A continuous flow process for the synthesis of 4,6-diaminoresorcinol salts
By combining acetyl-protected phenolic hydroxyl group post-nitration in a continuous flow reactor with a fixed-bed reactor, the problems of poor process stability and large emissions of waste gas, wastewater, and solid waste in the synthesis of 4,6-diaminoresorcinol salts have been solved, achieving the production of the target product with high purity and high yield, which is suitable for industrial production.
CN121609635BActive Publication Date: 2026-06-12ASTATECH (CHENGDU) BIOPHARM CORP +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ASTATECH (CHENGDU) BIOPHARM CORP
- Filing Date
- 2026-02-02
- Publication Date
- 2026-06-12
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Figure CN121609635B_ABST
Abstract
The application provides a continuous flow synthesis method of 4,6-diaminoresorcinol salt and belongs to the technical field of chemical synthesis. The continuous flow synthesis route of acetyl-protected phenolic hydroxyl-nitration-nitro reduction and simultaneous deacetylation-acidification is used to synthesize 4,6-diaminoresorcinol salt through automatic control. The whole reaction process is carried out in a closed environment, and the reaction safety and the reaction efficiency are improved. The application controls the dosage, the pumping speed, the reaction time and the reaction temperature and other conditions of each reactant, so that the synthesized 4,6-diaminoresorcinol salt has high purity and high yield. The purity and the yield of the product can reach 99.9% and 85.0% respectively, and the application has a wide application prospect in continuous flow industrial production.
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Citation Information
Patent Citations
CN101250118A
CN104177265A