Particle, method for producing same, and pharmaceutical composition
By dispensing bioactive substance-containing droplets and removing solvent without heat or stress, the method maintains the substance's activity, addressing deactivation issues in existing particle production methods.
JP2026055749APending Publication Date: 2026-03-31ETRIA CO LTD
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Patent Information
- Application Number
- JP2024189535
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-09-18
- Filing Date
- 2024-10-29
- Publication Date
- 2026-03-31
AI Technical Summary
Technical Problem
Existing methods for producing fine particles containing bioactive substances face challenges such as deactivation or elution of the substances due to heating, shaking, or stirring, leading to a decrease in physiological activity.
Method used
A method involving dispensing a bioactive substance-containing solution as droplets and removing the solvent to form particles without applying heat or external stress, maintaining the physiological activity of the substance.
Benefits of technology
This method effectively suppresses the decrease in physiological activity during particle production, ensuring the bioactive substance's integrity and functionality.
✦ Generated by Eureka AI based on patent content.
Abstract
To provide a method for producing particles capable of suppressing reduction of a physiologically active amount during production of the particles.SOLUTION: The method for producing particles includes a physiologically active substance-containing liquid preparation step of preparing a physiologically active substance-containing liquid containing a physiologically active substance, a discharge step of discharging the physiologically active substance-containing liquid as droplets, and a granulation step of removing a solvent from the droplets to granulate the particles, wherein a physiological activity ratio {physiological activity amount B / physiological activity amount A}*100 of a physiological activity amount B in the particles after the granulation step to a physiological activity amount A in the physiologically active substance before the physiologically active substance-containing liquid preparation step is 80% or more.SELECTED DRAWING: None
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