Application of Artemisia annua component complex in the preparation of topical formulations for the prevention or improvement of blackheads and acne

By inhibiting squalene peroxidation and selectively regulating Malassezia through a complex of Artemisia annua components, the problem of preventing and improving blackheads and acne on oily skin is solved, achieving non-irritating skin stabilization.

CN121774930BActive Publication Date: 2026-05-26INSTITUTE OF CHINESE MATERIA MEDICA CHINA ACADEMY OF CHINESE MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INSTITUTE OF CHINESE MATERIA MEDICA CHINA ACADEMY OF CHINESE MEDICAL SCIENCES
Filing Date
2026-03-06
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies for preventing and improving blackheads and acne on oily skin rely on strong exfoliation or strong broad-spectrum antibacterial agents, which can cause irritation and microecological imbalance. They are difficult to effectively inhibit squalene peroxidation and regulate the skin's microecology.

Method used

Using a compound of Artemisia annua components, including camphene and artemisinin, a topical formulation is prepared in the form of a transparent or semi-transparent nano-microemulsion by inhibiting the peroxidation of squalene in sebum and selectively regulating Malassezia, thus avoiding the irritation of strong exfoliation and strong broad-spectrum antibacterial activity.

Benefits of technology

It effectively inhibits the formation of squalene peroxidation products, reduces blackheads and oil oxidation dullness, reduces Malassezia-related irritation, maintains the skin's microecological balance, achieves long-term stability, and does not rely on strong exfoliation or strong broad-spectrum antibacterial agents.

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Abstract

This invention discloses the application of an artemisia annua compound as the sole active ingredient in the preparation of topical formulations for the prevention or improvement of blackheads and acne. Based on 100% of the total mass of the topical formulation, the artemisia annua compound accounts for 0.1% to 0.22%, and is composed of the following raw materials in parts by mass: camphene 4 to 10 parts, artemisinin 1 part. This invention also discloses a topical formulation for the prevention or improvement of blackheads and acne, the sole active ingredient of which is an artemisia annua compound. Based on 100% of the total mass of the topical formulation, the artemisia annua compound accounts for 0.1% to 0.22%, and is composed of the following raw materials in parts by mass: camphene 4 to 10 parts, artemisinin 1 part. The artemisia annua compound of this invention can significantly reduce the formation of squalene peroxide in a UVA-induced squalene photo-oxidation model, and shows stronger inhibition against Malassezia and less impact on Staphylococcus epidermidis in a Malassezia vs. symbiotic bacteria comparison model.
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Citation Information

Patent Citations

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