Method for establishing anti-metabolic chemotherapeutic drug carcinogenic fatigue model
By pre-administering lipid-based solvents to experimental animals for 15–20 days followed by intraperitoneal injection of antimetabolite chemotherapeutic drugs, combined with rotarod fatigue and exhaustive swimming experiments, the problems of long experimental cycles and high animal mortality rates in existing technologies have been solved. A highly efficient antimetabolite chemotherapeutic drug-induced carcinogenic fatigue model has been established, which is suitable for the study of carcinogenic fatigue mechanisms and drug screening.
Patent Information
- Application Number
- CN202411575494.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-06
- Publication Date
- 2026-05-08
AI Technical Summary
Existing methods for establishing carcinogenic fatigue models induced by antimetabolite chemotherapy drugs suffer from problems such as excessively long experimental cycles, cumbersome testing procedures, and high animal mortality rates, and lack of unified standards and effective testing indicators.
The model was established by pre-administering lipid-based solvents to experimental animals for 15–20 days, followed by intraperitoneal injection of antimetabolite chemotherapy drugs. The third day after modeling was selected as the sampling point, and the degree of animal fatigue was detected using rotarod fatigue test and exhaustive swimming test as indicators.
It shortens the experimental cycle, reduces animal mortality, improves the success rate and operability of the model, effectively reflects cancer-related fatigue, and facilitates drug screening and evaluation.