On-line detection device for intermediate of dexamethasone sodium phosphate injection

Abstract

The utility model discloses an online detection device of dexamethasone sodium phosphate injection intermediate belongs to pharmacy detection field, including support, install ultraviolet spectrophotometer equipment on the support to setting liquid dilution bucket on the support, the liquid dilution bucket discharge opening is connected with the hose, and the bottom end of hose is connected with the pipe head, and the support is provided with the drive mechanism that drives the pipe head to move up and down, is provided with the cuvette on ultraviolet spectrophotometer equipment, and the support is provided with two clamps symmetrically, and two clamps all are pasted in the outer wall of cuvette, through the cooperation of above each device, through the gear drive first rack and second rack lift, to drive the pipe head realizes accurate lifting, and the cooperation clamp holds the cuvette, distinguishes from manual dosing, and the cuvette is fixed in the exactly same position every time, makes liquid to be able to follow the pipe head accurate and enter the inside of cuvette, greatly improves the detection efficiency.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical testing technology, specifically to an online detection device for intermediates of dexamethasone sodium phosphate injection. Background Technology

[0002] Dexamethasone sodium phosphate injection is a type of glucocorticoid drug, mainly used to treat rheumatoid arthritis, lupus erythematosus, bronchial asthma, dermatitis, ulcerative colitis, acute leukemia, and diseases in hematology, gastroenterology, dermatology, respiratory medicine, and rheumatology.

[0003] Currently, dexamethasone sodium phosphate injection is generally detected using a UV spectrophotometer. The method involves pouring the liquid into a cuvette and placing the cuvette into the sample chamber for detection. However, due to the small size of the cuvette, liquid may overflow from the opening or spill onto the outer wall of the cuvette when pouring the liquid. This requires cleaning the cuvette with a cleaning cloth, which can easily cause liquid to spill out of the cuvette, greatly affecting the detection efficiency.

[0004] Therefore, this invention provides an online detection device for dexamethasone sodium phosphate injection intermediates to solve the above problems. Utility Model Content

[0005] (a) Technical problems to be solved

[0006] This invention provides an online detection device for intermediates of dexamethasone sodium phosphate injection, which aims to solve the problems mentioned in the background art.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, this utility model provides the following technical solution:

[0009] As a preferred technical solution of this application, it includes a bracket, an ultraviolet spectrophotometer device mounted on the bracket, and a drug dilution tank set on the bracket;

[0010] The outlet of the drug dilution tank is connected to a flexible hose, and the bottom end of the flexible hose is connected to a tube head. The support is equipped with a drive mechanism to drive the tube head to move up and down.

[0011] The ultraviolet spectrophotometer is equipped with a cuvette, and two clamps are symmetrically arranged on the support. Both clamps are attached to the outer wall of the cuvette, and the support is equipped with a movable mechanism to drive the two clamps to move towards each other.

[0012] As a preferred technical solution of this application, the driving mechanism includes a rotating rod and a first driving member;

[0013] A rotating rod is rotatably connected to the bracket, and a gear is connected to the rotating rod. A first rack meshes with the outer wall of the gear. The first rack is connected to the side wall of the tube head. A first driving component is provided on the bracket for driving the gear to rotate forward and backward.

[0014] As a preferred technical solution of this application, the first driving member includes an electric actuator;

[0015] An electric actuator is mounted on the bracket, and a second rack is connected to the end of the electric actuator. The second rack meshes with the side wall of the gear.

[0016] As a preferred technical solution of this application, the active mechanism includes a slide bar and a second driving member;

[0017] Two sliding rods are symmetrically slidably connected to the bracket. Each end of the two sliding rods is connected to a triangular plate. The side wall of each triangular plate is connected to a corresponding clamping plate through a connecting rod. Each triangular plate is connected to a spring. The other end of each spring is connected to the bracket. The second driving member is used to push the two triangular plates to separate.

[0018] As a preferred technical solution of this application, the second driving component includes a connecting plate and a pressure plate;

[0019] A pressure plate is attached between the two triangular plates, and a connecting plate is connected to the top of the pressure plate. The top of the connecting plate is connected to the lower end of the rack.

[0020] As a preferred technical solution of this application, the lower end of the pressure plate is set as a triangle, which is used in conjunction with the two triangular plates.

[0021] As a preferred technical solution of this application, each of the clamps is configured as an arc shape, and a rubber pad is connected to the inner wall of each clamp.

[0022] (III) Beneficial Effects

[0023] The gears drive the first and second racks to rise and fall, thereby enabling the tube head to rise and fall precisely. Combined with the clamping plate to hold the cuvette, unlike manual dosing, the cuvette is fixed in the exact same position every time, allowing the reagent to enter the cuvette precisely along the tube head, greatly improving the detection efficiency. Attached Figure Description

[0024] Figure 1 A three-dimensional structural schematic diagram of an online detection device for intermediates of dexamethasone sodium phosphate injection;

[0025] Figure 2 A three-dimensional structural schematic diagram of an online detection device for intermediates of dexamethasone sodium phosphate injection;

[0026] Figure 3 A three-dimensional structural diagram of the tube head and gears of the online detection device for dexamethasone sodium phosphate injection intermediate;

[0027] Figure 4 A three-dimensional structural diagram of the clamping plate and triangular plate of the online detection device for dexamethasone sodium phosphate injection intermediate;

[0028] Figure 5 A three-dimensional structural diagram of the triangular plate and pressure plate of the online detection device for dexamethasone sodium phosphate injection intermediate;

[0029] In the picture:

[0030] 1. Support frame; 11. Ultraviolet spectrophotometer; 111. Cuvette; 12. Drug dilution tank; 2. Tube; 21. Tube head; 3. Drive mechanism; 31. Rotating rod; 32. Gear; 33. First rack; 34. First drive component; 341. Second rack; 4. Clamping plate; 5. Movable mechanism; 51. Sliding rod; 52. Triangular plate; 53. Connecting rod; 54. Spring; 55. Second drive component; 551. Connecting plate; 552. Pressure plate. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] This invention provides an online detection device for intermediates in dexamethasone sodium phosphate injection, such as... Figure 1-5 As shown, the online detection device for the intermediate of dexamethasone sodium phosphate injection includes a support 1, an ultraviolet spectrophotometer 11 mounted on the support 1, and a drug dilution tank 12 mounted on the support 1.

[0033] The outlet of the drug dilution tank 12 is connected to a hose 2, and the bottom end of the hose 2 is connected to a tube head 21. A drive mechanism 3 is provided on the bracket 1 to drive the tube head 21 to move up and down.

[0034] The ultraviolet spectrophotometer device 11 is equipped with a cuvette 111. Two clamps 4 are symmetrically arranged on the support 1. Both clamps 4 are attached to the outer wall of the cuvette 111. The support 1 is equipped with an active mechanism 5 that drives the two clamps 4 to move towards each other.

[0035] like Figure 2 and Figure 3 As shown, the drive mechanism 3 includes a rotating rod 31 and a first drive member 34;

[0036] A rotating rod 31 is rotatably connected to the bracket 1, and a gear 32 is connected to the rotating rod 31. A first rack 33 meshes with the outer wall of the gear 32. The first rack 33 is connected to the side wall of the tube head 21. A first driving member 34 is provided on the bracket 1 to drive the gear 32 to rotate in both directions.

[0037] like Figure 1 As shown, the first drive unit 34 includes an electric actuator;

[0038] An electric actuator is mounted on the bracket 1, and a second rack 341 is connected to the end of the electric actuator. The second rack 341 meshes with the side wall of the gear 32.

[0039] like Figure 4 As shown, the active mechanism 5 includes a slide bar 51 and a second drive member 55;

[0040] Two sliding rods 51 are symmetrically slidably connected on the bracket 1. Each end of the two sliding rods 51 is connected to a triangular plate 52. The side wall of each triangular plate 52 is connected to the corresponding clamping plate 4 through a connecting rod 53. Each triangular plate 52 is connected to a spring 54. The other end of each spring 54 is connected to the bracket 1. The second driving member 55 is used to push the two triangular plates 52 to separate.

[0041] like Figure 4 As shown, the second driving component 55 includes a connecting plate 551 and a pressure plate 552;

[0042] A pressure plate 552 is attached between the two triangular plates 52. A connecting plate 551 is connected to the top of the pressure plate 552. The top of the connecting plate 551 is connected to the lower end of the rack 33.

[0043] like Figure 5 As shown, the lower end of the pressure plate 552 is set as a triangle, which is used in conjunction with two triangular plates 52.

[0044] like Figure 4 As shown, each clamp 4 is designed to be arc-shaped, and each clamp 4 has a rubber pad attached to its inner wall.

[0045] Working principle: The intermediate raw material of dexamethasone sodium phosphate injection is put into the dilution tank 12 and mixed with the solvent at a preset ratio, such as 1:100. The second rack 351 is driven to move upward by the electric actuator, which causes the gear 32 to drive the rotating rod 31 to rotate, thereby causing the first rack 33 to move downward. The first rack 33 drives the bottom end of the tube head 21 into the cuvette 111. When the first rack 33 moves downward, it simultaneously drives the connecting plate 551 and the pressure plate 552 to press down, causing the lower end of the triangle of the pressure plate 552 to push the two triangular plates 52 outward. The connecting rod 53 connects the triangular plates 52 and the clamping plate 4, so that the triangular plates 52 are separated. When the clamping plate 4 clamps the cuvette 111, the clamping plate 4, in conjunction with the rubber pad, ensures the stability of the cuvette 111 and reduces shaking. Then, the dilution tank 12 is opened, allowing the liquid to enter the tube head 21 through the tubing 2. Next, the ultraviolet spectrophotometer 11 scans at a wavelength of 240nm and calculates the concentration of the intermediate by measuring the absorbance. When the electric push rod drives the second rack 351 to move down, the gear 32 drives the rotating rod 31 to reverse, causing the first rack 33 to move up, thereby disengaging the tube head 21 from the cuvette 111. Under the action of the spring 54, when the tube head 21 is reset, the clamping plate 4 can also quickly return to its original position.

[0046] The above are merely preferred embodiments of this utility model, but the scope of protection of this utility model is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in this utility model, based on the technical solution and inventive concept of this utility model, should be included within the scope of protection of this utility model.

Claims

1. An online detection device for intermediates of dexamethasone sodium phosphate injection, comprising a support (1), an ultraviolet spectrophotometer (11) mounted on the support (1), and a drug dilution tank (12) mounted on the support (1); characterized in that: The outlet of the drug dilution tank (12) is connected to a hose (2), and the bottom end of the hose (2) is connected to a tube head (21). The support (1) is provided with a drive mechanism (3) for driving the tube head (21) to move up and down. The ultraviolet spectrophotometer device (11) is equipped with a cuvette (111), and two clamps (4) are symmetrically arranged on the support (1). Both clamps (4) are attached to the outer wall of the cuvette (111), and the support (1) is equipped with an active mechanism (5) that drives the two clamps (4) to move towards each other.

2. The online detection device for dexamethasone sodium phosphate injection intermediates according to claim 1, characterized in that: The drive mechanism (3) includes a rotating rod (31) and a first drive member (34). A rotating rod (31) is rotatably connected to the bracket (1), and a gear (32) is connected to the rotating rod (31). A first rack (33) meshes with the outer wall of the gear (32). The first rack (33) is connected to the side wall of the tube head (21). A first driving member (34) is provided on the bracket (1) for driving the gear (32) to rotate forward and backward.

3. The online detection device for dexamethasone sodium phosphate injection intermediates according to claim 2, characterized in that: The first drive unit (34) includes an electric actuator; An electric push rod is installed on the bracket (1), and a second rack (341) is connected to the end of the electric push rod. The second rack (341) meshes with the side wall of the gear (32).

4. The online detection device for dexamethasone sodium phosphate injection intermediates according to claim 1, characterized in that: The active mechanism (5) includes a slide bar (51) and a second drive member (55); Two sliding rods (51) are symmetrically slidably connected to the bracket (1). Each of the two sliding rods (51) is connected to a triangular plate (52) at its end. The side wall of each triangular plate (52) is connected to the corresponding clamp (4) through a connecting rod (53). Each triangular plate (52) is connected to a spring (54). The other end of each spring (54) is connected to the bracket (1). The second driving member (55) is used to push the two triangular plates (52) to separate.

5. The online detection device for dexamethasone sodium phosphate injection intermediates according to claim 4, characterized in that: The second driving component (55) includes a connecting plate (551) and a pressure plate (552); A pressure plate (552) is attached between the two triangular plates (52), and a connecting plate (551) is connected to the top of the pressure plate (552). The top of the connecting plate (551) is connected to the lower end of the first rack (33).

6. The online detection device for dexamethasone sodium phosphate injection intermediates according to claim 5, characterized in that: The lower end of the pressure plate (552) is set as a triangle, which is used in conjunction with the two triangular plates (52).

7. The online detection device for dexamethasone sodium phosphate injection intermediates according to claim 1, characterized in that: Each of the clamps (4) is configured to be arc-shaped, and each of the clamps (4) has a rubber pad attached to its inner wall.

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