Applications of eucommia ulmoide total alkaloid

Abstract

The invention discloses applications of an eucommia ulmoide total alkaloid for preparing a combination with a sedative-hypnotic effect, and also discloses applications of the eucommia ulmoide total alkaloid for preparing the combination used for treatment of insomnia, anxiety or convulsion; the eucommia ulmoide total alkaloid is prepared by extracting, separating and purifying an eucommia ulmoidespark, an eucommia ulmoide leaf, an eucommia ulmoide male flower and / or eucommia ulmoide whole-plant. The invention extracts, separates and purifies the plant eucommia ulmoide. The invention obtains the eucommia ulmoide total alkaloid by extracting, separating and purifying plant eucommia ulmoide and carries out the application research of the eucommia ulmoide total alkaloid in the sedative-hypnotic field; the result indicates that the eucommia ulmoide total alkaloid has obvious sedative-hypnotic effect and anti-convulsion effect, is a natural active matter for researching and developing a novel health-caring food and new drugs with the sedative-hypnotic effect, can be used for curing the nervous system diseases such as insomnia, anxiety or convulsion and has no side effects or spiritual dependency.

Description

technical field

[0001] The invention relates to the application of a total alkaloid of Eucommia ulmoides. Background technique

[0002] Insomnia is a clinically frequently-occurring disease with complex etiology and prone to repeated attacks. At present, the sedative and hypnotic drugs commonly used in western medicine and western medicine have certain side effects and dependence. The sedative and hypnotic effects of traditional Chinese medicine have become a hot research topic in recent years.

[0003] Eucommia ulmoides Oliv., a deciduous tree, belonging to Pinaceae; branchlets smooth, yellowish-brown or paler, with lamellar pith, bark, branches and leaves all containing gelatin; simple leaves alternate, elliptic or egg-shaped Shape, apex acuminate, base broadly cuneate, margin serrated, young leaves sparsely pubescent above, densely hairy below, old leaves smooth above, sparsely hairy at the lower veins; flowers unisexual, dioecious, at the same time as leaves Open, or ...

Examples

Embodiment 1

[0029] Example 1 Study on the hypnotic and sedative activity of total alkaloids of Eucommia ulmoides:

[0030] 1. Materials and equipment

[0031] 1.1 Main materials and reagents

[0032] Eucommia: taken from the Eucommia planting base in XX County, XX City; Sodium Pentobarbital, a product of Sigma Company in Shanghai; Nicotine, 0.9% Sodium Chloride Solution, Diazepam, Shanghai Shiyi Chemical Reagent Co., Ltd. company.

[0033] 1.2 Main instruments and equipment

[0034] GJ-1 photoelectric counter, Tianjin Medical Equipment Repair Factory.

[0035] 1.3 Experimental animals

[0036] Kunming mice, common grade, 20-30g (male), provided by the Animal Experiment Center of Henan University of Science and Technology.

[0037] 2. Test method

[0038] 2.1 Influence on the autonomous activity of mice:

[0039] Animal grouping: Before the experiment, put the mice into the activity box of the GJ-1 photoelectric counter, start the recorder to record the number of activities within 5...

Embodiment 2

[0069] The preparation of embodiment 2 health-care medicinal tea:

[0070] Add 3 grams of Eucommia ulmoides total alkaloids to 50 kilograms of tea leaves (choose one from black tea, green tea and flower tea), mix well, transfer to a pulverizer to make the particle size of the material 15-30 mesh, add 47 kilograms of compound sweetener, and mix thoroughly. Pack it into a special paper bubble bag, cover it with an aluminum-plastic composite bag, seal it, 5-8 grams per bag, and make a sedative and hypnotic health care tea in a bag.

Embodiment 3

[0071] The preparation of embodiment 3 health-care granules:

[0072] Take the total alkaloids of Eucommia ulmoides obtained by extraction and separation, mix with an appropriate amount of fruit juice powder, sugar and other adjuvants, pass through a 12-mesh sieve, dry at 75°C, package into bags, and prepare various granules with sedative and hypnotic effects, each bag containing biological Base 100 mg.

technical field

[0001] The invention relates to the application of a total alkaloid of Eucommia ulmoides. Background technique

[0002] Insomnia is a clinically frequently-occurring disease with complex etiology and prone to repeated attacks. At present, the sedative and hypnotic drugs commonly used in western medicine and western medicine have certain side effects and dependence. The sedative and hypnotic effects of traditional Chinese medicine have become a hot research topic in recent years.

[0003] Eucommia ulmoides Oliv., a deciduous tree, belonging to Pinaceae; branchlets smooth, yellowish-brown or paler, with lamellar pith, bark, branches and leaves all containing gelatin; simple leaves alternate, elliptic or egg-shaped Shape, apex acuminate, base broadly cuneate, margin serrated, young leaves sparsely pubescent above, densely hairy below, old leaves smooth above, sparsely hairy at the lower veins; flowers unisexual, dioecious, at the same time as leaves Open, or ...

Examples

Embodiment 1

[0029] Example 1 Study on the hypnotic and sedative activity of total alkaloids of Eucommia ulmoides:

[0030] 1. Materials and equipment

[0031] 1.1 Main materials and reagents

[0032] Eucommia: taken from the Eucommia planting base in XX County, XX City; Sodium Pentobarbital, a product of Sigma Company in Shanghai; Nicotine, 0.9% Sodium Chloride Solution, Diazepam, Shanghai Shiyi Chemical Reagent Co., Ltd. company.

[0033] 1.2 Main instruments and equipment

[0034] GJ-1 photoelectric counter, Tianjin Medical Equipment Repair Factory.

[0035] 1.3 Experimental animals

[0036] Kunming mice, common grade, 20-30g (male), provided by the Animal Experiment Center of Henan University of Science and Technology.

[0037] 2. Test method

[0038] 2.1 Influence on the autonomous activity of mice:

[0039] Animal grouping: Before the experiment, put the mice into the activity box of the GJ-1 photoelectric counter, start the recorder to record the number of activities within 5...

Embodiment 2

[0069] The preparation of embodiment 2 health-care medicinal tea:

[0070] Add 3 grams of Eucommia ulmoides total alkaloids to 50 kilograms of tea leaves (choose one from black tea, green tea and flower tea), mix well, transfer to a pulverizer to make the particle size of the material 15-30 mesh, add 47 kilograms of compound sweetener, and mix thoroughly. Pack it into a special paper bubble bag, cover it with an aluminum-plastic composite bag, seal it, 5-8 grams per bag, and make a sedative and hypnotic health care tea in a bag.

Embodiment 3

[0071] The preparation of embodiment 3 health-care granules:

[0072] Take the total alkaloids of Eucommia ulmoides obtained by extraction and separation, mix with an appropriate amount of fruit juice powder, sugar and other adjuvants, pass through a 12-mesh sieve, dry at 75°C, package into bags, and prepare various granules with sedative and hypnotic effects, each bag containing biological Base 100 mg.

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