A composition with moisturizing and skin-nourishing effects and its application

Abstract

This invention provides a composition with moisturizing and skin-nourishing effects and its application. The composition comprises collagen, sodium hyaluronate, shea butter, and tocopherol. The collagen includes any one or a combination of at least two of recombinant human type III collagen, recombinant human type IV collagen, or recombinant human type XVII collagen. This invention creatively discovers that the four components—collagen, sodium hyaluronate, shea butter, and tocopherol—can positively influence each other and synergistically enhance their effects, significantly increasing the moisture content of the stratum corneum and improving skin elasticity, thus achieving excellent moisturizing, antioxidant, and skin-nourishing effects.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition with moisturizing and skin-nourishing effects and its application. Background Technology

[0002] As the largest organ in the human body, the skin not only plays a vital physiological role in protecting the body and resisting external environmental stimuli, but its hydration and smoothness also directly affect the body's appearance and skin health. The skin on the hands, being the most frequently exposed and active part of the body, exhibits significant differences in physiological structure compared to the face and other parts of the body: the hands have fewer sebaceous glands, secreting only one-third the amount of sebum as the face, making them prone to losing natural moisturizing factors. Furthermore, the stratum corneum is uneven in thickness, with the skin on the back of the hands being particularly thin and lacking the protection of fatty tissue, resulting in a relatively fragile barrier function and difficulty in effectively retaining moisture. With the improvement of people's living standards and the comprehensive enhancement of skincare awareness, hand care has gradually gained importance, and hand cream has become an essential category in daily skincare. Market demand continues to rise, driving the cosmetics industry to conduct extensive research in the field of hand moisturizing and hydrating technology.

[0003] CN112370407A discloses a hand cream comprising the following ingredients in parts by weight: 6-12 parts squalane, 10-15 parts coconut oil, 3-8 parts celery seed oil, 6-15 parts bergamot essential oil, 1-5 parts ginkgo extract, 3-8 parts perilla extract, 2-6 parts Bletilla striata extract, 2-6 parts Tribulus terrestris extract, 8-15 parts peony flower extract, 5-10 parts palmitic acid, 3-6 parts oleic acid, 6-12 parts cetyl alcohol, 8-12 parts beeswax, 4-8 parts oxalate, 20-40 parts moisturizer, 10-20 parts water-soluble polymer, 5-15 parts water-soluble lipids, 3-8 parts antioxidant, and 3-8 parts preservative. The hand cream uses safe and readily available ingredients, has excellent effects in preventing melanin deposition and whitening and isolating the skin, effectively inhibits bacteria, and is comprehensive and highly effective in moisturizing and hydrating the skin.

[0004] CN117731563A discloses a lanolin moisturizing hand cream, comprising the following ingredients in parts by weight: 20-30 parts Scutellaria baicalensis extract; 10 parts lanolin; 5-10 parts sweet almond oil; 2-6 parts grape seed oil; 1-6 parts high molecular weight hyaluronic acid; 1-5 parts comfrey essential oil; and 5 parts glycerin. This hand cream is made from pure natural raw materials, has no toxic side effects, effectively improves dry skin on the hands, has excellent moisturizing effects, is suitable for a wide range of people, and meets people's daily needs.

[0005] However, current hand care products on the market still suffer from numerous technical shortcomings, failing to meet consumers' high-quality demands for efficient, gentle, long-lasting moisturizing, and multi-functional synergy. On the one hand, most products offer only short-lived moisturizing effects, achieving only surface hydration without penetrating deep into the skin. On the other hand, some products, in pursuit of moisturizing effects, excessively increase the proportion of oily ingredients, resulting in a thick, sticky texture that is difficult to absorb after application, easily causing problems such as staining clothes, clogging pores, and triggering breakouts. They are unsuitable for oily skin and hot, humid environments. Therefore, developing a product with a reasonable formula, long-lasting moisturizing effects, deep hydration and barrier repair, while also considering skin feel and safety, has become a pressing technical problem for those skilled in the art. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the present invention provides a composition with moisturizing and skin-nourishing effects and its application.

[0007] To achieve this objective, the present invention adopts the following technical solution: In a first aspect, the present invention provides a composition having moisturizing and skin-nourishing effects, the composition comprising collagen, sodium hyaluronate, shea butter and tocopherol. The collagen includes any one or a combination of at least two of recombinant human type III collagen, recombinant human type IV collagen, or recombinant human type XVII collagen.

[0008] The collagen described in this invention, as a major structural protein of human skin, contains a large number of hydrophilic groups in its molecular structure. This allows it to quickly absorb moisture from the environment and lock it onto the skin surface, replenishing the stratum corneum and relieving dryness and tightness. Simultaneously, it forms a thin, breathable protective film on the skin surface, reducing transepidermal water loss and prolonging moisturizing time. The sodium hyaluronate described has excellent moisturizing, anti-aging, repairing, and lubricating functions, quickly replenishing skin moisture, and is especially suitable for relieving dehydration and flaking of the hands caused by frequent handwashing and contact with detergents. The shea butter described is a gentle moisturizer. The moisturizing ingredients are highly similar to the components of the sebum film on the surface of human skin, making them easily absorbed by the skin on the hands without causing a sticky feeling. After absorption, they can quickly moisturize the skin, especially improving dryness, roughness, and cracking of the hands caused by insufficient sebum secretion. The tocopherol, or vitamin E, has moisturizing, skin-nourishing, and antioxidant effects, which can lock in moisture on the skin surface, reduce moisture loss, and relieve dryness of the hands. This invention creatively discovers that the above four components, when combined, can have a positive synergistic effect, significantly increasing the moisture content of the stratum corneum and improving skin elasticity, resulting in excellent moisturizing, antioxidant, and skin-nourishing effects.

[0009] Preferably, the composition having moisturizing and skin-nourishing effects comprises, by weight, 0.01-1 parts collagen, 0.01-1 parts sodium hyaluronate, 0.5-3 parts shea butter and 0.1-1 parts tocopherol.

[0010] The amount of collagen used in the moisturizing and skin-nourishing composition of the present invention can be 0.03 parts, 0.05 parts, 0.08 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, or 0.9 parts, etc. The amount of sodium hyaluronate used can be 0.03 parts, 0.05 parts, 0.08 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, or 0.9 parts, etc. The amount of avocado fruit oil used can be 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, or 2.8 parts, etc.; The dosage of tocopherol can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, or 0.9 parts, etc.

[0011] Preferably, the collagen comprises a combination of recombinant human type III collagen and recombinant human type XVII collagen.

[0012] Preferably, the mass ratio of recombinant human type III collagen to recombinant human type XVII collagen is 1:(0.5-1.5), for example, it can be 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, 1:1.3 or 1:1.4, etc.

[0013] Preferably, the composition having moisturizing and skin-nourishing effects further includes sunflower seed oil and / or purslane extract.

[0014] Preferably, the composition having moisturizing and skin-nourishing effects further includes sunflower seed oil and purslane extract.

[0015] As a preferred technical solution of the present invention, the combination of sunflower seed oil and purslane extract can further improve the moisturizing, skin-nourishing, and antioxidant stability of the composition, thereby enabling the composition to form a stable moisturizing and antioxidant system, reducing water evaporation, moisturizing the skin, and achieving long-lasting moisturizing and antioxidant effects.

[0016] Preferably, the composition having moisturizing and skin-nourishing effects further comprises, by weight, 0.1-2 parts of sunflower seed oil (e.g., 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, or 1.9 parts, etc.) and 0.1-1 parts of purslane extract (e.g., 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, or 0.9 parts, etc.).

[0017] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0018] Secondly, the present invention provides the application of the composition with moisturizing and skin-nourishing effects as described in the first aspect in the preparation of cosmetics.

[0019] Preferably, the cosmetic includes any one of the following: serum, lotion, face cream, hand cream, eye cream, spray, sunscreen, shower gel, facial cleanser, or face mask.

[0020] Preferably, the composition with moisturizing and skin-nourishing effects has a mass percentage content of 0.1-15% in the cosmetic, for example, it can be 0.2%, 0.5%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13% or 14%, etc.

[0021] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0022] Thirdly, the present invention provides a moisturizing hand cream, the components of which include the composition having moisturizing and skin-softening effects as described in the first aspect, emollients, humectants, emulsifiers, thickeners, antioxidants, and water.

[0023] The moisturizing hand cream formula of this invention incorporates a composition with moisturizing and skin-softening effects. This composition works synergistically with other ingredients to provide multiple benefits, including hydration, moisture retention, skin moisturization, and antioxidant effects. This effectively addresses core issues such as dry and rough hand skin.

[0024] Preferably, the moisturizing hand cream comprises, by weight, 1-5 parts of the composition having moisturizing and skin-nourishing effects as described in the first aspect, 1-8 parts of the emollient, 1-10 parts of the humectant, 1-3 parts of the emulsifier, 1-5 parts of the thickener, 0.1-1 parts of the antioxidant, and 55-96 parts of water.

[0025] The amount of the moisturizing and skin-moisturizing composition in the moisturizing hand cream of the present invention can be 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, or 4.8 parts, etc. The amount of the emollient added can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, or 7.5 parts, etc.; The amount of the humectant added can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, or 9.5 parts, etc.; The amount of emulsifier added can be 1.1 parts, 1.3 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, or 2.9 parts, etc.; The amount of the thickener added can be 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, or 4.8 parts, etc.; The amount of antioxidant added can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, or 0.9 parts, etc.; The amount of water added can be 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, or 95 parts, etc.

[0026] Preferably, the emollient comprises triglyceride (ethylhexanoate) and / or polydimethylsiloxane.

[0027] Preferably, the moisturizer includes any one or a combination of at least two of glycerin, 1,2-pentanediol, butylene glycol, or 1,2-hexanediol.

[0028] Preferably, the emulsifier comprises cetearyl alcohol polyether-20.

[0029] Preferably, the thickener comprises any one or a combination of at least two of cetearyl alcohol, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, sorbitan isostearate, polysorbate-60, or xanthan gum.

[0030] Preferably, the antioxidant includes p-hydroxyacetophenone.

[0031] Preferably, the moisturizing hand cream also includes skin conditioning agents.

[0032] Preferably, the moisturizing hand cream further comprises 0.1-2 parts by weight of a skin conditioning agent, such as 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, or 1.8 parts.

[0033] Preferably, the skin conditioning agent comprises any one or a combination of at least two of allantoin, pentapeptide-3, hexapeptide-3, or mannitol.

[0034] Preferably, the skin conditioning agent is a combination of allantoin, pentapeptide-3, hexapeptide-3 and mannitol.

[0035] In this invention, allantoin can quickly absorb moisture from the environment and combine with natural moisturizing factors in the stratum corneum of the hand skin to replenish the moisture of the stratum corneum and relieve dryness, tightness, and peeling of the hands; the pentapeptide-3 and hexapeptide-3 are small molecule active peptides with multiple effects such as moisturizing, skin moisturizing, and anti-oxidation, which meet the needs of anti-aging and moisturizing of the hand skin; the mannitol contains multiple hydrophilic hydroxyl groups in its molecular structure and has excellent moisture absorption and water-locking ability, which can quickly absorb moisture from the environment and replenish the moisture of the stratum corneum of the hand skin; the combination of these four ingredients can further improve the moisturizing and skin moisturizing effect of the hand cream.

[0036] Preferably, the moisturizing hand cream also includes excipients.

[0037] Preferably, the excipients further include any one or a combination of at least two of corn starch, flavoring, sodium chloride, or sodium dihydrogen phosphate.

[0038] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0039] Fourthly, the present invention provides a method for preparing a moisturizing hand cream as described in the third aspect, the method comprising: (1) Mix the emulsifier and emollient, stir, and obtain the oil phase; Water, humectant, antioxidant, and thickener are mixed and stirred to obtain an aqueous phase; (2) The oil phase and water phase obtained in step (1) are mixed, cooled, and then a composition with moisturizing and skin-moisturizing effects is added and homogenized to obtain the moisturizing hand cream.

[0040] Preferably, the mixing temperature during the aqueous phase preparation in step (1) is 75-85℃ (e.g., 76℃, 78℃, 80℃, 82℃ or 84℃, etc.), the stirring speed is 50-300 rpm (e.g., 60 rpm, 100 rpm, 150 rpm, 200 rpm or 250 rpm, etc.), and the time is 20-40 min (e.g., 22 min, 25 min, 28 min, 30 min, 32 min, 35 min or 38 min, etc.).

[0041] Preferably, the mixing temperature during the preparation of the oil phase in step (1) is 75-85℃ (e.g., 76℃, 78℃, 80℃, 82℃ or 84℃, etc.), the stirring speed is 50-300 rpm (e.g., 60 rpm, 100 rpm, 150 rpm, 200 rpm or 250 rpm, etc.), and the time is 20-40 min (e.g., 22 min, 25 min, 28 min, 30 min, 32 min, 35 min or 38 min, etc.).

[0042] Preferably, the temperature reduction to 35-40°C in step (2) can be, for example, 36°C, 37°C, 38°C or 39°C.

[0043] Preferably, the rotational speed for homogenization in step (2) is 1000-2000 rpm, for example, it can be 1100 rpm, 1300 rpm, 1500 rpm, 1700 rpm or 1900 rpm, etc.

[0044] Preferably, step (2) further includes adding skin conditioning agents and / or excipients after cooling.

[0045] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0046] Compared with the prior art, the present invention has the following beneficial effects: (1) The present invention creatively discovers that the four components of collagen, sodium hyaluronate, shea butter and tocopherol can interact positively and synergistically enhance each other, which can significantly increase the moisture content of the stratum corneum and improve skin elasticity, and play an excellent role in moisturizing, anti-oxidation and skin moisturizing.

[0047] (2) The moisturizing hand cream formula of the present invention adds a composition with moisturizing and skin-moisturizing effects. It works synergistically with other ingredients to make the product have multiple effects such as hydration, water retention, skin moisturization and anti-oxidation. It can effectively solve the core problems of dry and rough hand skin. Detailed Implementation

[0048] The technical solution of the present invention will be further illustrated below through specific embodiments. Those skilled in the art should understand that the embodiments described are merely illustrative of the present invention and should not be construed as limiting the invention in any way.

[0049] The weight parts mentioned in the following examples and comparative examples are based on the actual active ingredients contained in commercially available raw materials. These commercially available raw materials may also selectively contain any one or a combination of at least two of the following: solvents, fillers, diluents, stabilizers, pH adjusters, antibacterial agents, antioxidants, or impurities within permissible limits.

[0050] The sources of some of the raw materials used in the embodiments or comparative examples of this invention are shown in the table below: All other raw materials can be used as long as they are purchased from authorized distributors.

[0051] Example 1 This embodiment provides a composition with moisturizing and skin-nourishing effects, wherein the composition with moisturizing and skin-nourishing effects comprises, by weight, 0.5 parts collagen, 0.5 parts sodium hyaluronate, 2 parts shea butter, 0.8 parts tocopherol, 1 part sunflower seed oil, and 0.5 parts purslane extract. The collagen is recombinant human type III collagen and recombinant human type XVII collagen in a mass ratio of 1:1.

[0052] Example 2 This embodiment provides a composition with moisturizing and skin-nourishing effects, wherein the composition with moisturizing and skin-nourishing effects comprises, by weight, 1 part collagen, 0.1 part sodium hyaluronate, 3 parts shea butter, 0.5 parts tocopherol, 2 parts sunflower seed oil and 0.3 parts purslane extract. The collagen is recombinant human type III collagen and recombinant human type XVII collagen in a mass ratio of 2:3.

[0053] Example 3 This embodiment provides a composition with moisturizing and skin-nourishing effects, wherein the composition with moisturizing and skin-nourishing effects comprises, by weight, 0.1 parts collagen, 1 part sodium hyaluronate, 1 part shea butter, 1 part tocopherol, 0.5 parts sunflower seed oil and 1 part purslane extract. The collagen is recombinant human type III collagen and recombinant human type XVII collagen in a mass ratio of 2:1.

[0054] Example 4 This embodiment provides a composition with moisturizing and skin-nourishing effects. The only difference between this composition and Example 1 is that it does not include sunflower seed oil and purslane extract. The remaining components and dosages are the same as in Example 1.

[0055] Example 5 This embodiment provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and that of Example 1 is that the composition does not include sunflower seed oil. The reduction in the amount of sunflower seed oil is made up by purslane extract. The remaining components and dosages are the same as those of Example 1.

[0056] Example 6 This embodiment provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and that of Example 1 is that the composition does not include purslane extract. The reduction in the amount of purslane extract is made up by sunflower seed oil. The remaining components and amounts are the same as those of Example 1.

[0057] Example 7 This embodiment provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and that of Example 1 is that the collagen is recombinant human type III collagen, and the total amount of collagen is kept unchanged. The other components and their amounts are the same as those in Example 1.

[0058] Example 8 This embodiment provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and that of Example 1 is that the collagen is recombinant human type XVII collagen, and the total amount of collagen is kept unchanged. The other components and their amounts are the same as those in Example 1.

[0059] Comparative Example 1 This comparative example provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and Example 1 is that it does not contain collagen. The reduction is made up by sodium hyaluronate, shea butter and tocopherol in proportion to the amount of collagen. The remaining components and amounts are the same as in Example 1.

[0060] Comparative Example 2 This comparative example provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and Example 1 is that it does not include sodium hyaluronate in the components. The reduction is made up by collagen, shea butter and tocopherol in proportion to the parts. The remaining components and amounts are the same as in Example 1.

[0061] Comparative Example 3 This comparative example provides a composition with moisturizing and skin-nourishing effects. The only difference between this composition and Example 1 is that it does not include shea butter in its components. The reduction is made up by collagen, sodium hyaluronate and tocopherol in proportion to the number of parts. The remaining components and amounts are the same as in Example 1.

[0062] Comparative Example 4 This comparative example provides a composition with moisturizing and skin-nourishing effects. The only difference between the composition with moisturizing and skin-nourishing effects and Example 1 is that the composition does not include tocopherol. The reduction is made up by collagen, sodium hyaluronate and shea butter in proportion. The remaining components and amounts are the same as in Example 1.

[0063] Application Examples 1-3 The application example provides three types of moisturizing hand creams, the components of which are shown in the table below. The preparation method of the moisturizing hand cream in Application Example 1 is as follows: (1) Mix the emulsifier and emollient at 80°C and 100 rpm for 25 min to obtain the oil phase; (2) Mix water, humectant, antioxidant and thickener at 80℃ and 100rpm for 25min to obtain an aqueous phase; (3) After mixing the oil phase and the water phase, the temperature is lowered to 38°C, and then a composition with moisturizing and skin-moisturizing effects, skin conditioning agents and excipients are added. After homogenization at 1000 rpm, the mixture is allowed to stand to obtain the moisturizing hand cream.

[0064] The preparation methods of the products in Application Examples 2 and 3 are the same as those described above.

[0065] Application Example 4-8 The application examples provide five types of moisturizing hand creams. The only difference between these moisturizing hand creams and Application Example 1 is that the moisturizing and skin-moisturizing composition of Example 1 is replaced with an equal amount of the moisturizing and skin-moisturizing composition of Examples 4-8. The remaining components and dosages are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0066] Application Example 9 This application example provides a moisturizing hand cream. The only difference between this moisturizing hand cream and Application Example 1 is that it does not include a skin conditioning agent. The reduction in the amount of skin conditioning agent is made up by water. The remaining components and dosages are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0067] Application Example 10 This application example provides a moisturizing hand cream. The only difference between this moisturizing hand cream and Application Example 1 is that the skin conditioning agent does not include allantoin. The reduction is made up by pentapeptide-3, hexapeptide-3 and mannitol in proportion. The remaining components and dosages are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0068] Application Example 11 This application example provides a moisturizing hand cream. The only difference between this moisturizing hand cream and Application Example 1 is that the skin conditioning agent does not include pentapeptide-3. The reduced amount is made up by allantoin, hexapeptide-3 and mannitol in proportion. The remaining components and amounts are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0069] Application Example 12 This application example provides a moisturizing hand cream. The only difference between this moisturizing hand cream and Application Example 1 is that the skin conditioning agent does not include hexapeptide-3. The reduced amount is made up by allantoin, pentapeptide-3 and mannitol in proportion. The remaining components and amounts are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0070] Application Example 13 This application example provides a moisturizing hand cream. The only difference between this moisturizing hand cream and Application Example 1 is that the skin conditioning agent does not include mannitol. The reduced amount is made up by allantoin, pentapeptide-3 and hexapeptide-3 in proportion to the parts. The remaining components and amounts are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0071] Compare and contrast examples 1-4 The comparative application examples provide four types of moisturizing hand creams. The only difference between these moisturizing hand creams and Application Example 1 is that the moisturizing and skin-moisturizing composition of Example 1 is replaced with an equal amount of the moisturizing and skin-moisturizing composition of Comparative Examples 1-4. The remaining components and amounts are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0072] Comparative Application Example 5 This comparative application example provides a moisturizing hand cream. The only difference between the moisturizing hand cream and Application Example 1 is that the composition of Example 1 with moisturizing and skin-moisturizing effects is not included in the ingredients. The reduction is made up by water. The remaining components and dosages are the same as in Application Example 1. The preparation method is the same as in Application Example 1.

[0073] Test Example 1: Evaluation of Moisturizing Effect Test samples: Samples provided in Application Examples 1-13 and Comparative Application Examples 1-5.

[0074] Test Method: 108 subjects (half male and half female), aged 25-40 years, with dry, rough, and cracked hand skin were selected and divided into 18 groups of 6 subjects (half male and half female). Each group was tested with one sample. Before the test, all subjects thoroughly washed the back of their hands with a mild cleanser. The cleanser was applied twice daily, morning and evening, at a dosage of 0.01 g / cm³. 2 The test ended after 4 weeks (28 days). After the test, the change rate of stratum corneum moisture content and the change rate of skin elasticity R2 value were measured using a Cutometer MPA580. The test results are shown in Table 1.

[0075] Table 1 As shown in Table 1, compared with Comparative Application Example 5, the moisturizing hand cream of the present invention, by adding a composition with moisturizing and skin-moisturizing effects, can significantly improve skin elasticity and achieve a significant moisturizing and skin-moisturizing effect.

[0076] As can be seen from application examples 4-6, the ratio of sunflower seed oil to purslane extract has an impact on the moisturizing effect of the product, and the two have a synergistic effect in moisturizing. As can be seen from application examples 7-8, collagen can only better improve the moisturizing and skin-nourishing effect of the product when it is combined in the way that is defined in this invention; As can be seen from Application Examples 9-12, when a skin conditioning agent is added to the product, and the skin conditioning agent is a specific combination of the present invention, the moisturizing and skin-nourishing effect of the product can be more significant. As can be seen from the comparative application examples 1-4, the four components of collagen, sodium hyaluronate, shea butter and tocopherol have a synergistic effect on firming. All four are indispensable, and the absence of any one component will reduce the moisturizing effect of the product.

[0077] Test Example 2: Evaluation of Antioxidant Effect Test subjects: Samples prepared for use cases 1-3 and comparative application examples 1-5 were used to evaluate the antioxidant effect of DPPH.

[0078] Test method: Take 1 g of product, add 2 mL of anhydrous ethanol, dissolve completely, then add 2 mL of 60 μmol / L DPPH solution and mix well. Let stand for 30 min, zero the instrument with anhydrous ethanol, and measure the absorbance at 517 nm as Ai; In the same way, take 2 mL of anhydrous ethanol solvent + 2 mL of DPPH solution, mix well and measure the absorbance as Ac; Take another 1 g of product, dissolve it, add 2 mL of anhydrous ethanol, then add another 2 mL of anhydrous ethanol solvent, mix well and measure the absorbance as Aj.

[0079] Calculate its free radical scavenging rate using the following formula.

[0080] Clearance rate (%) = [1 - (Ai - Aj) / Ac] × 100% Where Aj represents the contribution of the sample itself to the absorbance; Ai represents the absorbance of the sample after the DPPH treatment; and Ac represents the absorption of DPPH itself at the measurement wavelength.

[0081] The higher the DPPH scavenging rate, the stronger the antioxidant capacity of the composition to scavenge free radicals. The results are shown in Table 2 (each sample was measured in parallel 5 times, and the data are presented as average values).

[0082] Table 2 The results showed that the composition and hand cream with moisturizing effect involved in the present invention have good free radical scavenging and antioxidant effects. Among them, collagen, sodium hyaluronate, shea butter and tocopherol promote each other in antioxidant effect and have an unexpected synergistic effect.

[0083] Test Example 3: Safety Evaluation Experiment Safety assessment: The specific method was as follows: Forty volunteers aged 20-35 years (half male and half female) with no history of allergies were selected. Each subject used the samples prepared in Examples 1-3. After cleaning the subject's arm, the patch applicator containing the sample was applied to the selected location on the arm using non-irritating adhesive tape. After application, the patch was gently pressed with the fingers to ensure even application to the skin, and left for 24 hours. During these 24 hours, the subject kept the patch area dry and avoided strenuous exercise, scratching, and prolonged sun exposure. After 24 hours, the applicator was removed and marked. After 30 minutes, once the pressure marks disappeared, the applicator was evaluated under sufficient light.

[0084] The grading criteria for adverse skin reactions are shown in Table 3: Table 3 The results are shown in Table 4: Table 4 As shown in Table 4, all subjects had negative reactions, indicating that the product prepared according to the present invention has no adverse reactions on the human body and is highly safe.

[0085] The applicant declares that this invention illustrates a composition with moisturizing and skin-nourishing effects and its application through the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of the raw materials of this invention, addition of auxiliary components, and selection of specific methods, etc., all fall within the protection scope and disclosure scope of this invention.

[0086] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0087] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A composition having moisturizing and skin-nourishing effects, characterized in that, The composition with moisturizing and skin-nourishing effects includes collagen, sodium hyaluronate, shea butter, and tocopherol; The collagen includes any one or a combination of at least two of recombinant human type III collagen, recombinant human type IV collagen, or recombinant human type XVII collagen.

2. The composition with moisturizing and skin-nourishing effects as described in claim 1, characterized in that, The composition having moisturizing and skin-nourishing effects, by weight, comprises 0.01-1 part collagen, 0.01-1 part sodium hyaluronate, 0.5-3 parts shea butter, and 0.1-1 part tocopherol.

3. The composition with moisturizing and skin-nourishing effects as described in claim 1 or 2, characterized in that, The collagen includes a combination of recombinant human type III collagen and recombinant human type XVII collagen; Preferably, the mass ratio of the recombinant human type III collagen to the recombinant human type XVII collagen is 1:(0.5-1.5).

4. The composition with moisturizing and skin-nourishing effects as described in any one of claims 1-3, characterized in that, The composition with moisturizing and skin-nourishing effects also includes sunflower seed oil and / or purslane extract. Preferably, the composition having moisturizing and skin-nourishing effects further includes sunflower seed oil and purslane extract; Preferably, the composition having moisturizing and skin-nourishing effects further comprises, by weight, 0.1-2 parts of sunflower seed oil and 0.1-1 parts of purslane extract.

5. The use of a composition having moisturizing and skin-nourishing effects as described in any one of claims 1-4 in the preparation of cosmetics.

6. The application as described in claim 5, characterized in that, The cosmetics include any one of the following: serum, lotion, face cream, hand cream, eye cream, spray, sunscreen, shower gel, facial cleanser, or face mask; Preferably, the composition having moisturizing and skin-nourishing effects has a mass percentage content of 0.1-15% in the cosmetic.

7. A moisturizing hand cream, characterized in that, The moisturizing hand cream comprises a composition having moisturizing and skin-nourishing effects as described in any one of claims 1-4, an emollient, a humectant, an emulsifier, a thickener, an antioxidant, and water.

8. The moisturizing hand cream as described in claim 7, characterized in that, The moisturizing hand cream comprises, by weight, 1-5 parts of the composition having moisturizing and skin-nourishing effects as described in any one of claims 1-4, 1-8 parts of emollient, 1-10 parts of moisturizer, 1-3 parts of emulsifier, 1-5 parts of thickener, 0.1-1 parts of antioxidant, and 55-96 parts of water. Preferably, the emollient comprises triglyceride (ethylhexanoate) and / or polydimethylsiloxane; Preferably, the moisturizer includes any one or a combination of at least two of glycerin, 1,2-pentanediol, butylene glycol, or 1,2-hexanediol; Preferably, the emulsifier comprises cetearyl alcohol polyether-20; Preferably, the thickener comprises any one or a combination of at least two of cetearyl alcohol, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, sorbitan isostearate, polysorbate-60, or xanthan gum; Preferably, the antioxidant includes p-hydroxyacetophenone.

9. The moisturizing hand cream as described in claim 7 or 8, characterized in that, The moisturizing hand cream also contains skin conditioning agents; Preferably, the moisturizing hand cream further comprises 0.1-2 parts by weight of a skin conditioning agent; Preferably, the skin conditioning agent comprises any one or a combination of at least two of allantoin, pentapeptide-3, hexapeptide-3, or mannitol; Preferably, the skin conditioning agent is a combination of allantoin, pentapeptide-3, hexapeptide-3 and mannitol; Preferably, the moisturizing hand cream also includes excipients. Preferably, the excipients further include any one or a combination of at least two of corn starch, flavoring, sodium chloride, or sodium dihydrogen phosphate.

10. A method for preparing a moisturizing hand cream as described in any one of claims 7-9, characterized in that, The preparation method includes: (1) Mix the emulsifier and emollient, stir, and obtain the oil phase; Water, humectant, antioxidant, and thickener are mixed and stirred to obtain an aqueous phase; (2) Mix the oil phase and water phase obtained in step (1), cool down and add the composition with moisturizing and skin-moisturizing effects, and homogenize to obtain the moisturizing hand cream; Preferably, in step (1), the mixing temperature during aqueous phase preparation is 75-85℃, the stirring speed is 50-300 rpm, and the time is 20-40 min; Preferably, in step (1), the mixing temperature during oil phase preparation is 75-85℃, the stirring speed is 50-300 rpm, and the time is 20-40 min; Preferably, the temperature is reduced to 35-40℃ in step (2); Preferably, the rotational speed for homogenization in step (2) is 1000-2000 rpm; Preferably, step (2) further includes adding skin conditioning agents and / or excipients after cooling.

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