Virus filtration device and its control system

Abstract

A virus removal filtration device, comprising an air inlet device, a pressure reducing device, a pressure control module, a liquid storage device, a virus removal filter column and a collection device. A pressure reducing device and a pressure control module are connected to the pipeline between the air inlet device and the liquid storage device, and electromagnetic solenoid valves are respectively arranged on the pipelines of each liquid storage device; The control system of the virus removal filtration device includes a central processor and a display. The signal acquisition ends of the central processor are respectively connected to the signal output ends of a pressure sensor, a temperature sensor, a pressure sensor before the virus removal filter column and a weighing sensor, for collecting and processing the acquisition signals of each sensor; The signal output ends of the central processor are respectively connected to the signal input ends of the actuators of an automatic regulating valve and an electromagnetic solenoid valve. The device and system of the present invention can accurately control and regulate the pressure, and perform online and timely control on the virus removal filtration device.

Description

Technical Field

[0001] The present invention relates to the field of biotechnology, and particularly to a virus removal filtration device and its system. Background Art

[0002] In the existing virus removal system, compressed air is used to convey the liquid in the liquid storage container through a multi-channel valve, and the processed solution is collected after passing through the virus removal device. However, its disadvantage is that the liquid in the liquid storage container is directly extruded by compressed air. When the pressure in the system changes or needs to be adjusted, automatic adjustment cannot be achieved. Therefore, its pressure is not easy to control, and constant pressure conveyance cannot be achieved. Summary of the Invention

[0003] In order to overcome the above deficiencies of the prior art, the virus removal filtration device and its control system adopted by the present invention can achieve constant pressure conveyance and pressure adjustment.

[0004] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0005] The virus removal filtration device includes an air inlet device. The outlet of the air inlet device is respectively connected to a plurality of liquid storage devices through pipelines. A pressure reducing device and a pressure control module are connected to the pipeline between the air inlet device and the liquid storage devices; the plurality of liquid storage devices are arranged in parallel; the outlets of the plurality of liquid storage devices are connected to the inlet of the virus removal filter column through a pipeline, and the outlet of the virus removal filter column is respectively connected to the inlets of a collection bag and a waste liquid bag; a temperature sensor and a pressure sensor before virus removal filtration are respectively arranged on the pipeline connecting the outlets of the plurality of liquid storage devices and the inlet of the virus removal filter column.

[0006] Further, the air inlet device includes an air compressor or a compressed gas cylinder.

[0007] Further, the pressure reducing device includes a pressure reducing valve and a pressure gauge connected in series. The pressure is adjusted to a specific value through the pressure reducing valve and the pressure gauge.

[0008] Further, the pressure control module includes an automatic regulating valve. The inlet of the automatic regulating valve is connected to the outlet of the air inlet device. The outlet of the automatic regulating valve is respectively connected to the air inlets of the plurality of liquid storage devices arranged in parallel through a plurality of pipelines, and electromagnetic switching valves are respectively arranged on the plurality of pipelines; a pressure sensor is arranged between the automatic regulating valve and the plurality of liquid storage devices.

[0009] Further, the pressure control module further includes a silencer, and the silencer is connected to the pipeline between the automatic regulating valve and the plurality of liquid storage devices through an electromagnetic switching valve.

[0010] Further, the liquid storage device adopts a double-layer liquid storage bag device or a sealed bottle.

[0011] Furthermore, the double-layer liquid storage bag device includes: a support housing, an inner deformable bag body is placed inside the outer support housing, an outer deformable bag body is arranged between the outer support housing and the inner deformable bag body, and the inner deformable bag body is sealed inside the outer deformable bag body; an inner liquid inlet pipe and an inner liquid outlet pipe are connected to the inner deformable bag body, and the inner liquid inlet pipe and the inner liquid outlet pipe sequentially pass through the outer deformable bag body and the outer support housing; an outer air inlet pipe is connected to the outer deformable bag body, and the outer air inlet pipe passes through the outer support housing.

[0012] Furthermore, the inner liquid inlet pipe and the inner liquid outlet pipe are arranged at the ends of the inner deformable bag body; the outer air inlet pipe is arranged at the other end of the outer deformable bag body relative to the end of the inner deformable bag body.

[0013] Furthermore, the inner liquid inlet pipe and the inner liquid outlet pipe are arranged on the upper surface and / or the lower surface of the inner deformable bag body, on the same side or on different sides; the outer air inlet pipe is arranged on the upper surface or the lower surface of the outer deformable bag body.

[0014] Furthermore, the outer support housing is divided into an upper housing and a lower housing, and the upper housing and the lower housing can be disassembled and installed.

[0015] Furthermore, a pre-filter column loop is arranged on the pipeline between the outlets of the multiple liquid storage devices and the temperature sensor, and pinch valves are respectively arranged on the inlet and outlet pipelines of the pre-filter column and on the pipeline between the inlet and the outlet.

[0016] Furthermore, a pre-filter pressure sensor is arranged on the pipeline between the outlets of the multiple liquid storage devices and the pre-filter column loop.

[0017] Furthermore, the pipeline at the outlet of the virus removal filter column is connected to a sampling port through a peristaltic pump.

[0018] Furthermore, a weighing sensor is arranged on the collection bag for monitoring the collection amount of the product.

[0019] Furthermore, pinch valves are respectively arranged on the outlet pipelines of the multiple liquid storage devices, on the inlet and outlet pipelines of the virus removal filter column, and on the inlet pipelines of the collection bag and the waste liquid bag.

[0020] The control system of the virus removal and filtration device described above includes a central processing unit. The signal acquisition ends of the central processing unit are respectively connected to the signal output ends of a pressure sensor, a temperature sensor, a pre-filtration pressure sensor, a pre-filter pressure sensor, and a weighing sensor, for collecting and processing the acquisition signals of each sensor. The signal output ends of the central processing unit are respectively connected to the signal input ends of the actuators of an automatic regulating valve and an electromagnetic switch valve, and a display. The display is used to display the temperature, the pre-filtration pressure, the pre-filter pressure, and the weight of the collection bag. The automatic regulating valve and the electromagnetic switch valve are used to control the pressure.

[0021] By using the virus removal and filtration device and the control system of the present invention, the compressed air or the air source pressure can be adjusted for output according to needs. When the pressure in the system changes or needs to be adjusted, automatic adjustment can be performed, and the control of the output pressure is more precise and dynamic, and constant pressure transmission can be achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the first embodiment of the device of the present invention;

[0023] Figure 2 It is a schematic diagram of the second embodiment of the device of the present invention;

[0024] Figure 3 It is an attached view of the first embodiment of the double-layer liquid storage bag device of the present invention;

[0025] Figure 4A It is an attached view of the second embodiment of the double-layer liquid storage bag device of the present invention;

[0026] Figure 4B It is a side view of the second embodiment of the double-layer liquid storage bag device of the present invention;

[0027] Figure 5 It is a schematic diagram of the control system of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0028] Figure 1Schematic diagram of an embodiment of the device of the present invention. The device air source is an air compressor or a compressed gas cylinder, which is shown through a manual pressure reducing valve 11 and a pressure gauge 12, and after being adjusted to a specific pressure, it enters the pressure control module 20. The pressure control module 20 is composed of an automatic pressure regulating valve 21, a pressure sensor 22, an electromagnetic switching valve 23, and a silencer 24, with internal closed-loop control, and outputs a stable pressure to the sealed bottle 30 filled with the operating liquid. An electromagnetic switching valve 23 is respectively arranged in each branch of the sealed bottle 30, and the opening degrees of the electromagnetic switching valves 23 in each branch of the sealed bottle 30 are the same or different. Through the opening degree of the electromagnetic switching valve, the liquid in each branch sealed bottle 30 can be adjusted to be transported according to the required flow rate or pressure. The sealed bottle 30 can be pre-filled with different operating liquids according to the process. In this embodiment, there are 4 sealed bottles 30, which are respectively filled with injection water, product 1, product 2, and buffer solution, and the outlet on / off is controlled by the pinch valve 31 in each path. A pressure sensor 45 is arranged on the pipeline before the pre-filter column circuit 40, and whether the operating liquid passes through the pre-filter column 41 is controlled by the pre-filter column inlet pipeline valve 42, the pre-filter column outlet pipeline valve 43, and the short-circuit pipeline valve 44 between the inlet and outlet. In this embodiment, the pre-filter column inlet pipeline valve 42, the pre-filter column outlet pipeline valve 43, and the short-circuit pipeline valve 44 between the inlet and outlet are all pinch valves. A temperature sensor 54 and a pressure sensor 55 are arranged before the virus removal filter column 51, and a waste discharge port is provided. The inlet and outlet pipelines of the virus removal filter column 51 are respectively provided with an inlet valve 52 and an outlet valve 53. In this embodiment, the inlet valve 52 and the outlet valve 53 are both pinch valves. A branch for sampling by a peristaltic pump 56 is arranged on the outlet pipeline of the virus removal filter column 51. A collection bag 61 and a waste liquid bag 62 are arranged at the end of the virus removal device. Inlet valves 63 and 64 are respectively arranged on the inlet pipelines of the collection bag 61 and the waste liquid bag 62 to select the branch for the liquid to enter. The collection bag 62 is provided with a weighing sensor 65 to monitor the collection amount of the product.

[0029] Figure 2 Schematic diagram of the second embodiment of the device of the present invention. Different from the first embodiment, the liquid storage device in this embodiment is a double-layer liquid storage bag 30'. The opening degrees of the electromagnetic switching valves 23 in each branch of each double-layer liquid storage bag 30' are the same or different. Through the opening degree of the electromagnetic switching valve, the liquid in each branch double-layer liquid storage bag 30' can be adjusted to be transported according to the required flow rate or pressure.

[0030] Refer to Figure 3Schematic diagram of the first embodiment of the double-layer liquid storage bag 30' of the present invention, including an external support housing 1. The external support housing 1 is made of stainless steel and can withstand an air pressure of ≥ 3 Bar as a whole. An inner deformable bag 2 is placed inside the external support housing 1. An outer deformable bag 3 is arranged between the inner deformable bag 2 and the external support housing 1. The inner deformable bag 2 is hermetically placed inside the outer deformable bag 3. One end of the inner deformable bag 2 is connected to an inner liquid inlet pipe 4 and an inner liquid outlet pipe 5. The inner liquid inlet pipe 4 and the inner liquid outlet pipe 5 sequentially pass through the outer deformable bag 3 and the external support housing 1. The inner liquid inlet pipe 4 is connected to the outside to inject the operating fluid to be stored and transported into the inner deformable bag 2, and the inner liquid outlet pipe 5 is used to output the operating fluid downstream; the other end of the outer deformable bag 3 opposite to the end of the inner deformable bag is connected to an outer air inlet pipe 6, and the outer air inlet pipe 6 passes through the external support housing 1.

[0031] During use, the air source of an air compressor or a compressed gas cylinder is adjusted to a specific pressure through a manual pressure reducing valve 11 and a pressure gauge 12 and then enters the pressure control module 20. The pressure control module 20 outputs a stable pressure to the double-layer disposable liquid storage bag 30. The stable gas enters the outer deformable bag 3 through the outer air inlet pipe 6. The gas pressure pushes the inner deformable bag 2 to deform, thereby squeezing out the liquid in the inner deformable bag 2 and outputting it through the inner liquid outlet pipe 5. Using the double-layer liquid storage bag 30 as a liquid storage device can better control the pressure of the transported liquid, and can maintain a constant pressure for liquid transportation. At the same time, it can ensure airtightness and hygiene requirements, and avoid liquid contamination and bacteria generation caused by direct contact between air and liquid.

[0032] The external support housing 1 is divided into an upper housing and a lower housing. The upper housing and the lower housing can be disassembled and installed. When it is necessary to replace the inner deformable bag 2 and the outer deformable bag 3, directly disassemble the upper housing and the lower housing and take them out. Therefore, only the airtightness of the outer deformable bag 3 needs to be ensured, and there is no need to ensure the airtightness of the external support housing 1, and there is no need to replace the external support housing 1.

[0033] Refer to Figures 4A - 4B Schematic diagram of the second embodiment of the double-layer liquid storage bag 30' of the present invention. Different from the foregoing first embodiment, in this embodiment, the inner liquid inlet pipe 4 and the inner liquid outlet pipe 5 are arranged on the upper surface of the inner deformable bag 2; the outer air inlet pipe 6 is arranged on the upper surface of the outer deformable bag 3; the inner liquid inlet pipe 4, the inner liquid outlet pipe 5 and the air inlet pipe 6 are arranged in a triangular layout.

[0034] Figure 5Schematic diagram of the control system of the present invention. The control system of the virus removal and filtration device includes a central processing unit. The signal acquisition ends of the central processing unit are respectively connected to the signal output ends of a pressure sensor, a temperature sensor, a pre-filtration pressure sensor, a pre-filter pressure sensor, and a weighing sensor, for collecting and processing the acquisition signals of each sensor. The signal output ends of the central processing unit are respectively connected to the signal input ends of the actuators of an automatic regulating valve and an electromagnetic switching valve, and a display. The display is used to display the temperature, the pre-filtration pressure, the pre-filter pressure, and the weight of the collection bag. The automatic regulating valve and the electromagnetic switching valve are used to control the pressure.

[0035] The above are only some embodiments of the present invention. For those of ordinary skill in the art, without departing from the inventive concept of the present invention, several deformations and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A virus removal filtration device, characterized in that, It includes an air inlet device, a pressure reducing device, a pressure control module, a liquid storage device, a virus removal filter column, and a collection device; the outlet of the air inlet device is connected to one or more liquid storage devices through a pipeline, and a pressure reducing device and a pressure control module are connected to the pipeline between the air inlet device and the liquid storage device; the outlet of the liquid storage device is connected to the inlet of the virus removal filter column through a pipeline, and the outlet of the virus removal filter column is connected to the inlet of the collection device; The liquid storage device adopts a double-layer liquid storage bag device; The double-layer liquid storage bag device includes an external support housing, an inner deformable bag body is placed inside the external support housing, an outer deformable bag body is arranged between the inner deformable bag body and the external support housing, the inner deformable bag body is hermetically placed inside the outer deformable bag body, one end of the inner deformable bag body is connected to an inner liquid inlet pipe and an inner liquid outlet pipe, the inner liquid inlet pipe and the inner liquid outlet pipe sequentially pass through the outer deformable bag body and the external support housing, the inner liquid inlet pipe is connected to the outside to inject the operating fluid to be stored and transported into the inner deformable bag body, and the inner liquid outlet pipe is used to output the operating fluid downstream; The other end of the outer deformable bag body relative to the end of the inner deformable bag body is connected to an outer air inlet pipe, and the outer air inlet pipe passes through the external support housing; The pressure control module includes an automatic regulating valve, the inlet of the automatic regulating valve is connected to the outlet of the air inlet device, the outlet of the automatic regulating valve is respectively connected to the air inlets of a plurality of liquid storage devices arranged in parallel through multiple pipelines, and electromagnetic switching valves are respectively arranged on the pipelines of the plurality of liquid storage devices; a pressure sensor is arranged between the automatic regulating valve and the plurality of liquid storage devices.

2. The virus removal filtration device according to claim 1, wherein The plurality of liquid storage devices are arranged in parallel.

3. The virus removal filtering device according to claim 1, characterized in that, The air inlet device includes an air compressor or a compressed gas cylinder; the pressure reducing device includes a pressure reducing valve and a pressure gauge connected in series in sequence.

4. The virus removal filtration device according to claim 3, wherein The pressure control module further includes a silencer, and the silencer is connected to the pipeline between the automatic regulating valve and the plurality of liquid storage devices through an electromagnetic switching valve.

5. The virus removal filtration device according to claim 1, characterized in that, Temperature sensors and pressure sensors before the virus removal filter column are respectively arranged on a pipeline connecting the outlets of the plurality of liquid storage devices and the inlet of the virus removal filter column.

6. A control system for the virus removal filter device according to any one of claims 1-5, including a central processing unit and a display, the signal acquisition end of the central processing unit is respectively connected to the signal output ends of the pressure sensor, the temperature sensor, the pressure sensor before the virus removal filter column, and the weighing sensor; the signal output end of the central processing unit is respectively connected to the signal input ends of the actuators of the automatic regulating valve and the electromagnetic switching valve; the display is connected to the signal output end of the central processing unit.

7. The control system of the virus removal filtration device according to claim 6, characterized in that The signal acquisition end of the central processing unit is further connected to a pressure sensor before the pre-filter column.

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