, the glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive has adjustable initial tack, adhesive strength, cohesive strength, and the ability to promote drug penetration in wounds.

[0029] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0030] This invention utilizes glycolipids with different structures to modify polyurethane pressure-sensitive adhesives. Since the glycolipid structure includes sugar ring structures and saturated or unsaturated fatty acid portions with different carbon chain lengths, the selection of the glycolipid structure and the control of the pressure-sensitive adhesive structure content can be achieved by choosing the sugar ring content and fatty acid chain length, thereby regulating the initial tack, adhesion, and cohesion of the polyurethane pressure-sensitive adhesive. Because the glycolipid selected in this patent possesses the aforementioned structure, when used as a chain extender and crosslinking agent in the polyurethane pressure-sensitive adhesive, it can both increase the soft segment content and improve initial tack while maintaining good phase separation, thus maintaining or improving cohesion. This solves the problem of the contradiction between initial tack and cohesion in the prior art, and pressure-sensitive adhesives suitable for different scenarios can be obtained by controlling the structure.

[0031] The glycolipids selected in this invention have a cellular phospholipid-like structure, which can alter cell membrane permeability by inserting into the cellular phospholipid bilayer, thereby promoting drug penetration into cells. This avoids the decrease in mechanical properties of the pressure-sensitive adhesive caused by the introduction of penetration enhancers. Furthermore, compared with existing technologies that add penetration enhancers, glycolipid-modified pressure-sensitive adhesives better promote the absorption of drugs by cells. Detailed Implementation

[0032] The present invention will be further illustrated below with reference to specific embodiments. It should be understood that the following specific embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention.

[0033] Unless otherwise specified, the raw materials or equipment used in the following examples or comparative examples are commercially available or prepared in-house:

[0034] Rhamnolipids, as used in the embodiments and comparative examples of this invention, refer to the product obtained by separating and purifying the concentrated fermentation broth produced by Pseudomonas aeruginosa fermentation. The preparation process is as follows:

[0035] Rhamnolipid fermentation broth: First, *Pseudomonas aeruginosa* was inoculated onto a solid culture medium using the streak plate method to activate the strain. Then, a single colony was picked from the activated strain and inoculated into a seed culture medium (composed of: 10.0 g / L peptone, 5.0 g / L yeast extract, and 10.0 g / L NaCl), and cultured at 30°C for 6 hours to obtain the seed culture. The seed culture was then inoculated into a fermentation medium (composed of: 5 g / L yeast extract, 5 g / L urea, 10 g / L sodium nitrate, 4 g / L Na₂HPO₄, 4 g / L KH₂PO₄, 0.4 g / L CaCl₂, and 2 g / L MgSO₄) at an inoculation rate of 1-10 vol% to obtain the rhamnolipid fermentation broth.

[0036] Separation and purification: The rhamnolipin fermentation broth was centrifuged at 6000 rpm for 15 min, the supernatant was collected, and 38 wt.% concentrated hydrochloric acid was added to adjust the pH to 1.5-2.0. The mixture was then allowed to stand at 4℃ for 24 h, and centrifuged again at 6000 rpm for 10 min to collect the precipitate. The precipitate was mixed with 3 times its volume of methanol, filtered through a 30000 Da ultrafiltration membrane, and the filtrate was collected. The methanol was then removed by rotary evaporation at 70℃ for 3 h to obtain a paste. The paste was mixed with an equal volume of water, and the pH was adjusted to above 6.0 with 3M sodium hydroxide aqueous solution. The mixture was stirred and dissolved for 2 h, pre-frozen at -80℃ for 3 h, and then freeze-dried at -86℃ for 48 h to obtain rhamnolipin.

[0037] Sophorolipase, SOFOBOTON TM Sophorolipids, Boton Bio

[0038] Mannosyl erythritol ester, Toyobo Corporation

[0039] Isocyanates, TDI-80, Wanhua Chemical

[0040] Polyether, PEG1000A, Wanhua Chemical

[0041] Chain extender, 1,3-butanediol, Sigma-Aldrich

[0042] hardener, 6856F, Wanhua Chemical

[0043] Solvent, ethyl acetate, Sigma-Aldrich

[0044] Catalyst, DY-20, Shanghai Deyin Chemical Co., Ltd.

[0045] Collagen, Bloomcolla TM Recombinant humanized type III collagen (“COL3-MD”), Bloomage Biotechnology

[0046] Example 1

[0047] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0048] a) Polyisocyanate: TDI-80, 20 g;

[0049] b) Polyether polyol: PEG1000, 77.5 g

[0050] c) Glycolipids: Unneutralized rhamnolipids, 6 g

[0051] d) Curing agent: 6856F, 1g

[0052] e) Catalyst: DY-20, 0.5 g

[0053] f) Collagen: Bloomcolla TM Recombinant type III humanized collagen, 5 g

[0054] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0055] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 80°C to obtain polyurethane prepolymer;

[0056] b) After the temperature of the polyurethane prepolymer drops to 60°C, add the glycolipid and react for 3 hours to obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0057] c) Add curing agent and collagen to material A, stir for 30 minutes, scrape onto release film, cool to room temperature, and obtain glycolipid modified wound healing polyurethane pressure-sensitive adhesive.

[0058] Example 2

[0059] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0060] a) Polyisocyanate: TDI-80, 30g;

[0061] b) Polyether polyol: PEG1000, 58g

[0062] c) Glycolipids: Unneutralized rhamnolipids, 13g

[0063] d) Curing agent: 6856F, 1g

[0064] e) Catalyst: DY-20, 0.5g

[0065] f) Collagen: Bloomcolla TM Recombinant Type III humanized collagen, 5g

[0066] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0067] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 90°C to obtain polyurethane prepolymer;

[0068] b) After the temperature of the polyurethane prepolymer drops to 45°C, add the glycolipid and react for 5 hours to obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0069] c) Add curing agent and collagen to material A, stir for 20 minutes, coat onto release film, and cool to room temperature to obtain glycolipid-modified drug-permeable polyurethane pressure-sensitive adhesive.

[0070] Example 3

[0071] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0072] a) Polyisocyanate: TDI-80, 25g;

[0073] b) Polyether polyol: PEG1000, 71g

[0074] c) Glycolipids: Unneutralized rhamnolipids, 8g

[0075] d) Curing agent: 6856F, 1g

[0076] e) Catalyst: DY-20, 0.5g

[0077] f) Collagen: Bloomcolla TM Recombinant Type III humanized collagen, 5g

[0078] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0079] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 70°C to obtain polyurethane prepolymer;

[0080] b) After the temperature of the polyurethane prepolymer drops to 55°C, add the glycolipid and react for 4 hours to obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0081] c) Add curing agent and collagen to material A, stir for 30 minutes, coat onto release film, and cool to room temperature to obtain glycolipid-modified drug-permeable polyurethane pressure-sensitive adhesive.

[0082] Example 4

[0083] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0084] a) Polyisocyanate: TDI-80, 30g;

[0085] b) Polyether polyol: PEG1000, 58g

[0086] c) Chain extender: 1,3-Butanediol, 6g

[0087] d) Glycolipids: Unneutralized rhamnolipids, 8g

[0088] e) Curing agent: 6856F, 1g

[0089] f) Catalyst: DY-20, 0.5g

[0090] g) Collagen: Bloomcolla TM Recombinant Type III humanized collagen, 5g

[0091] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0092] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 80°C to obtain polyurethane prepolymer;

[0093] b) After the temperature of the polyurethane prepolymer drops to 55°C, add glycolipids and chain extenders, react for 5 hours, and obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0094] c) Add curing agent and collagen to material A, stir for 30 minutes, coat onto release film, and cool to room temperature to obtain glycolipid-modified drug-permeable polyurethane pressure-sensitive adhesive.

[0095] Example 5

[0096] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0097] a) Polyisocyanate: TDI-80, 30g;

[0098] b) Polyether polyol: PEG1000, 58g

[0099] c) Chain extender: 1,3-Butanediol, 4g

[0100] d) Glycolipids: Unneutralized rhamnolipids, 9g

[0101] e) Curing agent: 6856F, 1g

[0102] f) Catalyst: DY-20, 0.5g

[0103] g) Collagen: Bloomcolla TM Recombinant Type III humanized collagen, 5g

[0104] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0105] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 80°C to obtain polyurethane prepolymer;

[0106] b) After the temperature of the polyurethane prepolymer drops to 55°C, add glycolipids and chain extenders, react for 5 hours, and obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0107] c) Add curing agent and collagen to material A, stir for 30 minutes, coat onto release film, and cool to room temperature to obtain glycolipid-modified drug-permeable polyurethane pressure-sensitive adhesive.

[0108] Example 6

[0109] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0110] a) Polyisocyanate: TDI-80, 30g;

[0111] b) Polyether polyol: PEG1000, 58g

[0112] c) Glycolipids: Unneutralized rhamnolipids, 13g

[0113] d) Curing agent: 6856F, 1g

[0114] e) Catalyst: DY-20, 0.5g

[0115] f) Collagen: BloomcollaTM Recombinant type III humanized collagen, 1g

[0116] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0117] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 80°C to obtain polyurethane prepolymer;

[0118] b) After the temperature of the polyurethane prepolymer drops to 55°C, add the glycolipid and react for 5 hours to obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0119] c) Add curing agent and collagen to material A, stir for 30 minutes, coat onto release film, and cool to room temperature to obtain glycolipid-modified drug-permeable polyurethane pressure-sensitive adhesive.

[0120] Example 7

[0121] 1. A glycolipid-modified polyurethane pressure-sensitive adhesive for promoting wound healing was prepared. The raw materials were:

[0122] a) Polyisocyanate: TDI-80, 30g;

[0123] b) Polyether polyol: PEG1000, 58g

[0124] c) Glycolipids: Unneutralized rhamnolipids, 13g

[0125] d) Curing agent: 6856F, 1g

[0126] e) Catalyst: DY-20, 0.5g

[0127] f) Collagen: Bloomcolla TM Recombinant Type III humanized collagen, 8g

[0128] 2. Glycolipid-modified wound-healing polyurethane pressure-sensitive adhesive, the steps are as follows:

[0129] a) Add solvent and isocyanate to a reaction vessel, then gradually add polyether polyol and catalyst, and heat to 80°C to obtain polyurethane prepolymer;

[0130] b) After the temperature of the polyurethane prepolymer drops to 55°C, add the glycolipid and react for 5 hours to obtain glycolipid-modified polyurethane pressure-sensitive adhesive A.

[0131] c) Add curing agent and collagen to material A, stir for 30 minutes, coat onto release film, and cool to room temperature to obtain glycolipid-modified drug-permeable polyurethane pressure-sensitive adhesive.

[0132] Example 8

[0133] The polyurethane pressure-sensitive adhesive material was prepared using the same method as in Example 7, except that the added glycolipid was replaced with unneutralized sophorolipid.

[0134] Example 9

[0135] The polyurethane pressure-sensitive adhesive material was prepared using the same method as in Example 7, except that the added glycolipid was replaced with unneutralized mannosyl erythritol ester.

[0136] Comparative Example 1

[0137] The polyurethane pressure-sensitive adhesive material was prepared using the same method as in Example 1, except that no glycolipids were added and the amount of 1,3-butanediol added was 4g.

[0138] Comparative Example 2

[0139] The polyurethane pressure-sensitive adhesive material was prepared using the same method as in Example 2, except that no glycolipids were added and the amount of 1,3-butanediol added was 9g.

[0140] Comparative Example 3

[0141] The polyurethane pressure-sensitive adhesive material was prepared using the same method as in Example 3, except that no glycolipids were added and the amount of 1,2-pentanediol added was 6g.

[0142] Comparative Example 4

[0143] The polyurethane pressure-sensitive adhesive material was prepared using the same method as in Example 6, except that no collagen was added.

[0144] The polyurethane pressure-sensitive adhesives prepared in the examples and comparative examples were tested for adhesion strength and wound healing time. The testing methods are as follows:

[0145] 1) Initial tack test: in accordance with GB 4852-2002.

[0146] 2) Adhesion test: in accordance with GB 2792-2014.

[0147] 3) Holding power test: in accordance with GB 4851-2014.

[0148] 4) Wound healing time test: Make a wound about 0.5cm long and 2mm deep on the back of the mouse, apply the material to the wound surface, and test the wound healing time.

[0149] Table 1. Physical properties of the rapid hemostatic and wound-healing materials prepared in the examples and comparative examples.

[0150] serial number Initial tack (ball number #) 180° peel strength (N) Holding power (h) Wound healing time (d) Example 1 16 8 8.5 8 Example 2 13 11.05 14.3 7 Example 3 15 8.89 9.8 8 Example 4 11 10.56 12.7 11 Example 5 12 10.89 13.4 9 Example 6 14 12.11 15 13 Example 7 12 10.86 12 5 Example 8 13 9.87 10.8 7 Example 9 14 8.45 9.9 8 Comparative Example 1 11 4.12 4.9 14 Comparative Example 2 6 10.34 12.4 14 Comparative Example 3 9 4.85 5.3 15 Comparative Example 4 14 11.05 14.7 17

[0151] A comparison of Examples 1-9 with Comparative Examples 1-4 shows that the addition of glycolipids can regulate the initial tack and holding power of the pressure-sensitive adhesive. Furthermore, the presence of glycolipids is beneficial for wound healing. A comparison of Examples 5, 6, 7 and Comparative Example 2 shows that rhamnose glycolipid-modified polyurethane pressure-sensitive adhesive can enhance the wound-healing properties of medications.

[0152] The above are merely specific embodiments of the present invention and should not be construed as limiting the invention to the content described in the embodiments. Any changes or modifications that can be easily conceived by those skilled in the art within the spirit and scope of the present invention should be included within the protection scope of the present invention.

Claims

1. A polyurethane pressure sensitive adhesive, characterized in that, The raw materials include the following weight percentages: a) polyisocyanate 10-40%, preferably 15-30%; b) polyether polyol 45%-85%, preferably 55-78%; c) chain extender 0-20%, preferably 0-10%; d) sugar lipid 2%-20%, preferably 4%-15%; e) curing agent 0.5%-4%, preferably 0.5%-2%; f) catalyst 0.02%-0.2%, preferably 0.05%-1.8%; g) functional component 0%-20%, preferably 0.5%-10%.

2. The polyurethane pressure sensitive adhesive according to claim 1, characterized in that, The polyisocyanate includes one or more of toluene diisocyanate, isophorone diisocyanate, diphenylmethane diisocyanate, 4,4'-dicyclohexylmethane diisocyanate, hexamethylene diisocyanate, p-phenylene diisocyanate, naphthalene diisocyanate, 1,4-cyclohexane diisocyanate, xylylene diisocyanate, cyclohexane dimethylene diisocyanate, trimethyl 1,6-hexamethylene diisocyanate, tetramethyl m-xylylene diisocyanate, dimethyl diphenylmethane diisocyanate; Preferably, the polyether polyol includes one or more of polyethylene glycol, polypropylene glycol; Preferably, the chain extender includes one or more of small molecule diols, preferably one or more of propylene glycol, butanediol, pentanediol; Preferably, the catalyst includes one or more of organobismuth catalysts, amine catalysts, or triazine trimerization catalysts, preferably one or more of a combination of bismuth octoate, bisdimethylaminoethyl ether, pentamethyldiethylene triamine, bismuth neodecanoate, triazine trimerization catalysts; Preferably, the curing agent includes one or more of isocyanate trimer, amino resin, preferably one or more of hexamethylene diisocyanate trimer, toluene diisocyanate trimer, amino resin; Preferably, the solvent includes one or more of ethyl acetate, acetone, 1,4-butanediol, 1,3-butanediol; Preferably, the functional component includes one or more of collagen, polypeptide, amino acid.

3. The polyurethane pressure sensitive adhesive according to claim 1 or 2, characterized in that, The sugar lipid is a sugar lipid that has not been neutralized by a basic substance; Preferably, the sugar lipid is selected from one or more of rhamnolipid, sophorolipid, mannosyl erythritol lipid, preferably rhamnolipid.

4. The method of producing a polyurethane pressure-sensitive adhesive according to any one of claims 1 to 3, characterized in that, The method includes the following steps: 1) mixing and reacting isocyanate, polyether polyol, and catalyst to obtain a polyurethane prepolymer; 2) adding sugar lipid and optional chain extender to the polyurethane prepolymer and reacting to obtain sugar lipid-modified polyurethane pressure-sensitive adhesive raw material A; 3) adding curing agent and optional functional component to the sugar lipid-modified polyurethane pressure-sensitive adhesive raw material A, mixing uniformly, coating onto a release film, and cooling to room temperature to obtain a sugar lipid-modified polyurethane pressure-sensitive adhesive.

5. The production method according to claim 4, characterized by, The reaction temperature in step 1) is 70-90°C; Preferably, the reaction temperature in step 2) is 45-65°C, and the reaction time is 2-5h.