A coiled tube heating device using the flow cell method

Abstract

A coil heating device using the flow cell method, comprising a constant temperature water tank, a water tank cover plate, a heating device, a solvent inlet pipe, a solvent outlet pipe, a heating shield, a detection frame, a three-way valve island, a tubing rinsing valve island, a pressure valve, a photoelectric switch, and a diversion pipe; the water tank cover plate is arranged on the top surface of the constant temperature water tank; the heating device is arranged on one side of the top surface of the water tank cover plate; both the solvent inlet pipe and the solvent outlet pipe are arranged on the top surface of the heating device; the heating shield is arranged on the top surface of the water tank cover plate; the detection frame is arranged on the top surface of the heating shield; the three-way valve island is arranged at one end inside the detection frame; the tubing rinsing valve island is arranged at one end inside the detection frame; the pressure valve is arranged in the middle inside the detection frame; the photoelectric switch is arranged at one end inside the detection frame; the diversion pipe is arranged at the top end inside the detection frame. The present invention provides good fixation for the heating device and has high heating efficiency; the solvent and the heating device are heated in a cycle, and the solvent can be subjected to functions such as cycle temperature control and water pressure monitoring.

Description

Technical Field

[0001] The present invention relates to the technical field of medical experimental equipment applications, and particularly to a coil heating device for a flow-through cell method. Background Art

[0002] The flow-through cell method uses an instrument to simulate the human body's internal environment, perform solvent circulation, and flush and release drugs. In order to make the drug more closely approximate the true temperature of the internal circulation during the dissolution and release process, it is necessary to keep the solvent flowing in the flow-through cell at a constant temperature of 37°C during the drug dissolution process. The existing solvent heating method is to fix the solvent cup on the heating water tank through the cup holder, fill the heating water tank with water, directly place the heating pipe at the bottom of the water tank, heat the water area through the heating pipe, and then the water area exchanges heat with the solvent cup to heat the solvent. The existing circulating heating of the solvent has the following defects: (1) When using the heating pipe directly placed in the water area for heating, there is no good fixation for the heating pipe, and the heating pipe is prone to displacement with the water flow in the heating water tank, affecting the heating effect; the heating efficiency of the heating pipe is relatively low; the local temperature in the water area of the heating water tank is relatively high, the water flow disturbance in the water area is small, and the overall temperature distribution of the water area is uneven, making it difficult to grasp and control the overall temperature in the water tank, resulting in a temperature deviation during the heat exchange process between the water area and the solvent cup, and it is difficult to keep the temperature of the solvent in the solvent cup controlled at 37°C; (2) In the solvent circulation system, the solvent is stored in the solvent cup, and the solvent cup is heated by the water area of the heating water tank. The heating rate of the solvent is slow, the solvent cannot quickly reach 37°C, and the solvent in the solvent cup directly undergoes a circulation effect, without a device for precisely controlling the temperature of the solvent at 37°C, so that the drug is always dissolved in the solvent at 37°C for the dissolution test. Summary of the Invention

[0003] In order to solve the above existing problems, the present invention discloses a coil heating device for a flow-through cell method, and its specific technical solution is as follows: A coil heating device for a flow-through cell method includes a constant temperature water tank, a water tank cover plate, a heating device, a solvent inlet pipe, a solvent outlet pipe, a heating shield, a detection rack, a three-way valve island, a pipe flushing valve island, a pressure valve, an optoelectronic switch, and a diversion pipe;

[0004] The water tank cover plate is arranged on the top surface of the constant temperature water tank and is fixedly arranged with the constant temperature water tank; the heating device is arranged on one side of the top surface of the water tank cover plate; the solvent inlet pipe is arranged on the top surface of the heating device; the solvent outlet pipe is arranged on the top surface of the heating device; the heating mask is arranged on the top surface of the water tank cover plate and is buckled on the top surface of the heating device, and the heating mask is rotatably arranged with the constant temperature water tank through a movable hinge; the detection frame is arranged on the top surface of the heating mask, and the detection frame is fixedly arranged with the heating mask; the three-way valve island is arranged at one end inside the detection frame, and the three-way valve island is supported and fixed through a first bracket; the pipe flushing valve island is arranged at one end inside the detection frame, and the pipe flushing valve island is supported and fixed through a second bracket; the pressure valve is arranged in the middle inside the detection frame and is arranged on one side of the three-way valve island. A pressure valve fixing block is arranged outside the pressure valve, and the pressure valve is embedded in the pressure valve fixing block. The pressure valve fixing block is fixedly supported through a third bracket; the photoelectric switch is arranged at one end inside the detection frame and is arranged on one side of the pressure valve, and the photoelectric switch is fixed in the detection frame through a pipe clamp; the diversion pipe is arranged at the top end inside the detection frame and is arranged on one side of the pipe flushing valve island, and the diversion pipe is fixedly supported through a fourth bracket;

[0005] The solvent outlet pipe extends into the detection frame through a pipeline and is communicated with the inlet end of the corresponding three-way valve island; the side-end outlet of the three-way valve island is communicated with one end of the corresponding pressure valve through a pipeline; the other end of the pressure valve is communicated with a pipeline, and the pipeline is embedded in the pipe clamp; the top-end outlet of the three-way valve island is communicated with the bottom end of the corresponding pipe flushing valve island through a pipeline; one end outlet of the pipe flushing valve island is communicated with a solvent cup through a pipeline; one end outlet of the pipe flushing valve island is communicated with the corresponding diversion pipe through a pipeline, and one end of the diversion pipe is communicated with a flow cell through a pipeline.

[0006] Further, the heating device includes a heating fixing plate, a heating wire, a connecting head, a direct head and a connecting wire; the heating fixing plate is embedded in the top surface of the water tank cover plate; the heating wire is arranged in the constant temperature water tank, and one end of each heating wire penetrates out of the heating fixing plate and is fixedly plugged with the connecting head; the connecting wire is arranged on the top surface of the heating fixing plate, and both ends of the connecting wire are fixedly plugged with the connecting head; the plug joints of the connecting wire and the plug joints of the heating wire are respectively thread-fixed with both ends of the direct head to realize the connection between the connecting wire and the heating wire.

[0007] Furthermore, the solvent inlet pipe is arranged inside the heating water tank. One end of each solvent inlet pipe penetrates and extends out of the heating fixing plate and is fixedly plugged with the connector. The solvent outlet pipe is arranged inside the heating water tank. One end of each solvent outlet pipe penetrates and extends out of the heating fixing plate and is fixedly plugged with the connector. The solvent inlet pipe and the solvent outlet pipe are communicated with each other.

[0008] Furthermore, the heating wires are arranged in two rows. Each row of heating wires is arranged in two layers. Each layer of heating wires has a circular coiled pipe structure. The adjacent two heating wires connected by a single connecting wire are arranged obliquely in the upper and lower layers.

[0009] Furthermore, the connecting wire has an inverted "U" shaped structure.

[0010] Furthermore, the solvent inlet pipe is arranged at the center of the top surface of the heating fixing plate and between the heating wires. The solvent outlet pipe is arranged on one side of the top surface of the heating fixing plate.

[0011] Furthermore, the detection rack includes a rack bottom plate, rack side plates, a rack back plate, a rack cover plate and a rack handle. The rack side plates are symmetrically arranged on both sides. The top edge and the bottom edge of each rack side plate are bent. The bottom sides of the two rack side plates are fixed to the top surface of the heating mask. The rack bottom plate is arranged between the bottom sides of the two rack side plates and is fixed to the two rack side plates. A rack bottom plate through hole is arranged on one side of the surface of the rack bottom plate. The cross section of the rack back plate is in a "C" shaped structure. The rack back plate is arranged at one end of the two machine side plates and is fixed to the two rack side plates. The rack cover plate is buckled on the top sides of the rack side plates, and the two sides of the rack cover plate are fixed to the top sides of the two rack side plates. The rack handle is arranged on one side of one rack side plate and is vertically fixed to the rack side plate.

[0012] Furthermore, the three-way valve island is arranged opposite to the top end of the rack bottom plate through hole. The first bracket is arranged on one side of the three-way valve island. The cross section of the first bracket is in an "L" shaped structure. The bottom surface of the first bracket is fixed to the rack bottom plate. The top side surface of the second bracket is fixed to the side surface of the three-way valve island.

[0013] Furthermore, the pipe flushing valve island is arranged opposite to the top end of the three-way valve island. The second brackets are arranged at both ends of the pipe flushing valve island. The cross section of each second bracket at each end is in an "L" shaped structure. The bottom surface of each second bracket at each end is fixed to the rack bottom plate. The top side surface of each second bracket at each end is fixed to the end surface of the pipe flushing valve island. The pipe flushing valve island and the three-way valve island are arranged in the same direction.

[0014] Furthermore, the pressure valves are arranged in a horizontal array, and each pressure valve is arranged opposite to the outlet of the three-way valve island; the third bracket is arranged on the bottom side of the pressure valve, the third bracket is in a "Z" shape, the bottom surface of the third bracket is fixed to the frame bottom plate, and the top surface of the third bracket is fixed to the pressure valve fixing block.

[0015] Furthermore, the pipe clamps are arranged in a horizontal array on the top surface of the frame bottom plate, the top surface of each pipe clamp is in a groove shape to form a pipe clamp card slot, and each pipe clamp card slot is arranged opposite to the pressure valve; the photoelectric switch is arranged on the top surface of the pipe clamp and straddles the top surface of the pipe clamp card slot.

[0016] Furthermore, the diversion pipes are arranged in a horizontal array, the diversion pipes are arranged at the same height as the pipe flushing valve island, and each diversion pipe is arranged opposite to the outlet of the pipe flushing valve island; the fourth bracket is arranged between the third bracket and the pipe clamp, the cross section of the fourth bracket is in a "C" shape, the bottom surface of the fourth bracket is fixed to the frame bottom plate, and the diversion pipe is arranged on the top surface of the fourth bracket.

[0017] Furthermore, a temperature sensor is arranged at the bottom end of each diversion pipe, the temperature sensor is vertically fixed at the bottom end of the diversion pipe, and the end of the temperature sensor extends into the interior of the diversion pipe.

[0018] The beneficial effects of the present invention are as follows:

[0019] (1) When the heating device heats the water area of the constant temperature water tank in the present invention, the heating device fixes the heating wire in the form of a heating fixing plate. The heating wires are arranged in an array pattern in the constant temperature water tank, and multiple groups of heating wires are inserted into the constant temperature water tank, providing good fixation for the heating wires. When the water circulates in the constant temperature water tank, there is no offset of the heating wires, ensuring a good heating effect; at the same time, the heating wires in the present invention are designed as coiled pipe structures and are arranged in a staggered manner up and down, greatly reducing the structural size of the heating wires, increasing the heat exchange area between the heating wires and the water area, and connecting adjacent two heating wire structures with connecting wires to modularize the heating wires, further improving the heating effect of the heating wires; the heating wires cooperate with the water flow in the constant temperature water tank, and the temperature distribution in the water area is uniform, enabling precise temperature control of the water area in the solvent cup at 37°C.

[0020] (2) The present invention is provided with a heating device to circulate and heat the solvent. The solvent is heated and controlled to circulate between the heating device and the solvent cup before reaching 37°C. When the solvent reaches 37°C, it flows through the flow cell for drug dissolution circulation. By using the pipe flushing valve island to switch the flow direction of the solvent, precise temperature control of the solvent can be achieved, and it is ensured that the solvent always operates at 37°C.

[0021] (3) The device of the present invention is additionally designed with a water pressure detection for the circulating solvent. Through the function of the three-way valve island, it can be detected that when the circulating pressure of the solvent is greater than 0.1 MPa, an audible and visual alarm will be given to warn the test personnel, ensuring that the circulating pipeline of the solvent maintains a safe pressure circulation, and the safety performance of the device is high. Description of the Drawings

[0022] Figure 1 It is the front view of the overall structure of the present invention.

[0023] Figure 2 It is the schematic diagram of the solvent flow in the device of the present invention.

[0024] Figure 3 It is the schematic diagram of the partial structure at the heating device and the detection rack of the present invention.

[0025] Figure 4 It is the schematic diagram of the structure of the heating device of the present invention.

[0026] List of Reference Numerals:

[0027] Constant temperature water tank 1;

[0028] Water tank cover plate 2;

[0029] Heating device 3;

[0030] Heating fixing plate 3-1, heating wire 3-2, connecting head 3-3, straight head 3-4, connecting wire 3-5;

[0031] Solvent inlet pipe 4;

[0032] Solvent outlet pipe 5;

[0033] Heating shield 6;

[0034] Detection rack 7;

[0035] Rack bottom plate 7-1, rack bottom plate through hole 7-1-1, rack side plate 7-2, rack back plate 7-3, rack cover plate 7-4, rack handle 7-5;

[0036] Three-way valve island 8;

[0037] Pipe flushing valve island 9;

[0038] Pressure valve 10;

[0039] Pressure valve fixing block 10-1;

[0040] Photoelectric switch 11;

[0041] Diversion pipe 12;

[0042] First support 13;

[0043] Second support 14;

[0044] Third support 15;

[0045] Pipe clamp 16;

[0046] Pipe clamp card slot 16-1;

[0047] Fourth support 17;

[0048] Temperature sensor 18. Specific implementation mode

[0049] In order to make the technical solution of the present invention clearer and more definite, the present invention will be further described below with reference to the accompanying drawings. Any solution obtained by equivalent replacement of the technical features of the technical solution of the present invention and conventional reasoning falls within the protection scope of the present invention. The fixed connection, fixed setting, and fixed structure mentioned in this embodiment are all well-known technologies in the art such as gluing, welding, screw connection, bolt and nut connection, and riveting.

[0050] As can be seen from the accompanying drawings, a coil heating device 3 using the flow cell method includes a constant temperature water tank 1, a water tank cover plate 2, a heating device 3, a solvent inlet pipe 4, a solvent outlet pipe 5, a heating mask 6, a detection rack 7, a three-way valve island 8, a pipe flushing valve island 9, a pressure valve 10, a photoelectric switch 11, and a diversion pipe 12;

[0051] The water tank cover plate 2 is arranged on the top surface of the constant temperature water tank 1 and is fixedly arranged with the constant temperature water tank 1; the heating device 3 is arranged on one side of the top surface of the water tank cover plate 2; the solvent inlet pipe 4 is arranged on the top surface of the heating device 3; the solvent outlet pipe 5 is arranged on the top surface of the heating device 3; the heating shield 6 is arranged on the top surface of the water tank cover plate 2 and is buckled on the top surface of the heating device 3, and the heating shield 6 is rotatably arranged with the constant temperature water tank 1 through a movable hinge; the detection rack 7 is arranged on the top surface of the heating shield 6, and the detection rack 7 is fixedly arranged with the heating shield 6; the three-way valve island 8 is arranged at one end inside the detection rack 7, and the three-way valve island 8 is supported and fixed through the first bracket 13; the pipe flushing valve island 9 is arranged at one end inside the detection rack 7, and the pipe flushing valve island 9 is supported and fixed through the second bracket 14; the pressure valve 10 is arranged in the middle inside the detection rack 7 and is arranged on one side of the three-way valve island 8, a pressure valve fixing block 10-1 is arranged outside the pressure valve 10, the pressure valve 10 is embedded in the pressure valve fixing block 10-1, and the pressure valve fixing block 10-1 is fixedly supported through the third bracket 15; the photoelectric switch 11 is arranged at one end inside the detection rack 7 and is arranged on one side of the pressure valve 10, and the photoelectric switch 11 is fixed in the detection rack 7 through a pipe clamp 16; the diversion pipe 12 is arranged at the top end inside the detection rack 7 and is arranged on one side of the pipe flushing valve island 9, and the diversion pipe 12 is fixedly supported through the fourth bracket 17;

[0052] The solvent outlet pipe 5 extends into the detection rack 7 through a pipeline and is communicated with the inlet end of the corresponding three-way valve island 8; the side-end outlet of the three-way valve island 8 is communicated with one end of the corresponding pressure valve 10 through a pipeline; the other end of the pressure valve 10 is communicated with a pipeline, and the pipeline is embedded in the pipe clamp 16; the top-end outlet of the three-way valve island 8 is communicated with the bottom end of the corresponding pipe flushing valve island 9 through a pipeline; one end outlet of the pipe flushing valve island 9 is communicated with a solvent cup through a pipeline; one end outlet of the pipe flushing valve island 9 is communicated with the corresponding diversion pipe 12 through a pipeline, and one end of the diversion pipe 12 is communicated with a flow cell through a pipeline.

[0053] Further, the heating device 3 includes a heating fixed plate 3-1, heating wires 3-2, connecting heads 3-3, straight heads 3-4 and connecting wires 3-5; the heating fixed plate 3-1 is embedded in the top surface of the water tank cover plate 2; the heating wires 3-2 are arranged in the constant temperature water tank 1, and one end of each heating wire 3-2 penetrates out of the heating fixed plate 3-1 and is fixedly plugged with the connecting head 3-3; the connecting wires 3-5 are arranged on the top surface of the heating fixed plate 3-1, and both ends of the connecting wire 3-5 are fixedly plugged through the connecting head 3-3; the plug joints of the connecting wire 3-5 and the plug joints of the heating wires 3-2 are respectively threadedly fixed to both ends of the straight head 3-4, so as to connect the connecting wire 3-5 and the heating wire 3-2.

[0054] Further, the solvent inlet pipe 4 is arranged in the heating water tank, and one end of each solvent inlet pipe 4 penetrates out of the heating fixed plate 3-1 and is fixedly plugged with the connecting head 3-3; the solvent outlet pipe 5 is arranged in the heating water tank, and one end of each solvent outlet pipe 5 penetrates out of the heating fixed plate 3-1 and is fixedly plugged with the connecting head 3-3, and the solvent inlet pipe 4 and the solvent outlet pipe 5 are communicated.

[0055] Further, the heating wires 3-2 are arranged in two rows, each row of heating wires 3-2 is arranged in two layers, and each layer of heating wires 3-2 is in a circular coil structure; the adjacent two heating wires 3-2 connected by a single connecting wire 3-5 are arranged obliquely in the upper and lower layers.

[0056] Further, the connecting wire 3-5 is in an inverted "U" shape structure.

[0057] Further, the solvent inlet pipe 4 is arranged at the center of the top surface of the heating fixed plate 3-1 and is arranged between the heating wires 3-2; the solvent outlet pipe 5 is arranged on one side of the top surface of the heating fixed plate 3-1.

[0058] Further, the detection frame 7 includes a frame bottom plate 7-1, a frame side plate 7-2, a frame back plate 7-3, a frame cover plate 7-4 and a frame handle 7-5. The frame side plates 7-2 are symmetrically arranged on both sides, and the top and bottom edges of the frame side plates 7-2 on each side are bent. The bottom sides of the frame side plates 7-2 on both sides are fixed to the top surface of the heating shield 6. The frame bottom plate 7-1 is arranged between the bottom sides of the frame side plates 7-2 on both sides and is fixed to the frame side plates 7-2 on both sides. The surface of the frame bottom plate 7-1 is A rack bottom plate through hole 7-1-1 is provided on the side; the cross-section of the rack back panel 7-3 is a "匚"-shaped structure, the rack back panel 7-3 is arranged at one end of the machine side panels on both sides, and the rack back panel 7-3 is fixed to the rack side panels 7-2 on both sides; the rack cover panel 7-4 is buckled on the top side of the rack side panel 7-2, and the two sides of the rack cover panel 7-4 are fixed to the top sides of the rack side panels 7-2 on both sides; the rack handle 7-5 is arranged on one side of the rack side panel 7-2 on one side, and is vertically fixed to the rack side panel 7-2.

[0059] Furthermore, the three-way valve island 8 is arranged at the top end of the through hole 7-1-1 of the rack bottom plate; the first bracket 13 is arranged on one side of the three-way valve island 8, and the cross-section of the first bracket 13 is an "L"-shaped structure. The bottom surface of the first bracket 13 is fixed to the rack bottom plate 7-1, and the top side surface of the second bracket 14 is fixed to the side surface of the three-way valve island 8.

[0060] Furthermore, the lubricating valve island 9 is arranged at the top of the three-way valve island 8; the second bracket 14 is arranged at both ends of the lubricating valve island 9, and the cross-section of the second bracket 14 at each end is an "L"-shaped structure, the bottom surface of the second bracket 14 at each end is fixed to the rack bottom plate 7-1, and the top side surface of the second bracket 14 at each end is fixed to the end surface of the lubricating valve island 9, and the lubricating valve island 9 and the three-way valve island 8 are arranged in the same direction.

[0061] Furthermore, the pressure valves 10 are arranged in a horizontal array, and each of the pressure valves 10 is arranged in opposition to the outlet of the three-way valve island 8; the third bracket 15 is arranged on the bottom side of the pressure valve 10, and the third bracket 15 is a "Z"-shaped structure. The bottom surface of the third bracket 15 is fixed to the frame bottom plate 7-1, and the top surface of the third bracket 15 is fixed to the pressure valve fixing block 10-1.

[0062] Further, the pipe clamps 16 are arranged in a horizontal array on the top surface of the frame bottom plate 7-1. The top surface of each pipe clamp 16 is in a groove shape, forming a pipe clamp card slot 16-1. Each pipe clamp card slot 16-1 is arranged in alignment with the pressure valve 10; the photoelectric switch 11 is arranged on the top surface of the pipe clamp 16 and straddles the top surface of the pipe clamp card slot 16-1.

[0063] Further, the diversion pipes 12 are arranged in a horizontal array. The diversion pipes 12 are arranged at the same height as the pipe moistening valve island 9. Each diversion pipe 12 is arranged in alignment with the outlet of the pipe moistening valve island 9; the fourth support 17 is arranged between the third support 15 and the pipe clamp 16. The cross-section of the fourth support 17 is in a "C" shape. The bottom surface of the fourth support 17 is fixed to the frame bottom plate 7-1, and the diversion pipe 12 is arranged on the top surface of the fourth support 17.

[0064] Further, a temperature sensor 18 is provided at the bottom end of each diversion pipe 12. The temperature sensor 18 is vertically fixed to the top end of the diversion pipe 12, and the end of the temperature sensor 18 extends into the interior of the diversion pipe 12.

[0065] The system principle of the present invention is:

[0066] The heating device heats the heating wire to heat the water area in the constant temperature water tank; the solvent is introduced through the solvent inlet pipe and discharged from the solvent outlet pipe. The solvent is heated in the constant temperature water tank. The solvent flows into the three-way valve island through the pipeline. Part of the solvent flows out from the side end of the three-way valve island and fills the pipeline connected to the pressure valve. When the pressure in the pipeline is greater than 0.1 MPa, the pressure valve is in the conducting state, and the solvent flows through the pressure valve. When the solvent in the pipeline flows through the pipe clamp, the photoelectric switch detects the solvent flow and uploads the signal to the controller for alarm prompt. The solvent flowing through the pipe clamp is connected to the waste liquid bucket; the solvent flowing out from the top end of the three-way valve island enters the pipe moistening valve island. Part of the solvent flows out from one end outlet of the pipe moistening valve island and directly returns to the solvent cup. Part of the solvent flows out from the other end outlet of the pipe moistening valve island and fills the pipeline connected to the diversion pipe. When the temperature of the solvent in the diversion pipe reaches 37 °C, the pipe moistening valve island closes the pipeline connected to the solvent cup, and all the solvent is discharged from the pipe moistening valve island to the diversion pipe. The solvent flows into the flow cell through the pipeline to start the drug circulation dissolution test.

[0067] The beneficial effects of the present invention are:

[0068] (1) When the heating device heats the water area of the constant temperature water tank in the present invention, the heating device adopts the form of fixing the heating wire with a heating fixing plate. The heating wires are arranged in an array in the constant temperature water tank, and multiple groups of heating wires are inserted into the constant temperature water tank, which can fix the heating wires well. When the water circulates in the constant temperature water tank, there is no deviation of the heating wires, ensuring a good heating effect. At the same time, the heating wires in the present invention are designed as coil structures and are arranged in a staggered manner up and down, greatly reducing the structural size of the heating wires and increasing the heat exchange area between the heating wires and the water area. By connecting adjacent two heating wire structures with connecting wires, the heating wires are modularly arranged, further improving the heating effect of the heating wires. The heating wires cooperate with the water flow in the constant temperature water tank, and the temperature distribution in the water area is uniform, and the temperature of the water in the solvent cup can be accurately controlled at 37°C.

[0069] (2) The present invention sets a heating device to circulate and heat the solvent. Before controlling the temperature of the solvent to 37°C, the solvent is circulated and heated between the heating device and the solvent cup. When the solvent reaches 37°C, the solvent flows through the flow-through cell for drug dissolution circulation. By using a flow control valve island to switch the flow direction of the solvent, the temperature of the solvent can be accurately controlled, and it is ensured that the solvent always operates at 37°C.

[0070] (3) The device of the present invention is additionally designed with a water pressure detection for the circulating solvent. Through the function of the three-way valve island, it can be detected that when the circulating pressure of the solvent is greater than 0.1 MPa, an audible and visual alarm can be given to warn the test personnel, ensuring that the circulating pipeline of the solvent maintains a safe pressure circulation, and the safety performance of the device is high.

Claims

1. A coil heating device using the flow cell method, characterized in that, it includes a constant temperature water tank (1), a water tank cover plate (2), a heating device (3), a solvent inlet pipe (4), a solvent outlet pipe (5), a heating shield (6), a detection rack (7), a three-way valve island (8), a tubing rinsing valve island (9), a pressure valve (10), a photoelectric switch (11) and a diversion pipe (12); The water tank cover plate (2) is arranged on the top surface of the constant temperature water tank (1) and is fixedly arranged with the constant temperature water tank (1); the heating device (3) is arranged on one side of the top surface of the water tank cover plate (2); the solvent inlet pipe (4) is arranged on the top surface of the heating device (3); the solvent outlet pipe (5) is arranged on the top surface of the heating device (3); the heating shield (6) is arranged on the top surface of the water tank cover plate (2) and is buckled on the top surface of the heating device (3), and the heating shield (6) is rotatably arranged with the constant temperature water tank (1) through a movable hinge; the detection rack (7) is arranged on the top surface of the heating shield (6), and the detection rack (7) is fixedly arranged with the heating shield (6); the three-way valve island (8) is arranged at one end inside the detection rack (7), and the three-way valve island (8) is supported and fixed through a first bracket (13); the tubing rinsing valve island (9) is arranged at one end inside the detection rack (7), and the tubing rinsing valve island (9) is supported and fixed through a second bracket (14); the pressure valve (10) is arranged in the middle inside the detection rack (7) and is arranged on one side of the three-way valve island (8), a pressure valve fixing block (10-1) is arranged outside the pressure valve (10), the pressure valve (10) is embedded in the pressure valve fixing block (10-1), and the pressure valve fixing block (10-1) is fixedly supported through a third bracket (15); the photoelectric switch (11) is arranged at one end inside the detection rack (7) and is arranged on one side of the pressure valve (10), and the photoelectric switch (11) is fixed in the detection rack (7) through a pipe clamp (16); the diversion pipe (12) is arranged at the top end inside the detection rack (7) and is arranged on one side of the tubing rinsing valve island (9), and the diversion pipe (12) is fixedly supported through a fourth bracket (17); The solvent outlet pipe (5) extends into the detection rack (7) through a pipeline and is communicated with the inlet end of the corresponding three-way valve island (8); the side end outlet of the three-way valve island (8) is communicated with one end of the corresponding pressure valve (10) through a pipeline; the other end of the pressure valve (10) is communicated with a pipeline, and the pipeline is embedded in the pipe clamp (16); the top end outlet of the three-way valve island (8) is communicated with the bottom end of the corresponding tubing rinsing valve island (9) through a pipeline; one end outlet of the tubing rinsing valve island (9) is communicated with a solvent cup through a pipeline; one end outlet of the tubing rinsing valve island (9) is communicated with the corresponding diversion pipe (12) through a pipeline, and one end of the diversion pipe (12) is communicated with a flow cell through a pipeline; The heating device (3) includes a heating fixed plate (3-1), a heating wire (3-2), a connection head (3-3), a direct head (3-4) and a connection wire (3-5); the heating fixed plate (3-1) is embedded in the top surface of the water tank cover plate (2); the heating wire (3-2) is arranged in the constant temperature water tank (1), and one end of each heating wire (3-2) penetrates out of the heating fixed plate (3-1) and is fixedly inserted with the connection head (3-3); the connection wire (3-5) is arranged on the top surface of the heating fixed plate (3-1), and both ends of the connection wire (3-5) are fixedly inserted with the connection head (3-3); the insertion joints of the connection wire (3-5) and the insertion joints of the heating wire (3-2) are respectively thread-fixed with both ends of the direct head (3-4) to realize the connection between the connection wire (3-5) and the heating wire (3-2). The solvent inlet pipe (4) is arranged in the constant temperature water tank, and one end of each solvent inlet pipe (4) penetrates out of the heating fixed plate (3-1) and is fixedly inserted with the connection head (3-3); the solvent outlet pipe (5) is arranged in the constant temperature water tank, and one end of each solvent outlet pipe (5) penetrates out of the heating fixed plate (3-1) and is fixedly inserted with the connection head (3-3), and the solvent inlet pipe (4) and the solvent outlet pipe (5) are arranged in a communicating manner. The heating wires (3-2) are arranged in two rows, each row of heating wires (3-2) is arranged in two layers, and each layer of heating wires (3-2) is in a circular coil structure; the adjacent two heating wires (3-2) connected by a single connection wire (3-5) are arranged obliquely in the upper and lower layers.

2. The coil heating device for the flow cell method according to claim 1, characterized in that The detection frame (7) comprises a frame bottom plate (7-1), a frame side plate (7-2), a frame back plate (7-3), a frame cover plate (7-4) and a frame handle (7-5); the frame side plates (7-2) are symmetrically arranged on both sides; the top edge and the bottom edge of the frame side plate (7-2) on each side are bent; the bottom sides of the frame side plates (7-2) on both sides are fixed to the top surface of the heating shield (6); the frame bottom plate (7-1) is arranged between the bottom sides of the frame side plates (7-2) on both sides and is fixed to the frame side plates (7-2) on both sides; one side of the surface of the frame bottom plate (7-1) is provided with a machine The rack bottom plate through hole (7-1-1) is provided; the cross section of the rack back plate (7-3) is in a "匚"-shaped structure; the rack back plate (7-3) is arranged at one end of the rack side plates (7-2) on both sides, and the rack back plate (7-3) is fixed to the rack side plates (7-2) on both sides; the rack cover plate (7-4) is buckled on the top side of the rack side plates (7-2), and the two sides of the rack cover plate (7-4) are fixed to the top sides of the rack side plates (7-2) on both sides; the rack handle (7-5) is arranged on one side of the rack side plate (7-2) and is vertically fixed to the rack side plate (7-2).

3. A coil heating device for a flow cell method according to claim 2, It is characterized in that The three-way valve island (8) is arranged at the top end of the through hole (7-1-1) of the frame bottom plate; the first bracket (13) is arranged on one side of the three-way valve island (8); the cross-section of the first bracket (13) is an "L"-shaped structure; the bottom surface of the first bracket (13) is fixed to the frame bottom plate (7-1), and the top side surface of the second bracket (14) is fixed to the side surface of the three-way valve island (8).

4. A coil heating device for a flow cell method according to claim 3, It is characterized in that The lubricating valve island (9) is arranged at the top of the three-way valve island (8); the second bracket (14) is arranged at both ends of the lubricating valve island (9), and the cross-section of the second bracket (14) at each end is an "L"-shaped structure. The bottom surface of the second bracket (14) at each end is fixed to the frame bottom plate (7-1), and the top side surface of the second bracket (14) at each end is fixed to the end surface of the lubricating valve island (9). The lubricating valve island (9) and the three-way valve island (8) are arranged in the same direction.

5. The coil heating device of the flow cell method according to claim 2, It is characterized in that The pressure valves (10) are arranged in a transverse array, and each of the pressure valves (10) is arranged in alignment with the outlet of the three-way valve island (8); the third bracket (15) is arranged on the bottom side of the pressure valve (10), and the third bracket (15) is in a "Z"-shaped structure. The bottom surface of the third bracket (15) is fixed to the frame bottom plate (7-1), and the top surface of the third bracket (15) is fixed to the pressure valve fixing block (10-1).

6. A coil heating device by the flow cell method according to claim 2, characterized in that, the pipe clamps (16) are arranged in a horizontal array on the top surface of the frame bottom plate (7-1), the top surface of each pipe clamp (16) is in a groove shape to form a pipe clamp card slot (16-1), and each pipe clamp card slot (16-1) is arranged in alignment with the pressure valve (10); the photoelectric switch (11) is arranged on the top surface of the pipe clamp (16) and straddles the top surface of the pipe clamp card slot (16-1).

7. A coil heating device by the flow cell method according to claim 2, characterized in that, the diversion pipes (12) are arranged in a horizontal array, the diversion pipes (12) are arranged at the same height as the pipe flushing valve island (9), and each diversion pipe (12) is arranged in alignment with the outlet of the pipe flushing valve island (9); the fourth bracket (17) is arranged between the third bracket (15) and the pipe clamp (16), the cross section of the fourth bracket (17) is in a "C" shape, the bottom surface of the fourth bracket (17) is fixed to the frame bottom plate (7-1), and the diversion pipe (12) is arranged on the top surface of the fourth bracket (17); a temperature sensor (18) is provided at the bottom end of each diversion pipe (12), the temperature sensor (18) is vertically fixed to the top end of the diversion pipe (12), and the end of the temperature sensor (18) extends into the interior of the diversion pipe (12).

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