A detection device

Abstract

The present invention discloses a detection device, comprising a first cavity for collecting and a second cavity for detecting, wherein a detection element is arranged in the second cavity, the first cavity and the second cavity can be closed and connected, and further comprising a third cavity for sample quantification, wherein the third cavity can transfer the sample from the first cavity to the second cavity quantitatively. The detection device of the present invention can collect samples for secondary detection while collecting the detection samples, which is simple and fast, and the detection device of the present invention can quantitatively collect samples and perform accurate quantitative detection, and the detection results are true and reliable with high accuracy; the detection device of the present invention is simple to use and easy to operate.

Description

Technical Field

[0001] The present invention relates to a detection device, in particular to a device capable of performing detection and collection. Background Art

[0002] At present, detection devices for detecting whether a sample contains an analyte are widely used in hospitals or homes. These detection devices for rapid diagnosis include one or more test strips, such as early pregnancy tests, etc. This rapid diagnosis detection device is very convenient and can obtain test results on the test strip in one minute, or at most ten minutes.

[0003] After the test is completed, the sample in the urine cup currently on the market will be contaminated by the test reagent and cannot be used for the second confirmation test, such as described in US Patent No. 7,300,633.

[0004] There are a large number of disposable detection devices that combine collection and detection in the prior art, such as the one described in Chinese Patent 2008103055231, which includes a cup body (equivalent to a collection chamber), a test board containing test paper (equivalent to a detection chamber) is provided on the side of the cup body, and the area where the cup body and the test board are located can be connected. As described in paragraph 0005 of the specification of the document, the person being tested places urine in the urine cup, and the positioning component at this time controls the liquid outlet on the test board to be disconnected from the connecting hole on the cup body. When the tester needs to conduct a test, the tester adjusts the positioning component to connect the liquid outlet with the connecting hole, and at the same time inverts the cup body, so that urine flows into the test strip cavity and the reaction is started autonomously. When the reaction is over, the results are interpreted and recorded, and the urine cup is turned over, so that the urine in the detection area and the urine in the urine cup are separated. In this way, controlling the amount of urine flowing into the test area requires the tester to operate based on his or her own experience and work habits. It is impossible to determine the amount of liquid sample that enters the test area and runs on the test strip. However, in the process of precision testing, the control of the sample amount often has a great impact on the test results.

[0005] In view of the above-mentioned technical problems, it is necessary to improve them and provide other ways to solve the shortcomings of existing traditional technologies. Summary of the invention

[0006] The technical problem to be solved by the present invention is to provide a detection device which can not only collect, detect and re-collect liquid samples, but also realize accurate quantitative detection.

[0007] The technical solution adopted by the present invention to solve the above technical problems is:

[0008] A detection device includes a first cavity for collection and a second cavity for detection, wherein a detection element is arranged in the second cavity, and the first cavity and the second cavity can be closed and connected, and further includes a third cavity for sample quantification, wherein the third cavity can transfer the sample from the first cavity to the second cavity quantitatively. In some preferred modes, the third cavity can obtain the liquid sample while the first cavity is collecting, and in some preferred modes, the third cavity can also obtain the liquid sample after the first cavity has completed the collection.

[0009] Further, the first cavity is provided with an opening that can communicate with the third cavity. In some preferred embodiments, an opening is provided on one side of the first cavity, and the opening can communicate with the third cavity. In some preferred embodiments, the opening can be closed. In some preferred embodiments, the third cavity is provided with an opening that communicates with the first cavity. In some preferred embodiments, the range of the opening of the third cavity is at least not less than the range of the opening of the first cavity. In some preferred embodiments, when the opening of the third cavity overlaps or partially overlaps with the opening of the first cavity, and a liquid sample can be allowed to pass through the overlapped portion, it can be considered that the first cavity and the third cavity are connected.

[0010] Further, the third cavity can be connected to the first cavity or the second cavity respectively. In some preferred embodiments, the third cavity can be connected to the first cavity first, and after the sample is quantified in the third cavity, the third cavity is isolated from the first cavity, and then the third cavity is connected to the second cavity to perform quantitative detection of the sample. In some preferred embodiments, when the third cavity is connected to the first cavity, it is isolated from the second cavity, and in some preferred embodiments, when the third cavity is connected to the second cavity, it is isolated from the first cavity.

[0011] Further, the third cavity is provided with a sealing structure. In some preferred embodiments, the mouth of the third cavity is provided with a sealing structure, and in some preferred embodiments, when the third cavity is closed, the sealing structure seals the mouth of the third cavity to prevent the liquid sample from entering or flowing out of the third cavity, and in some preferred embodiments, when the third cavity is connected to the first cavity or the second cavity, the sealing structure seals at the connection point or the opening to prevent the liquid sample from flowing to places other than the first cavity and the third cavity.

[0012] Furthermore, the third cavity includes at least one pipetting area for transferring the sample from the first cavity to the second cavity. In some preferred embodiments, the third cavity may have one, two or more pipetting areas, and these pipetting areas can all achieve sample quantification. In some preferred embodiments, these pipetting areas can be connected to the first cavity respectively. In some preferred embodiments, these pipetting areas can each store liquid independently. In some preferred embodiments, the liquid storage volume of these pipetting areas can be the same or different. In some preferred embodiments, these pipetting areas can be connected to the first cavity or the second cavity respectively in turn, so as to perform quantitative detection at intervals. In some preferred embodiments, adjacent pipetting areas can be seamlessly connected to the next pipetting area to avoid leakage between the two pipetting areas.

[0013] Further, the detection element can move in the second cavity. In some preferred embodiments, the second cavity can accommodate the detection element and the sample. In some preferred embodiments, under certain conditions, the detection element may not contact the sample. When the conditions change, the detection element will contact the sample. In some preferred embodiments, the movement of the detection element can cause the detection element and the sample to separate or contact.

[0014] Furthermore, the third cavity can move with the detection element, so as to be connected with the first cavity or the second cavity respectively. In some preferred embodiments, the movement of the detection element can drive the third cavity to be connected or disconnected with the first cavity, and in some preferred embodiments, the movement of the detection element can drive the third cavity to be connected or disconnected with the second cavity.

[0015] Furthermore, a linkage element is included, and the linkage element can drive the detection element to move. In some preferred embodiments, the movement of the detection element is achieved under the action of an external force. In some preferred embodiments, the linkage element can be linked with other components of the detection device to drive the detection element to move. In some preferred embodiments, the linkage element can be other components on the detection device, such as a cover.

[0016] Furthermore, the second cavity is provided with a channel that allows the sample in the third cavity to enter. In some preferred embodiments, the channel can be provided between the first cavity and the second cavity. In some preferred embodiments, the first cavity and the second cavity have a common wall surface. In some preferred embodiments, the third cavity can slide on the common wall surface. A clearance gap can be provided on the wall surface. When the third cavity moves to the clearance gap, the liquid sample stored therein will flow into the second cavity. In some preferred embodiments, the common wall surface has a certain slope. In some preferred embodiments, when the third cavity moves on the wall surface, its opening is downward to facilitate the outflow of the liquid sample.

[0017] Furthermore, it also includes a fourth cavity for collecting secondary confirmation test samples, and the fourth cavity can be connected or isolated from the first cavity. In some preferred embodiments, the linkage element can simultaneously link the connection or isolation of the fourth cavity and the first cavity. For example, when the linkage element drives the detection element to move, the fourth cavity and the first cavity can be connected at the same time. In some preferred embodiments, the first cavity is provided with an opening that can be connected to the fourth cavity. In some preferred embodiments, the fourth cavity can collect samples simultaneously with the first cavity.

[0018] Furthermore, it also includes a partition element for connecting or isolating the first cavity and the fourth cavity.

[0019] Further, a linkage element is included, and the linkage element can be linked with the partition element so that the partition element connects or isolates the first cavity and the fourth cavity. In some preferred embodiments, the partition element can be linked by the linkage element so as to connect or isolate the first cavity and the fourth cavity. In some preferred embodiments, the linkage element can simultaneously link the partition element and the detection element.

[0020] Further, when the partition element partitions the first cavity and the fourth cavity, the first cavity can be separated from the fourth cavity. In some preferred embodiments, the first cavity is provided with a passage leading to the fourth cavity, in some preferred embodiments, the fourth cavity is provided with an opening, in some preferred embodiments, the fourth cavity and the first cavity are detachably combined, in some preferred embodiments, the fourth cavity can be separated from the first cavity, and in some preferred embodiments, a closing element of the fourth cavity can also be provided, and after the fourth cavity and the first cavity are separated, the fourth cavity can be closed to form a closed independent cavity, so as to store liquid samples for secondary detection.

[0021] Further, the linkage element includes a cover body, and the cover body can be linked to the detection element and / or the partition element when it is closed. In some preferred embodiments, the cover body will close downward with the cup body when it is closed, and the cover body can press down the detection element while moving downward, so that the detection element moves in the second cavity.

[0022] Furthermore, there is a certain angle between the detection element and the bottom of the detection device.

[0023] The beneficial effects of the present invention are:

[0024] (1) The detection device of the present invention can collect samples for secondary detection at the same time as collecting the detection samples, which is simple and fast; the detection device of the present invention can collect samples quantitatively and perform accurate quantitative detection, and the detection results are true and reliable with high accuracy; and the detection device of the present invention is simple to use and easy to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1is an exploded view of the device of the present invention (wherein the second chamber is on the left).

[0026] Figure 2 It is an exploded view of the device of the present invention in another state (wherein the second chamber is on the right).

[0027] Figure 3 yes Figure 2 Schematic diagram of the structure of the device assembled.

[0028] Figure 4 It is a structural schematic diagram of the partition element.

[0029] Figure 5 It is a schematic diagram of the structure of the first bottle cap.

[0030] Figure 6 It is a structural schematic diagram in which the first bottle cap and the cap body are in a separated state.

[0031] Figure 7 This is a schematic diagram of the structure in which the cover body is connected with the first connecting member.

[0032] Figure 8 1 is a schematic structural diagram showing that the first connecting member and the partition element are in a separated state.

[0033] Fig. 9 It is a schematic diagram of the structure of the cup body (in the figure, in order to show the structure of the bottom of the second cavity, the bottom support is hidden).

[0034] Fig.10 yes Fig. 9 Schematic diagram of the structure after cutting open.

[0035] Fig.11 It is a schematic diagram of the structure of the insert.

[0036] Fig.12 It is a front view of the insert.

[0037] Fig.13 It is a schematic diagram of the structure of the pipetting area.

[0038] Fig.14 It is a structural schematic diagram of the device of the present invention in an initial state.

[0039] Fig.15 yes Fig.14 sectional view of .

[0040] Fig.16 It is a schematic structural diagram of the device of the present invention when the cover is in an open state.

[0041] Fig.17 yes Fig.16 Cross-sectional view (cover is hidden).

[0042] Fig.18 It is a cross-sectional view of the device of the present invention when the cover body is covering the cup body.

[0043] Fig.19 It is a structural schematic diagram of the device of the present invention when the cover body completely covers the cup body.

[0044] Fig. 20 yes Fig.19 sectional view of .

[0045] Fig.21 It is a structural schematic diagram in which the first bottle cap and the cap body are separated, and the fourth cavity and the first cavity are separated after the sample test is completed.

[0046] Fig. 22 It is a structural schematic diagram of the fourth cavity in a closed state. DETAILED DESCRIPTION

[0047] The specific implementation modes of the present invention are further described in detail below in conjunction with the accompanying drawings. It should be pointed out that the embodiments are only specific explanations of the present invention and should not be regarded as limitations of the present invention.

[0048] For specific embodiments, refer to the attached Figure 1-22 .

[0049] like Figure 1-3 As shown, the present invention provides a detection device, comprising a first chamber 1 for collection and a second chamber for detection, the first chamber 1 and the second chamber can be closed and connected, and further comprising a third chamber for sample quantification, the third chamber can quantitatively transfer the sample from the first chamber 1 to the second chamber. Figure 1-3 As shown, in this embodiment, the detection device includes a cover body and a cup body, the cup body includes a first cavity 1, a second cavity and a third cavity, the cover body 7 can cover the first cavity 1, the cover body 7 and the first cavity 1 are connected by threads, in other embodiments, the cover body 7 and the first cavity 1 can also be connected by snap-fitting or other connection methods; in some preferred methods, the first cavity 1, the second cavity and the third cavity can be connected in pairs, when the two cavities are connected, the liquid sample can be transferred between the two cavities; the third cavity can transfer a certain amount of liquid sample to the second cavity; in this embodiment, the second cavity and the third cavity are on the same side of the first cavity 1, so that it is convenient for the third cavity to transfer the liquid sample to the second cavity.

[0050] In some preferred embodiments, Figure 1-3As shown, the second cavity includes a second cavity 2 and a base 20. The base 20 can receive the liquid sample transferred from the third cavity or the first cavity to the second cavity. In this embodiment, the base 20 and the second cavity 2 are connected by welding. In other preferred embodiments, the base 20 and the second cavity 2 can also be connected by other methods, such as bonding. After the second cavity 2 and the base 20 are fixedly connected to form a whole, there will be no leakage. In some preferred embodiments, the second cavity 2 is tilted and the base 20 is also tilted. The inclination angle of the base 20 and the second cavity 2 is consistent. However, the bottom surface of the base 20 is a horizontal plane, and the base 20 can be placed horizontally on the horizontal plane, which makes the device more stable and is conducive to the detection. In some preferred embodiments, the angle between the second cavity 2 and the horizontal plane is greater than 0. ο Less than 90 ο This is conducive to the third chamber transferring the liquid sample to the second chamber.

[0051] In some preferred embodiments, Figure 1-3 As shown, the second cavity is provided with an insert 21, the insert 21 includes an insert plate 211, the upper end of the insert plate 211 is fixedly connected to a first support plate 212, and in some preferred embodiments, a latch 23 is fixedly connected to the upper surface of the first support plate 212; in some preferred embodiments, as Fig.15 As shown, the plug plate 211 is arranged close to the side wall of the second cavity 2, and the inclination angle of the plug plate 211 is consistent with the inclination angle of the second cavity 2. In some preferred embodiments, the upper surface of the second cavity is provided with a plug hole 22, and the plug pin 23 can be inserted into the plug hole 22 and extend out of the plug hole 22 to expose the head of the plug pin 23; the plug pin 23 is inserted into the plug hole 22, and the plug sheet 21 is installed inside the second cavity, as shown in FIG. Figure 3 As shown, when the latch 23 is pressed downward, the inserting piece 21 can move downward.

[0052] In some preferred embodiments, Figure 11-12As shown, at least one detection element placement area 24 is provided on the side wall of the plug board 211 for placing detection elements. Multiple detection element placement areas 24 can be used to place detection elements for detecting the same or different substances, and can realize simultaneous detection of one or more substances; in some preferred modes, a partition arm 25 is provided between multiple detection element placement areas 24, and each detection element is separated and does not affect each other; in some preferred modes, a protrusion is provided in the detection element placement area 24, and the protrusion can fix the detection element so that the detection element is in a fixed position, ensuring the smooth progress of the detection, making the detection result more accurate and reliable, and the setting of the protrusion can avoid the displacement and fall of the detection element during the detection. In some preferred modes, the protrusion includes a first protrusion 26 and a second protrusion 27, and the first protrusion 26 and the second protrusion 27 cooperate with each other, so that the detection element is more stable. In some preferred modes, a guide channel 28 is also provided at the lower part of the detection element placement area 24, and the guide channel 28 can guide the liquid sample to contact the detection element, avoiding the liquid sample from contacting the detection element in large quantities, affecting the accuracy of the detection result. In some preferred embodiments, the detection element is parallel to the outer wall of the second cavity 2, and the detection element is also inclined. The detection element and the second cavity 2 are inclined at the same angle, so that a certain angle is formed between the detection element and the bottom of the detection device; compared with the detection element being arranged perpendicular to the horizontal plane, the detection element is in an inclined state, so that the liquid sample can enter the detection element more quickly and quickly complete the running board detection on the detection element.

[0053] In some preferred embodiments, Figure 1-2 As shown, the third cavity is arranged inside the second cavity. In some preferred embodiments, the third cavity is arranged on the plug board 211. In some preferred embodiments, the third cavity is arranged on the back side of the detection element placement area on the plug board 211, so that the third cavity can move with the movement of the plug sheet 21.

[0054] Furthermore, the first cavity 1 is provided with an opening 4 which can be communicated with the third cavity, and the liquid sample can enter the third cavity from the first cavity through the opening 4 to realize the transfer of the liquid sample; in some preferred embodiments, the third cavity can obtain the liquid sample from the opening 4 while the first cavity 1 collects the liquid sample; in some preferred embodiments, the third cavity can also obtain the liquid sample from the opening 4 after the first cavity 1 has completed the collection.

[0055] In some preferred embodiments, Fig.15 , 17As shown in Figures 18, the opening 4 is provided on the side wall of the first cavity 1, and the opening 4 can be connected with the third cavity. After the third cavity is connected with the opening 4, the liquid sample can be transferred from the first cavity to the third cavity; in some preferred embodiments, the opening 4 can be closed. In some preferred embodiments, the third cavity is provided with a mouth connected with the first cavity 1. In some preferred embodiments, the mouth range of the third cavity is at least not less than the range of the opening 4 of the first cavity 1. When the opening 4 completely overlaps with the mouth, the liquid sample flows out from the opening 4 and enters the third cavity from the mouth. If the mouth range is smaller than the opening 4 range, then the liquid sample flows out from the opening 4, and only a part of it enters the third cavity from the mouth. At the same time, the other liquid samples will flow to other places, wasting the liquid samples. Moreover, it is possible that when the liquid sample flows out from the opening 4 and enters the third cavity through the mouth, part of the liquid sample will flow into the second cavity. This will make it impossible to determine the amount of liquid entering the second cavity, and it is impossible to achieve quantitative running, which affects the detection results. In some preferred embodiments, when the mouth of the third cavity overlaps or partially overlaps with the opening 4 of the first cavity 1 and the liquid sample can be allowed to pass through the overlapped portion, it can be considered that the first cavity 1 and the third cavity are connected.

[0056] Further, the third cavity can be connected to the first cavity 1 or the second cavity respectively; Fig.15 , 17 As shown in FIG. 18 , when the third cavity is connected to the first cavity 1 , the liquid sample can enter the third cavity from the first cavity 1 . Fig. 20 As shown, when the third cavity is connected to the second cavity, the liquid sample can enter the second cavity from the third cavity, so that the liquid sample can be transferred. In some preferred embodiments, the third cavity can be connected to the first cavity 1 first, and after the sample is quantified in the third cavity, the third cavity is isolated from the first cavity 1, and then the third cavity is connected to the second cavity for quantitative detection of the sample. In some preferred embodiments, when the third cavity is connected to the first cavity 1, the third cavity is isolated from the second cavity, such as Fig.15 , 17 As shown in 18, this can ensure that when the liquid sample in the first cavity 1 enters the third cavity, the liquid sample in the third cavity will not enter the second cavity. Then, when the third cavity and the second cavity are connected, the volume of the liquid sample entering the second cavity is certain, and the purpose of quantitative detection can be achieved; if, when the liquid sample in the first cavity 1 enters the third cavity, the liquid sample in the third cavity enters the second cavity at the same time, then, in the end, the volume of the liquid sample entering the second cavity is uncertain, and therefore, quantitative detection cannot be achieved in the second cavity. In some preferred embodiments, when the third cavity and the second cavity are connected, the third cavity is in a partitioned state with the first cavity 1, such as Fig. 20As shown, this can ensure that when the liquid sample in the third cavity enters the second cavity, the liquid sample in the first cavity 1 will not enter the third cavity (in some embodiments, when there are multiple third cavities, the third cavity here refers to the same third cavity). Then, when the third cavity and the second cavity are connected, the volume of the liquid sample entering the second cavity is certain, and the purpose of quantitative detection can be achieved; if, when the liquid sample in the third cavity enters the second cavity, the liquid sample in the first cavity 1 enters the third cavity at the same time (in some embodiments, when there are multiple third cavities, the third cavity here refers to the same third cavity), then, in the end, the volume of the liquid sample entering the second cavity is uncertain, and therefore, quantitative detection cannot be achieved in the second cavity.

[0057] Furthermore, if Figure 1-2 As shown, the third chamber is provided with a sealing structure 30, such as Fig.13 As shown, a groove is provided at the boundary of the third cavity, and the sealing structure can be stuck in the groove to play a sealing role; in this embodiment, a sealing soft glue is selected for sealing, and the sealing soft glue is assembled into the groove at the boundary of the third cavity; the setting of the sealing structure 30 can ensure that the liquid sample entering the third cavity will not leak. If the liquid sample entering the third cavity is constantly leaking and entering the second cavity, then the third cavity may not be able to store the liquid sample, or the third cavity cannot store a certain volume of liquid sample, and the volume of the liquid sample entering the second cavity is also uncertain, which will not play the role of quantitative running board detection; in some preferred embodiments, the mouth of the third cavity is provided with a sealing structure 30, so that the sealing effect is better, and in some preferred embodiments, the sealing structure 30 is closed when the third cavity is closed. When the third cavity is connected to the first cavity 1 or the second cavity, the sealing structure 30 seals the mouth of the third cavity to prevent the liquid sample from entering or flowing out of the third cavity. This ensures that the third cavity can store a certain volume of liquid sample, which is convenient for quantitative running. In some preferred embodiments, when the third cavity is connected to the first cavity 1 or the second cavity, the sealing structure 30 seals at the connection point or the opening to prevent the liquid sample from flowing to places other than the second cavity and the third cavity. In this way, when the third cavity and the first cavity 1 are connected, the liquid sample in the first cavity 1 can flow to the third cavity and will not flow into places other than the third cavity. This can improve efficiency and enable the third cavity to store a certain amount of liquid sample more quickly. When the third cavity and the second cavity are connected, the liquid sample in the third cavity can all flow to the second cavity, and then can be quantified without flowing into places other than the second cavity.

[0058] Furthermore, the third chamber comprises at least one pipetting area 6 for transferring the sample from the first chamber 1 to the second chamber. In some preferred embodiments, the third chamber may have one, two or more pipetting areas 6, and these pipetting areas 6 can achieve quantitative transfer of the sample, such as Figure 2As shown, in this embodiment, there are two pipetting areas 6. In some preferred embodiments, these pipetting areas 6 can be connected to the first cavity 1 respectively, so that the pipetting areas 6 can obtain liquid samples from the first cavity respectively for quantitative storage; in some preferred embodiments, these pipetting areas 6 can store liquid independently without affecting each other, and in some preferred embodiments, the liquid storage volumes of these pipetting areas 6 can be the same or different, such as Figure 2 , 13 As shown, in this embodiment, the liquid storage volume of the transfer area 6 is the same. In some preferred embodiments, these transfer areas 6 can be connected to the first cavity 1 or the second cavity respectively in sequence, and these transfer areas 6 are connected to the first cavity 1 in sequence, so that the liquid sample in the first cavity 1 can be transferred to multiple transfer areas in sequence, and these transfer areas 6 can be connected to the second cavity in sequence, so that multiple transfer areas can be quantitatively transferred to the second cavity in sequence. In some preferred embodiments, as Fig.15 , 17 As shown in FIG. 18 , adjacent pipetting areas 6 can be seamlessly connected to the next pipetting area 6 to avoid leakage between the two pipetting areas 6 .

[0059] Further, the detection element can move in the second cavity. In some preferred embodiments, Figure 1 As shown, the second cavity can accommodate the detection element and the sample. The detection element is placed in the detection element placement area 24 on the insert 21. The sample is mainly concentrated in the bottom of the second cavity. Some samples are tested on the detection element. In some preferred embodiments, under certain conditions, the detection element may not contact the sample. When the conditions change, the detection element will contact the sample. For example, at the beginning, Fig.15 As shown, the third cavity is connected to the first cavity 1, and the liquid sample in the first cavity 1 enters the third cavity but does not enter the second cavity. The detection element does not contact the sample. When the conditions change, such as Fig. 20 As shown, the liquid sample in the third cavity enters the bottom of the second cavity, and the liquid sample at the bottom of the second cavity contacts the detection element through the guide channel 28 for detection; in some preferred embodiments, the movement of the detection element can cause the detection element and the sample to separate or contact; the detection element can move with the insert 21, such as Fig.17 As shown, at this time, the liquid sample is in the third cavity, the liquid sample has not entered the second cavity, and there is no liquid sample in the second cavity. Therefore, the detection element and the liquid sample are separated, the insert 21 continuously moves downward, and the liquid sample in the third cavity continuously enters the bottom of the second cavity. The liquid sample at the bottom of the second cavity can contact the detection element through the guide channel 28.

[0060] Furthermore, the third cavity can move with the detection element, so as to be connected with the first cavity 1 or the second cavity respectively, such as Figure 1As shown, the third cavity is arranged on the back of the detection element placement area 24 of the insert 21. The insert 21 is continuously moved downward, the detection element is continuously moved downward, the third cavity is also continuously moved downward, and the position of the liquid storage area is also moved downward. The third cavity is first connected with the first cavity 1, as shown in FIG. Fig.15 As shown; during the continuous downward movement, the third cavity will be connected with the second cavity, as shown Fig. 20 In some preferred embodiments, the movement of the detection element can drive the third cavity to connect or disconnect with the first cavity. As the detection element moves, the third cavity moves continuously. Fig.15 As shown, at this time, the third cavity is connected to the first cavity; Fig. 20 As shown, at this time, a transfer area 6 of the third cavity is separated from the first cavity; in some preferred embodiments, the movement of the detection element can drive the third cavity to be connected or separated from the second cavity; Fig.17 , 18 As shown, at this time, the third cavity and the second cavity are separated, and as the detection element moves, the third cavity moves continuously, as shown in FIG. Fig. 20 As shown, at this time, a pipetting area 6 of the third chamber is communicated with the second chamber.

[0061] Furthermore, the detection device further includes a linkage element, which can drive the detection element to move. In some preferred embodiments, the movement of the detection element is achieved under the action of an external force. In some preferred embodiments, the linkage element can be linked with other components of the detection device to drive the detection element to move. In some preferred embodiments, the linkage element can be other components on the detection device, such as the cover 7. Figure 3 , 14 As shown in 15 and 18, in this embodiment, the linkage element is the cover body 7. The cover body 7 is rotated to move downward, and the cover body 7 contacts the latch 23 on the plug 21. Then, the cover body 7 is continued to be rotated, and the plug 21 is pressed and moves downward, thereby moving the detection element.

[0062] Furthermore, the second cavity is provided with a channel that allows the sample in the third cavity to enter. In some preferred embodiments, the channel can be provided between the first cavity 1 and the second cavity. In some preferred embodiments, the first cavity 1 and the second cavity have a common wall surface 9, such as Fig.10 , 15 In some preferred embodiments, the third cavity can slide on this common wall 9, and a clearance gap 8 can be provided on this wall 9, such as Fig.10As shown, when the third cavity moves to the clearance gap 8, the liquid sample stored therein will flow into the second cavity. In some preferred embodiments, the common wall surface 9 has a certain slope. In some preferred embodiments, the inclination angle of the common wall surface 9 is consistent with the inclination angle of the second cavity 2. In some preferred embodiments, when the third cavity moves on the wall surface 9, the mouth of the third cavity is downward, which facilitates the outflow of the liquid sample.

[0063] Furthermore, the detection device also includes a fourth chamber 10 for collecting secondary confirmation test samples, such as Figure 1-3 As shown in 14-22, the fourth cavity 10 can be connected to or separated from the first cavity 1. In some preferred embodiments, the fourth cavity 10 and the first cavity 1 are detachably combined. The fourth cavity 10 and the first cavity 1 can be connected by snap connection or thread connection. In other preferred embodiments, the fourth cavity 10 and the first cavity 1 can also be connected by other methods. In some preferred embodiments, as Figure 9-10 As shown, the first cavity 1 has a first connecting channel 31, and the first cavity 1 is connected to the fourth cavity 10 through the first connecting channel 31. The first connecting channel 31 protrudes from the bottom surface of the first cavity, and the first connecting channel 31 is a cylindrical channel; Fig.21 As shown, the fourth cavity 10 has a protruding second connecting channel 32, which is also a cylindrical channel. The diameter of the second connecting channel 32 is greater than the diameter of the first connecting channel 31. Then, the second connecting channel 32 can be sleeved on the outside of the first connecting channel 31, so that the liquid sample in the first connecting channel 31 can completely enter the second connecting channel 32 and then flow into the fourth cavity, and the liquid sample will not leak out and flow to other places except the second connecting channel 32; Fig.16 , 17 As shown, the first connecting channel 31 is connected to the second connecting channel 32, and at this time, the fourth chamber 10 and the first chamber 1 are in a connected state; if a plug or other partition is inserted into the first connecting channel 31, then the fourth chamber 10 and the first chamber 1 are separated. In some preferred embodiments, the fourth chamber 10 can collect samples at the same time as the first chamber 1, such as Fig.16 , 17 As shown, after the fourth cavity 10 is connected to the first cavity 1, a liquid sample is added into the first cavity 1, and then the liquid sample will enter the fourth cavity from the first cavity, and the fourth cavity 10 and the first cavity 1 can collect samples at the same time.

[0064] Furthermore, if Figure 1-2 As shown, the detection device also includes a partition element for connecting or partitioning the first cavity 1 and the fourth cavity 10. In some preferred embodiments, as shown in FIG. Figure 4 As shown, the partition element includes a second connecting member 61 and a head, and the second connecting member 61 and the head are integrally formed. In some preferred embodiments, such as Figure 8 As shown, the second connecting member 61 of the partition element can be connected and fixed with the first connecting member 33. In some preferred embodiments, the first connecting member 33 is fixedly connected with the cover body 7 and can be integrally formed. In some preferred embodiments, the first connecting member 33 is cylindrical, and one end of the first connecting member 33 away from the cover body 7 is provided with a cylindrical opening. In some preferred embodiments, the second connecting member 61 is cylindrical, and the second connecting member 61 is connected with the first connecting member 33, and can be connected by a snap connection or a threaded connection or other connection methods, such as Figure 8 As shown, in this embodiment, the second connecting member can be inserted into the cylindrical opening of the first connecting member to achieve connection.

[0065] In some preferred embodiments, the head of the partition element has a tip 35, and the head of the partition element can enter the first connecting channel 31, thereby isolating the first cavity 1 and the fourth cavity 10. When the head of the partition element is pulled out of the first connecting channel 31, the first cavity 1 and the fourth cavity 10 can be connected. Figure 1 , 2 As shown in Figures 4 and 8, the head of the partition element 80 is provided with a first protrusion 36 and a second protrusion 361. In some preferred embodiments, the first protrusion 36 and the second protrusion 361 are arranged in parallel, and the first protrusion 36 and the second protrusion 361 are both arranged on the outer periphery of the head of the partition element 80. In some preferred embodiments, a sealing ring is arranged between the first protrusion 36 and the second protrusion 361, and the first protrusion 36 can prevent the sealing ring from moving up, and the second protrusion 361 can prevent the sealing ring from moving down; in some preferred embodiments, there can be one or more sealing rings, which can play a sealing role and can completely isolate the first cavity 1 and the fourth cavity 10 to prevent the liquid sample from flowing out of the connecting gap.

[0066] In some preferred embodiments, Figure 4 , 8 As shown, the head of the partition element is provided with two second openings 37, which are arranged opposite to each other and can be connected. In some preferred embodiments, the second openings 37 are located below the sealing ring 36 and above the tip 35; in some preferred embodiments, as Figure 4 , 8As shown, the head of the partition element has a cavity, and the two second openings 37 can be connected to the cavity. The liquid sample can enter the cavity from the second openings 37. This cavity can temporarily store a certain volume of liquid sample. In this way, if the fourth cavity is already full of liquid samples, and the partition element is linked by the linkage element, the partition element continues to move downward and continuously enters the fourth cavity 10, the partition element will encounter resistance. At this time, the liquid sample in the fourth cavity can enter the cavity through the second openings 37, so that the resistance encountered by the partition element is reduced, and it does not affect the partition element from continuing to enter the fourth cavity. When the partition element completely enters the fourth cavity, the sealing ring 36 can completely isolate the connection between the first cavity and the fourth cavity. At this time, the fourth cavity can be separated from the first cavity.

[0067] Furthermore, the linkage element can be linked with the partition element so that the partition element connects or partitions the first cavity 1 and the fourth cavity 10; Figure 8 As shown, in this embodiment, the linkage element is the cover body 7, the first connecting member 33 is fixedly connected to the cover body 7, and the partition element is fixedly connected to the first connecting member 33. Therefore, when the linkage element moves, the partition element will move accordingly. When the cover body 7 is continuously rotated and tightened, the partition element will continue to move downward until it enters the first connecting channel 31. Fig. 20 As shown, at this time, the first cavity 1 and the fourth cavity 10 are in a partitioned state. When the cover 7 is continuously rotated and loosened, the partition element will continuously move upward, and the partition element can be separated from the first connecting channel 31, so that the first cavity 1 and the fourth cavity 10 are in a connected state. In some preferred embodiments, the partition element can be linked by a linkage element to connect or isolate the first cavity 1 and the fourth cavity 10. In some preferred embodiments, the linkage element can simultaneously link the partition element and the detection element; Figure 1-2 As shown, in this embodiment, the linkage element is the cover body 7, and the partition element is fixedly connected to the cover body 7. The partition element will move with the movement of the cover body 7; the detection element is located on the plug 21, the pin 23 is inserted into the hole 22 and extends out of the hole 22, and the cover body 7 is located above the hole 22. When the cover body 7 is continuously rotated and tightened, the partition element will continue to move downward, and the pin 23 is subjected to the pressure of the cover body 7, so that the plug 21 continues to move downward, and the detection element continues to move downward, so the linkage element can simultaneously link the partition element and the detection element.

[0068] Further, when the partition element partitions the first cavity 1 and the fourth cavity 10, the first cavity 1 can be separated from the fourth cavity 10. In some preferred embodiments, the fourth cavity 10 can be separated from the first cavity 1, such as Fig.21As shown, the partition element separates the first cavity 1 and the fourth cavity 10. At this time, the fourth cavity can be pulled downward to separate the fourth cavity 10 from the first cavity 1. In some preferred embodiments, a closing element of the fourth cavity 10 can also be provided. After the fourth cavity 10 is separated from the first cavity 1, the fourth cavity 10 can be closed to form a closed independent cavity, so as to store the liquid sample for secondary detection, such as Figure 6 , 21 As shown in Figure 22, the closing element is the first bottle cap 12, and the first bottle cap 12 can cover the fourth cavity 10. The first bottle cap 12 is provided with an internal thread inside, and the outer wall of the second connecting channel 32 of the fourth cavity 10 is provided with an external thread. The internal thread and the external thread cooperate with each other to achieve the connection and covering of the first bottle cap 12 and the fourth cavity 10, so that the liquid sample stored in the fourth cavity 10 can be protected and the liquid sample stored in the fourth cavity 10 will not leak out or be damaged.

[0069] In some preferred embodiments, Figure 6 As shown, the first bottle cap 12 can be fixed on the cover body 7, the upper surface of the cover body 7 is provided with a pit 38, the middle of the pit 38 is provided with a convex column 39, the inside of the convex column 39 is hollow, and the upper end of the convex column 39 has a first opening 43. In some preferred embodiments, as Figure 5 As shown, the first bottle cap 12 is provided with a column 40 that cooperates with the first opening 43, and the column 40 can be inserted into the first opening 43 to achieve the combination of the first bottle cap 12 and the cover body 7; in some preferred embodiments, as shown in Figures 5-6, the protrusion 39 is cylindrical, and the column 40 is a cylindrical body. The cylinder 40 can be inserted into the cylindrical protrusion 39 to achieve the combination of the two. In some preferred embodiments, as shown in Figures 5-6, Figure 5 As shown, a circular side wall 42 is further provided inside the first bottle cap 12, and the circular side wall 42 surrounds the outer circumference of the column 40. Figure 6 As shown, the outer side wall of the boss 39 is provided with a raised rib 41, and the circular side wall 42 can cooperate with the raised rib 41 to tighten the combination of the first bottle cap 12 and the cover body 7; in some preferred embodiments, there can be multiple raised ribs 41, and in some preferred embodiments, multiple raised ribs 41 are evenly arranged on the outer side wall of the boss 39. The setting of the raised ribs 41 can be used to fix the first bottle cap 12. When necessary, the first bottle cap 12 can be pulled out and separated from the cover body 7, and the first bottle cap 12 can be covered on the second connecting channel 32 of the fourth cavity 10 to achieve the closure of the fourth cavity 10.

[0070] Further, the linkage element includes a cover body 7. In some preferred embodiments, an arrow is provided on the cover body. By rotating in the direction indicated by the arrow, the cover body 7 can be tightened so that the cover body 7 continuously covers the first cavity; in some preferred embodiments, the cover body 7 can be linked to the detection element and / or the partition element when covering; in the process of the cover body 7 covering the first cavity 1, that is, the process of continuously rotating and tightening the cover body 7, the cover body 7 continuously moves downward, the cover body 7 contacts the insert 21, and then the cover body 7 continues to be rotated downward, the insert 21 is subjected to pressure and moves downward, thereby causing the detection element to move; Figure 1-2 ,16, the cover body 7 is connected to the partition element, then, in the process of the cover body 7 covering the first cavity 1, that is, the process of continuously rotating and tightening the cover body 7, the cover body 7 continuously moves downward, and the partition element will also continuously move downward, so the cover body 7 can be linked to the detection element and / or the partition element when covering. In some preferred embodiments, when the cover body 7 is covered, it will move downward and close to the first cavity, and while the cover body 7 moves downward, it can press down the insert 21, and the insert 21 will move in the second cavity, so that the detection element moves in the second cavity.

[0071] In some preferred embodiments, the cup body further includes a supporting side wall 51, such as Figure 1-2 As shown, the supporting side wall 51 is an arc-shaped side wall, and the supporting side wall 51 is fixedly connected to the side wall of the first cavity. In some preferred embodiments, the supporting side wall 51 does not completely surround the fourth cavity 10, but leaves a gap, so that it is convenient for the user to install or disassemble the fourth cavity 10; in some preferred embodiments, the bottom of the supporting side wall 51 is horizontal, so that the supporting side wall 51 can be placed horizontally on a horizontal plane, so that the entire device can be placed stably, which is convenient for transportation or detection. In some preferred embodiments, the supporting side wall 51 is set at a position opposite to the second cavity, which can better balance the entire device and make the device more stable.

[0072] The present invention also provides a method for using the detection device. Figure 1-22 The embodiments described in the following are described. Fig.15 As shown, the detection device is in an initial state, at this time, the insert 21 is in the second cavity, the plug 23 is inserted in the insertion hole 22, one pipetting area 6 of the third cavity is connected to the opening 4 of the first cavity 1, the other pipetting area is close to the wall 9, the fourth cavity is connected to the first cavity, the tip 35 of the partition element is in the first connecting channel 31, and the cover 7 is not in contact with the plug 23;

[0073] First, (1) open the cover 7 and add a liquid sample into the first chamber 1, such as Fig.16As shown; the first cavity 1 is connected to the fourth cavity, and the liquid sample flows into the fourth cavity 10 from the first connecting channel of the first cavity. The liquid sample in the fourth cavity 10 is continuously increased. When the liquid sample in the fourth cavity 10 is full, the liquid sample is stored in the first cavity 1, and the liquid sample in the first cavity 1 enters the third cavity through the opening 4. Fig.17 As shown;

[0074] Secondly, (2) the cover body 7 is rotated to cover the first cavity downward. During this process, the cover body 7 is linked with the partition element to continuously enter the fourth cavity 10, the cover body 7 contacts the latch 23, the insert moves downward, the detection element also moves downward, and the third cavity transfer area also moves downward continuously. The third cavity transfer area will continuously store the liquid sample until it is full of the transfer area. Fig.18 Continue to rotate the cover 7, the liquid in the third chamber transfer area continues to enter the second chamber, until the cover 7 completely covers the first chamber 1, as shown Figure 19-20 As shown, the insert 21 is pressed to the lowest position, the third cavity is in communication with the second cavity, and the liquid sample in the third cavity is completely transferred to the bottom support of the second cavity, and the sample can be tested at this time;

[0075] (3) After the test is completed, the reading can be obtained by observing the outer side of the second cavity. Since the cup body is set to be transparent, it is also convenient to take photos and record the test results. Fig. 20 As shown, since the first cavity and the fourth cavity 10 are completely separated by the partition element, the first bottle cap 12 and the fourth cavity 10 can be removed at this time, and the first bottle cap 12 is screwed tightly onto the fourth cavity 10, and the liquid in the fourth cavity 10 can be used for secondary confirmation detection.

Claims

1. A detection device, characterized in that: It includes a first cavity for collecting and a second cavity for detecting, wherein a detection element is arranged in the second cavity, and the first cavity and the second cavity can be closed and communicated, and further includes a third cavity for sample quantification, wherein the third cavity can transfer the sample from the first cavity to the second cavity quantitatively; The first cavity is provided with an opening that can communicate with the third cavity, the opening is arranged on the side wall of the first cavity, the third cavity is arranged on the plug board, and the third cavity can move with the movement of the plug board; The third chamber comprises a plurality of pipetting areas for transferring samples from the first chamber to the second chamber, the pipetting areas are all capable of achieving sample quantification, the pipetting areas are each capable of independently storing liquid, the pipetting areas are sequentially connected to the first chamber or the second chamber respectively, so as to perform quantitative detection at intervals, and adjacent pipetting areas can be seamlessly connected to the next pipetting area, so as to avoid leakage between the two pipetting areas; The second cavity is provided with a channel capable of allowing the sample in the third cavity to enter, the channel is arranged between the first cavity and the second cavity, the first cavity and the second cavity have a common wall surface, the third cavity can slide on the common wall surface, a clearance notch is arranged on the wall surface, when the third cavity moves to the clearance notch, the liquid sample stored therein flows into the second cavity; The third cavity is provided with a sealing structure, which seals the mouth of the third cavity when the third cavity is closed, preventing the liquid sample from entering or flowing out of the third cavity, ensuring that the third cavity can store a certain volume of liquid sample, facilitating quantitative running of the plate, and when the third cavity is connected to the first cavity or the second cavity, the sealing structure seals at the connection point or the opening to prevent the liquid sample from flowing to places other than the second cavity and the third cavity. In this way, when the third cavity and the first cavity are connected, the liquid sample in the first cavity can flow to the third cavity, and will not flow into places other than the third cavity, so that the third cavity can store quantitative liquid samples; when the third cavity and the second cavity are connected, the liquid sample in the third cavity can all flow to the second cavity, and then be quantitatively determined, and will not flow into places other than the second cavity.

2. A detection device according to claim 1, characterized in that: The detection element is movable within the second cavity.

3. A detection device according to claim 2, characterized in that: The third cavity can move with the detection element, so as to be connected with the first cavity or the second cavity respectively.

4. A detection device according to claim 2, characterized in that: A linkage element is included, and the linkage element can drive the detection element to move.

5. A detection device according to claim 1, characterized in that: It also includes a fourth cavity for collecting secondary confirmation test samples, and the fourth cavity can be connected to or isolated from the first cavity.

6. A detection device according to claim 5, characterized in that: Also included is a partition element for connecting or partitioning the first cavity and the fourth cavity.

7. A detection device according to claim 6, characterized in that: A linkage element is included, and the linkage element can be linked with the partition element so that the partition element connects or partitions the first cavity and the fourth cavity.

8. A detection device according to claim 7, characterized in that: When the partition element partitions the first chamber and the fourth chamber, the first chamber can be separated from the fourth chamber.

9. A detection device according to claim 7, characterized in that: The linkage element comprises a cover body, and the cover body can link the detection element and the partition element when the cover body is closed.

10. A detection device according to claim 1, characterized in that: There is a certain angle between the detection element and the bottom of the detection device.

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