Genetically modified non-human animal with human or chimeric trbc
Patent Information
- Application Number
- PCT/CN2025/080851
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-06-06
- Filing Date
- 2025-03-05
- Publication Date
- 2025-10-02
AI Technical Summary
Traditional drug research and development methods using in vitro and in vivo animal models fail to replicate human body environments, leading to high failure rates and discrepancies between animal test results and clinical trials due to differences in tumor microenvironments and immune cell interactions.
Development of genetically modified non-human animals expressing human or chimeric TRBC proteins, allowing for the creation of animal models that mimic human biological systems, facilitating drug screening and evaluation of anti-TRBC antibodies and drugs targeting TRBC.
The animal models provide a powerful tool for studying TRBC function and screening cancer drugs, reducing development costs and time by bridging the gap between animal and human disease states, and enabling effective drug screening and treatment of immune-related diseases.