Inula flower extract, composition, and preparation method therefor and use thereof

Abstract

An Inula flower extract, a composition, and a preparation method therefor and use thereof. The preparation method for the Inula flower extract comprises: mixing Inula flower with an extraction solvent, and carrying out soaking, extraction, and filtration to obtain a crude Inula flower extract; and mixing the crude Inula flower extract with a color fixing agent, adjusting pH, and carrying out programmed heating treatment to obtain the Inula flower extract.

Description

Inula japonica extract, composition, preparation method and application thereof TECHNICAL FIELD

[0001] The present application relates to the technical field of skin care products, in particular to an Inula japonica extract, a composition, a preparation method and application thereof. BACKGROUND

[0002] Skin aging is a direct manifestation of biological aging, and the main phenomena are wrinkle proliferation, rough skin and loss of elasticity, etc. Skin aging not only affects the appearance of the face, but also can cause psychological problems such as depression, and even is related to the occurrence of many diseases. Although skin aging is inevitable, it is possible to delay skin aging.

[0003] Plant extracts are favored by consumers due to their natural, green and healthy concept. Many plant extracts can smooth the skin, remove skin aging wrinkles and improve skin elasticity, thereby having the effect of delaying skin aging. Inula japonica has a long history of medicinal use in China, has the effects of descending qi, eliminating phlegm, removing water and stopping vomiting, is a commonly used drug for clinical treatment of wind-cold cough, chest and diaphragm stuffiness, vomiting and qi, and is a representative medicinal flavor with sinking medicinal properties. Modern pharmacological studies have shown that Inula japonica mainly contains sesquiterpenes, flavonoids, phenolic acids, steroids, volatile oils, polysaccharides and other compounds, and Inula japonica and its effective components have good pharmacological activities in anti-inflammatory, anti-tumor, neuroprotective, anti-aging, hypoglycemic and lipid-lowering, anti-allergic, anti-atherosclerosis, anti-myocardial injury, antioxidant, anti-melanin production, anti-liver injury and other fields.

[0004] However, Inula japonica extract has not been widely used in the field of cosmetics or skin care products. It is of great significance to develop a preparation method with high content of effective components of Inula japonica, stable performance and controllable quality, and to apply the Inula japonica extract with optimized extraction efficiency to the field of skin care products for the in-depth development and wide application of Inula japonica. SUMMARY

[0005] One object of the present application is to provide an Inula japonica extract with good effect on delaying skin aging, comprising flavones and polyphenols; and the mass ratio of the flavones to the polyphenols is (1.5-2.1):(0.6-1.1).

[0006] In the specific embodiment of the present application, the mass ratio of the flavones to the polyphenols is (1.8-2.1):(0.8-1.1).

[0007] One object of the present application is to provide a preparation method capable of preparing Inula japonica extract with stable properties, comprising mixing Inula japonica with an extraction solvent, soaking, extracting and filtering to obtain a crude Inula japonica extract;

[0008] Mix the rough extract of Inula japonica with a color fixing agent, adjust pH, and perform programmed temperature treatment to obtain the Inula japonica extract.

[0009] In the specific embodiment of the present application, the ratio of Inula japonica to extraction solvent is 1:20-1:80.

[0010] In the specific embodiment of the present application, the ratio of Inula japonica to extraction solvent is 1:30-1:50.

[0011] In the specific embodiment of the present application, the temperature of extraction is 60-80℃.

[0012] In the specific embodiment of the present application, the time of extraction is 0.5-3h.

[0013] In the specific embodiment of the present application, the time of extraction is 1-2h.

[0014] In the specific embodiment of the present application, the time of soaking is 0.5-2h.

[0015] In the specific embodiment of the present application, the turbidity of the rough extract of Inula japonica is ≤5.0.

[0016] In the specific embodiment of the present application, the pH is adjusted to 5.5-6.5.

[0017] In the specific embodiment of the present application, the color fixing agent comprises at least one of disodium EDTA, sodium hexametaphosphate, sodium trimetaphosphate, sodium polyphosphate, sodium dihydrogen phosphate, and vitamin C.

[0018] In the specific embodiment of the present application, the color fixing agent comprises disodium EDTA.

[0019] In the specific embodiment of the present application, the mass of the color fixing agent is 0.01%-0.1% of the mass of the rough extract of Inula japonica.

[0020] In the specific embodiment of the present application, the mass of the color fixing agent is 0.04%-0.08% of the mass of the rough extract of Inula japonica.

[0021] In the specific embodiment of the present application, the programmed temperature treatment comprises:

[0022] The rough extract of Inula japonica is heated to 70-80℃ and kept for 10-30min to obtain a first liquid phase system;

[0023] The first liquid phase system is heated to 80-90℃ and kept for 10-30min to obtain a second liquid phase system;

[0024] The second liquid phase system is warmed to 90-100℃, and kept for 1-5h, to obtain the extract of Inula britannica L.

[0025] In the specific embodiments of the present application, the extraction solvent comprises water and / or alcohol.

[0026] In the specific embodiments of the present application, the alcohol comprises monohydric alcohol and / or polyhydric alcohol.

[0027] In the specific embodiments of the present application, the monohydric alcohol comprises at least one of methanol, ethanol, 1-propanol, 2-propanol, n-butanol, isobutyl alcohol, 1-pentanol, 2-pentanol, 3-pentanol, 1-hexanol, 2-hexanol, 3-hexanol, 1-heptanol, 2-heptanol, 3-heptanol, 4-heptanol, 1-octanol, 2-octanol, 3-octanol, 4-octanol, 1-nonanol, 2-nonanol, 3-nonanol, 4-nonanol, 5-nonanol, 1-decanol, 2-decanol, 3-decanol, 4-decanol, 5-decanol.

[0028] In the specific embodiments of the present application, the polyhydric alcohol comprises at least one of ethylene glycol, 1,2-propanediol, 1,3-propanediol, glycerol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2-propaneglycol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 1,2,5-pentanetriol, 1,2-hexanediol.

[0029] In the specific embodiments of the present application, the mass fraction of alcohol in the extraction solvent ranges from 0.1% to 100%.

[0030] In the specific embodiments of the present application, the mass fraction of alcohol in the extraction solvent ranges from 40% to 80%.

[0031] In the specific embodiments of the present application, the above-mentioned Inula britannica L. extract or the Inula britannica L. extract prepared by the above-mentioned preparation method is applied in the preparation of cosmetics.

[0032] In the specific embodiments of the present application, a composition comprising the above-mentioned Inula britannica L. extract or the Inula britannica L. extract prepared by the above-mentioned preparation method is further provided.

[0033] In the specific embodiments of the present application, the composition further comprises water, a stabilizer, a humectant, and a preservative.

[0034] In the specific embodiments of the present application, the composition comprises Inula britannica L. extract 1% to 50%, stabilizer 0.03% to 0.05%, humectant 1.5% to 2.5%, and preservative 0.5% to 1%, with the balance being water.

[0035] Compared with the prior art, the application has the following beneficial effects:

[0036] (1) The prepared Inula japonica extract has good stability, and the active index content is still stable under long-term storage conditions, and the stable color and turbidity states can still be maintained.

[0037] (2) The obtained Inula japonica extract has obvious improvement effects on improving skin roughness, skin fish tail wrinkle depth, mandibular line angle, skin elasticity and tightness. BRIEF DESCRIPTION OF DRAWINGS

[0038] In order to more clearly illustrate the technical solutions in the specific embodiments or the prior art, the drawings needed to be used in the specific embodiments or the prior art description will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present application, and those skilled in the art can obtain other drawings according to these drawings without creative labor. DETAILED DESCRIPTION

[0039] The technical solutions of the present application will be described clearly and completely below in combination with the drawings and specific embodiments, but those skilled in the art will understand that the following described embodiments are part of the embodiments of the present application, not all the embodiments, and are only used to illustrate the present application, and should not be regarded as limiting the scope of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application. The specific conditions are not specified in the embodiments, and are carried out according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not specified by the manufacturer, and are conventional products that can be purchased on the market.

[0040] In one aspect of the present application, an Inula japonica extract is provided, comprising flavones and polyphenols, and the mass ratio of the flavones to the polyphenols is (1.5-2.1):(0.6-1.1).

[0041] The Inula japonica extract with the mass ratio of flavones to polyphenols kept in a specific range has more significant effects of improving skin elasticity, improving skin roughness and fish tail wrinkle depth, and delaying skin aging.

[0042] In the specific embodiments of the present application, the mass ratio of the flavones to the polyphenols is (1.8-2.1):(0.8-1.1).

[0043] In one aspect of the present application, a preparation method of an Inula japonica extract is provided, comprising: mixing Inula japonica with an extraction solvent, soaking, extracting, filtering to obtain a crude Inula japonica extract; adding a color fixing agent to the crude Inula japonica extract, adjusting pH, and treating by programmed temperature to obtain the Inula japonica extract.

[0044] In the preparation method of the present application, the Inula japonica is mixed with the extraction solvent to obtain a crude Inula japonica extract, and the Inula japonica extract obtained by mixing with the color fixing agent and then adjusting the pH and treating by programmed temperature has good stability, and can still maintain stable chroma and turbidity under long-term storage conditions.

[0045] In the specific embodiment of the present application, the Inula japonica is mixed with the extraction solvent, and the soaking time is 0.5-2 h.

[0046] In the specific embodiment of the present application, the Inula japonica is mixed with the extraction solvent, and the soaking time can be 0.5, 1, 1.5 or 2 h, or a time between any two of the above values.

[0047] In the specific embodiment of the present application, the Inula japonica is mixed with the extraction solvent, and the soaking time is 0.5-1 h. After the Inula japonica is mixed with the extraction solvent, the soaking is performed for a period of time, and then the extraction is performed at a higher temperature, which can effectively promote the leaching of beneficial components of the Inula japonica during the extraction.

[0048] In the specific embodiment of the present application, the ratio of the Inula japonica to the extraction solvent m / V is 1:20-1:80. Specifically, the ratio of the Inula japonica to the extraction solvent is the ratio between the mass (g) of the Inula japonica and the volume (mL) of the extraction solvent, i.e., the ratio of the Inula japonica to the extraction solvent is 1 g:20 mL-1 g:80 mL.

[0049] In the specific embodiment of the present application, the ratio of the Inula japonica to the extraction solvent can be 1:20, 1:30, 1:40, 1:50, 1:60, 1:70 or 1:80, or a ratio between any two of the above values.

[0050] In the specific embodiment of the present application, the ratio of the Inula japonica to the extraction solvent is 1:30-1:50.

[0051] In the extraction, the mass of the Inula japonica and the mass of the extraction solvent are kept in a suitable range, which can make the beneficial components in the Inula japonica fully leached, while avoiding excessive use of the extraction solvent to cause waste of reagents.

[0052] In the specific embodiment of the present application, the Inula japonica is mixed with the extraction solvent, and the temperature during the extraction is 60-80℃.

[0053] In the specific embodiment of the present application, the Inula japonica is mixed with the extraction solvent, and the temperature during the extraction can be 60, 65, 70, 75 or 80℃, or a temperature between any two of the above values.

[0054] In the specific embodiment of the present application, the extraction temperature of the Inula japonica and the extraction solvent is 70-80℃.

[0055] In the extraction process, the temperature is kept in a suitable range, which can improve the leaching efficiency of the beneficial components in the Inula japonica and also improve the stability of the obtained Inula japonica extract, so that the color or turbidity can be kept stable during the long-term maintenance process.

[0056] In the specific embodiment of the present application, the extraction time of the Inula japonica and the extraction solvent is 0.5-3h.

[0057] In the specific embodiment of the present application, the extraction time of the Inula japonica and the extraction solvent can be 0.5, 1, 1.5, 2, 2.5 or 3h, or also can be the time between any two of the above values.

[0058] In the specific embodiment of the present application, the extraction time of the Inula japonica and the extraction solvent is 1-2h.

[0059] In the specific embodiment of the present application, the extraction solvent includes water and / or alcohol. The extraction solvent can be water, can be alcohol, or can be a solution containing water and alcohol.

[0060] In the specific embodiment of the present application, the alcohol includes monohydric alcohol and / or polyhydric alcohol.

[0061] In the specific embodiment of the present application, the monohydric alcohol includes at least one of methanol, ethanol, 1-propanol, 2-propanol, n-butanol, isobutyl alcohol, 1-pentanol, 2-pentanol, 3-pentanol, 1-hexanol, 2-hexanol, 3-hexanol, 1-heptanol, 2-heptanol, 3-heptanol, 4-heptanol, 1-octanol, 2-octanol, 3-octanol, 4-octanol, 1-nonanol, 2-nonanol, 3-nonanol, 4-nonanol, 5-nonanol, 1-decanol, 2-decanol, 3-decanol, 4-decanol, 5-decanol.

[0062] In the specific embodiment of the present application, the polyhydric alcohol includes at least one of ethylene glycol, 1,2-propanediol, 1,3-propanediol, glycerol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2-propaneglycol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 1,2,5-pentanetriol, 1,2-hexanediol.

[0063] In the specific embodiment of the present application, the alcohol includes ethanol and / or butanediol.

[0064] In the specific embodiment of the present application, the mass fraction of alcohol in the extraction solvent ranges from 0.1% to 100%.

[0065] In the specific embodiments of the present application, the mass fraction of alcohol in the extraction solvent is 0.1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% or 100%, or a mass fraction between any two of the above values.

[0066] In the specific embodiments of the present application, the mass fraction of alcohol in the extraction solvent is 40%-80%.

[0067] In the specific embodiments of the present application, the mixture of Inula japonica and the extraction solvent is filtered after extraction. The filtering method can be any conventional filtering method, for example, the mixture can be filtered through 100-mesh gauze and then refined through H70 paperboard to obtain the Inula japonica crude extract.

[0068] In the specific embodiments of the present application, the turbidity of the Inula japonica crude extract obtained after filtration is ≤5.0. It can be understood that the turbidity of the Inula japonica crude extract obtained after mixing Inula japonica with the extraction solvent can be maintained at a relatively low level by using a conventional filtering method, and the stability of the obtained Inula japonica extract can be further improved.

[0069] In the specific embodiments of the present application, the Inula japonica crude extract is mixed with a color fixing agent, and the pH is adjusted to 5.5-6.5. Specifically, after mixing the Inula japonica crude extract with the color fixing agent, a pH adjusting agent is added to the mixture to adjust the pH of the mixture to an appropriate range, so that the reaction system is more stable. The pH adjusting agent can be at least one of sodium hydroxide, potassium hydroxide, citric acid and malic acid.

[0070] In the specific embodiments of the present application, the color fixing agent comprises at least one of disodium EDTA, sodium hexametaphosphate, sodium trimetaphosphate, sodium polyphosphate, sodium dihydrogen phosphate and vitamin C.

[0071] In the specific embodiments of the present application, the color fixing agent comprises disodium EDTA.

[0072] Disodium EDTA, sodium hexametaphosphate, sodium trimetaphosphate, sodium polyphosphate, sodium dihydrogen phosphate and vitamin C are commonly used reagents or additives in the field of cosmetics. The Inula japonica crude extract prepared by mixing the above substances does not introduce reagents that are not suitable for use in the field of cosmetics, and additional processes are not required for removal.

[0073] In the specific embodiments of the present application, the mass of the color fixing agent is 0.01%-0.1% of the mass of the Inula japonica crude extract.

[0074] In the specific embodiments of the present application, the mass of the fixing agent is 0.01%, 0.03%, 0.05%, 0.08% or 0.1% of the mass of the crude Inula japonica extract, or a ratio between any two of the above values.

[0075] In the specific embodiments of the present application, the mass of the fixing agent is 0.04%-0.08% of the mass of the crude Inula japonica extract.

[0076] Adding a small amount of the fixing agent and then performing programmed temperature treatment can enable the obtained Inula japonica extract to have good stability.

[0077] In the specific embodiments of the present application, the method of programmed temperature treatment comprises:

[0078] The crude Inula japonica extract is warmed to 70-80℃ and kept for 10-30 min to obtain a first liquid phase system;

[0079] The first liquid phase system is warmed to 80-90℃ and kept for 10-30 min to obtain a second liquid phase system;

[0080] The second liquid phase system is warmed to 90-100℃ and kept for 1-5 h to obtain the Inula japonica extract.

[0081] In the specific embodiments of the present application, the temperature of the warming treatment of the crude Inula japonica extract can be 70, 72, 75, 78 or 80℃, or a temperature between any two of the above values.

[0082] In the specific embodiments of the present application, the temperature of the warming treatment of the crude Inula japonica extract is 75-78℃.

[0083] In the specific embodiments of the present application, the time of the warming treatment of the crude Inula japonica extract can be 10, 15, 20, 25 or 30 min, or a time between any two of the above values.

[0084] In the specific embodiments of the present application, the time of the warming treatment of the crude Inula japonica extract is 15-26 min.

[0085] In the specific embodiments of the present application, the temperature of the warming treatment of the first liquid phase system can be 80, 82, 85, 88 or 90℃, or a temperature between any two of the above values.

[0086] In the specific embodiments of the present application, the temperature of the warming treatment of the first liquid phase system is 85-88℃.

[0087] In the specific embodiments of the present application, the time of the warming treatment of the first liquid phase system can be 10, 15, 20, 25 or 30 min, or a time between any two of the above values.

[0088] In the specific embodiment of the present application, the first liquid phase system temperature raising treatment time is 15-26 min.

[0089] In the specific embodiment of the present application, the second liquid phase system temperature raising treatment temperature can be 90, 92, 95, 98 or 100℃, or a temperature between any two of the above.

[0090] In the specific embodiment of the present application, the second liquid phase system temperature raising treatment temperature is 95-98℃.

[0091] In the specific embodiment of the present application, the second liquid phase system temperature raising treatment time can be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5 h, or a time between any two of the above.

[0092] In the specific embodiment of the present application, the second liquid phase system temperature raising treatment time is 2-4 h.

[0093] The temperature raising process is performed in three temperature raising stages. The reaction system formed by the inula japonica crude extract and the color fixing agent is treated by the above-mentioned temperature raising process, so that the inula japonica extract with low turbidity and stable color can be obtained under long-term storage conditions.

[0094] In the specific embodiment of the present application, an inula japonica extract is provided, which is prepared by the above-mentioned preparation method.

[0095] In the specific embodiment of the present application, the inula japonica extract comprises flavones and polyphenols.

[0096] In the specific embodiment of the present application, the mass ratio of the flavones to the polyphenols is (1.5-2.1):(0.6-1.1).

[0097] In the specific embodiment of the present application, the mass ratio of the flavones to the polyphenols is (1.8-2.1):(0.8-1.1).

[0098] In the specific embodiment of the present application, a composition is provided, which comprises the inula japonica extract prepared by the above-mentioned method.

[0099] In the specific embodiment of the present application, the composition further comprises water, a stabilizer, a humectant and a preservative. It can be understood that the amounts of the inula japonica extract, the stabilizer, the humectant and the preservative in the composition can be adjusted according to actual needs.

[0100] In the specific embodiment of the present application, the composition comprises 1-50% of the Inula japonica extract, 0.03-0.05% of the stabilizer, 1.5-2.5% of the humectant, and 0.5-1% of the preservative by mass percentage, with the balance being water. It can be understood that when the amounts of the Inula japonica extract, the stabilizer, the humectant, and the preservative in the composition are within the above ranges, the resulting composition has a significant improvement effect on improving the roughness of the skin, the depth of the fish tail wrinkles of the skin, the angle of the jaw line, the elasticity of the skin, and the tightness of the skin.

[0101] In the specific embodiment of the present application, the stabilizer in the composition comprises disodium ethylenediaminetetraacetate.

[0102] In the specific embodiment of the present application, the humectant comprises glycerol.

[0103] In the specific embodiment of the present application, the preservative comprises at least one of phenoxyethanol, benzyl alcohol, phenethyl alcohol, benzoic acid, sodium benzoate, p-hydroxyacetophenone, and 1,2-hexanediol.

[0104] The following is further specifically described by using specific examples.

[0105] Example 1

[0106] The Inula japonica extract is prepared by using the following method:

[0107] 1) The Inula japonica and an ethanol aqueous solution with a mass fraction of 70% are mixed, soaked for 0.6 h, warmed to 70°C, and extracted for 1 h, and the obtained mixture is filtered with 100-mesh gauze and then refined with H70 paper board to obtain a crude Inula japonica extract; wherein the solid-liquid ratio m / v of the Inula japonica and the ethanol aqueous solution is 1:30, and the turbidity of the crude Inula japonica extract is 1.81.

[0108] 2) The crude Inula japonica extract is mixed with disodium EDTA, stirred until the solution is clear and transparent to obtain a mixed solution; the pH of the mixed solution is adjusted to 5.62; wherein the mass of the disodium EDTA is 0.05% of the mass of the crude Inula japonica extract;

[0109] 3) The mixed solution after the pH adjustment in step 2) is subjected to programmed temperature rising treatment, and the specific process of the programmed temperature rising is as follows: warmed to 75°C, and kept for 20 min to obtain a first liquid phase system; the first liquid phase system is warmed to 85°C, and kept for 20 min to obtain a second liquid phase system; the second liquid phase system is warmed to 95°C, and kept for 3 h to obtain the Inula japonica extract.

[0110] Example 2

[0111] The Inula japonica extract is prepared by using the following method:

[0112] 1) mix Inula japonica and 50% butanediol aqueous solution, soak for 0.8h, heat to 77℃, extract for 1.5h, filter the obtained mixed phase with 100 mesh gauze, and then fine filter with H70 paper board to obtain Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and butanediol aqueous solution is 1:30, and the turbidity of Inula japonica crude extract is 1.96;

[0113] 2) mix Inula japonica crude extract and disodium EDTA, stir until the solution is clear and transparent to obtain a mixed solution; adjust the pH of the mixed solution to 6.11; wherein the mass of disodium EDTA is 0.04% of the mass of Inula japonica crude extract;

[0114] 3) perform programmed temperature treatment on the mixed solution after adjusting the pH in step 2), and the specific process of programmed temperature is as follows: heat to 75℃, and extract for 20min to obtain a first liquid phase system; heat the first liquid phase system to 86℃, and extract for 17min to obtain a second liquid phase system; heat the second liquid phase system to 96℃, and extract for 3h to obtain Inula japonica extract.

[0115] Example 3

[0116] Inula japonica extract is prepared by the following method:

[0117] 1) mix Inula japonica and 50% butanediol aqueous solution, soak for 0.5h, heat to 75℃, and extract for 1h to obtain Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and butanediol aqueous solution is 1:40, and the turbidity of Inula japonica crude extract is 2.41;

[0118] 2) mix Inula japonica crude extract and disodium EDTA, stir until the solution is clear and transparent to obtain a mixed solution; adjust the pH of the mixed solution to 5.89; wherein the mass of disodium EDTA is 0.05% of the mass of Inula japonica crude extract;

[0119] 3) perform programmed temperature treatment on the mixed solution after adjusting the pH in step 2), and the specific process of programmed temperature is as follows: heat to 74℃, and extract for 15min to obtain a first liquid phase system; heat the first liquid phase system to 85℃, and extract for 20min to obtain a second liquid phase system; heat the second liquid phase system to 97℃, and extract for 4h to obtain Inula japonica extract.

[0120] Example 4

[0121] Inula japonica extract is prepared by the following method:

[0122] 1) mix Inula japonica and 50% by mass butanediol aqueous solution, soak for 0.5 h, warm up to 75℃, and extract for 1 h; filter the obtained mixed phase with 100-mesh gauze, and then fine filter with H70 paper board to obtain Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and butanediol aqueous solution is 1:40, and the turbidity of the Inula japonica crude extract is 2.51;

[0123] 2) mix the Inula japonica crude extract and disodium EDTA, stir until the solution is clear and transparent to obtain a mixed solution; adjust the pH of the mixed solution to 6.00; wherein the mass of disodium EDTA is 0.08% of the mass of the Inula japonica crude extract;

[0124] 3) perform programmed temperature treatment on the mixed solution after adjusting the pH in step 2), and the specific process of programmed temperature treatment is as follows: warm up to 78℃, and keep warm for 15 min to obtain a first liquid phase system; warm up the first liquid phase system to 89℃, and keep warm for 20 min to obtain a second liquid phase system; warm up the second liquid phase system to 95℃, and keep warm for 4 h to obtain the Inula japonica extract.

[0125] Example 5

[0126] The Inula japonica extract is prepared by the following method:

[0127] 1) mix Inula japonica and 50% by mass butanediol aqueous solution, soak for 0.5 h, warm up to 75℃, and extract for 1 h; filter the obtained mixed phase with 100-mesh gauze, and then fine filter with H70 paper board to obtain Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and butanediol aqueous solution is 1:40, and the turbidity of the Inula japonica crude extract is 2.51;

[0128] 2) mix the Inula japonica crude extract and disodium EDTA, stir until the solution is clear and transparent to obtain a mixed solution; adjust the pH of the mixed solution to 6.00; wherein the mass of disodium EDTA is 0.08% of the mass of the Inula japonica crude extract;

[0129] 3) perform programmed temperature treatment on the mixed solution after adjusting the pH in step 2), and the specific process of programmed temperature treatment is as follows: warm up to 78℃, and keep warm for 15 min to obtain a first liquid phase system; warm up the first liquid phase system to 89℃, and keep warm for 20 min to obtain a second liquid phase system; warm up the second liquid phase system to 95℃, and keep warm for 4 h to obtain the Inula japonica extract.

[0130] Example 6

[0131] The Inula japonica extract is prepared by the following method:

[0132] 1) Inlet Inula helenium and 50% butanediol aqueous solution, soak for 0.5h, heat to 75℃, extract for 1h, filter the mixture with 100 mesh gauze, then filter with H70 paperboard, get the crude extract of Inula helenium; wherein, the ratio of material to liquid m / v is 1:40, the turbidity of the crude extract of Inula helenium is 2.43;

[0133] 2) Mix the crude extract of Inula helenium with sodium trimetaphosphate, stir until the solution is clear and transparent, get the mixture; adjust the pH of the mixture to 6.04; wherein, the mass of sodium trimetaphosphate is 0.1% of the mass of the crude extract of Inula helenium;

[0134] 3) The mixture after adjusting the pH in step 2) is subjected to programmed temperature treatment, the specific process of programmed temperature is: heat to 76℃, keep warm for 19min, get the first liquid phase system; heat the first liquid phase system to 86℃, keep warm for 26min, get the second liquid phase system; heat the second liquid phase system to 95℃, keep warm for 4h, get the extract of Inula helenium.

[0135] Example 7

[0136] The extract of Inula helenium is prepared by the following method:

[0137] 1) Inlet Inula helenium and 50% butanediol aqueous solution, soak for 0.5h, heat to 75℃, extract for 1h, filter the mixture with 100 mesh gauze, then filter with H70 paperboard, get the crude extract of Inula helenium; wherein, the ratio of material to liquid m / v is 1:40, the turbidity of the crude extract of Inula helenium is 2.05;

[0138] 2) Mix the crude extract of Inula helenium with sodium trimetaphosphate, stir until the solution is clear and transparent, get the mixture; adjust the pH of the mixture to 6.37; wherein, the mass of sodium trimetaphosphate is 0.1% of the mass of the crude extract of Inula helenium;

[0139] 3) The mixture after adjusting the pH in step 2) is subjected to programmed temperature treatment, the specific process of programmed temperature is: heat to 73℃, keep warm for 17min, get the first liquid phase system; heat the first liquid phase system to 84℃, keep warm for 25min, get the second liquid phase system; heat the second liquid phase system to 93℃, keep warm for 4h, get the extract of Inula helenium.

[0140] Comparative Example 1

[0141] The extract of Inula helenium is prepared by the following method:

[0142] 1) mix Inula japonica and 50% butanediol aqueous solution, soak for 0.5 h, heat to 75℃, and extract for 1 h, filter the obtained mixed phase with 100-mesh gauze, and then fine filter with H70 paper board to obtain Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and butanediol aqueous solution is 1:40, and the turbidity of the Inula japonica crude extract is 2.07;

[0143] 2) adjust the pH of the Inula japonica crude extract to 5.98;

[0144] 3) perform programmed temperature treatment on the mixed solution after adjusting the pH in step 2), and the specific process of programmed temperature treatment is as follows: heat to 78℃, and extract for 19 min to obtain a first liquid phase system; heat the first liquid phase system to 89℃, and extract for 20 min to obtain a second liquid phase system; heat the second liquid phase system to 95℃, and extract for 4 h to obtain the Inula japonica extract.

[0145] Comparative Example 2

[0146] The Inula japonica extract is prepared by the following method:

[0147] 1) mix Inula japonica and 50% butanediol aqueous solution, soak for 0.8 h, heat to 77℃, and extract for 1.5 h, filter the obtained mixed phase with 100-mesh gauze, and then fine filter with H70 paper board to obtain Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and butanediol aqueous solution is 1:30, and the turbidity of the Inula japonica crude extract is 1.95;

[0148] 2) perform programmed temperature treatment on the Inula japonica crude extract in step 1), and the specific process of programmed temperature treatment is as follows: heat to 75℃, and extract for 20 min to obtain a first liquid phase system; heat the first liquid phase system to 86℃, and extract for 16 min to obtain a second liquid phase system; heat the second liquid phase system to 96℃, and extract for 3 h to obtain the Inula japonica mixed solution;

[0149] 3) mix the Inula japonica mixed solution with disodium EDTA, stir until the solution is clear and transparent to obtain a mixed solution; adjust the pH of the mixed solution to 6.13 to obtain the Inula japonica extract; wherein the mass of disodium EDTA is 0.04% of the mass of the Inula japonica crude extract.

[0150] Comparative Example 3

[0151] The Inula japonica extract is prepared by the same method as in Example 4, except that in step 3), instead of performing programmed temperature treatment, the mixed solution after adjusting the pH in step 2) is directly heated to 95℃, and extracted for 4 h to obtain the Inula japonica extract.

[0152] Comparative Example 4

[0153] The Inula japonica extract is prepared by the following method:

[0154] 1) Inula japonica and a 50% mass fraction of butanediol aqueous solution are mixed, soaked for 0.5 h, heated to 75°C, and extracted for 1 h. The obtained mixed phase is filtered with 100 mesh gauze and then refined with H70 paperboard to obtain an Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and the butanediol aqueous solution is 1:40, and the turbidity of the Inula japonica crude extract is 2.04;

[0155] 2) The Inula japonica crude extract is mixed with disodium EDTA, and stirred until the solution is clear and transparent to obtain a mixed solution. The pH of the mixed solution is adjusted to 5.87; wherein the mass of disodium EDTA is 0.05% of the mass of the Inula japonica crude extract;

[0156] 3) The mixed solution after pH adjustment in step 2) is subjected to programmed temperature treatment: heated to 74°C, and extracted for 15 min to obtain a first liquid phase system; the first liquid phase system is heated to 85°C, and extracted for 20 min to obtain a second liquid phase system; the second liquid phase system is heated to 97°C, and extracted for 7 h to obtain the Inula japonica extract.

[0157] Comparative Example 5

[0158] The Inula japonica extract is prepared by the following method:

[0159] 1) Inula japonica and a 50% mass fraction of butanediol aqueous solution are mixed, soaked for 0.5 h, heated to 75°C, and extracted for 1 h. The obtained mixed phase is filtered with 100 mesh gauze and then refined with H70 paperboard to obtain an Inula japonica crude extract; wherein the solid-liquid ratio m / v of Inula japonica and the butanediol aqueous solution is 1:40, and the turbidity of the Inula japonica crude extract is 0.37;

[0160] 2) The Inula japonica crude extract is mixed with disodium EDTA, and stirred until the solution is clear and transparent to obtain a mixed solution. The pH of the mixed solution is adjusted to 5.89; wherein the mass of disodium EDTA is 0.05% of the mass of the Inula japonica crude extract;

[0161] 3) The mixed solution after pH adjustment in step 2) is subjected to programmed temperature treatment: heated to 74°C, and extracted for 20 min to obtain a first liquid phase system; the first liquid phase system is heated to 85°C, and extracted for 15 min to obtain a second liquid phase system; the second liquid phase system is heated to 97°C, and extracted for 0.5 h to obtain the Inula japonica extract.

[0162] Comparative Example 6

[0163] The Inula japonica extract is prepared by the following method, which comprises:

[0164] 1) Inosculum and 50% butanediol aqueous solution, and disodium EDTA were mixed, soaked for 0.8h, and heated to 77℃, and the extraction time was 1.5h. The obtained mixed phase was filtered with 100 mesh gauze, and then refined with H70 paperboard to obtain the inosculum crude extract. In the process, the solid-liquid ratio m / v of inosculum and butanediol aqueous solution was 1:30, the mass of disodium EDTA was 0.05% of the mass of butanediol aqueous solution, and the turbidity of the inosculum crude extract was 1.44;

[0165] 2) The pH of the inosculum crude extract was adjusted to 6.12;

[0166] 3) The mixed solution after adjusting the pH in step 2) was subjected to programmed temperature treatment. The specific process of programmed temperature was as follows: heated to 75℃, and kept for 19min to obtain the first liquid phase system; the first liquid phase system was heated to 86℃, and kept for 18min to obtain the second liquid phase system; the second liquid phase system was heated to 96℃, and kept for 3h to obtain the inosculum extract.

[0167] Comparative Example 7

[0168] The inosculum extract was prepared by the following method:

[0169] 1) Inosculum and 50% butanediol aqueous solution, and disodium EDTA were mixed, soaked for 0.8h, and heated to 77℃, and the extraction time was 1.5h. The obtained mixed phase was filtered with 100 mesh gauze, and then refined with H70 paperboard to obtain the inosculum crude extract. In the process, the solid-liquid ratio m / v of inosculum and butanediol aqueous solution was 1:30, the mass of disodium EDTA was 0.05% of the mass of butanediol aqueous solution, and the turbidity of the inosculum crude extract was 1.44;

[0170] 2) The pH of the inosculum crude extract was adjusted to 6.12;

[0171] 3) The mixed solution after adjusting the pH in step 2) was heated to 96℃, and kept for 3h to obtain the inosculum extract.

[0172] The beneficial ingredients, color and turbidity of the samples obtained in the above examples and comparative examples were detected, and the appearance and odor of the samples were observed under the conditions of 0, 5, 10d, respectively. The specific results are shown in Table 1.

[0173] Table 1: Effective substance content, appearance and physicochemical indexes of examples 1-7 and comparative examples 1-7 under the condition of 55℃ for 0, 5, 10d

[0174] As shown in the data in Table 1, the color and turbidity of the extract of Inula japonica prepared by the method of the present application change very little after a period of time (5 days, 10 days) at 55℃, and the color and turbidity state both show good effects.

[0175] As shown in the color and turbidity detection results of Comparative Examples 1, 2, 6 and 7, when no fixing agent is added, or the fixing agent is added when the Inula japonica is mixed with the extraction solvent, or the fixing agent is added after the programmed temperature increase, the stability of the prepared Inula japonica extract is obviously deteriorated, the turbidity obviously increases after 5 days at 55℃, and the change range of the color is also obviously increased, especially after 10 days, the change range of the color and turbidity is further obviously enlarged.

[0176] As shown in the detection data of Comparative Example 4, the extraction time is too long at the last stage of the programmed temperature increase, which has no positive effect on the increase of the effective component content in the Inula japonica extract, and the stability of the product is obviously weakened, and turbidity appears after 5 days and 10 days at 55℃.

[0177] As shown in the detection data of Comparative Examples 3 and 5, the extraction time is too short at the last stage of the programmed temperature increase, or no programmed temperature increase is performed, and the color and turbidity state of the obtained Inula japonica extract is also unstable, and the color and turbidity change greatly after a period of time.

[0178] In order to further verify the effect of the Inula japonica extract prepared by the preparation method of the present application, two formula products are used for effect test, and the formulas of the two formula products are as follows:

[0179] Formula 1: Inula japonica extract prepared by Examples 1-5 and Comparative Examples 1-3, Comparative Example 6 and Comparative Example 7, 5% by mass fraction, ethylenediaminetetraacetic acid disodium salt 0.04%, glycerol 2%, preservative 1%, and the balance is water; the obtained formula samples are respectively recorded as Example 1A, Example 2A, Example 3A, Example 4A, Example 5A, Comparative Example 1A, Comparative Example 2A, Comparative Example 3A, Comparative Example 6A and Comparative Example 7A.

[0180] Formula 2: ethylenediaminetetraacetic acid disodium salt 0.04%, glycerol 2%, preservative 1%, and the balance is water; the obtained sample is recorded as Formula Sample A.

[0181] The amount of each substance in the above Formula 1 is only a specific amount configuration for effect test. The amount of each substance in the composition of the present application has good anti-aging effect within a reasonable range, and the effect test of the present application is only used as an example for illustration. In actual application, the amount of Inula japonica extract or the amount of each substance in the composition can be adjusted according to actual needs.

[0182] (1) Skin roughness Ra test results:

[0183] 150 volunteers were selected to use the product of formula 1 for 2 months, and formula 2 was used as a control for testing. The specific test method is as follows:

[0184] The test site room temperature (25±1) ℃, relative humidity (40±5) %, the test subjects should be kept in stable state before testing. After using the same cleansing product for cleansing, sit still for 30 min before testing;

[0185] 150 volunteers were divided into 10 groups. After cleansing, before using the sample, the EVASKIN instrument was used to collect images of the left and right faces. Half of the face of each group of subjects was treated with a face mask containing inula japonica extract (test area), and the other half of the face was treated with a face mask without inula japonica extract (control area). After 15 minutes, the mask was removed, and after cleansing with water, the EVASKIN instrument was used again to collect imaging data of the test area and the control area. Finally, the skin roughness Ra data of the test area and the control area on the cheeks were obtained during processing, and t-test analysis was performed using SPSS statistical software.

[0186] The effect of inula japonica extract on reducing skin roughness Ra was evaluated by comparing the changes in indicators before and after use, as well as between the test area and the control area. The test results are shown in Table 2 below.

[0187] Table 2: Improvement effect of skin roughness Ra of formula samples A, examples 1A-5A, comparative examples 1A-3A, comparative example 6A and comparative example 7A Note: In the above table, *: comparison before and after use, P<0.05; #: comparison within the group, P<0.05.

[0188] As shown in Table 2, after using the formula samples of examples 1A-5A and comparative examples 1A-3A, comparative example 6A and 7A, the skin roughness Ra was significantly smaller than before (p<0.05). When compared between groups, the skin roughness Ra after using the formula samples of examples 1A-5A, comparative examples 1A-3A, comparative example 6A, and comparative example 7A was significantly smaller than that of formula sample A (p<0.05). However, the improvement effect of examples 1A-5A was significantly higher than that of comparative examples 1A-3A, comparative example 6A, and comparative example 7A, and the effect of example 4A was the best.

[0189] (2) Fish tail wrinkle depth test results:

[0190] 150 volunteers were selected and each used the product of formula 1 for 2 months, while formula 2 was used as a control for testing. The specific testing method is as follows:

[0191] The room temperature of the testing site was (25±1)℃, the relative humidity was (40±5)%, and the volunteers should be in a stable state before testing. After using the same cleansing product for cleansing, the volunteers sat still for 30 minutes in the testing environment before testing;

[0192] 150 volunteers were divided into 10 groups. After cleansing, the EVASKIN instrument was used to collect images of the left and right faces before using the samples. Half-face experiments were conducted on the 10 groups of volunteers, with one half of the face being applied with a face mask containing inula japonica extract (test area) and the other half being applied with a face mask base without inula japonica extract (control area). After 15 minutes, the face mask was removed, and after cleansing with water, the EVASKIN instrument was used again to collect imaging data of the test area and the control area. Finally, the cheek skin fish tail wrinkle depth data obtained by processing was collected from the test area and the control area, and t-test analysis was performed using SPSS statistical software.

[0193] The anti-wrinkle effect of inula japonica extract in reducing fish tail wrinkle depth was evaluated by testing the changes in indicators before and after use, as well as between the test area and the control area. The test results are shown in Table 3 below.

[0194] Table 3 Improvement effect of skin fish tail wrinkle depth of formula samples A, examples 1A-5A, comparative examples 1A-3A, comparative example 6A and comparative example 7A Note: In the above table, *: comparison before and after use, P<0.05; #: comparison within the group, P<0.05.

[0195] As can be seen from Table 3, after using the formula samples of examples 1A-5A and comparative examples 1A-3A, comparative example 6A and comparative example 7A, the skin fish tail wrinkle depth was significantly shallower than before use (p<0.05); when compared between groups, the skin fish tail wrinkle depth after using the formula samples of examples 1A-5A and comparative examples 1A-3A, comparative example 6A and comparative example 7A was significantly smaller than that of formula sample A (p<0.05). The improvement effect of examples 1A-5A was still significantly higher than that of comparative examples 1A-3A, comparative example 6A and comparative example 7A. Among them, example 4A had the best effect.

[0196] (3) Test results of improving the mandibular line:

[0197] 150 volunteers were selected and each used the product of formula 1 for 2 months, while formula 2 was used as a control for testing. The specific testing method is as follows:

[0198] The test site is at room temperature (25±1) °C, relative humidity (40±5) %, and the subjects should be in a stable state before the test. After cleansing with the same cleansing product, the subjects sit still for 30 minutes in the test environment before the test begins;

[0199] The 150 volunteers were divided into 10 groups. After cleansing, VISIA-CR imaging was used to collect the front photos before using the samples. Half-face experiments were performed on the 10 groups of subjects, with one half of the face being applied with a face mask containing inula japonica extract (test area) and the other half being applied with a face mask without inula japonica extract (control area). After 15 minutes, the face masks were removed, and the subjects were again applied with water to clean their faces. The front photos were collected again, and the angle between the horizontal line and the mandibular line on both sides was measured using PS software. The t-test analysis was performed using SPSS statistical software.

[0200] The effect of inula japonica extract on mandibular line lifting was evaluated by testing the changes in the test area and the control area before and after use. The test results are shown in Table 4 below.

[0201] Table 4: Changes in the angle of the mandibular line for Examples 1A-5A, Comparative Examples 1A-3A, Comparative Example 6A, Comparative Example 7A, and Formula Sample A Note: In the above table, *: comparison before and after use, P<0.05; #: comparison within the group, P<0.05.

[0202] As shown in Table 4, the angle of the mandibular line was significantly improved (p<0.05) after using the formula samples of Examples 1A-5A and Comparative Examples 1A-3A, Comparative Example 6A, and Comparative Example 7A compared to before use. When compared between groups, the angle of the mandibular line was significantly higher (p<0.05) after using the formula samples of Examples 1A-5A and Comparative Examples 1A-3A, Comparative Example 6A, and Comparative Example 7A compared to Formula Sample A. The effect of Examples 1A-5A on lifting the mandibular line was significantly higher than that of Comparative Examples 1A-3A, Comparative Example 6A, and Comparative Example 7A. Among them, Example 4A had the best effect.

[0203] (4) Skin elasticity test results

[0204] 150 volunteers were selected to use Formula 1 product for 2 months, with Formula 2 as a control for testing. The specific test method is as follows:

[0205] The test site is at room temperature (25±1) °C, relative humidity (40±5) %, and the subjects should be in a stable state before the test. After cleansing with the same cleansing product, the subjects sit still for 30 minutes in the test environment before the test begins;

[0206] 150 volunteers were divided into 10 groups, after cleansing, before using the samples, the skin elasticity tester Cutometer dual MPA580 was used to collect data on the left and right sides of the face, 10 groups of subjects were subjected to half-face experiments, half of the face of each group was applied with a face mask containing a jinyinhua extract (test area), and the other half of the face was applied with a face mask base without jinyinhua extract (control area). After 15 minutes, the mask was removed, and the elasticity data (R2 and F4) of the test area and the control area were collected again after cleansing with water. Each collection was performed at 3 points, and finally the data of the left and right sides were calculated by averaging the data of the three points. The SPSS statistical software was used for t-test analysis.

[0207] The effect of jinyinhua extract on increasing skin elasticity was evaluated by testing the changes in indicators before and after use, and between the test area and the control area. The test results are shown in Table 5 below.

[0208] Table 5 Change in skin elasticity (R2, tightness F4) of the samples of Examples 1A-5A, Comparative Examples 1A-3A, Comparative Example 6A and Comparative Example 7A, and Formula Sample A Note: *: comparison before and after use, P<0.05; #: comparison within the group, P<0.05.

[0209] As can be seen from Table 5, after using the samples of Examples 1A-5A and Comparative Examples 1A-3A, Comparative Example 6A and Comparative Example 7A, the skin elasticity (R2, tightness F4) was significantly increased (p<0.05) compared to before use; when compared between groups, the skin elasticity of the samples of Examples 1A-5A and Comparative Examples 1A-3A, Comparative Example 6A and Comparative Example 7A was significantly higher than that of Formula Sample A (p<0.05). The skin elasticity increasing effect of Examples 1A-5A was significantly higher than that of Comparative Examples 1A-3A, Comparative Example 6A and Comparative Example 7A. Among them, Example 4A had the best effect.

[0210] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application, and are not limiting; although the present application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that they can still modify the technical solutions described in the foregoing examples, or make equivalent substitutions for part or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solution to deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. An extract of Inula britannica, characterized in that, Comprise: flavones and polyphenols; the mass ratio of flavones to polyphenols is (1.5-2.1):(0.6-1.1); Preferably, the mass ratio of flavones to polyphenols is (1.8-2.1):(0.8-1.1).

2. A method for preparing an extract of Inula japonica, characterized by, Comprise: Mixing Inula japonica with an extraction solvent, soaking, extracting, filtering to obtain a crude Inula japonica extract; Mixing the crude Inula japonica extract with a color fixing agent, adjusting pH, and treating with programmed temperature to obtain the Inula japonica extract.

3. The preparation method of the knotweed extract according to claim 2, characterized in that, The solid-liquid ratio of the Inula japonica to the extraction solvent is 1:20-1:80; preferably, the solid-liquid ratio is 1:30-1:

50.

4. The preparation method of the knotweed extract according to claim 2, characterized in that, The temperature of the extraction is 60-80℃; Preferably, the extraction time is 0.5-3h; Preferably, the extraction time is 1-2h; Preferably, the soaking time is 0.5-2h; Preferably, the turbidity of the crude Inula japonica extract is ≤5.0; Preferably, the pH is adjusted to 5.5-6.

5.

5. The preparation method of the knotweed extract according to claim 2, characterized in that, The color fixing agent comprises at least one of disodium EDTA, sodium hexametaphosphate, sodium trimetaphosphate, sodium polyphosphate, sodium dihydrogen phosphate, and vitamin C; preferably, the color fixing agent comprises disodium EDTA; Preferably, the mass of the color fixing agent is 0.01%-0.1% of the mass of the crude Inula japonica extract; preferably, the mass of the color fixing agent is 0.04%-0.08% of the mass of the crude Inula japonica extract.

6. The preparation method of the knotweed extract according to claim 2, characterized in that, The programmed temperature treatment comprises: Raising the temperature of the crude Inula japonica extract to 70-80℃, and keeping the temperature for 10-30min to obtain a first liquid phase system; Raising the temperature of the first liquid phase system to 80-90℃, and keeping the temperature for 10-30min to obtain a second liquid phase system; Raising the temperature of the second liquid phase system to 90-100℃, and keeping the temperature for 1-5h to obtain the Inula japonica extract.

7. The preparation method of the knotweed extract according to claim 2, characterized in that, The extraction solvent comprises water and / or alcohol; Preferably, the alcohol comprises monohydric alcohol and / or polyhydric alcohol; Preferably, the monohydric alcohol comprises at least one of methanol, ethanol, 1-propanol, 2-propanol, n-butanol, isobutyl alcohol, 1-pentanol, 2-pentanol, 3-pentanol, 1-hexanol, 2-hexanol, 3-hexanol, 1-heptanol, 2-heptanol, 3-heptanol, 4-heptanol, 1-octanol, 2-octanol, 3-octanol, 4-octanol, 1-nonanol, 2-nonanol, 3-nonanol, 4-nonanol, 5-nonanol, 1-decanol, 2-decanol, 3-decanol, 4-decanol, 5-decanol; Preferably, the polyhydric alcohol comprises at least one of ethylene glycol, 1,2-propanediol, 1,3-propanediol, glycerol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2-propaneglycol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 1,2,5-pentanetriol, 1,2-hexanediol; Preferably, the mass fraction of alcohol in the extraction solvent ranges from 0.1% to 100%; preferably, the mass fraction of alcohol in the extraction solvent ranges from 40% to 80%.

8. Use of the extract of Inula britannica according to claim 1 or of the extract of Inula britannica prepared according to the method of any one of claims 2 to 7 for the preparation of a cosmetic product.

9. A composition characterized in that, The composition comprises the extract of Inula britannica according to claim 1 or the extract of Inula britannica prepared according to the method of any one of claims 2 to 7.

10. The composition of claim 9, wherein, The composition further comprises water, a stabilizer, a humectant and a preservative. Preferably, the composition comprises 1 to 50% of the extract of Inula britannica, 0.03 to 0.05% of the stabilizer, 1.5 to 2.5% of the humectant and 0.5 to 1% of the preservative, the remainder being water, in mass percentage.

9. Use of the extract of Inula britannica according to claim 1 or of the extract of Inula britannica prepared according to the method of any one of claims 2 to 7 for the preparation of a pharmaceutical product.

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