A full continuous flow green synthesis system and process of alisotox

The fully continuous flow green synthesis system solves the problems of catalyst recycling and uneven reaction in the synthesis of isaconazole, realizing efficient, low-cost, and green isaconazole production, improving product purity and yield, and reducing environmental pollution.

CN122399703APending Publication Date: 2026-07-17JIANGSU TOHOPE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-20
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing azaconazole synthesis technologies suffer from problems such as the inability to recycle catalysts, uneven reactions, low efficiency, severe pollution, and low yield and purity.

Method used

The fully continuous flow green synthesis system is adopted, including a catalytic recycling device, a microchannel reaction device, and a coupling separation device, to achieve catalyst recycling, precise control of reaction conditions, and efficient product separation. By utilizing cross-flow nanofiltration membrane modules and ionic liquid regeneration recycling, production costs are reduced and reaction efficiency and product purity are improved.

Benefits of technology

This technology enables efficient, low-cost, and green production of isaconazole, with high catalyst recovery rate, significantly improved product purity and yield, and reduced environmental pollution.

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Abstract

本申请涉及医药化工技术领域,尤其是涉及一种艾莎康唑的全连续流绿色合成系统及工艺;一种艾莎康唑的全连续流绿色合成系统,包括依次连接的催化循环装置、微通道反应装置和偶联分离装置,所述催化循环装置包括釜式反应器,所述釜式反应器通过管路连接有高压循环泵;釜式反应器出料口连接有错流纳滤膜组件,所述错流纳滤膜组件包括截留侧管路连接的一级纳滤膜,所述一级纳滤膜出料口透过侧管路连接有二级纳滤膜,所述二级纳滤膜连接有中间罐,本申请实现了艾莎康唑的全连续流绿色合成,降低了生产成本,提高了反应效率和产物纯度,减少了环境污染,提高生产效率。
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