Methylobacterium compositions for inhibition of plant pathogens and related methods

Methylobacterium strains are used to inhibit soilborne pathogens like Pythium and Fusarium, enhancing crop growth and yield by reducing disease severity and overcoming chemical fungicide resistance.

WO2025217399A1 Publication Date: 2025-10-16NEWLEAF SYMBIOTICS INC
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Patent Information

Application Number
PCT/US2025/024066
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-04-11
Filing Date
2025-04-10
Publication Date
2025-10-16

AI Technical Summary

Technical Problem

Current methods for mitigating plant diseases caused by soilborne pathogens such as Pythium and Fusarium species are inadequate, leading to significant crop losses and resistance to chemical fungicides, necessitating the development of effective microbial inoculants for extended protection.

Method used

Compositions comprising specific Methylobacterium strains, such as NLS0059, NLS0165, NLS0214, and others, are applied to plants or soil to inhibit infection and reduce disease severity by targeting oomycete and fungal pathogens, optionally combined with fungicides like strobilurin and Trichoderma.

Benefits of technology

The Methylobacterium strains effectively inhibit plant pathogen infections, reducing disease severity by at least 10-95% and improving growth metrics, yield, and methane mitigation in crops like rice, soybean, and other plants.

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Abstract

Compositions comprising Methylobacterium that inhibit infection by a oomycete or fungal plant pathogen and / or reduce severity of symptoms caused by a plant pathogenic oomycete or fungus, methods of making the compositions, and methods of treating plants to inhibit and / or reduce symptoms of oomycete and / or fungal infections are provided.
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