A microemulsion containing abamectin and indoxacarb, and a preparation method and application thereof

Abstract

The application belongs to the technical field of pesticides, and particularly relates to a microemulsion containing abamectin and indoxacarb as well as a preparation method and application thereof. The microemulsion contains abamectin and indoxacarb, wherein the abamectin accounts for 0.5-3% by weight, the indoxacarb accounts for 3-6% by weight, a phenol derivative polyoxyethylene ether accounts for 5-15% by weight, a polyalkylene oxide block copolymer accounts for 1-5% by weight, a cyclic ketone accounts for 40-55% by weight, a C3-C6 monohydric alcohol accounts for 2-8% by weight, and water accounts for the balance. The microemulsion has liquid beads reaching ultra-fineness, which is 1-2 orders of magnitude smaller than general liquid beads, has good spreading and permeability on plant and insect cells, and is more conducive to exertion of drug efficacy.

Description

Technical Field

[0001] This invention belongs to the field of pesticide technology, specifically relating to a microemulsion containing abamectin and indoxacarb, its preparation method, and its application. Background Technology

[0002] Microemulsions are composed of liquid pesticides, surfactants, water, stabilizers, etc., and belong to thermodynamically stable dispersion systems. Their characteristics include using water as a medium, containing little or no organic solvents, thus being non-flammable and non-explosive, safe in production, operation, storage, and transportation, with less environmental pollution, and saving a significant amount of organic solvents; the pesticide dispersion is extremely high, reaching a fine micronization level, with pesticide particles generally ranging from 0.1 to 0.01 micrometers, and their appearance is approximately transparent or semi-transparent liquid.

[0003] Avermectin is a widely used agricultural and veterinary fungicide, insecticide, and acaricide. It is a sixteen-membered macrocyclic lactone compound produced by the fermentation of *Streptomyces avermitilis*. Avermectin has stomach poison and contact action against mites and insects, but it does not kill eggs. Its mechanism of action differs from that of general insecticides; it interferes with neurophysiological activity, stimulating the release of γ-aminobutyric acid (GABA), which inhibits nerve conduction in arthropods. Adult mites, nymphs, and insect larvae exhibit paralysis upon contact with avermectin, becoming inactive and refusing to feed, and die after 2-4 days. Because it does not cause rapid dehydration in insects, its lethal effect is relatively slow. While avermectin has a direct contact effect on predatory insects and parasitic natural enemies, it leaves minimal residue on plant surfaces, thus causing minimal damage to beneficial insects. Avermectin is adsorbed by the soil and does not migrate; it is also decomposed by microorganisms, therefore it does not accumulate in the environment and can be used as a component of integrated pest management.

[0004] Indoxacarb is a new and highly effective insecticide that works by blocking sodium ion channels in insect nerve cells, causing the nerve cells to lose their function. It has contact and stomach poison effects and can effectively control a variety of pests on crops such as grains, cotton, fruits, and vegetables.

[0005] Currently, there are few reports on microemulsions using avermectin and indoxacarb together as technical grade agents. Summary of the Invention

[0006] To address the aforementioned technical problems, a first aspect of the present invention provides a microemulsion containing abamectin and indoxacarb, comprising, by weight percentage: 0.5-3% abamectin, 3-6% indoxacarb, 5-15% phenol derivative polyoxyethylene ether, 1-5% polyoxyethylene block copolymer, 40-55% cyclic ketone, 2-8% C3-C6 monohydric alcohol, and the balance being water.

[0007] As a preferred technical solution, the phenol derivative polyoxyethylene ether is selected from at least one of tristyrylphenol polyoxyethylene ether, stilbenephenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, naphthol polyoxyethylene ether, dibenzylphenol polyoxyethylene ether, and octylphenol polyoxyethylene ether.

[0008] As a preferred technical solution, the EO / PO mass ratio of the polyepoxyalkylene block copolymer is 1:1.5-2.

[0009] As a preferred technical solution, the EO / PO mass ratio of the polyepoxyalkylene block copolymer is 1:1.71.

[0010] As a preferred technical solution, the cyclic ketone is selected from at least one of cyclohexanone, 2-isopropylcyclohexanone, 3-ethylcyclopentan-1-one, epoxyisophorone, 5-methyl-2-pyrrolidone, 5-(hydroxymethyl)-3-methyl-2-pyrrolidone, and N-methylpyrrolidone.

[0011] As a preferred technical solution, the polarizability of the cyclic ketone is 10-12.

[0012] As a preferred technical solution, the C3-C6 monohydric alcohol is selected from at least one of n-propanol, 2-propanol, n-butanol, 2-butanol, n-pentanol, 2-pentanol, 3-pentanol, n-hexanol, 2-hexanol, and 3-hexanol.

[0013] As a preferred technical solution, the microemulsion further includes 0.1-0.8% antioxidant and 2-6% ethylene glycol.

[0014] A second aspect of the present invention provides a method for preparing the microemulsion, comprising the following steps: mixing abamectin, indoxacarb, phenol derivative polyoxyethylene ether, polyepoxide block copolymer, cyclic ketone, and C3-C6 monohydric alcohol evenly, and then adding water to obtain the microemulsion.

[0015] A third aspect of the present invention provides the application of the microemulsion in the control of rice stem borer, rice leaf roller, and rice leaf roller.

[0016] Beneficial effects: The microemulsion produces ultra-fine droplets, 1-2 times smaller than typical emulsion droplets, exhibiting excellent spreadability and penetration into plant and insect cells, thus enhancing efficacy. The microemulsion is highly stable, low in toxicity and residue, highly efficient, and resistant to UV radiation, high temperatures, and rain washout. It demonstrates good rain washout resistance even after rainfall occurs within two hours of application. Detailed Implementation

[0017] For the purposes of the detailed description below, it should be understood that the invention may take various alternative variations and sequences of steps unless expressly stated otherwise. Furthermore, except in any operational instance, or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term “about.” Therefore, unless indicated to the contrary, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0018] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0019] When a numerical range is disclosed herein, the range is considered continuous and includes the minimum and maximum values ​​of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to an integer, it includes every integer between the minimum and maximum values ​​of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be combined. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are included. For example, a specified range from “1 to 10” should be considered to include any and all subranges between the minimum value 1 and the maximum value 10. Exemplary subranges of the range 1 to 10 include, but are not limited to, 1 to 6.1, 3.5 to 7.8, 5.5 to 10, etc.

[0020] To address the aforementioned problems, this invention provides a microemulsion containing abamectin and indoxacarb, comprising, by weight percentage: abamectin 0.5-3%, indoxacarb 3-6%, phenol derivative polyoxyethylene ether 5-15%, polyoxyethylene block copolymer 1-5%, cyclic ketone 40-55%, C3-C6 monohydric alcohol 2-8%, and water as the balance.

[0021] The avermectin is a commercially available product, and there are no special restrictions on the manufacturers from which it can be purchased. Examples include Qilu Pharmaceutical (Inner Mongolia) Co., Ltd. and Yunnan Lilian Biotechnology Co., Ltd. The avermectin technical grade is a white to yellow crystalline powder, odorless, with a specific gravity of 1.16, and is stable when stored at room temperature.

[0022] The CAS number of indoxacarb is 144171-61-9; Chinese alias: Anda; indoxacarb / (2,4-di-tert-butylphenyl) phosphite; 7-chloro-2,5-dihydro-2-[N-(methoxycarbonyl)-4-(trifluoromethoxy)aniline formyl] indeno[1,2-E][1,3,4]diazine-4A(3H)-carboxylic acid methyl ester; Indoxacarb MP. Indoxacarb has a unique mechanism of action. It is rapidly converted into DCJW in insects. DCJW acts on the inactivated voltage-gated sodium channels of insect nerve cells, irreversibly blocking the transmission of nerve impulses in insects, disrupting the transmission of nerve impulses, resulting in pests' movement disorders, inability to feed, paralysis, and ultimately death.

[0023] The phenol derivative polyoxyethylene ether is selected from at least one of triphenylvinylphenol polyoxyethylene ether, diphenylvinylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, naphthol polyoxyethylene ether, dibenzylphenol polyoxyethylene ether, and octylphenol polyoxyethylene ether.

[0024] The mass ratio of EO / PO of the polyalkylene oxide block copolymer is 1:1.5 - 2; preferably, the mass ratio of EO / PO of the polyalkylene oxide block copolymer is 1:1.71.

[0025] Among them, EO refers to ethylene oxide, and PO refers to propylene oxide.

[0026] Preferably, the manufacturer of the polyalkylene oxide block copolymer is AkzoNobel, and the model is Ethylan NS-500LQ.

[0027] The cyclic ketone is selected from at least one of cyclohexanone, 2-isopropylcyclohexanone, 3-ethylcyclopentan-1-one, epoxyisophorone, 5-methyl-2-pyrrolidone, 5-(hydroxymethyl)-3-methyl-2-pyrrolidone, and N-methylpyrrolidone; preferably, the polarizability of the cyclic ketone is 10 - 12; more preferably, the cyclic ketone includes cyclohexanone and N-methylpyrrolidone; the weight ratio of cyclohexanone to N-methylpyrrolidone is 1 - 3:1.

[0028] This application achieves a clear and transparent microemulsion by adding phenol derivative polyoxyethylene ether and polyethylene oxide block copolymer. The two work synergistically. Microemulsions obtained by using phenol derivative polyoxyethylene ether or polyethylene oxide block copolymer alone are cloudy or layered. However, when both phenol derivative polyoxyethylene ether and polyethylene oxide block copolymer are added, the microemulsion becomes cloudy when placed at 0°C or 54°C. The applicant unexpectedly discovered that when cyclic ketone and C3-C6 monohydric alcohol are added, and the polarizability of the cyclic ketone is 10-12, the microemulsion is stable and does not layer after being placed at 0°C for 7 days. It is speculated that the cyclic ketone and C3-C6 monohydric alcohol work synergistically and are more present at the oil-water interface, which reduces the interface flexibility and promotes interface bending.

[0029] The C3-C6 monohydric alcohol is selected from at least one of n-propanol, 2-propanol, n-butanol, 2-butanol, n-pentanol, 2-pentanol, 3-pentanol, n-hexanol, 2-hexanol, and 3-hexanol; preferably, the C3-C6 monohydric alcohol is n-butanol.

[0030] Through further research, the applicant discovered that when the EO / PO mass ratio of the polyoxyethylene block copolymer is 1:(1.5-2) and the C3-C6 monohydric alcohol is n-butanol, the microemulsion maintains low-temperature stability and remains stable, clear, and transparent even after being placed at 54°C for 14 days. It is speculated that the phenol derivative polyoxyethylene ether and the polyoxyethylene block copolymer form micelles with a certain structure, with EO and PO bending and surrounding each other in a 1:(1.5-2) ratio. At the same time, the oxygen atoms in the polyoxyethylene ether and EO are connected to water through hydrogen bonds, and the hydroxyl groups are interspersed within them through hydrogen bonds or dipole interactions. The hydrocarbon chains are inserted into the micelles and interact with hydrophobic groups, thereby increasing the interfacial strength.

[0031] Preferably, the microemulsion further includes a surfactant prepared by alkoxylation reaction using hydrophobic compounds containing active hydrogen and alkoxy compounds as raw materials; there are no particular restrictions on the manufacturer of the surfactant prepared by alkoxylation reaction using hydrophobic compounds containing active hydrogen and alkoxy compounds as raw materials; in this application, the manufacturer of the surfactant prepared by alkoxylation reaction using hydrophobic compounds containing active hydrogen and alkoxy compounds as raw materials is BASF, and the model is Emulan lvs;

[0032] To achieve high and low temperature stability of microemulsions, the system contains emulsifiers, water, alcohols, etc. When subjected to external forces, the energy at the gas-liquid interface changes, forming a large amount of liquid film at the gas-liquid interface, which is actually detrimental to the use of microemulsions. The applicant found that when the phenol derivative polyoxyethylene ether is styrene-based phenol polyoxyethylene ether and the cyclic ketone is cyclohexanone and N-methylpyrrolidone; and when the microemulsion also includes Emulan lvs, the foaming property of the microemulsion is <60mL. It is speculated that Emulan lvs is a surfactant prepared by alkoxide reaction of hydrophobic compounds containing active hydrogen and alkoxy hydrocarbons as raw materials. The intramolecular or intermolecular hydrogen bonds between Emulan lvs and adjacent compounds such as styrene-based phenol polyoxyethylene ether reduce the surface charge of the liquid film, thus making the liquid film unstable. In particular, when the phenol derivative polyoxyethylene ether is of type 601# and the weight ratio of cyclohexanone and N-methylpyrrolidone is 1-3:1, the foaming property of the microemulsion is 40mL, and it has good hard water stability.

[0033] More preferably, the microemulsion further includes 0.1-0.8% antioxidant and 2-6% ethylene glycol;

[0034] The antioxidant can react with chain-growing free radicals in auto-oxidation, eliminating free radicals and thus interrupting the chain reaction; extending the service life of the microemulsion; preferably, the antioxidant is selected from at least one of eugenol, L-cysteine, vitamin E, vitamin C, tea polyphenols, BHA, BHT, TBHQ, and epoxidized soybean oil. Preferably, the antioxidant is BHT; the CAS number of BHT is 128-37-0.

[0035] More preferably, the microemulsion containing abamectin and indoxacarb comprises, by weight percentage, 1.5% abamectin, 4.5% indoxacarb, 10% phenol derivative polyoxyethylene ether, 3% polyoxyethylene block copolymer, 48% cyclic ketone, 6% C3-C6 monohydric alcohol, 0.5% antioxidant, 4% ethylene glycol, and the balance being water.

[0036] Ethylene glycol CAS number 107-21-1.

[0037] A second aspect of the present invention provides a method for preparing the microemulsion, comprising the following steps: mixing abamectin, indoxacarb, phenol derivative polyoxyethylene ether, polyepoxide block copolymer, cyclic ketone, and C3-C6 monohydric alcohol evenly, and then adding water to obtain the microemulsion.

[0038] Preferably, the preparation method of the microemulsion includes the following steps: mixing a surfactant, cyclic ketone, and C3-C6 monohydric alcohol prepared by alkoxide reaction of avermectin, indoxacarb, phenol derivative polyoxyethylene ether, polyepoxide block copolymer, hydrophobic compound containing active hydrogen and alkoxy hydrocarbon compound as raw materials, and then adding water, antioxidant and ethylene glycol to obtain the microemulsion.

[0039] The microemulsion droplets are ultrafine, 1-2 times smaller than ordinary emulsion droplets, and have good spreadability and permeability to plant and insect cells, which is more conducive to the efficacy of the drug.

[0040] The present invention will now be described in detail through embodiments. It should be noted that the following embodiments are only for further illustration of the present invention and should not be construed as limiting the scope of protection of the present invention. Non-essential improvements and adjustments made by those skilled in the art based on the above description of the present invention still fall within the scope of protection of the present invention.

[0041] In addition, unless otherwise stated, all raw materials used are commercially available.

[0042] Example

[0043] Example 1

[0044] A microemulsion containing abamectin and indoxacarb, comprising, by weight percentage: 1.5% abamectin, 4.5% indoxacarb, 10% phenol derivative polyoxyethylene ether, 3% polyoxyalkylene block copolymer, 7% surfactant prepared by alkoxylation reaction from hydrophobic compounds containing active hydrogen and alkoxy hydrocarbons, 48% cyclic ketone, 6% C3-C6 monohydric alcohol, 0.5% antioxidant, 4% ethylene glycol, and water as balance.

[0045] The phenol derivative polyoxyethylene ether, model number 601#, was purchased from Hebei Lantian Chemical Co., Ltd.

[0046] The polyepoxyalkylene block copolymer has an EO / PO mass ratio of 1:1.71, is manufactured by AkzoNobel, and is model Ethylan NS-500LQ.

[0047] The cyclic ketones include cyclohexanone and N-methylpyrrolidone; the weight ratio of cyclohexanone to N-methylpyrrolidone is 1.7:1.

[0048] The C3-C6 monohydric alcohol is n-butanol;

[0049] The antioxidant is BHT.

[0050] The surfactant, manufactured by BASF using hydrophobic compounds containing active hydrogen and alkoxy hydrocarbons as raw materials via alkoxylation reaction, is model Emulan lvs.

[0051] The preparation method of the microemulsion includes the following steps: avermectin, indoxacarb, phenol derivative polyoxyethylene ether, polyepoxide block copolymer, hydrophobic compound containing active hydrogen and alkoxy hydrocarbon compound as raw materials are mixed evenly via alkoxide reaction to produce surfactant, cyclic ketone, C3-C6 monohydric alcohol, and then water, antioxidant and ethylene glycol are added to obtain the microemulsion.

[0052] Comparative Example 1

[0053] A microemulsion containing abamectin and indoxacarb, implemented in the same manner as in Example 1, except that it does not contain phenol derivative polyoxyethylene ether.

[0054] Comparative Example 2

[0055] A microemulsion containing abamectin and indoxacarb, implemented in the same manner as in Example 1, except that it does not contain polyepoxide block copolymers.

[0056] Comparative Example 3

[0057] A microemulsion containing avermectin and indoxacarb, implemented in the same manner as in Example 1, except that it contains no cyclic ketones.

[0058] Comparative Example 4

[0059] A microemulsion containing abamectin and indoxacarb, implemented in the same manner as in Example 1, except that it does not contain C3-C6 monohydric alcohols.

[0060] Comparative Example 5

[0061] A microemulsion containing avermectin and indoxacarb, implemented in the same manner as in Example 1, except that cyclohexanone is replaced with isophorone.

[0062] Comparative Example 6

[0063] A microemulsion containing abamectin and indoxacarb, implemented in the same manner as in Example 1, except that the C3-C6 monohydric alcohol is replaced with ethanol.

[0064] Comparative Example 7

[0065] A microemulsion containing abamectin and indoxacarb, implemented in the same manner as in Example 1, except that the C3-C6 monohydric alcohol is replaced with n-hexanol.

[0066] Comparative Example 8

[0067] A microemulsion containing abamectin and indoxacarb, implemented in the same manner as in Example 1, except that the polyepoxide block copolymer is replaced with Pluronic F127.

[0068] Comparative Example 9

[0069] A microemulsion containing abamectin and indoxacarb is implemented in the same way as in Example 1, except that the surfactant prepared by alkoxylation reaction of hydrophobic compounds and alkoxy hydrocarbons containing active hydrogen is replaced with a dispersing powder.

[0070] Comparative Example 10

[0071] A microemulsion containing abamectin and indoxacarb, the specific implementation method is the same as in Example 1, except that the surfactant is prepared by alkoxylation reaction using hydrophobic compounds containing active hydrogen and alkoxy hydrocarbon compounds as raw materials.

[0072] Comparative Example 11

[0073] A microemulsion containing abamectin and indoxacarb, the specific implementation method is the same as in Example 1, except that the phenol derivative polyoxyethylene ether is nonylphenol polyoxyethylene ether.

[0074] Performance testing

[0075] (1) Microemulsion efficacy test

[0076] When the microemulsion described in Example 1 was sprayed evenly at a rate of 40 mL / mu during the peak hatching period of rice leaf roller eggs, the mortality rate was 78% after 48 hours and over 96% after 72 hours. When the microemulsion described in Example 1 was sprayed evenly at a rate of 80 mL / mu during the larval stage of rice stem borer, the mortality rate was 45% after 48 hours and 85% after 72 hours. The mortality rate (%) was calculated as follows: (number of insects before application - number of insects after application) × 100 / number of insects before application.

[0077] (2) Low temperature stability test: Refer to GB / T 19137-2003; after being placed at 0℃ for 7 days, the appearance is clear and transparent, which is qualified; if it is layered or cloudy, it is unqualified.

[0078] High temperature stability test; refer to GB / T 19136-2003; after being placed at 54℃ for 14 days, a clear and transparent appearance is acceptable, while layering or turbidity is unacceptable.

[0079] Persistent foaming test (1 minute, mL): Refer to GB / T 28137-2011; foaming of less than or equal to 40 mL is excellent; foaming of more than 40 mL but less than or equal to 60 mL is medium; foaming of more than 60 mL is poor.

[0080] Hard water stability test: Refer to GB / T1603-2001, observe the appearance. A clear and transparent appearance is acceptable, while layering or turbidity is unacceptable.

[0081] The microemulsion of Example 1 is clear and transparent, and its low-temperature stability, high-temperature stability, and sustained foaming properties are all satisfactory; its hard water stability is also satisfactory.

[0082] Comparative Example 1 failed to form a clear and transparent microemulsion; Comparative Example 2 failed to form a clear and transparent microemulsion.

[0083] The microemulsion in Comparative Example 3 was clear and transparent, but its low-temperature stability and high-temperature stability were both substandard, and its persistent foaming properties were poor.

[0084] The microemulsion in Comparative Example 4 was clear and transparent, but its low-temperature stability and high-temperature stability were both substandard, and its persistent foaming properties were poor.

[0085] The microemulsion in Comparative Example 5 was clear and transparent, but its low-temperature stability and high-temperature stability were both substandard, and its persistent foaming properties were moderate.

[0086] The microemulsion in Comparative Example 6 was clear and transparent, but its low-temperature stability and high-temperature stability were both substandard, and its persistent foaming properties were moderate.

[0087] The microemulsion of Comparative Example 7 was clear and transparent, with qualified low-temperature stability, unqualified high-temperature stability, and medium persistent foaming properties.

[0088] The microemulsion of Comparative Example 8 was clear and transparent, but its low-temperature stability and high-temperature stability were both substandard, and its persistent foaming properties were moderate.

[0089] The microemulsion of Comparative Example 9 was clear and transparent, but its low-temperature stability and high-temperature stability were unqualified, its persistent foaming properties were poor, and its hard water resistance was unqualified.

[0090] The microemulsion of Comparative Example 10 was clear and transparent, but its low-temperature stability and high-temperature stability were both substandard, and its sustained foaming ability was medium; its hard water resistance was also substandard.

[0091] The microemulsion of Comparative Example 11 was clear and transparent, with qualified low-temperature stability and qualified high-temperature stability, but poor persistent foaming properties.

[0092] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention in any other way. Any person skilled in the art may make changes or equivalent modifications to the above-disclosed technical content. However, any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A microemulsion containing avermectin and indoxacarb, characterized in that, The composition, by weight percentage, includes 0.5-3% abamectin, 3-6% indoxacarb, 5-15% phenol derivative polyoxyethylene ether, 1-5% polyepoxide block copolymer, 40-55% cyclic ketones, 7% surfactant prepared by alkoxylation reaction of hydrophobic compounds containing active hydrogen and alkoxy hydrocarbons, 2-8% C3-C6 monohydric alcohols, and the balance being water; the cyclic ketones include cyclohexanone and N-methylpyrrolidone; the weight ratio of cyclohexanone to N-methylpyrrolidone is 1-3:1; the EO / PO mass ratio of the polyepoxide block copolymer is 1:1.5-2; the C3-C6 monohydric alcohol is selected from n-butanol; The phenol derivative polyoxyethylene ether is designated as model 601#. The surfactant, manufactured by BASF using hydrophobic compounds containing active hydrogen and alkoxy hydrocarbons as raw materials via alkoxylation reaction, is model Emulan lvs.

2. The microemulsion as described in claim 1, characterized in that, The EO / PO mass ratio of the polyepoxyalkylene block copolymer is 1:1.

71.

3. The microemulsion as described in claim 1, characterized in that, The microemulsion also includes 0.1-0.8% antioxidant and 2-6% ethylene glycol.

4. A method for preparing a microemulsion as described in any one of claims 1-3, characterized in that, Includes the following steps: The surfactant, cyclic ketone, and C3-C6 monohydric alcohol prepared by alkoxide reaction of abamectin, indoxacarb, phenol derivative polyoxyethylene ether, polyepoxide block copolymer, hydrophobic compound containing active hydrogen, and alkoxy hydrocarbon compound are mixed evenly, and then water is added to obtain the final product.

5. The application of the microemulsion as described in any one of claims 1-4 in the control of rice stem borer, rice leaf roller, and rice leaf roller.