Method to reduce the calcification of a biological heart valve prosthesis by a titanium containing coating in combination with UV irradiation

A titanium-coated biological heart valve prosthesis treated with UV irradiation reduces calcification by 70%, enhancing durability and eliminating the need for blood thinners, addressing premature calcification and durability issues.

WO2025214824A1 Publication Date: 2025-10-16PFM MEDICAL TITANIUM GMBH
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Patent Information

Application Number
PCT/EP2025/058865
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-04-09
Filing Date
2025-04-01
Publication Date
2025-10-16

AI Technical Summary

Technical Problem

Biological heart valves made from glutaraldehyde-fixed pericardium experience premature calcification due to chemical processes and antigenicity, leading to reduced durability and the need for chronic anticoagulation therapy.

Method used

A method involving a titanium-containing coating on the biological heart valve prosthesis, followed by UV irradiation with wavelengths between 100 nm and 450 nm, to reduce calcification and enhance durability.

Benefits of technology

The method significantly reduces calcification by 70% after 9 weeks, allowing for implantation without extracorporeal circulation and eliminating the need for blood thinners, thereby reducing the risk of internal bleeding.

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Abstract

The invention relates to a method to reduce the calcification of a biological heart valve prosthesis by a titanium containing coating in combination with UV irradiation. The method for treating the biological heart valve prosthesis with a titanium containing coating, particularly a glutaraldehyde-fixed pericardium, comprising the steps of: a) treating the biological heart valve prosthesis with a titanium containing coating; and b) irradiating the treated biological heart valve prosthesis with light of a wavelength between 100 nm and 450 nm. This results in a biological heart valve prosthesis by a hypothesized polymerization with a homogenous surface.
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