Dual-mode ion transmission device and method

Abstract

The present invention provides a dual-mode ion transmission device and method, the dual-mode ion transmission device includes a multipole transmission rod and a first ion lens, the first ion lens is arranged at the ion outlet of the multipole transmission rod; the second ion lens is arranged at the outer side of the multipole transmission rod, the angle between the ion transmission direction in the second ion lens and the ion transmission direction in the multipole transmission rod is a right angle or an acute angle; the ions ejected from the second ion lens enter the multipole transmission rod from the gap between two adjacent transmission rods; the first electrode is cylindrical, arranged between the first ion lens and the second ion lens, and is located at the outer side of the multipole transmission rod; the angle between the central axis of the first electrode and the central axis of the multipole transmission rod is a right angle or an acute angle; the first group of electrodes includes at least two electrodes, which are arranged adjacent to the first ion lens and the second ion lens respectively; the potential difference between the first electrode and the at least two electrodes is equal. The present invention has the advantages of accurate detection and the like.

Description

Technical Field

[0001] The present invention relates to mass spectrometry, and more particularly to a dual-mode ion transmission device and method. Background Art

[0002] Mass spectrometer is a commonly used high-end precision analytical instrument. In mass spectrometry, it is common to adjust the deflection and focusing of ion beams by electric field (potential) to achieve ion beams of different incident energies flying at a reasonable deflection angle.

[0003] The traditional single-path ion optical system can guide and focus the divergent ion beam into the mass spectrometer, but its ion transmission path is too simple, with only a single input and a single output.

[0004] Currently, there is no multi-channel ion lens on the market, which is used to introduce ion beams from different ion sources and converge them to a common back-end transmission and mass analyzer. In view of the significant impact of the ion optical transmission system on the analytical performance of the instrument, in order to increase the ion transmission efficiency, eliminate the impact of photons and neutral particles on the instrument, and improve the sensitivity of the instrument and the ion transmission method, it is necessary to provide a new type of multi-channel ion optical system. Summary of the invention

[0005] In order to solve the deficiencies in the above-mentioned prior art solutions, the present invention provides a dual-mode ion transmission device, which expands the diversity of mass spectrometer applications.

[0006] The objective of the present invention is achieved through the following technical solutions:

[0007] A dual-mode ion transmission device, the dual-mode ion transmission device comprising a multipole transmission rod and a first ion lens, wherein the first ion lens is arranged at the ion outlet of the multipole transmission rod; the dual-mode ion transmission device further comprises:

[0008] A second ion lens, wherein the second ion lens is arranged at the outer side of the multipole transmission rod, and the angle between the ion transmission direction in the second ion lens and the ion transmission direction in the multipole transmission rod is a right angle or an acute angle; the ions emitted from the second ion lens enter the multipole transmission rod from the gap between two adjacent transmission rods;

[0009] A first electrode, wherein the first electrode is cylindrical and is disposed between the first ion lens and the second ion lens and is located at the outer side of the multipole transmission rod; an angle between a central axis of the first electrode and a central axis of the multipole transmission rod is a right angle or an acute angle;

[0010] A first group of electrodes, the first group of electrodes includes at least two electrodes, which are respectively arranged adjacent to the first ion lens and the second ion lens; the potential difference between the first electrode and the at least two electrodes is equal.

[0011] The present invention also aims to provide a dual-mode ion transport method, which is achieved through the following technical solutions:

[0012] According to the dual-mode ion transmission method of the dual-mode ion transmission device, the dual-mode ion transmission method is:

[0013] DC electrostatic field mode: the power supply applies a DC voltage to the first electrode and the multipolar transmission rod, and the potential difference between the first electrode and the first group of electrodes is equal;

[0014] The ions emitted from the second ion lens are deflected, and the deflected ions are transmitted into the multipole transmission rod and finally emitted from the first ion lens;

[0015] RF field mode: the power source applies RF voltage to the multi-pole transmission rod, and the first electrode and the first group of electrodes are grounded;

[0016] The ions are transmitted in the multi-stage transmission rod and finally ejected from the first ion lens.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] It has two working modes, which can guide ions in two directions to a common first ion lens in the same lens group, thus expanding the diversity of mass spectrometer applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The disclosure of the present invention will become easier to understand with reference to the accompanying drawings. It is easy for those skilled in the art to understand that these drawings are only used to illustrate the technical solution of the present invention and are not intended to limit the scope of protection of the present invention. In the drawings:

[0020] Figure 1 is a simplified structural diagram of a dual-mode ion transmission device according to an embodiment of the present invention;

[0021] Figure 2 is a side view of a dual-mode ion transport device according to an embodiment of the present invention;

[0022] Figure 3 is a schematic diagram of ion transmission in a first working mode according to an embodiment of the present invention;

[0023] Figure 4 Schematic diagram of ion transmission in the second working mode according to an embodiment of the present invention. DETAILED DESCRIPTION

[0024] Figure 1-4The following description describes the optional embodiments of the present invention to teach those skilled in the art how to implement and reproduce the present invention. In order to teach the technical solution of the present invention, some conventional aspects have been simplified or omitted. It should be understood by those skilled in the art that variations or substitutions derived from these embodiments will be within the scope of the present invention. It should be understood by those skilled in the art that the following features can be combined in various ways to form multiple variations of the present invention. Thus, the present invention is not limited to the following optional embodiments, but is only limited by the claims and their equivalents.

[0025] Embodiment 1:

[0026] Figure 1-2 A schematic diagram of the structure of the dual-mode ion transmission device according to an embodiment of the present invention is shown as follows: Figure 1-2 As shown, the dual-mode ion transmission device comprises:

[0027] A multipole transmission rod 80 and a first ion lens 11, wherein the first ion lens 11 is arranged at the ion outlet of the multipole transmission rod 80;

[0028] The second ion lens 12 is a cylindrical structure, and the second ion lens 12 is arranged on the outer side of the multipole transmission rod 80. The angle between the ion transmission direction in the second ion lens 12 and the ion transmission direction in the multipole transmission rod 80 is a right angle or an acute angle. The ions emitted from the second ion lens 12 enter the multipole transmission rod 80 from the gap between two adjacent transmission rods 81-82.

[0029] A first electrode 21, wherein the first electrode 21 is in a columnar shape, such as a cylinder, and is disposed between the first ion lens 11 and the second ion lens 12, and is located at the outer side of the multipole transmission rod 80; the angle between the central axis of the first electrode 21 and the central axis of the multipole transmission rod 80 is a right angle or an acute angle;

[0030] A first group of electrodes, the first group of electrodes includes at least two electrodes 23-24, which are respectively arranged adjacent to the first ion lens 11 and the second ion lens 12, so that the potential difference between the first electrode 21 and the at least two electrodes 23-24 is equal, such as the voltages applied to at least two electrodes are equal and not zero, or at least two electrodes are grounded.

[0031] In order to ensure that the ions can be deflected and transmitted into the multipole transmission rod after being ejected from the second ion lens, the dual-mode ion transmission device further includes:

[0032] The second electrode 22 is arranged between the first ion lens 11 and the second ion lens 12, and the multipole transmission rod 80, the first electrode 21 and the second electrode 22 are arranged in sequence.

[0033] In order to ensure that the ions are deflected and transmitted into the multipole transmission rod after being ejected from the second ion lens, further, the first group of electrodes includes:

[0034] A third electrode 23, wherein the third electrode 23 is disposed at an outer portion of the second ion lens 12 away from the first electrode 21;

[0035] The fourth electrode 24 is disposed on an outer side of the first ion lens 11 away from the first electrode 21 .

[0036] In order to reduce the complexity of the structure and ensure that the ions are deflected into the multipole transmission rod for transmission after being ejected from the second ion lens, the third electrode 23 and the fourth electrode 24 are further symmetrical about the first radial direction of the first electrode 21, and the first ion lens 11 and the second ion lens 12 are respectively symmetrical about the first radial direction.

[0037] In order to ensure that the ions ejected from the second ion lens are deflected 90 degrees and enter the multipole transmission rod for transmission, further, the inner diameter R of the first ion lens 11 and / or the second ion lens 12 satisfies: R=2.871·r·a; the distance L2 between the end face of the first ion lens 11 and the end face of the multipole transmission rod 80 which are relatively positioned is e·r, the distance L7 between the end face of the second ion lens 12 facing the multipole transmission rod 80 and the central axis of the multipole transmission rod is j·r, and the distance L8 from the central axis of the second ion lens 12 to the end face of the ion outlet of the multipole transmission rod 80 is k·r, a∈(1, 1.3), e∈(0.1, 0.5), j∈(3, 6), k∈(4, 6), and r is the diameter of the transmission rod.

[0038] The diameter D1 of the first electrode 21 satisfies: D1=c·r, the distance L4 from the central axis of the first electrode 21 to the central axis of the multipole transmission rod 80=d·r, the distance L5 from the central axis of the first electrode 21 to the end face of the ion outlet of the multipole transmission rod 80=h·r, r is the diameter of the transmission rod 81-84, c∈(2.5, 5), d∈(3, 5), h∈(0.5, 1.5), and r is the diameter of the transmission rod.

[0039] The distance L6 from the end face of the third electrode 23 facing the second ion lens 12 to the ion outlet end face of the multipole transmission rod 80 is f·r, the length L1 of the third electrode 23 along the direction parallel to the central axis of the second ion lens 12 is b·r, the length L2 of the fourth electrode 24 along the direction parallel to the central axis of the multipole transmission rod 80 is b·r, and the length L3 of the fourth electrode 24 along the direction parallel to the central axis of the multipole transmission rod 80 is g·r, f∈(3,5), b∈(3,4), g∈(2,3), and r is the diameter of the transmission rod.

[0040] The dual-mode ion transmission method of the embodiment of the present invention, that is, the working mode of the dual-mode ion transmission device, is as follows:

[0041] DC electrostatic field mode: the power source applies a DC voltage to the first electrode and the multipolar transmission rod, and the potential difference between the first electrode and the first group of electrodes is equal: the voltage applied to at least two electrodes of the first group of electrodes is equal and not zero, or at least two electrodes are grounded;

[0042] The ions emitted from the second ion lens are deflected, and the deflected ions enter the multipole transmission rod for transmission, and finally are emitted from the first ion lens, such as Figure 3 As shown;

[0043] RF field mode: the power source applies RF voltage to the multi-pole transmission rod, and the first electrode and the first group of electrodes are grounded;

[0044] The ions are transmitted in the multi-stage transmission rod and finally ejected from the first ion lens, such as Figure 4 shown.

[0045] Embodiment 2:

[0046] An application example of the dual-mode ion transmission device and method according to Example 1 of the present invention.

[0047] In this application example, Figure 1-2 As shown, the multipole transmission rod 80 uses quadrupole rods 81-84, and the four transmission rods are symmetrically distributed. The connecting line between the transmission rods 81-82 and the connecting line between the transmission rods 83-84 are parallel to the central axis of the multipole transmission rod, and the connecting line between the transmission rods 81-83 and the connecting line between the transmission rods 82-84 are perpendicular to the central axis of the multipole transmission rod.

[0048] The central axis of the first ion lens 11 is collinear with the central axis of the multipole transmission rod 80, and the distance between the end face of the ion outlet of the multipole transmission rod 80 is L2=e·r, and the inner diameter R=2.871·r·a; the central axis of the second ion lens 12 is perpendicular to the central axis of the multipole transmission rod 80, the inner diameter R=2.871·r·a, the distance between the end face of the second ion lens 12 facing the multipole transmission rod and the central axis of the multipole transmission rod 80 is L7=j·r, and the distance between the central axis of the second ion lens 12 and the end face of the ion outlet of the multipole transmission rod 80 is L8=k·r, a∈(1,1.3), e∈(0.1,0.5), j∈(3,6), k∈(4,6), and r is the diameter of the transmission rods 81-84;

[0049] The first electrode 21 is a cylinder, the angle between the central axis and the central axis of the multipole transmission rod 80 is a right angle, and is parallel to the central axis of the second ion lens 12; the diameter D1 of the first electrode 21 satisfies: D1=c·r, the distance L4 from the central axis of the first electrode 21 to the central axis of the multipole transmission rod 80 is d·r, the distance L5 from the central axis of the first electrode 21 to the end face of the ion outlet of the multipole transmission rod 80 is h·r, r is the diameter of the transmission rod, c∈(2.5, 5), d∈(3, 5), h∈(0.5, 1.5), and r is the diameter of the transmission rod;

[0050] The second electrode 22 is a rectangular parallelepiped, and the central axis is perpendicular to the central axis of the multipole transmission rod 80 and parallel to the central axis of the first electrode 21; the longitudinal section of the second electrode 22 is a square; the multipole transmission rod 80, the first electrode 21 and the second electrode 22 are arranged in sequence, and the second electrode 22 has a groove extending parallel to the central axis of the first electrode 21 at the position adjacent to the first electrode 21, and part of the first electrode 21 is in the groove; the bottom wall of the groove is an arc surface, which is located on the circumference of a circle with a diameter of D2=k·r, and on the longitudinal section with the central axis of the multipole transmission rod 80, the diagonal 72 of the cross section of the second electrode 22 is perpendicular to the line 71 between the vertex and the center of the first electrode 21; k∈(3,6), r is the diameter of the transmission rods 81-84;

[0051] The first group of electrodes includes a third electrode 23 and a fourth electrode 24; a distance L6=f·r from the end face of the planar third electrode 23 facing the second ion lens 12 to the ion outlet end face of the multipole transmission rod 80, and a length L1=b·r of the third electrode 23 along a direction parallel to the central axis of the second ion lens 12; a length L2=b·r of the planar fourth electrode 24 along a direction parallel to the central axis of the multipole transmission rod 80, and a length L3=g·r of the fourth electrode 24 along a direction parallel to the central axis of the multipole transmission rod 80, f∈(3,5), b∈(3, 4), g∈(2, 3), r is the diameter of the transmission rod; the upper end face of the third electrode 23 is flush with the upper end face of the second ion lens 12, and in the direction parallel to the central axis of the second ion lens 12, the length of the third electrode 23 is greater than the length of the second ion lens 12; the end face of the second electrode 22 away from the second ion lens 12 is flush with the end face of the first ion lens 11 away from the multipole transmission rod 80 and the end face of the fourth electrode 24, and in the direction parallel to the central axis of the multipole transmission rod 80, the length of the fourth electrode 24 is greater than the length of the first ion lens 11.

[0052] In the DC electrostatic field working mode, the second ion lens applies a -100V DC voltage, the third electrode and the fourth electrode are grounded, the second electrode applies a -10V DC voltage, the first electrode applies a -495V voltage, the first ion lens applies a -10V DC voltage, the first transmission rod applies a -180V DC voltage, the second transmission rod applies a -180V DC voltage, the third transmission rod applies a -110V DC voltage, and the fourth transmission rod applies a -110V DC voltage. Under the optimized voltage parameters, ions enter from the second ion lens, deflect 90 degrees into the multipole transmission rod, and finally eject from the first ion lens, such as Figure 3 shown.

Claims

1. A dual-mode ion transmission device, comprising a multipole transmission rod and a first ion lens, wherein the first ion lens is arranged at the ion outlet of the multipole transmission rod; characterized in that: The dual-mode ion transmission device further comprises: A second ion lens, wherein the second ion lens is arranged at the outer side of the multipole transmission rod, and the angle between the ion transmission direction in the second ion lens and the ion transmission direction in the multipole transmission rod is a right angle or an acute angle; the ions emitted from the second ion lens enter the multipole transmission rod from the gap between two adjacent transmission rods; A first electrode, wherein the first electrode is cylindrical and is disposed between the first ion lens and the second ion lens and is located at the outer side of the multipole transmission rod; an angle between a central axis of the first electrode and a central axis of the multipole transmission rod is a right angle or an acute angle; A first group of electrodes, the first group of electrodes includes at least two electrodes, which are respectively arranged adjacent to the first ion lens and the second ion lens, and the potential difference between the first electrode and the at least two electrodes is equal.

2. The dual-mode ion transmission device according to claim 1, characterized in that: The dual-mode ion transmission device further comprises: The second electrode is arranged between the first ion lens and the second ion lens, and the multipole transmission rod, the first electrode and the second electrode are arranged in sequence.

3. The dual-mode ion transmission device according to claim 1 or 2, characterized in that: The first set of electrodes comprises: a third electrode, the third electrode being disposed at an outer portion of the second ion lens away from the first electrode; A fourth electrode is disposed on an outer side of the first ion lens away from the first electrode.

4. The dual-mode ion transmission device according to claim 3, characterized in that: The third electrode and the fourth electrode are symmetrical about a first radial direction of the first electrode, and the first ion lens and the second ion lens are respectively symmetrical about the first radial direction.

5. The dual-mode ion transmission device according to claim 1, characterized in that: The first set of electrodes is grounded.

6. The dual-mode ion transmission device according to claim 1, characterized in that: The angle between the central axis of the first electrode and the central axis of the multipole transmission rod is a right angle, and is parallel to the central axis of the second ion lens.

7. The dual-mode ion transmission device according to claim 6, characterized in that: The inner diameter R of the first ion lens and / or the second ion lens satisfies: R=2.871·r·a; the distance between the end face of the first ion lens and the end face of the multipole transmission rod which are relatively positioned is L2=e·r, the distance between the end face of the second ion lens facing the multipole transmission rod and the central axis of the multipole transmission rod is L7=j·r, and the distance from the central axis of the second ion lens to the end face of the ion outlet of the multipole transmission rod is L8=k·r, a∈(1,1.3), e∈(0.1,0.5), j∈(3,6), k∈(4,6), and r is the diameter of the transmission rod.

8. The dual-mode ion transmission device according to claim 6, characterized in that: The diameter D1 of the first electrode satisfies: D1=c·r, the distance from the central axis of the first electrode to the central axis of the multipole transmission rod L4=d·r, the distance from the central axis of the first electrode to the end face of the ion outlet of the multipole transmission rod L5=h·r, c∈(2.5,5), d∈(3,5), h∈(0.5,1.5), r is the diameter of the transmission rod.

9. The dual-mode ion transmission device according to claim 3, characterized in that: The distance L6=f·r from the end face of the third electrode facing the second ion lens to the ion outlet end face of the multipole transmission rod, the length L1=b·r of the third electrode along the direction parallel to the central axis of the second ion lens, the length L1=b·r of the fourth electrode along the direction parallel to the central axis of the multipole transmission rod, and the length L3=g·r of the fourth electrode along the direction parallel to the central axis of the multipole transmission rod, f∈(3,5), b∈(3,4), g∈(2,3).

10. The dual-mode ion transmission method of the dual-mode ion transmission device according to any one of claims 1 to 9, wherein the dual-mode ion transmission method is: DC electrostatic field mode: the power supply applies a DC voltage to the first electrode and the multipolar transmission rod, and the potential difference between the first electrode and the first group of electrodes is equal; The ions emitted from the second ion lens are deflected, and the deflected ions are transmitted into the multipole transmission rod and finally emitted from the first ion lens; RF field mode: the power source applies RF voltage to the multi-pole transmission rod, and the first electrode and the first group of electrodes are grounded; The ions are transmitted through the multipole transfer rods and finally ejected from the first ion lens.

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