Method for efficiently recovering vildagliptin from vildagliptin mother liquor

The disubstituted impurities in the vildagliptin mother liquor are converted into vildagliptin through N-dealkylation reaction, which solves the problems of resource waste and environmental pollution of the refined mother liquor, and achieves efficient recovery and environmentally friendly treatment, making it suitable for industrial applications.

CN122079849APending Publication Date: 2026-05-26ZHEJIANG GUOBANG PHARMA +1
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Patent Information

Application Number
CN202610199319.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-11
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies cannot effectively recover disubstituted impurities and residual vildagliptin from the mother liquor generated during multiple refining processes of crude vildagliptin, leading to resource waste and environmental pollution.

Method used

An N-dealkylation reaction was employed, using peroxyacid compounds as oxidants to convert disubstituted impurities into vildagliptin under mild conditions. Combined with Fe2+ salts as catalysts, the disubstituted impurities in the mother liquor were selectively removed, and the residual vildagliptin was recovered.

Benefits of technology

It achieves high conversion rates of dual-substituted impurities and high yields of vildagliptin, reduces waste liquid discharge and environmental treatment costs, improves raw material utilization, and is suitable for large-scale industrial production.

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Abstract

The invention provides a method for efficiently recovering vildagliptin from a vildagliptin mother solution, and belongs to the technical field of pharmaceutical chemistry. According to the method, the disubstituted impurity-containing vildagliptin mother liquor is taken as a treatment object, and additional alkyl substituent groups in the disubstituted impurity are selectively removed through N-dealkylation reaction, so that the impurity is directionally converted into the target product vildagliptin, and waste resource utilization is realized. Complex equipment does not need to be introduced, reaction conditions are mild, the conversion rate of disubstituted impurities is larger than or equal to 90%, the total yield of vildagliptin is increased by 5-8%, and no new process impurities are generated; the hydrogen peroxide is used as an industrial common oxidant, the cost is low, the byproduct is only water, the environmental protection pressure is remarkably reduced, and the method is completely adaptive to the existing industrial production process and has outstanding economic value and environmental protection significance.
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