An antibacterial and antiviral micro-nanostructure flexible film and its application
By designing a micro-nano structure flexible film and composite functional layer in antibacterial and antiviral materials, the problems of contamination of chemical methods and prone to falling off in the prior art are solved, and efficient microbial adhesion inhibition and stability improvement are achieved.
Patent Information
- Application Number
- CN202010841185.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2020-08-19
- Publication Date
- 2024-12-20
- Estimated Expiration
- 2040-08-19
AI Technical Summary
The existing antibacterial and antiviral materials mainly rely on chemical methods, and have problems with secondary pollution and environmental pollution. The nanostructured antibacterial membrane is prone to fall off in high temperature and high humidity environments, and its ability to inhibit bacteria is insufficient.
Design an antibacterial and antiviral micro-nano structure flexible film, adopt a flexible film layer with micro-nano structure and a composite functional layer, and prevent microorganisms from adhesion by setting the first and second micro-nano structures, and monitor it in real time through the composite functional layer. Environmental status and temperature regulation to enhance antibacterial and antiviral effects.
More than 95.0% of microbial cells and virus adhesion inhibition effects were achieved, antibacterial and antiviral performance was improved, and stability was maintained in high temperature and high humidity environments.
Smart Images
Figure CN111844975B_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the field of biomedicine technology and relates to antibacterial and antiviral material technology, specifically an antibacterial and antiviral micro-nanostructure flexible film and its application. Background Art
[0002] Microorganisms and viruses can attach to and deposit on the surface of objects, grow and multiply on the surface of objects to form sources of pollution or pathogens, which can pose a threat to human health.
[0003] At present, the antibacterial and antiviral treatment of the surface of objects is mainly carried out by chemical methods, such as: using bleach, ammonia, and other commonly used cleaning agents to disinfect and sterilize the surface of objects. However, the use of disinfectants will cause secondary pollution to the surface of objects, and the discharge of disinfectants will also cause certain environmental pollution. There are also some antibacterial materials on the market that use chemical reactions to treat the surface of objects. Antibacterial materials mainly mix antibacterial substances or antibacterial coatings in the materials, and sterilize the surface of objects through antibacterial substances or antibacterial coatings. However, mixed antibacterial substances are mostly chemical substances, and the uncontrolled release of chemical substances during use will cause potential dangers to users; antibacterial coatings will gradually fall off under external environments such as high temperature and high humidity, thereby losing their antibacterial and antiviral functions.
[0004] At present, there are also applications of designed antibacterial films, whose mechanism of action is to reduce the adhesion of pathogens on the surface of objects through physical methods. Antibacterial films mostly use nanostructures. However, the ability of existing nanostructured antibacterial films to inhibit bacteria varies. Once a small number of bacteria adhere to the surface of an object, the bacteria will still grow and multiply rapidly.
[0005] Therefore, it is necessary to design a new antibacterial film that can reduce the adhesion of pathogens on the surface of objects. Summary of the invention
[0006] The purpose of the present invention is to design an antibacterial and antiviral micro-nano structure flexible film. The micro-nano structure flexible film uses a flexible film with a micro-nano structure to perform antibacterial and antiviral treatment on the surface of an object. The antibacterial and antiviral mechanism is to reduce and prevent the attachment of microorganisms such as bacteria and viruses to the surface of the object. At the same time, when a small amount of microorganisms are attached to the micro-nano structure of the flexible film, due to the special design of the micro-nano structure (such as a composite functional layer and other structures), the growth and reproduction of the microorganisms are inhibited, and the surface of the microbial cells or viruses will be damaged, thereby achieving the purpose of antibacterial and antiviral treatment. The micro-nano structure flexible film of the present invention has a wide range of applications, and can be used on the surface of equipment such as medical devices, and can also be adhered to or implanted on the surface of a biological body, etc.
[0007] The technical solution to achieve the purpose of the invention is as follows: an antibacterial and antiviral micro-nanostructure flexible film, comprising a flexible film layer, the upper surface of the flexible film layer is processed with a first micro-nano structure, and the lower surface of the flexible film layer is provided with a composite functional layer.
[0008] The first micro-nano structure includes a plurality of first protrusions uniformly arranged on the upper surface of the flexible film layer, and a second micro-nano structure is arranged between adjacent first protrusions.
[0009] Or the first micro-nano structure includes a plurality of first recessed portions uniformly arranged on the upper surface of the flexible film layer, and a second micro-nano structure is further arranged between adjacent first recessed portions.
[0010] The first micro-nano structure and the second micro-nano structure are used to prevent microorganisms from adhering to the upper surface of the flexible film layer.
[0011] The antibacterial and antiviral micro-nanostructure flexible film of the present invention is improved on the basis of the existing array-type (such as dot matrix) nanostructure. By setting the first micro-nanostructure and the second micro-nanostructure, it can prevent microbial cells or viruses from adhering to the surface of the flexible film layer, and reduce the probability of microbial cells or viruses growing and reproducing on the surface of the flexible film layer.
[0012] In one embodiment of the present invention, the second micro-nano structure includes a plurality of second protruding portions or second concave portions uniformly arranged between adjacent first protruding portions or adjacent first concave portions.
[0013] Furthermore, the height of the first protrusion is greater than the height of the second protrusion.
[0014] Furthermore, the depth of the first recessed portion is greater than the depth of the second recessed portion.
[0015] In a preferred embodiment of the present invention, the first protrusion, the second protrusion, the first recess, and the second recess are in the shape of strips, dots, or blocks. The strips, dots, blocks, etc. can inhibit the growth of specific bacteria through structural characteristics, and can destroy the surface state of cells or viruses to achieve antibacterial and antiviral functions.
[0016] As an improvement to the above-mentioned micro-nanostructure flexible film, the composite functional layer includes a test component and a communication module electrically connected to the test component, and the test component is used to collect changes in the environment in which the flexible film layer is located, and send the collected signals to the digital terminal via the communication module. The setting of the test component of the composite functional layer can monitor the state of the environment in which the flexible film layer is located in real time, assist the flexible film layer in antibacterial and antibacterial properties, and improve the antibacterial and antiviral effects of the flexible film layer.
[0017] Preferably, the test component includes one or more of a radio frequency module, an energy module, a sensor module, a computing module, and a storage module. The radio frequency module can convert radio signals into wired electrical signals to facilitate the transmission of detection signals; the energy module can provide electrical energy for the test component to ensure the normal operation of each module; when the antibacterial and antiviral micro-nano structure flexible film is applied to the surface of an organism, the sensor module can measure the surface temperature of the organism, the heart rate of the organism, the humidity of the environment in which the organism is located, and the atmospheric pressure and other parameter values; when the antibacterial and antiviral micro-nano structure flexible film is applied to medical devices and other equipment, the sensor module can measure the temperature, humidity, atmospheric pressure and other parameters of the environment in which the equipment is located; the computing module can calculate the chemical signals measured by the sensor; and the storage module can store the data detected by the sensor module and the data calculated by the computing module.
[0018] As an improvement to the above-mentioned composite functional layer, the composite functional layer also includes a functional module, which receives a debugging signal sent by a digital terminal via a communication module, adjusts the temperature of the flexible film layer, and can destroy the growth and reproduction environment of microorganisms or viruses, thereby inactivating microorganisms attached to the surface of the micro-nano structure.
[0019] Compared with the prior art, the beneficial effects of the present invention are as follows: the antibacterial and antiviral micro-nano structure flexible film of the present invention has a simple structure and is easy to process. The coordinated use of the first micro-nano structure and the second micro-nano structure on the flexible film layer can inhibit the attachment, growth and reproduction of microbial cells and viruses on its surface, and the antibacterial effect can reach more than 95.0%. At the same time, a composite functional layer is provided under the flexible film layer, and the composite functional layer can assist the flexible film layer in antibacterial and antibacterial, thereby improving the antibacterial and antiviral effects of the flexible film layer. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only for the purpose of more clearly illustrating the technical solutions of the embodiments of the present invention or the prior art. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.
[0021] Figure 1 Schematic diagram of the antibacterial and antiviral micro-nanostructure flexible film of the present invention;
[0022] Figure 2 A schematic diagram of the second structure of the antibacterial and antiviral micro-nanostructure flexible film of the present invention;
[0023] Figure 3 A third structural schematic diagram of the antibacterial and antiviral micro-nanostructure flexible film of the present invention;
[0024] Figure 4 A fourth structural schematic diagram of the antibacterial and antiviral micro-nanostructure flexible film of the present invention;
[0025] Among them, 1. flexible film layer; 3. first protruding portion; 5. first recessed portion; 6. second protruding portion; 7. second recessed portion; 8. composite functional layer. DETAILED DESCRIPTION
[0026] The present invention will be further described below in conjunction with specific embodiments, and the advantages and features of the present invention will become clearer as the description proceeds. However, these embodiments are exemplary only and do not constitute any limitation to the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solution of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.
[0027] In the description of this embodiment, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the invention.
[0028] In addition, the terms "first", "second", "third", etc. are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "plurality" means two or more.
[0029] Embodiment 1:
[0030] Please refer to Figure 1 - Figure 4 As shown, an antibacterial and antiviral micro-nanostructure flexible film, in this embodiment, the micro-nanostructure flexible film includes a flexible film layer 1, the upper surface of the flexible film layer 1 is processed with a first micro-nano structure, and the lower surface of the flexible film layer 1 is provided with a composite functional layer 8.
[0031] Among them, Figure 1 - Figure 3 As shown, the first micro-nano structure includes a plurality of first protrusions 3 uniformly arranged on the upper surface of the flexible film layer 1 , and a second micro-nano structure is further arranged between adjacent first protrusions 3 .
[0032] Or, if Figure 4 As shown, the first micro-nano structure includes a plurality of first recessed portions 5 uniformly arranged on the upper surface of the flexible film layer 1 , and a second micro-nano structure is further arranged between adjacent first recessed portions 5 .
[0033] In this embodiment, the first micro-nano structure and the second micro-nano structure on the upper surface of the flexible film layer 1 are directly processed and formed on the flexible film layer 1, which avoids the risk of deformation or falling off of the first micro-nano structure and the second micro-nano structure in an environment of high heat or high humidity.
[0034] In this embodiment, the second micro-nano structure includes a plurality of second protrusions 6 or second depressions 7 uniformly arranged between adjacent first protrusions 3 or adjacent first depressions 5. Figure 1 - Figure 2 As shown, the second micro-nano structure is formed by a plurality of second protrusions 6, such as Figure 3 - Figure 4 As shown, the second micro-nano structure is formed by a plurality of second recessed portions 7. In this embodiment, Figure 1 - Figure 4 As shown, the second micro-nano structure includes two second protrusions 6 or two second depressions 7. It should be noted that the number of second protrusions 6 or second depressions 7 in the second micro-nano structure is determined according to the distance between the first micro-nano structures and the width of the second protrusions 6 or second depressions 7.
[0035] The first micro-nano structure and the second micro-nano structure are used to prevent microorganisms from adhering to the upper surface of the flexible film layer 1 .
[0036] In this embodiment, the height of the first protrusion 3 is greater than the height of the second protrusion 6, wherein the distance between adjacent first protrusions 3 is 10 nanometers to 200 micrometers; the number of second recessed portions 7 or second protrusions 6 of the second micro-nano structure between adjacent first protrusions 3 is 1 to 10; the height of the first protrusion 3 is 10 nanometers to 200 micrometers, and the height of the second protrusion 6 is 10 nanometers to 200 micrometers. The purpose of this setting is to 1. puncture the surface cell membrane of the microorganism to inactivate it and 2. establish a micro-nano structural barrier to compress the growth environment of the microorganism and thus prevent the growth of the microorganism.
[0037] In this embodiment, the depth of the first recessed portion 4 is greater than the depth of the second recessed portion 7, wherein the distance between adjacent first recessed portions 4 is 10 nanometers to 200 micrometers; the number of second recessed portions 7 or second raised portions 6 of the second micro-nano structure between adjacent first recessed portions 4 is 1 to 10; the depth of the first recessed portion 4 is 10 nanometers to 200 micrometers, and the depth of the second recessed portion 7 is 10 nanometers to 200 micrometers.
[0038] Here, it should be noted that the parameters between the first protruding portion 3, the second protruding portion 6, the first recessed portion 4, and the second recessed portion 7 can be adjusted according to different micro-nanostructure flexible films, and are not limited to the above-mentioned parameter data.
[0039] In this embodiment, the first protrusion 3, the second protrusion 6, the first recessed portion 4, and the second recessed portion 7 are in the shape of strips, dots, or blocks. The strips, dots, blocks, etc. can inhibit the growth of specific bacteria through their structural characteristics, and can destroy the surface state of cells or viruses to achieve antibacterial and antiviral functions.
[0040] In this embodiment, the flexible film layer 1 and the composite functional layer 8 of the antibacterial and antiviral micro-nanostructure flexible film are both made of medical flexible materials with a high degree of safety.
[0041] The antibacterial and antiviral micro-nanostructure flexible film is improved on the basis of the existing array-type (such as dot matrix) nanostructure. By setting the first micro-nanostructure and the second micro-nanostructure, it can prevent microbial cells or viruses from adhering to the surface of the flexible film layer 1, and reduce the probability of microbial cells or viruses growing and reproducing on the surface of the flexible film layer 1.
[0042] Embodiment 2:
[0043] This embodiment improves the antibacterial and antiviral micro-nanostructure flexible film in Embodiment 1.
[0044] like Figure 1 - Figure 4 As shown, the micro-nanostructured flexible film further includes a composite functional layer 8. The provision of the composite functional layer 8 can assist the flexible film layer 1 in antibacterial and antimicrobial properties, thereby improving the antibacterial and antiviral effects of the flexible film layer 1.
[0045] The composite functional layer 8 includes a test component and a communication module electrically connected to the test component. The test component is used to collect changes in the environment in which the flexible film layer is located, and send the collected signals to the digital terminal via the communication module. The setting of the test component of the composite functional layer 8 can monitor the state of the environment in which the flexible film layer is located in real time, assist the flexible film layer in antibacterial and antibacterial properties, and improve the antibacterial and antiviral effects of the flexible film layer.
[0046] Furthermore, the test component includes one or more of a radio frequency module, an energy module, a sensor module, a computing module, and a storage module. The radio frequency module can convert radio signals into wired electrical signals to facilitate the transmission of detection signals; the energy module can provide electrical energy for the test component to ensure the normal operation of each module; when the antibacterial and antiviral micro-nano structure flexible film is applied to the surface of a biological body, the sensor module can measure the biological surface temperature, the biological heart rate, the humidity of the biological environment, and the atmospheric pressure and other parameter values; when the antibacterial and antiviral micro-nano structure flexible film is applied to medical devices and other equipment, the sensor module can measure the temperature, humidity, atmospheric pressure and other parameters of the equipment environment; the computing module can calculate the chemical signals measured by the sensor; the storage module can store the data detected by the sensor module and the data calculated by the computing module.
[0047] As an improvement to the above-mentioned composite functional layer 8, the composite functional layer also includes a functional module, which receives a debugging signal sent by the digital terminal via the communication module, adjusts the temperature of the flexible film layer, and can destroy the growth and reproduction environment of microorganisms or viruses, thereby inactivating microorganisms attached to the surface of the micro-nano structure.
[0048] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
[0049] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.
Claims
1. An antibacterial and antiviral micro-nanostructure flexible film, characterized in that: It comprises a flexible film layer, wherein the upper surface of the flexible film layer is processed with a first micro-nano structure, and the lower surface of the flexible film layer is provided with a composite functional layer; The first micro-nano structure comprises a plurality of first protrusions uniformly arranged on the upper surface of the flexible film layer, and a second micro-nano structure is further arranged between adjacent first protrusions; Or the first micro-nano structure includes a plurality of first recessed portions uniformly arranged on the upper surface of the flexible film layer, and a second micro-nano structure is further arranged between adjacent first recessed portions; The first micro-nano structure and the second micro-nano structure are used to prevent microorganisms from adhering to the upper surface of the flexible film layer. The first micro-nano structure and the second micro-nano structure are directly formed on the flexible film layer.
2. The micro-nanostructure flexible film according to claim 1, characterized in that: The second micro-nano structure includes a plurality of second protruding portions or second concave portions uniformly arranged between adjacent first protruding portions or adjacent first concave portions.
3. The micro-nanostructure flexible film according to claim 2, characterized in that: The height of the first protrusion is greater than the height of the second protrusion.
4. The micro-nanostructure flexible film according to claim 2, characterized in that: The depth of the first recessed portion is greater than the depth of the second recessed portion.
5. The micro-nanostructure flexible film according to any one of claims 2 to 4, characterized in that: The first convex portion, the second convex portion, the first concave portion, and the second concave portion are in the shape of strips, dots, or blocks.
6. The micro-nanostructure flexible film according to claim 1, characterized in that: The composite functional layer includes a test component and a communication module electrically connected to the test component. The test component is used to collect changes in the environment where the flexible film layer is located, and send the collected signals to the digital terminal via the communication module.
7. The micro-nanostructure flexible film according to claim 6, characterized in that: The test component includes one or more of a radio frequency module, an energy module, a sensor module, a computing module, and a storage module.
8. The micro-nanostructure flexible film according to claim 6 or 7, characterized in that: The composite functional layer also includes a functional module, which receives a debugging signal sent by the digital terminal via the communication module, adjusts the temperature of the flexible film layer, and inactivates the microorganisms attached to the surface of the micro-nano structure.
9. Use of the antibacterial and antiviral micro-nanostructure flexible film according to any one of claims 1 to 8 on the surface of medical devices or biological bodies.