Moisturizing and soothing composition and preparation method therefor

Abstract

The present invention relates to the technical field of cosmetic preparation, and particularly to a moisturizing and soothing composition and a preparation method therefor. A Radix Adenophorae extract, a Radix Ampelopsis extract, a Saxifrage extract, an Artemisia argyi extract, a lithospermum officinale extract, and a Radix Astragali extract are scientifically compounded at specific dosages to obtain the moisturizing and soothing composition having excellent performance, so that the moisturizing and soothing composition has obvious advantages in moisturizing and soothing aspects. The raw materials of the moisturizing and soothing composition of the present invention are obtained from natural plant sources, no toxic reagent is used in the preparation process, and the product properties are mild, thereby being capable of well satisfying the skin care requirements of people having sensitive skin.

Description

A moisturizing and soothing composition and preparation method thereof Technical Field

[0001] The present invention relates to the technical field of cosmetic preparation, and in particular to a moisturizing and soothing composition and a preparation method thereof. Background Art

[0002] Sensitive skin is a common skin defect. This type of skin has high reactivity and poor tolerance, and is prone to allergies. It is a skin condition in which the skin barrier function is damaged. It mainly occurs on the face and has subjective symptoms such as burning, redness, stinging, and itching. It may be accompanied by objective signs such as erythema, capillary dilation, and desquamation. In severe cases, even allergic reactions such as redness, swelling, and rash may occur. The occurrence of sensitive skin is related to damaged skin barrier function, skin neuroimmune disorders, and skin microecological imbalance. Dry skin is more prone to symptoms of sensitive skin than other skin types.

[0003] Due to increasingly severe environmental pollution, the development of diverse cosmetics, and growing awareness of skin health, concerns about skin sensitivity are growing. Cosmetics containing natural plant-based ingredients are increasingly popular among consumers due to their mild properties, safety, and significant effectiveness. The incorporation of appropriate plant-based ingredients to achieve anti-allergic, anti-inflammatory, and soothing effects has become a hot topic in cosmetics product development. However, the selection of appropriate plants, their combination with other cosmetic ingredients, and the reduction of production complexity and costs still require targeted research by technical R&D personnel.

[0004] CN112999141A discloses a composition and cream for manufacturing skin care products. The composition includes 3-7 parts of Atractylodes macrocephala, 8-15 parts of Artemisia argyi essential oil, 7-15 parts of Acorus calamus essential oil, 6-12 parts of Duckweed, 8-12 parts of Snake skin, 30-65 parts of Kochia scoparia fruit, 6-10 parts of Frankincense oil, and 8-16 parts of Myrrh essential oil. The document claims that the technical solution is mild and non-irritating, promotes skin cell metabolism, brightens the skin, and whitens the complexion.

[0005] CN105748351A discloses a plant composition and its application. The plant composition is prepared by extracting 50-80 parts of Osmanthus fragrans, 40-70 parts of Tripterygium wilfordii, 35-65 parts of Cyperus rotundus, and 25-55 parts of Gerbera herb. The document claims that the plant composition has the functions of repairing damaged cells, improving skin immunity, and protecting the moisture of the skin's stratum corneum. When used in cosmetics, it has significant effects on repairing and protecting sensitive skin.

[0006] CN110339331A discloses a soothing plant essential oil containing clove oil, turpentine oil, ginger root oil, lavender oil, frankincense oil, olive oil, myrrh oil, cinnamon oil, Chuanxiong oil, Scots pine leaf oil, safflower seed oil, eucalyptus globulus leaf oil, mugwort oil, menthol, menthyl carboxamide, isododecane, methyl salicylate, tetrahydropiperine, camphor, bisabolol, siler root extract, and notopterygium wilfordii extract. This soothing plant essential oil is primarily composed of plant essential oils that have calming, stress-relieving, and sleep-improving effects. It is intended for external use to reduce the intake of harmful substances in the human body. It is claimed to be easy to use, well-absorbed, odorless, and soothing upon application, resulting in a relaxing and enjoyable experience.

[0007] As can be seen, existing technologies utilize plant ingredients to achieve anti-allergic, repairing, anti-inflammatory, and soothing effects. However, these solutions often suffer from numerous components, complex formulations, and lack of definitive proof of efficacy. This makes it challenging for researchers to develop products with superior soothing properties. Therefore, there is an urgent need to develop a cosmetic composition that can impart excellent soothing properties to meet market demand for soothing cosmetics.

[0008] Summary of the Invention

[0009] The purpose of the present invention is to provide a moisturizing and soothing composition, which selects suitable plant raw materials to extract active ingredients, and scientifically compounded according to specific dosages, and has excellent moisturizing and soothing effects.

[0010] To achieve the above object, the present invention adopts the following technical solutions:

[0011] A moisturizing and soothing composition comprises the following ingredients by weight: 20%-40% of Adenophora adenophora extract, 5%-20% of Ampelopsis pilosula extract, 10%-30% of Saxifraga herb extract, 10%-25% of Artemisia argyi extract, 10%-25% of Ginkgo biloba extract, and 5%-25% of Astragalus membranaceus extract.

[0012] Preferably, the composition comprises the following components by weight percentage: 30%-35% of Adenophora Root extract, 5%-10% of Bletilla striata extract, 15%-30% of Saxifraga Herba extract, 10%-20% of Artemisia argyi extract, 10%-20% of Ginkgo Biloba Extract, and 10%-25% of Astragalus Membranaceus extract.

[0013] Preferably, the composition comprises the following components by weight percentage: 35% of Adenophora Root extract, 5% of Bletilla striata extract, 30% of Saxifraga Herba extract, 10% of Artemisia argyi extract, 10% of Lithospermum officinale extract and 10% of Astragalus membranaceus extract.

[0014] Adenophora: A plant of the genus Adenophora in the Campanulaceae family. Its roots are mainly used as medicine or to extract active ingredients. The active ingredients of Adenophora roots are mainly β-sitosterol, β-sitosterol-β-D-pyranoglucopyranoside, cypermethrin, and octacosanoids. Adenophora root extract has a broad-spectrum antibacterial effect and also has a certain inhibitory effect on fungi.

[0015] Bletilla striata: It is the tuberous root of Bletilla striata, a plant of the genus Ampelopsis in the grape family. It contains active ingredients such as β-sitosterol, fumaric acid, and carotene. It has different degrees of inhibitory effects on skin fungi, and has significant inhibitory effects on Staphylococcus aureus, Shigella dysenteriae, etc., and also has certain moisturizing and whitening effects.

[0016] Saxifraga: The whole herb of Saxifraga, a plant of the genus Saxifraga of the family Saxifragaceae, contains active ingredients such as bergenin, quercetin, quercetin, gallic acid, etc. It has a significant inhibitory effect on elastase and has anti-aging, whitening, anti-inflammatory and other effects.

[0017] Artemisia: It is a plant of the genus Artemisia in the Asteraceae family. It contains volatile oils, including 2-methylbutanol, 2-hexenal, cis-3-hexen-1-ol, tricycloolefins and other ingredients. It has broad-spectrum antibacterial properties. In addition, it also has good moisturizing properties and certain anti-inflammatory properties.

[0018] Ginkgo Biloba: A plant of the genus Lithospermum in the Boraginaceae family, it contains active ingredients such as shikonin, naphthoquinone, phenolic acid, alkaloids, phenol, etc. Lithospermum has strong antibacterial properties and has obvious inhibitory effects on Staphylococcus aureus, Escherichia coli, Candida albicans, etc. It also has anti-inflammatory and antioxidant properties and can also be used in anti-aging products.

[0019] Astragalus: It is the root of Astragalus mongolica and Astragalus membranaceus, plants of the genus Astragalus in the legume family. It contains saponins and isoflavones, has obvious antioxidant effects, is used in anti-aging products, and also has certain anti-inflammatory and skin conditioning effects.

[0020] Methods for extracting plant active ingredients are well known to practitioners in the industry. The present invention does not limit the method for preparing plant extracts; conventional alcohol extraction and / or water extraction can be used, depending on the physical and chemical properties of the active ingredients. For example, the method for preparing a plant extract of the present invention may include the following steps: drying and pulverizing the plant material, extracting with ethanol, centrifuging the extract, and concentrating under reduced pressure to obtain a concentrate, and freeze-drying the concentrate to obtain an extract.

[0021] As a preferred solution, after adding ethanol, the extraction is leaching, the extraction temperature is 60-80° C., and the extraction time is 2-4 hours.

[0022] The present invention also provides a cosmetic comprising the moisturizing and soothing composition and a cosmetically acceptable base and / or additives.

[0023] Furthermore, the cosmetic contains 5-15% by mass of the moisturizing and soothing composition, and the balance is the matrix and / or additives, wherein the additives are selected from one or more of moisturizers, antioxidants, skin conditioners, thickeners, emollients, pH regulators, polypeptides, and anti-inflammatory agents.

[0024] The present invention also provides the use of the moisturizing and soothing composition for preparing cosmetics. Preferably, the cosmetics are selected from one of a facial cream, a facial mask, an emulsion, an essence, and a makeup remover. Depending on the different dosage forms of the cosmetics, corresponding other raw materials can be added.

[0025] Beneficial effects of the present invention: The present invention creatively scientifically compounds Adenophora radix extract, Bletilla striata extract, Saxifraga herb extract, Artemisia argyi extract, Ginkgo chinensis extract, and Astragalus membranaceus extract in specific dosages to obtain a moisturizing and soothing composition with excellent performance. Performance tests have shown that the moisturizing and soothing composition of the present invention has a hyaluronidase inhibition rate of more than 93% and a skin moisture content change rate of up to 167%, and has obvious advantages in moisturizing and soothing. Moreover, the moisturizing and soothing composition of the present invention can also obtain the expected moisturizing and soothing effect by adding it to a cosmetic composition in a certain dosage ratio, and has good compounding performance with common cosmetic ingredients. The raw materials of the moisturizing and soothing composition of the present invention are all of natural plant origin, no toxic reagents are used in the preparation process, the product is mild in nature, and can well meet the skin care needs of people with sensitive skin. Example

[0026] The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention. The following specific embodiments further describe the present invention.

[0027] Plant extract preparation

[0028] The present invention has no limitation on the preparation method of the plant extracts, and conventional alcohol extraction and / or water extraction can be used, and the selection is made according to the physical and chemical properties of the active ingredients.

[0029] As an example, the plant extracts of the present application are prepared by the following method:

[0030] (1) Adenophora adenophora extract: The root of Adenophora adenophora was dried and crushed, and 60% ethanol by volume was added at a solid-liquid ratio of 1:5, and the mixture was extracted at 75°C for 3 hours. The extract was centrifuged and concentrated under reduced pressure to obtain a concentrate, and the concentrate was freeze-dried to obtain the Adenophora adenophora extract.

[0031] (2) Bletilla striata extract: The root of Bletilla striata was dried and crushed, and 60% ethanol by volume was added at a solid-liquid ratio of 1:8, and the mixture was extracted at 60°C for 2 hours. The extract was centrifuged and concentrated under reduced pressure to obtain a concentrate, and the concentrate was freeze-dried to obtain the Bletilla striata extract.

[0032] (3) Saxifraga extract: The saxifrage was dried and crushed, and 70% by volume ethanol was added at a solid-liquid ratio of 1:5, and the mixture was extracted at 80°C for 3 hours. The extract was centrifuged and concentrated under reduced pressure to obtain a concentrate, and the concentrate was freeze-dried to obtain the saxifrage extract.

[0033] (4) Artemisia argyi extract: Artemisia argyi was dried and crushed, and 70% ethanol by volume was added according to a solid-liquid ratio of 1:8, and the extract was extracted at 75°C for 2 hours. The extract was centrifuged and concentrated under reduced pressure to obtain a concentrate, and the concentrate was freeze-dried to obtain the Artemisia argyi extract.

[0034] (5) Ginkgo lithospermum extract: The root of Ginkgo lithospermum was dried and crushed, and 70% ethanol by volume was added at a solid-liquid ratio of 1:6, and the mixture was extracted at 65°C for 4 hours. The extract was centrifuged and concentrated under reduced pressure to obtain a concentrated solution, and the concentrated solution was freeze-dried to obtain the Ginkgo lithospermum extract.

[0035] (6) Astragalus extract: The root of Astragalus was dried and crushed, and 60% ethanol by volume was added at a solid-liquid ratio of 1:5, and the mixture was extracted at 70°C for 2 h. The extract was centrifuged and concentrated under reduced pressure to obtain a concentrate, which was freeze-dried to obtain the Astragalus extract.

[0036] Study on the anti-allergic and soothing effect of the composition

[0037] Hyaluronidase is a major factor in allergic reactions. When an allergen first invades the body, the body produces the antibody IgE. When the allergen invades again, it binds to the IgE antibody on the surface of mast cells, triggering activation signals and releasing histamine. Histamine, activated by hyaluronidase, triggers an allergic reaction. Therefore, inhibiting hyaluronidase activity can effectively prevent the occurrence of allergic reactions. Hyaluronidase has a strong correlation with inflammatory and allergic reactions. Years of industry testing and research have also found that in vitro hyaluronidase inhibition testing methods are consistent with the conclusions of human soothing efficacy evaluations.

[0038] The present invention adopts the following method to determine the in vitro hyaluronidase inhibition rate: 0.1 mL of 2.5 mmol / L CaCl2 is added to 0.5 mL of hyaluronidase (600 U / mL), and the mixture is kept at 37°C for 20 minutes; 0.5 mL of sample solution is added, and the mixture is kept at 37°C for 20 minutes; 2 mL of 0.4 mg / mL sodium hyaluronate is added, and the mixture is kept at 37°C for 40 minutes; 1 mL of acetylacetone solution is added, the mixture is placed in a boiling water bath and heated for 15 minutes, and immediately cooled with ice water for 5 minutes; finally, 1.0 mL of Ehrlich reagent is added, the mixture is placed at room temperature for 60 minutes for color development, and the absorbance is measured at 530 nm.

[0039] The calculation formula for the inhibition rate of hyaluronidase by the sample is: Hyaluronidase inhibition rate (%) = [(V A -V B )-(V C -V D )] / (V A -V B )×100%

[0040] Where V A Indicates: absorbance of control solution (acetic acid buffer solution is used instead of sample solution); V B Indicates: absorbance of blank solution (acetic acid buffer solution is used instead of sample solution and enzyme solution); V C Indicates: absorbance of sample solution; V D Indicates: absorbance of sample blank solution (using acetate buffer solution instead of enzyme solution).

[0041] Each test example was prepared according to the components and mass percentages shown in Table 1. A sample solution with an extract mass concentration of 50% was prepared using a mixed solvent of ethanol and deionized water in a mass ratio of 1:1. The anti-allergic and soothing efficacy of each test example sample solution was tested according to the above method. The test results are shown in Table 1.

[0042] Table 1

[0043] As shown in Table 1, the test results show that when each plant extract is used alone, Artemisia argyi extract and Astragalus membranaceus extract have relatively good hyaluronidase inhibition performance, while Adenophora radix extract and Ampelopsis pilosula extract have poor hyaluronidase inhibition effect. When any five of the six plant extracts of the present invention are mixed, it is also difficult to obtain an ideal hyaluronidase inhibition effect. However, compared to Test Examples 9, 10, 11, and 13, Test Example 8 without Astragalus membranaceus extract and Test Example 12 without Artemisia argyi extract, the hyaluronidase inhibition rate is significantly lower, which also shows that the anti-allergic and soothing properties of Artemisia argyi extract and Astragalus membranaceus extract dominate among the several plant extracts of the present invention. The six plant extracts were mixed and used (since the mass percentage could not be completely divided into 6 parts, a roughly equal distribution method was adopted, see Table 1 Test Example 1). It can be found that although the dosage of Artemisia argyi extract and Astragalus membranaceus extract was greatly reduced relative to Test Example 5 and Test Example 7, the hyaluronidase inhibition rate of Test Example 1 was not significantly different from that of Test Example 5 and Test Example 7, indicating that there is a certain synergistic effect between the six plant extracts of the present invention, and the compound use can obtain a better hyaluronidase inhibition effect, suggesting that the compound use of Adenophora radix extract, Bletilla striata extract, Saxifraga officinalis extract, Artemisia argyi extract, Ginkgo chinensis extract, and Astragalus membranaceus extract can make the product have good anti-allergic and soothing effects.

[0044] Each embodiment and comparative example was prepared according to the components and mass percentages shown in Tables 2 and 3, and a sample solution with an extract mass concentration of 50% was prepared using a mixed solvent of ethanol and deionized water in a mass ratio of 1:1. The anti-allergic and soothing efficacy of the sample solution of each embodiment and comparative example was tested according to the above method. The test results are shown in Tables 2 and 3.

[0045] Table 2

[0046] Table 3

[0047] Table 2, 3 results can show that each plant extract of the present invention is compounded according to a specific dosage ratio, and an extract composition with a higher hyaluronidase inhibition rate can be obtained, and the anti-allergic soothing effect is excellent. Artemisia argyi extract and Astragalus extract themselves have good hyaluronidase inhibition performance, but simply increasing their dosage can not obtain the expected more hyaluronidase inhibition effect, which may be due to certain interactions between each extract active ingredient, and it is necessary to exert good anti-allergic soothing effect under the condition of a specific content ratio. The present invention has obtained the optimal dosage range of six kinds of plant extracts of the present invention through a large amount of creative work, which can make each plant extract active ingredient play a synergistic effect, and significantly improve the hyaluronidase inhibition performance of the present composition.

[0048] Study on the moisturizing and hydrating effect of the composition

[0049] The skin conductance of the subjects' forearms was measured using a high-frequency conductivity meter. A high conductance value indicates a high moisture content in the skin's stratum corneum. The specific testing steps are as follows: the subjects thoroughly cleaned their forearm skin, allowed it to air dry, and then marked an area of ​​skin and applied the composition of the embodiment or comparative example to be tested. The conductance of the skin area was tested 5 minutes after application, and again 60 and 120 minutes after application. Each embodiment or comparative example was tested once on three different subjects, and the test results were averaged. Each embodiment or comparative example was tested on a different subject. During the test, the subjects were exposed to an ambient temperature of 20-25°C and a relative humidity of 45-55%.

[0050] Since the conductivity test method has a correlation coefficient of up to 0.99 with the measured stratum corneum moisture content, it can very sensitively measure the stratum corneum moisture content. Therefore, for the convenience of test statistics, the change in conductivity value is used to represent the change in skin moisture content, that is, skin moisture content change rate / % = (E1-E0) / E0×100%, where E1 is the conductivity value of the skin area to be tested after the test sample is applied, and E0 is the initial conductivity value of the skin area to be tested before the test sample is applied. For Examples 1-6 and Comparative Examples 1-12, a sample solution with an extract mass concentration of 50% was prepared using a mixed solvent of ethanol and deionized water in a mass ratio of 1:1. The sample solutions of each Example and Comparative Example were tested for moisturizing and hydrating efficacy according to the skin moisture content determination method described above. The skin moisture content change rate at various time points after application of the test sample is shown in Table 4. A skin area near the skin area where the Example or Comparative Example sample was applied was marked and no reagent was applied to serve as a blank control group. Each subject was tested in the blank control group, and the results were averaged.

[0051] Table 4

[0052] For the composition comprising plant active ingredients, the amount of each component has an important impact on the performance that the product finally has. As shown in Table 4 test results, six kinds of plant extracts of the present invention are compounded with specific amounts. No matter whether it is 5min short-term moisturizing or 120min long-lasting moisturizing, the skin water content can be significantly increased compared to the initial state of the sample without applying the embodiment, with excellent moisturizing and hydrating effect. By contrast, although Comparative Examples 1-12 can improve the skin stratum corneum water content to a certain extent, the amount ratio of each plant extract is outside the scope of the present invention. Mixed use can not maximize the moisturizing effect of components such as Ampelopsis pilosula extract, Saxifraga extract, and Artemisia argyi extract, and the skin water content change rate still has a large gap compared to Example 1-6. It can also be seen that even if six kinds of plant extracts of the present invention are used, and the amount of the extract with moisturizing effect is increased, it is not necessarily to achieve ideal moisturizing and hydrating effect.

[0053] Research on the overall efficacy of cosmetics

[0054] The moisturizing and soothing composition of the present invention exhibits excellent compounding properties, is highly compatible with common cosmetic ingredients, and exhibits stable product properties and efficacy. Cosmetic samples were prepared according to the components and mass percentages shown in Table 5 using conventional industry preparation methods. The moisturizing and soothing efficacy of the cosmetic samples was tested using the aforementioned methods. The test results are shown in Table 5.

[0055] Table 5

[0056] As can be seen from the test results in Table 5, the cosmetic compositions containing the moisturizing and soothing compositions of the present invention also have excellent moisturizing, hydrating, and anti-inflammatory soothing effects. After compounding with common cosmetic ingredients, the hyaluronidase inhibition rate and the skin moisture content change rate after 120 minutes of the cosmetics of Examples 7-10 can all reach high levels. The dosage of the moisturizing and soothing compositions of Comparative Examples 13 and 14 is relatively low, making it difficult to exert the ideal anti-inflammatory and hydrating effect. The hyaluronidase inhibition rate and the skin moisture content change rate are low. The moisturizing and soothing compositions of Comparative Examples 15 and 16 are used in larger dosages. Although the cosmetic compositions can have excellent moisturizing and soothing effects, the advantages are not obvious compared to the cosmetics of the examples. Considering the actual production cost, it is unnecessary to use such a large dose of this moisturizing and soothing composition. Sodium hyaluronate is a classic and highly effective moisturizing ingredient in the cosmetics industry, and dipotassium glycyrrhizate is a common anti-inflammatory conditioning ingredient. Comparative Example 17 uses an equal mass of sodium hyaluronate to replace the moisturizing and soothing composition, and Comparative Example 18 uses an equal mass of dipotassium glycyrrhizate to replace the moisturizing and soothing composition. It can be seen that although the amount of sodium hyaluronate or dipotassium glycyrrhizate used in Comparative Examples 17 and 18 is increased compared to Example 7, their moisturizing and soothing effects are significantly lower than that of Example 7, indicating that the moisturizing and soothing composition of the present invention has better moisturizing, hydrating, anti-inflammatory and soothing properties.

[0057] The above embodiments are preferred implementation schemes of the present invention. In addition, the present invention can also be implemented in other ways. Any obvious replacement without departing from the concept of the present invention is within the scope of protection of the present invention.

Claims

1. A moisturizing and soothing composition, characterized in that: The composition comprises the following components by weight percentage: 20%-40% of Adenophora adenophora extract, 5%-20% of Bletilla striata extract, 10%-30% of Saxifraga herbacea extract, 10%-25% of Artemisia argyi extract, 10%-25% of Ginkgo biloba extract and 5%-25% of Astragalus membranaceus extract.

2. The moisturizing and soothing composition according to claim 1, characterized in that: The invention comprises the following components by weight percentage: 30%-35% of Adenophora adenophora extract, 5%-10% of Bletilla striata extract, 15%-30% of Saxifraga herbacea extract, 10%-20% of Artemisia argyi extract, 10%-20% of Ginkgo biloba extract and 10%-25% of Astragalus membranaceus extract.

3. The moisturizing and soothing composition according to claim 1, characterized in that: The invention comprises the following components by weight percentage: 35% of Adenophora radix extract, 5% of Bletilla striata extract, 30% of Saxifraga herbacea extract, 10% of Artemisia argyi extract, 10% of Lithospermum officinale extract and 10% of Astragalus membranaceus extract.

4. The moisturizing and soothing composition according to any one of claims 1 to 3, characterized in that: The extract preparation method comprises the following steps: drying and crushing the plant raw material, adding ethanol for extraction, centrifuging and reducing the pressure to concentrate the extract to obtain a concentrated solution, and freeze-drying the concentrated solution to obtain the extract.

5. The moisturizing and soothing composition according to claim 4, wherein the extraction after adding ethanol is immersion, the extraction temperature is 60-80°C, and the extraction time is 2-4h.

6. A cosmetic, characterized in that: The invention comprises the moisturizing and soothing composition according to any one of claims 1 to 5, and further comprises a cosmetically acceptable base and / or additives.

7. The cosmetic according to claim 6, characterized in that: The cosmetic comprises 5-15% by weight of the moisturizing and soothing composition, and the remainder is the matrix and / or additives, wherein the additives are selected from one or more of moisturizers, antioxidants, skin conditioners, thickeners, emollients, pH regulators, polypeptides, and anti-inflammatory agents.

8. Use of the moisturizing and soothing composition according to any one of claims 1 to 5 for preparing cosmetics.

9. The use according to claim 8, wherein the cosmetic is selected from the group consisting of a facial cream, a facial mask, an emulsion, an essence, and a makeup remover.

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