Oral pharmaceutical composition including Posaconazole
Patent Information
- Application Number
- DE602018090678
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2018-12-26
- Publication Date
- 2026-04-15
- Estimated Expiration
- 2038-12-26
AI Technical Summary
Existing oral pharmaceutical formulations of posaconazole suffer from high manufacturing costs, poor solubility, low dissolution rate, and inadequate bioavailability, necessitating an improved composition with enhanced stability and solubility.
A pharmaceutical composition comprising posaconazole in crystalline polymorph form I, dissolved in hydroxypropyl methylcellulose acetate succinate (HPMC-AS) with specific particle sizes and ratios, combined with enteric polymers and surfactants, processed through hot-melt extrusion or spray drying to enhance stability and solubility.
The composition achieves high solubility, bioavailability, and chemical stability, ensuring effective antifungal activity and prolonged shelf life, with improved particle size distribution and dissolution rates.