Methods for cascade amplifications of therapeutic payloads (CATP) & compositions for cancer immunotherapies and gene therapy

A nucleic acid construct composition with sa-mRNA and virus structural proteins delivered via LNPs addresses the specificity and delivery challenges of existing cancer treatments, achieving targeted cancer cell death and enhanced immune response.

WO2025189168A9 Publication Date: 2025-11-06SUNVAX MRNA THERAPEUTICS INC
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Patent Information

Application Number
PCT/US2025/019051
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-12-24
Filing Date
2025-03-07
Publication Date
2025-11-06

AI Technical Summary

Technical Problem

Current cancer treatments, including viral vectors, chemotherapy, and surgery, lack specificity to target cancerous cells while preserving normal cells, risking off-target effects and face challenges in manufacturing and delivery of therapeutic agents like mRNA, leading to immune responses and reduced efficacy.

Method used

A composition comprising a first nucleic acid construct encoding self-amplifying mRNA (sa-mRNA) and a second nucleic acid construct encoding virus structural proteins, delivered via a non-viral payload system, specifically an LNP, to enhance gene expression and viral particle production in cancer cells.

Benefits of technology

The composition induces targeted cancer cell death, increases gene expression by up to 500-fold, and enhances central memory CD8 T cell count, demonstrating improved cancer treatment efficacy with reduced off-target effects.

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Abstract

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncolytic defective virus compositions and methods of in vivo synthesis thereof. The composition includes a first nucleic acid construct encoding a self-amplifying mRNA (sa-mRNA) encoding at least one gene of interest (GOI) or a plurality of GOIs, a second nucleic acid construct encoding an mRNA encoding at least one virus structural protein, and at least one payload delivery system.
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