Heparin sodium crude product enzymolysis reaction tank
By designing a crude heparin sodium enzymatic hydrolysis reaction tank with defoaming, stirring, and spraying components, the problem of air bubbles affecting the enzymatic hydrolysis effect during stirring was solved, achieving full contact between the pig intestinal mucosa and the hydrolysate and cleaning of the tank interior.
Patent Information
- Application Number
- CN202423255076.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-28
- Publication Date
- 2025-12-23
- Estimated Expiration
- 2034-12-28
AI Technical Summary
During the preparation of crude heparin sodium, a large number of bubbles are generated at the liquid surface during stirring, which affects the contact between the pig intestinal mucosa and the enzymatic hydrolysate, resulting in poor enzymatic hydrolysis.
A crude heparin sodium enzymatic hydrolysis reaction vessel was designed, comprising a defoaming component, a stirring component, and a spraying component. The defoaming component removes bubbles through the interaction of a mesh inner plate, a secondary motor, and a defoaming frame. The stirring component effectively stirs the mixture through a central shaft and a stirring frame. The spraying component performs internal rinsing through an inner pipe and spray nozzles.
It effectively removes air bubbles, ensuring full contact between the pig intestinal mucosa and the enzymatic hydrolysate, thus improving the hydrolysis effect. Internal rinsing also ensures the cleanliness of the tank interior.
Smart Images
Figure CN223705598U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of enzymatic hydrolysis reaction tank, specifically, relates to a heparin sodium crude product enzymatic hydrolysis reaction tank. BACKGROUND
[0002] The enzyme hydrolysis tank is a device for realizing the biological enzyme hydrolysis reaction process for the purpose of chemical or physical production by using biological enzyme hydrolysis technology, through catalytic reaction on related organisms, so that the organisms are fully decomposed and converted, and is applied to textile dyeing, protein enzymolysis and industrial wastewater enzymolysis.
[0003] At present, in the preparation process of heparin sodium crude product, the heparin sodium raw material, i.e. pig intestinal mucosa, needs to be enzymolyzed first, and in the enzymolysis process, the pig intestinal mucosa and the enzyme hydrolysis agent need to be stirred in order to mix them fully, but air bubbles are easily generated during the stirring process, especially at the liquid surface, and the generated air bubbles are more, which affects the contact between the pig intestinal mucosa and the enzyme hydrolysis agent, and further affects the enzymolysis effect.
[0004] Therefore, the above problems are improved. UTILITY MODEL CONTENT
[0005] The utility model provides a heparin sodium crude product enzymatic hydrolysis reaction tank, solve in the related art in the stirring process air bubble is easy to produce, especially at the liquid surface, the air bubble that generates is more, influence pig intestinal mucosa and enzyme hydrolysis agent contact, further to the enzymolysis effect problem of influence.
[0006] The technical scheme of the utility model is as follows: including
[0007] The tank body, the fixed seat and the central shaft, the fixed seat is arranged at the top of the tank body, and the central shaft is rotatably connected in the tank body and the fixed seat;
[0008] The bubble removing assembly is arranged in the tank body;
[0009] The stirring assembly is arranged at the top of the central shaft and the tank body;
[0010] The spraying assembly is arranged at the inner top of the tank body;
[0011] The bubble removing assembly comprises a mesh inner plate, the mesh inner plate is arranged in the tank body, the mesh inner plate is rotatably connected outside the central shaft, and a secondary motor is arranged at the top of the tank body.
[0012] As a further technical scheme, the secondary motor output end is provided with a driving gear, the inner top of the tank body is provided with a sliding rail, the sliding rail is slidably connected with a rotating frame, and the rotating frame top is provided with an external gear.
[0013] As a further technical scheme, the outer gear is engaged with the driving gear box, and the rotating frame bottom is provided with a plurality of bubble removing frames which are slidably attached to the surface of the mesh inner plate.
[0014] As a further technical scheme, the stirring assembly comprises a main motor which is fixed to the top of the tank body, and transmission gears are arranged on the output end of the main motor and the central shaft.
[0015] As a further technical scheme, a sealing sleeve is arranged at the upper end of the central shaft, a connecting pipe is arranged outside the tank body, one end of the connecting pipe is rotatably connected with the sealing sleeve, the central shaft is hollow, a plurality of through holes are arranged at the bottom of the central shaft, and a pair of stirring frames are arranged on the central shaft.
[0016] As a further technical scheme, the spraying assembly comprises a pair of inner frames which are fixed to the inner top of the tank body, an inner pipeline is fixed to the inner frame, a plurality of spraying nozzles are arranged at the bottom of the inner pipeline, and a connecting pipe is arranged at the upper end surface of the inner pipeline.
[0017] As a further technical scheme, the top of the tank body is provided with an air inlet valve.
[0018] As a further technical scheme, the inner wall of the tank body is provided with an inner ring layer which is slidably attached to the outer surface of the rotating frame.
[0019] As a further technical scheme, one end of the connecting pipe is in a double-head structure, and control valves are arranged at both ends of the connecting pipe.
[0020] As a further technical scheme, the lower end of the central shaft is rotatably connected with the inner bottom of the tank body, and the through holes are located at the bottom of the tank body.
[0021] The working principle and beneficial effects of the utility model are as follows:
[0022] 1. The bubble removing assembly is arranged in the utility model, and through the interaction of the mesh inner plate, the auxiliary motor, the driving gear, the rotating frame, the outer gear and the bubble removing frame, the bubbles generated during stirring can be removed through the mesh inner plate, and the bubbles can be completely cleaned by the continuously rotating bubble removing frame, so that the reaction is not affected.
[0023] 2. The spraying assembly is arranged in the utility model, and through the interaction of the inner pipeline, the spraying nozzle and the connecting pipe, spraying can be performed downward on the inner top of the tank body, and the tank body can be completely cleaned by the discharging mode of the stirring assembly. DRAWINGS
[0024] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.
[0025] Figure 1 This is a schematic diagram of the structure of this utility model;
[0026] Figure 2 This is an isometric drawing of the present invention;
[0027] Figure 3 This is an isometric sectional view of the present invention;
[0028] Figure 4 This is an isometric sectional view of the present invention from another perspective;
[0029] Figure 5 Appendix to this utility model Figure 4 Enlarged view of part A in the middle;
[0030] Figure 6 Appendix to this utility model Figure 4 Enlarged view of part B in the middle section;
[0031] In the diagram: 1. Tank body; 2. Fixed base; 3. Central shaft; 4. Defoaming assembly; 4-1. Mesh inner plate; 4-2. Auxiliary motor; 4-3. Drive gear; 4-4. Slide rail; 4-5. Rotating frame; 4-6. External gear; 4-7. Defoaming frame; 5. Stirring assembly; 5-1. Main motor; 5-2. Transmission gear; 5-3. Sealing bushing; 5-4. Connecting pipe; 5-5. Port; 5-6. Stirring frame; 6. Spraying assembly; 6-1. Inner frame; 6-2. Inner pipe; 6-3. Spray nozzle; 6-4. Connecting pipe; 7. Air inlet valve; 8. Inner ring layer; 9. Control valve. Detailed Implementation
[0032] The technical solutions of this utility model will be clearly and completely described below with reference to the embodiments of this utility model. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this utility model.
[0033] like Figures 1-6 As shown, this embodiment proposes an enzymatic hydrolysis reactor for crude heparin sodium, including...
[0034] The tank body 1, the fixed base 2, and the central shaft 3 are provided. The fixed base 2 is located on the top of the tank body 1, and the central shaft 3 is rotatably connected between the tank body 1 and the fixed base 2.
[0035] Defoaming component 4 is installed inside tank 1;
[0036] Stirring assembly 5, stirring assembly 5 is arranged in the center shaft 3 and the top of the tank body 1;
[0037] Spray assembly 6, spray assembly 6 is arranged in the top of the tank body 1;
[0038] The defoaming assembly 4 includes a mesh inner plate 4-1, which is arranged inside the tank body 1 and is rotatably connected to the outside of the center shaft 3. A sub motor 4-2 is arranged at the top of the tank body 1, and a driving gear 4-3 is arranged at the output end of the sub motor 4-2. A slide rail 4-4 is arranged at the top of the tank body 1, and a rotating frame 4-5 is slidably connected to the slide rail 4-4. An external gear 4-6 is arranged at the top of the rotating frame 4-5, and the external gear 4-6 is engaged with the driving gear 4-3. A plurality of defoaming frames 4-7 are arranged at the bottom of the rotating frame 4-5, and the lower end surface of the defoaming frames 4-7 is slidably attached to the surface of the mesh inner plate 4-1.
[0039] In this embodiment, in order to realize the effect of defoaming, the defoaming assembly 4 is designed. The mesh inner plate 4-1 is arranged inside the tank body 1 for passing through the bubbles. The sub motor 4-2 and the driving gear 4-3 are arranged at the top of the tank body 1, and the driving gear 4-3 is located inside the tank body 1. The slide rail 4-4 is arranged at the top of the tank body 1 and is slidably connected to the rotating frame 4-5. The external gear 4-6 is arranged around the outside of the rotating frame 4-5 and is engaged with the driving gear 4-3. The rotating frame 4-5 can be rotated by the sub motor 4-2. The bottom of the rotating frame 4-5 is provided with a plurality of defoaming frames 4-7, which can eliminate the bubbles passing through the mesh inner plate 4-1.
[0040] Further, the stirring assembly 5 includes a main motor 5-1 fixed at the top of the tank body 1. A transmission gear 5-2 is arranged at the output end of the main motor 5-1 and on the center shaft 3. The transmission gears 5-2 are engaged with each other. A sealing sleeve 5-3 is arranged at the upper end of the center shaft 3. A connecting pipe 5-4 is arranged outside the tank body 1. One end of the connecting pipe 5-4 is rotatably connected to the sealing sleeve 5-3. The center shaft 3 is hollow. A plurality of through holes 5-5 are formed at the bottom of the center shaft 3. A pair of stirring frames 5-6 are arranged on the center shaft 3.
[0041] In this embodiment, in order to realize the stirring effect of discharging by suction, the stirring assembly 5 is designed. The main motor 5-1 is arranged at the top of the tank body 1. The transmission gears 5-2 are arranged at the output end of the main motor 5-1 and on the center shaft 3. The center shaft 3 can be driven to rotate by the main motor 5-1. The center shaft 3 is hollow and is provided with a sealing sleeve 5-3 at the upper end. The connecting pipe 5-4 is fixed outside the tank body 1 and is rotatably connected to the sealing sleeve 5-3. The connecting pipe 5-4 can be used to enter the material in cooperation with the hollow structure of the center shaft 3. The through holes 5-5 are arranged at the bottom of the center shaft 3 for injecting and extracting materials. The stirring frames 5-6 are arranged on the center shaft 3 and can complete the stirring during rotation.
[0042] Further, the spraying assembly 6 comprises a pair of inner frames 6-1 fixed on the inner top of the tank body 1, an inner pipeline 6-2 fixed on the inner frames 6-1, a plurality of spraying nozzles 6-3 arranged at the bottom of the inner pipeline 6-2, and a connecting pipe 6-4 arranged on the upper end surface of the inner pipeline 6-2 and located outside the tank body 1.
[0043] In the embodiment, in order to achieve the effect of internal flushing, the spraying assembly 6 is designed, two inner frames 6-1 are arranged on the inner top of the tank body 1 and the inner pipeline 6-2 is fixed thereon, the connecting pipe 5-4 is arranged at the top of the inner pipeline 6-2 for connecting the water supply device, and the plurality of spraying nozzles 6-3 are arranged at the bottom of the inner pipeline 6-2 for downward spraying and flushing.
[0044] Further, the tank body 1 is provided with an air inlet valve 7.
[0045] In the embodiment, the air inlet valve 7 is arranged to allow air to enter when the material is extracted outward.
[0046] Further, the inner wall of the tank body 1 is provided with an inner ring layer 8 which is in sealing sliding fit with the outer surface of the rotating frame 4-5.
[0047] In the embodiment, the inner ring layer 8 is arranged to allow the rotating frame 4-5 to be in a semi-sealed state to avoid being affected by liquid.
[0048] Further, one end of the connecting pipe 5-4 is in a double-head structure, and the connecting pipe 5-4 is provided with a control valve 9 at both ends.
[0049] In the embodiment, the double-head structure of the connecting pipe 5-4 allows the connecting pipe 5-4 to be connected to the injection device and the extraction device respectively, and the control valve 9 is arranged to facilitate switching.
[0050] Further, the lower end of the central shaft 3 is in sealing and rotating connection with the inner bottom of the tank body 1, and the through hole 5-5 is located at the bottom of the tank body 1.
[0051] In the embodiment, the through hole 5-5 is arranged at the bottom to facilitate the suction of all residues.
[0052] When reaction treatment is required, the connecting pipe 5-4 is connected to the injection device and the extraction device respectively, the injection device is started to inject the material into the tank body 1 through the through hole 5-5, the liquid level is stopped when reaching the bottom of the mesh inner plate 4-1, the main motor 5-1 is started to control the rotation of the central shaft 3, the stirring frame 5-6 is stirred, the auxiliary motor 4-2 is started when bubbles are generated, the outer gear 4-6 is driven by the driving gear to make the bubble removing frame 4-7 start to rotate, the bubbles are removed by scraping, the extraction device is started after the reaction is completed, and the material is extracted outward at the through hole 5-5, and the spraying nozzles 6-3 are started to flush downward by spraying when flushing is required.
[0053] The above merely preferred embodiments of the present application are not used to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims
1. A crude heparin sodium enzymatic reaction tank, characterized in that, Comprising A tank body (1), a fixed seat (2) arranged at the top of the tank body (1), and a central shaft (3) rotatably connected in the tank body (1) and the fixed seat (2); A defoaming assembly (4) arranged inside the tank body (1); A stirring assembly (5) arranged at the top of the central shaft (3) and the tank body (1); A spraying assembly (6) arranged at the top inside the tank body (1); The defoaming assembly (4) comprises a mesh inner plate (4-1) arranged inside the tank body (1), which is rotatably connected outside the central shaft (3), and a sub-motor (4-2) arranged at the top of the tank body (1).
2. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 1, characterized in that, The output end of the sub-motor (4-2) is provided with a driving gear (4-3), the inside top of the tank body (1) is provided with a sliding rail (4-4), the sliding rail (4-4) is slidably connected with a rotating frame (4-5), and the top of the rotating frame (4-5) is provided with an external gear (4-6).
3. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 2, characterized in that, The external gear (4-6) is engaged with the driving gear (4-3), and the bottom of the rotating frame (4-5) is provided with a plurality of defoaming frames (4-7) which are slidably attached to the surface of the mesh inner plate (4-1).
4. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 1, characterized in that, The stirring assembly (5) comprises a main motor (5-1) fixed at the top of the tank body (1), and a transmission gear (5-2) arranged on the output end of the main motor (5-1) and the central shaft (3).
5. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 4, characterized in that, The upper end of the central shaft (3) is provided with a sealing shaft sleeve (5-3), the outside of the tank body (1) is provided with a connecting pipe (5-4), one end of the connecting pipe (5-4) is rotatably connected with the sealing shaft sleeve (5-3), the central shaft (3) is hollow, a plurality of through holes (5-5) are formed in the bottom of the central shaft (3), and a pair of stirring frames (5-6) are arranged on the central shaft (3).
6. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 1, characterized in that, The spraying assembly (6) comprises a pair of inner frames (6-1) fixed at the inside top of the tank body (1), an inner pipeline (6-2) fixed on the inner frame (6-1), a plurality of spraying nozzles (6-3) arranged at the bottom of the inner pipeline (6-2), and a connecting pipe (6-4) arranged on the upper end surface of the inner pipeline (6-2).
7. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 1, characterized in that, The top of the tank body (1) is provided with an air inlet valve (7).
8. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 2, characterized in that, The inner wall of the tank body (1) is provided with an inner ring layer (8) which is sealingly and slidably attached to the outer surface of the rotating frame (4-5).
9. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 5, characterized in that, One end of the connecting pipe (5-4) is a double-headed structure, and control valves (9) are arranged at both ends of the connecting pipe (5-4).
10. The crude heparin sodium enzymatic hydrolysis reaction tank according to claim 5, characterized in that, The lower end of the central shaft (3) is sealingly and rotatably connected with the inner bottom of the tank body (1), and the through holes (5-5) are located at the bottom of the tank body (1).