Biochemical analyzer and biochemical analysis method

Abstract

The present invention belongs to the technical field of biochemical analyzers, and provides a biochemical analyzer. By arranging different operation stations linearly on the incubation tank module, driving a chip cartridge containing a disposable test reagent along the operation stations by the incubation tank module, and arranging operation mechanisms beside the operation stations to perform corresponding operations, the detection process of the biochemical analyzer equipped with the incubation tank module is made instant and simple, and the detection accuracy is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of biochemical analyzers, and particularly relates to a biochemical analyzer and a biochemical analysis method. Background Art

[0002] Currently, an annular incubation tank is often used in a biochemical analyzer to place reagent bottles and reaction cups. Among them, the reagent bottles are filled with reagent amounts for multiple persons to be used for detecting multiple samples. During specific sample detection, the reagent bottles are opened, and then a reagent suction device is used to suck the reagent and mix it with the sample in the reaction cup for detection. Summary of the Invention

[0003] Although the annular incubation tank of the existing biochemical analyzer can achieve sample detection, since the market positioning of the existing biochemical analyzer with an annular incubation tank is usually for large medical institutions, the annular incubation tank needs to be able to place multiple reaction cups and reagent bottles filled with a large amount of reagent measurement to meet the requirements of multiple-person testing. However, it is found in practice that the reagent in the reagent bottle usually cannot be used up after opening, thus causing the problem of the opening validity period, that is, when the remaining reagent after opening is used again after a certain period of time, it may cause a reduction in the sample detection accuracy. In addition, since the reaction cups and reagent bottles in the annular incubation tank exist independently, it is usually an important reason for the complex "calibration" process required during sample detection. "Calibration" requires professional operation and the operation process is complex, so that it is difficult to popularize the biochemical analyzer with an annular incubation tank in small medical institutions such as community hospitals.

[0004] In summary, the annular incubation tank of the existing biochemical analyzer has defects such as complex detection procedures of the biochemical analyzer and easy reduction of detection accuracy.

[0005] The present invention provides a biochemical analyzer to solve the above defects of the annular incubation tank of the existing biochemical analyzer. The biochemical analyzer includes:

[0006] An incubation tank module, including different operation stations arranged in a straight line, for driving a chip cartridge with a disposable test reagent sealed inside to move along the operation stations for biochemical detection;

[0007] An operating mechanism, arranged beside the operation stations to perform corresponding operations.

[0008] Specifically, the incubation tank module includes an incubation tank with a straight channel inside; along the direction of the straight channel on the upper surface of the incubation tank, a puncture position and a sample addition position communicating with the straight channel are arranged at intervals; a detection position communicating with the straight channel is arranged on the side surface of the incubation tank, and the side wall of the chip cartridge corresponding to the detection position is light-transmissive; a driving mechanism for driving the chip cartridge is arranged on one side of the straight channel.

[0009] Specifically, the operating mechanism includes a sampling mechanism disposed beside the sample addition position; the sampling mechanism includes a sample driving device for transporting a sample tube to a sampling station, an identification device for identifying the identity label of the sample tube on one side of the sample driving device, and a monitoring device for detecting the presence or absence of the sample tube on one side of the sample driving device.

[0010] Specifically, the operating mechanism includes a sampling mechanism disposed beside the sampling position; the sampling mechanism includes a lateral driving device mounted on a vertical plate and a vertical sample taking and placing device that can be driven by the lateral driving device to translate.

[0011] Specifically, the operating mechanism includes a puncturing mechanism disposed beside the puncturing position; the puncturing mechanism includes a puncturing driving device mounted on the puncturing mechanism body and a puncturing needle that can be driven by the puncturing driving device to puncture downward.

[0012] Specifically, the operating mechanism includes an optical detection mechanism disposed beside the detection position; the optical detection mechanism includes a light source device mounted on a base, a photoelectric conversion module, and a heat dissipation device for dissipating heat from the light source device.

[0013] Specifically, a position sensor for sensing the position information of the chip cartridge is further provided on one side of the incubation tank; the position sensor is disposed near the chip cartridge inlet of the linear channel.

[0014] Specifically, the distance from the puncturing position to the chip cartridge inlet of the linear channel is farther than the distance from the sample addition position to the chip cartridge inlet of the linear channel.

[0015] Specifically, a chip cartridge identification position is further provided on one side of the incubation tank; the chip cartridge identification position communicates with the linear channel, and the distance from it to the chip cartridge inlet of the linear channel is farther than the distance from the puncturing position to the chip cartridge inlet of the linear channel.

[0016] The present invention also provides a biochemical analysis method, including:

[0017] Setting different operating stations linearly on the incubation tank module;

[0018] Driving a chip cartridge containing a disposable test reagent along the operating stations by the incubation tank module to perform biochemical detection;

[0019] Layouting an operating mechanism beside the operating stations and performing corresponding operations through the operating mechanism.

[0020] The biochemical analyzer provided by the present invention sets different operation stations linearly on the incubation tank module. The incubation tank module drives a chip cartridge containing a disposable test reagent to move along the operation stations, and operation mechanisms are arranged beside the operation stations to perform corresponding operations, thereby effectively avoiding the problem of the expiration date after opening the bottle and the operation of the "calibration" process. As a result, the detection process of the biochemical analyzer equipped with this incubation tank module is instant and simple, and the detection accuracy is improved. Description of the Drawings

[0021] Figure 1 Schematic structural diagram of the biochemical analyzer provided for an embodiment;

[0022] Figure 2 Schematic structural diagram of the incubation tank module provided for an embodiment;

[0023] Figure 3 Schematic structural diagram of the sample injection mechanism provided for an embodiment;

[0024] Figure 4 Schematic structural diagram of the sampling mechanism provided for an embodiment;

[0025] Figure 5 Schematic structural diagram of the puncture mechanism provided for an embodiment;

[0026] Figure 6 Schematic structural diagram of the optical detection mechanism provided for an embodiment;

[0027] Figure 7 Schematic structural diagram of the liquid-electric unit provided for an embodiment;

[0028] Figure 8 Schematic flow diagram of a biochemical analysis method provided for an embodiment. Detailed Embodiments

[0029] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention.

[0030] In addition, in the description of the present invention, unless otherwise clearly defined and limited, the terms "installation", "connection", and "coupling" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can also be the communication inside two components. It can be a wireless connection or a wired connection. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] In addition, the technical features involved in different embodiments of the present invention described hereinafter can be combined with each other as long as they do not conflict with each other.

[0032] Next, the present invention proposes some preferred embodiments to teach those skilled in the art to implement.

[0033] Figure 1 The structural schematic diagram of a biochemical analyzer provided for an embodiment shows a biochemical analyzer, which includes: an incubation tank module 2 and an operating mechanism arranged on a bottom plate 1. The operating mechanism includes a sample injection mechanism 7, a sampling mechanism 5, a puncture mechanism 4, an optical detection mechanism 3, etc. A cleaning pool unit 8 can be arranged on one side of the incubation tank module 2 for cleaning the operating mechanism that needs to be cleaned. For example, cleaning the puncture mechanism 4 or the sampling mechanism 5. A liquid-electric unit 6 can be arranged at a common end of the incubation tank module 2 and the operating mechanism for liquid-electric connection with the incubation tank module 2, the operating mechanism, or the cleaning pool unit 8.

[0034] See Figure 1 , the incubation tank module 2 includes different operating stations arranged in a straight line for driving a chip cartridge containing a disposable test reagent to move along the operating stations; the operating mechanism is arranged beside the operating stations to perform corresponding operations.

[0035] In this embodiment, by arranging different operating stations in a straight line on the incubation tank module 2, driving the chip cartridge containing a disposable test reagent to move along the operating stations through the incubation tank module 2, arranging the operating mechanism beside the operating stations, and performing corresponding operations through the operating mechanism, the problems of the expiration date of opening a bottle and the operation of the "calibration" process are effectively avoided, so that the detection process of the biochemical analyzer equipped with the incubation tank module 2 is simple and immediate, and the detection accuracy is improved.

[0036] It should be noted that in the prior art, biochemical analysis equipment with a circular incubation tank structure has multiple different operation stations. For example, a puncture station, a sample addition station, and a detection station, etc. However, these stations are all arranged around the perimeter of the disc. Correspondingly, the operating mechanisms for completing the puncture operation, sample addition operation, and detection operation are arranged correspondingly around multiple different operation stations. The reason why the existing biochemical analysis equipment sets its incubation tank assembly into a circular structure is to perform sample analysis and detection for multiple samples and multiple test portions. Although the existing biochemical analysis equipment can complete sample analysis and detection for multiple samples and multiple test portions, it has defects such as complex analysis and detection operations of the equipment and reduced detection accuracy. The biochemical analyzer provided in this embodiment, based on the improvement of the incubation tank module 2, brings fundamental changes to the overall structure of the instrument, making the detection process of the biochemical analyzer with this incubation tank module 2 simple and the detection accuracy improved, so that the instrument can truly meet the needs of small medical institutions such as community hospitals for instant, simple, and single-sample detection.

[0037] It should also be noted that since the sample detection is completed by different operation stations arranged along a straight line on the incubation tank module 2, the operating mechanisms such as the sample injection mechanism 7, the sampling mechanism 5, the puncture mechanism 4, and the optical detection mechanism 3 can be arranged along the straight line where the different operation stations are located, so that the overall structure of the instrument is concise and compact.

[0038] Figure 2 It is a schematic structural diagram of the incubation tank module provided in an embodiment, showing an incubation tank module.

[0039] See Figure 2 , the incubation tank module 2 includes an incubation tank 205 with a straight channel inside; along the direction of the straight channel on the upper surface of the incubation tank 205, a puncture position 2052 and a sample addition position 2051 communicating with the straight channel are arranged at intervals; on the side surface of the incubation tank 205, detection positions (2054, 2055) communicating with the straight channel are provided; on one side of the straight channel, a driving mechanism 203 for driving a chip cartridge 204 containing a disposable test reagent to pass through is arranged.

[0040] Specifically, the driving mechanism 203 drives the chip cartridge 204 to pass through by driving the clamping and limiting mechanism to move. The clamping and limiting mechanism includes a limiting block 2020 and front and rear sliders (2021, 2023) connected by springs; the limiting block 2020 limits the chip cartridge 204; on one side of the front and rear sliders (2021, 2023), a rotary hook for rotatably clamping the chip cartridge 204 is provided, and one side is connected to the driving mechanism 203.

[0041] It should be noted that the driving mechanism 203 drives the chip cartridge 204 to pass through by driving the clamping and limiting mechanism to move, which can realize clamping the chip cartridge 204 for two-way transportation and precise positioning at the required position.

[0042] Among them, the front and rear sliders (2021, 2023) are connected by a spring, and a rotating hook for rotatably clamping the chip cassette 204 is provided on one side of the front and rear sliders (2021, 2023). The spring force can drive the movement of the front and rear sliders (2021, 2023), and further drive the rotation of the rotating hook on the front and rear sliders (2021, 2023) to clamp the chip cassette 204 seamlessly, thereby improving the positioning accuracy of the chip cassette 204.

[0043] In addition, the driving mechanism 203 can select linear driving mechanisms 203 such as a conveyor belt module and a lead screw motor module to achieve the purpose of driving the chip cassette 204 to travel back and forth along the linear channel.

[0044] Specifically, a position sensor 206 for sensing the position information of the chip cassette 204 is further provided on one side of the incubation tank 205, and the position sensor 206 can be arranged near the entrance of the chip cassette 204 in the linear channel. A chip cassette identification position 2053 is also provided on one side of the incubation tank 205, and the chip cassette identification position 2053 communicates with the linear channel.

[0045] Among them, the position sensor 206 and the chip cassette identification position 2053 can be arranged on the same side of the incubation tank 205 as the puncture position 2052 and the sample addition position 2051, or can be arranged on different sides of the incubation tank 205 from the puncture position 2052 and the sample addition position 2051.

[0046] Specifically, the distance between the chip cassette identification position 2053 and the entrance of the chip cassette 204 in the linear channel can be farther than the distance between the puncture position 2052 and the entrance of the chip cassette 204 in the linear channel, or can be closer than the distance between the puncture position 2052 and the entrance of the chip cassette 204 in the linear channel.

[0047] The distance between the puncture position 2052 and the entrance of the chip cassette 204 in the linear channel can be farther than the distance between the sample addition position 2051 and the entrance of the chip cassette 204 in the linear channel, or can be closer than the distance between the sample addition position 2051 and the entrance of the chip cassette 204 in the linear channel.

[0048] Between the chip cassette identification position 2053 and the puncture position 2052, detection positions (2054, 2055) can be provided. The detection positions (2054, 2055) include a transmission detection position and / or a scattering detection position 2055, and the transmission detection position 2054 and / or the scattering detection position 2055 can be arranged side by side.

[0049] Preferably, with reference to the entrance of the chip cassette 204 in the linear channel, the distances of the position sensor 206, the sample addition position 2051, the puncture position 2052, the detection positions (2054, 2055), and the chip cassette identification position 2053 from the entrance of the chip cassette 204 in the linear channel thus become farther.

[0050] It should be noted that by arranging the in-place sensor 206 near the entrance of the chip cassette 204 in the linear channel, it is possible to detect whether the chip cassette 204 is in place in the first instance, thereby triggering the progress of further processes. By arranging a transmission detection position 2054 and / or a scattering detection position 2055 between the chip cassette identification position 2053 and the puncture position 2052, an optical path can be established to perform biochemical analysis on the sample. By arranging the chip cassette identification position 2053 on one side of the incubation tank 205, the identification information (such as a two-dimensional code) of the chip cassette 204 can be identified, and the identity information of the chip cassette 204 can be confirmed, thereby avoiding errors in the detection object.

[0051] In this embodiment, by arranging the in-place sensor 206, the puncture position 2052, the sample addition position 2051, and the chip cassette identification position 2053 that are communicated with the linear channel at intervals along the direction of the linear channel on the upper surface of the incubation tank 205 having a linear channel inside, and arranging the detection positions (2054, 2055) that are communicated with the linear channel on the side surface of the incubation tank 205, and arranging a driving mechanism 203 on one side of the linear channel that can drive the chip cassette 204 containing a disposable test reagent to pass through, the problem of the expiration date of opening the bottle and the operation of the "calibration" process can be effectively avoided, so that the detection process of the biochemical analyzer equipped with the incubation tank 205 assembly is instant and simple, and the detection accuracy is improved.

[0052] It should be noted that since the test reagent sealed in the chip cassette 204 is a disposable reagent for single-person use, the test reagent is pre-sealed in the chip cassette 204 through a sealing film in a single-use dosage. At the same time, the pre-sealed reagent has been calibrated through a special "calibration" process, and there is no need to rely on a reagent "calibration" mechanism to perform complex "calibration" operations when using the test reagent, so that the overall volume of the biochemical analyzer equipped with the incubation tank 205 assembly is small and the detection process is instant and simple.

[0053] Among them, because the test reagent is a sealed disposable reagent for single-person use, it can not only effectively avoid the problem of the expiration date of opening the bottle and prevent the test accuracy from being reduced due to the reuse of the remaining reagent, but also avoid setting an additional reagent suction device to suck the reagent into the reaction cup, thereby effectively reducing a reagent loading and unloading process and effectively reducing the volume of the biochemical analyzer.

[0054] In addition, when specifically using the biochemical analyzer in this embodiment to detect and analyze a sample, the chip cartridge 204 is placed into the chip cartridge 204 inlet of the linear channel, and then the chip cartridge 204 is driven by the driving mechanism 203 to travel in the linear channel, where it undergoes puncture of the film sealing of the chip cartridge 204 at the puncture position 2052, receives sample addition to the punctured chip cartridge 204 at the sample addition position 2051, and then receives analysis of the biochemical reaction value of the reactant after mixing the sample and the reagent at the detection positions (2054, 2055), thereby enabling instant, efficient, and simple sample testing.

[0055] In addition, compared with a biochemical analyzer in the prior art that uses an annular incubation tank to place reagent bottles and reaction cups, where each reagent bottle contains a reagent amount for multiple samples for detection, the biochemical analyzer with the incubation tank assembly provided in this embodiment has the advantages of a compact overall machine volume, instant and simple detection procedures, and relatively high detection accuracy.

[0056] Specifically, the incubation tank 205 can be set to a long strip structure. The long strip structure of the incubation tank 205 is conducive to setting a linear channel, facilitating the arrangement of the puncture position 2052, the sample addition position 2051, and the detection positions (2054, 2055) along the linear channel, enabling other mechanisms of the biochemical analyzer to be arranged along the long strip structure of the incubation tank 205, thereby achieving the effect of concentrating the mechanism positions to reduce the overall machine volume of the biochemical analyzer.

[0057] It should also be noted that biochemical detection is a specific detection method, that is, a method of detecting by means of light passing through the side wall of the chip cartridge to irradiate the sample. Therefore, the part of the side wall of the chip cartridge 204 opposite to the detection positions (2054, 2055) needs to be light-transmissive so that light can pass through and irradiate the sample to be detected.

[0058] Since the detection positions (2054, 2055) communicating with the linear channel are provided on the side of the incubation tank 205, an optical path can be established to achieve biochemical analysis of the sample. At the same time, by emitting light through the optical path to irradiate the side wall of the chip cartridge 204, the light passes through the light-transmissive side wall to irradiate the sample, and then the light is detected by transmission turbidimetry and / or scattering turbidimetry, thereby obtaining the sample detection result.

[0059] It should also be noted that the incubation tank 205 has the functions of storing the reactant at a constant temperature and providing an appropriate reaction temperature, which can be specifically composed of a heating device, a temperature sensor, a temperature adjustment device, etc.

[0060] Figure 3 It is a schematic structural diagram of a sample injection mechanism provided in an embodiment, showing a sample injection mechanism.

[0061] See Figure 3, the operating mechanism includes a sampling mechanism 7 disposed beside the sample adding position; the sampling mechanism 7 includes a sample driving device for transporting the sample tube 7014 to the sampling station, an identification device 702 for identifying the identity label of the sample tube 7014 on one side of the sample driving device, and a monitoring device 703 for detecting the in-place situation of the sample tube 7014 on the opposite side of the identification device 702.

[0062] Specifically, the sample driving device includes: an injection driving motor conveyor belt assembly 7011 disposed on the injection driving device bracket 7012 and a sample bearing support 7013 fixed on the injection driving motor conveyor belt assembly 7011.

[0063] The sample tube 7014 is carried in a groove with an opening on one side of the sample bearing support 7013. The identification device includes a sample information code scanner 7021 fixed on the code scanner bracket 7022. The monitoring device includes a sample monitoring sensor 7031 fixed on the sample monitoring bearing bracket 7032.

[0064] It should be noted that the identity label of the sample tube can be used to record the sample information required for each sample detection. Specifically, a two-dimensional code or bar code can be used, etc. The sample information code scanner 7021 scans the sample information and checks it with the background to avoid incorrect sample delivery.

[0065] Figure 4 It is a schematic structural diagram of the sampling mechanism provided for an embodiment, showing a sampling mechanism.

[0066] See Figure 4 , the operating mechanism includes a sampling mechanism 5 disposed beside the sample adding position; the sampling mechanism 5 includes a horizontal driving device 503 installed on the vertical plate 501 and a vertical sample taking and placing device 502 that can be driven to translate by the horizontal driving device 503.

[0067] Specifically, the horizontal driving device includes a horizontal motor 5031 and a horizontal belt assembly that can be driven by the horizontal motor 5031.

[0068] The vertical sample taking and placing device is connected to the horizontal belt assembly and includes a shaker mixing device 5021, a preheating pool device 5022 behind the shaker mixing device 5021, a vertical driving motor 5024 on the left side of the shaker mixing device 5021, a liquid level detection device 5025 in front of the shaker mixing device 5021, a sampling needle anti-collision device 5023 between the shaker mixing device 5021 and the liquid level detection device 5025, and a sampling needle 5026 connected to the lower end of the liquid level detection device 5025.

[0069] It should be noted that the horizontal driving device can drive the vertical sample taking and placing device to move horizontally above the sample adding position, and then the vertical driving motor 5024 can drive the sampling needle 5026 to descend to the sample adding position for sample addition.

[0070] Figure 5 Schematic structural diagram of a puncture mechanism provided for an embodiment, showing a puncture mechanism.

[0071] Refer to Figure 5 , the operating mechanism includes a puncture mechanism 4 arranged beside the puncture position; the puncture mechanism 4 includes a puncture driving device installed on the body 405 of the puncture mechanism 4 and a puncture needle 401 that can be driven by the puncture driving device to puncture downward.

[0072] Specifically, the puncture needle 401 is fixed on the puncture needle fixing plate 402. The puncture driving device includes a linear guide pair 403 arranged on the right side of the body 405 of the puncture mechanism 4, an eccentric wheel 407 located on one side of the linear guide pair 403, a reset sensor 406 located on the left side of the eccentric wheel 407, and a puncture driving motor 404 located behind the eccentric wheel 407.

[0073] It should be noted that the puncture driving motor 404 can drive the puncture needle fixing plate 402 to move up and down on the linear guide pair 403, so as to drive the puncture needle 401 fixed on the puncture needle fixing plate 402 to puncture at the puncture position.

[0074] Figure 6 Schematic structural diagram of an optical detection mechanism provided for an embodiment, showing an optical detection mechanism.

[0075] Refer to Figure 6 , the operating mechanism includes an optical detection mechanism arranged beside the detection position; the optical detection mechanism includes a light source device, a photoelectric conversion module, and a heat dissipation device for dissipating heat from the light source device, which are installed on the base.

[0076] Specifically, the base includes a scattered light method optical module base 304 and a transmission light method optical module base 305. The light source device includes a scattered laser light source 303 installed on the scattered light method optical module base 304 and a transmission turbidimetry light source 301 installed on the transmission light method optical module base 305. A transmission method receiving plate shielding cover 306 is arranged on one side of the transmission light method optical module base 305, and a transmission method heat dissipation air duct 302 communicating with a heat dissipation fan 307 is arranged below the transmission turbidimetry light source 301.

[0077] It should be noted that refer to Figure 2 and Figure 6 , since the detection positions (2054, 2055) communicating with the linear channel are arranged on the side of the incubation tank 205, an optical path can be established to realize biochemical analysis of the sample.

[0078] Meanwhile, the side wall of the chip cartridge 204 is irradiated by light emitted through the optical path. The light irradiates the sample through the light-transmissive side wall, and then turbidimetry or nephelometry is performed on the light through the transmission turbidimetry light source 301 and / or the scattered laser light source 303, so as to obtain the sample detection result.

[0079] Figure 7 FIG. is a schematic structural diagram of a liquid-electric unit provided for an embodiment, showing a liquid-electric unit.

[0080] See Figure 7 , the liquid-electric unit includes a liquid path valve 601, a liquid pump 602, a PCB board unit 603, a chassis cooling fan 604, a cooling fan air duct 605, a plunger pump 607, and a pressure detection device 608 mounted on a liquid-electric unit bracket 606.

[0081] It should be noted that the PCB board unit 603 and other components such as the liquid path valve 601 are respectively arranged on two opposite plate surfaces of the liquid-electric unit bracket 606, so as to achieve liquid-electric separation.

[0082] The chassis cooling fan 604 and the cooling fan air duct 605 are connected and relatively arranged at the edge of the liquid-electric unit bracket 606, so as to achieve a good heat dissipation effect.

[0083] Figure 8 FIG. is a schematic flow diagram of a biochemical analysis method provided for an embodiment, showing a biochemical analysis method.

[0084] See Figure 8 , the biochemical analysis method includes:

[0085] S0. Set different operation stations along a straight line on the incubation tank module;

[0086] S1. Drive the chip cartridge containing the disposable test reagent along the operation stations through the incubation tank module for biochemical detection;

[0087] S2. Layout the operation mechanism beside the operation station and perform corresponding operations through the operation mechanism.

[0088] The biochemical analysis method provided by the present invention effectively avoids the problems of the expiration date of opening the bottle and the operation of the "calibration" process by setting different operation stations along a straight line on the incubation tank module 2, driving the chip cartridge containing the disposable test reagent along the operation stations through the incubation tank module 2, laying out the operation mechanism beside the operation station, and performing corresponding operations through the operation mechanism, so that the detection process of the biochemical analyzer equipped with the incubation tank module 2 is simple and immediate, and the detection accuracy is improved.

[0089] In a specific embodiment, a biochemical analysis method is provided, and the steps of the method are as follows:

[0090] Insert the chip cartridge into the linear channel, and use the chip cartridge in-place sensor to detect whether the chip cartridge is inserted in place and properly positioned.

[0091] After the chip cartridge clamping mechanism receives the working instruction from the in-place sensor, it clamps the chip cartridge and moves it to the end of the linear channel.

[0092] The chip cartridge that has moved to the end of the incubation tank has its information written by a scanner installed on the liquid-electric unit bracket of the liquid-electric unit.

[0093] After the information is written to the chip cartridge, the chip cartridge is punctured and sampled according to specific timing instructions.

[0094] Incubate.

[0095] When the chip cartridge is placed, at the same time, place the test tube sample on the sample carrier support of the sampling mechanism and trigger the sampling instruction. The sample undergoes a scheduling movement that cooperates with the chip cartridge according to specific timing.

[0096] The sampling mechanism is responsible for distributing the sample in the test tube to the corresponding chip cartridge as needed through the sampling needle, and at the same time distributing the reagent encapsulated with the chip cartridge to the reaction cup of the chip cartridge itself; after the sampling needle completes a sampling cycle of a sample and a reagent, it will be scheduled to the cleaning pool for cleaning.

[0097] After the sampling needle takes the sample and the reagent, it performs corresponding mixing actions through the oscillator mixing device fixed to the sampling mechanism.

[0098] The sampling needle is cleaned with the pre-heated cleaning liquid installed in the pre-heating pool on the sampling mechanism; the sampling needle is used in conjunction with the anti-collision device.

[0099] The movement trajectory of the sampling mechanism forms the sample position, the cleaning pool position, and the chip cartridge sampling position on the same straight line.

[0100] After completing a full cycle of information writing, puncturing, sampling, and detection, the chip cartridge is transported to the entrance of the linear channel by the clamping mechanism.

[0101] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims

1. A biochemical analyzer, characterized in that, Comprising: An incubation tank module, including different operation stations arranged in a straight line, for driving a chip cartridge containing a disposable test reagent to move along the operation stations for biochemical detection, and an operation mechanism, arranged beside the operation stations to perform corresponding operations; The incubation tank module includes an incubation tank with a straight channel inside. Along the direction of the straight channel on the upper surface of the incubation tank, a puncture position and a sampling position communicating with the straight channel are arranged at intervals. A detection position communicating with the straight channel is arranged on the side surface of the incubation tank. The side wall of the chip cartridge corresponding to the detection position is light-transmissive. A driving mechanism for driving the chip cartridge is arranged on one side of the straight channel; The operation mechanism includes a sampling mechanism arranged beside the sampling position. The sampling mechanism includes a sample driving device for transporting a sample tube to a sampling station, an identification device for identifying the identity label of the sample tube on one side of the sample driving device, and a monitoring device for detecting the presence or absence of the sample tube on one side of the sample driving device; The operation mechanism includes a sampling mechanism arranged beside the sampling position. The sampling mechanism includes a lateral driving device installed on a vertical plate and a vertical sampling and sample-taking device that can be driven by the lateral driving device to translate; The operation mechanism includes a puncture mechanism arranged beside the puncture position. The puncture mechanism includes a puncture driving device installed on the puncture mechanism body and a puncture needle that can be driven by the puncture driving device to puncture downward; 2. The biochemical analyzer according to claim 1, characterized in that, The operation mechanism includes an optical detection mechanism arranged beside the detection position; the optical detection mechanism includes a light source device, a photoelectric conversion module, and a heat dissipation device for dissipating heat from the light source device, all installed on a base; 3. The biochemical analyzer according to claim 1, characterized in that, One side of the incubation tank is also provided with a position sensor for sensing the position information of the chip cartridge; the position sensor is arranged near the chip cartridge entrance of the straight channel; 4. The biochemical analyzer according to claim 1, characterized in that, The distance from the puncture position to the chip cartridge entrance of the straight channel is farther than the distance from the sampling position to the chip cartridge entrance of the straight channel; 5. The biochemical analyzer according to claim 1, characterized in that, One side of the incubation tank is also provided with a chip cartridge identification position; the chip cartridge identification position communicates with the straight channel, and its distance from the chip cartridge entrance of the straight channel is farther than the distance from the puncture position to the chip cartridge entrance of the straight channel; 6. A biochemical analysis method for the biochemical analyzer according to any one of claims 1-5, characterized in that, Comprising: Arranging different operation stations in a straight line on the incubation tank module; Driving a chip cartridge containing a disposable test reagent to move along the operation stations through the incubation tank module for biochemical detection; Arranging an operation mechanism beside the operation stations and performing corresponding operations through the operation mechanism.

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