A full-process system for negative-pressure transmission pathological examination of infectious specimens

Abstract

The present invention discloses a full-process system for negative-pressure transmission pathological examination of infectious specimens, which includes an autopsy room, an organ specimen sampling room, a post-sampling specimen retention room, a pathological technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, and the pathological technology room are unidirectionally connected through an assembly line system and a transmission channel, and the negative pressure in each of the above rooms gradually decreases, so that the internal gas flow direction is unidirectional; the organ specimen sampling room is bidirectionally connected to the post-sampling specimen retention room through an assembly line system and a transmission channel. The monitoring and control room is connected to each room through a video conversation system and a remote operation system, and uploads the graphic and text information of the pathological examination to the pathological data analysis center through a wireless information system; an air inlet, exhaust and purification system is provided at the autopsy room and the pathological technology room ends. The negative-pressure closed automatic assembly line mode pathological dissection and sampling system designed by the present invention is suitable for pathological examination applications of organs and tissues.

Description

Technical Field

[0001] The present invention relates to the technical field of specimen examination, and specifically relates to a full-process system for negative-pressure transmission pathological examination of infectious specimens. Background Art

[0002] The progress of clinical medicine is inseparable from pathological anatomy; pathology reveals the essence of diseases, including the causes, pathogenesis, and changes and their laws that occur in the organs, tissues, cells, and even molecules of the body during the disease process, and is the foundation for the origin and development of modern medicine.

[0003] Infectious diseases, such as COVID-19 infection, are complex diseases mainly characterized by lung lesions, involving multiple organs throughout the body, and having a large damage range. Without in-depth understanding of the causes and pathological changes, clinical treatment work will face huge challenges. Through pathological anatomy and subsequent microscopic observation and molecular examination, the distribution of the virus in the human body and the state of organ damage can be intuitively understood, so as to understand the disease occurrence mechanism, transmission route, and target organs, providing key clues for clinical diagnosis and treatment.

[0004] At present, the pathological anatomy room is simply divided into a contaminated area and a clean area. The anatomists do not have a safe and effective pathological examination operation platform and related special facilities and equipment. The virus is very easy to spread and contaminate people and the anatomy room through media such as people, anatomical products, and air. Pathological workers are at high risk of exposure; at the same time, at present, the dissection and sampling of visceral specimens are all manual operations, and it takes a lot of time and labor costs for the pathological examination and sampling of a large number of visceral and tissue samples; at the same time, the existing pathological examination lacks a corresponding assembly-line design, and the processing process of specimens or samples cannot be carried out in an isolated and enclosed environment all the time. There is a great risk of exposure when dissecting, sampling, and fixing infectious tissue samples, and there is also a lack of automated and intelligent assembly-line pathological inspection and processing devices and systems at present. Summary of the Invention

[0005] In view of the above problems existing in the prior art, the present invention provides a full-process system for negative-pressure transmission pathological examination of infectious specimens. The whole system is an automated assembly-line pathological anatomy and sampling system, and has a closed structure with gradually decreasing negative pressure, which is suitable for the application of visceral and tissue pathological examinations.

[0006] To achieve the above technical objectives and reach the above technical effects, the present invention is realized through the following technical solutions:

[0007] A full-process system for negative-pressure transmission of pathological examinations of infectious specimens, including an autopsy room, an organ specimen sampling room, a specimen retention room after sampling, a pathological technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, and the pathological technology room are unidirectionally connected through a pipeline system and a transmission channel. The negative pressure in each of the above rooms gradually decreases, making the internal gas flow unidirectional. The organ specimen sampling room is bidirectionally connected to the specimen retention room after sampling through a pipeline system and a transmission channel. The monitoring and control room is connected to each room through a video dialogue system and a remote operation system, and uploads the graphic and text information of the pathological examination to the pathological data analysis center through a wireless information system. An air intake, exhaust, and purification system is provided at the autopsy room and the pathological technology room ends.

[0008] Further, the organ specimen sampling room is a closed cabinet structure as a whole, and is internally divided into a tissue specimen pretreatment component, a tissue specimen sampling component, a sample processing component, and a sample transmission component that are mutually connected. The operation countertops of each component are on the same plane and are equipped with independent conveyor belts.

[0009] The specimen pretreatment component is used for automatic or manual filling of the organ specimen fixing solution, specimen scanning and numbering, and timed or manual / automatic transmission of the specimen.

[0010] The specimen sampling component is used for gross examination and sampling of the specimen, assisting in continuous tissue sectioning of different thicknesses and processing of batch tissue blocks of different sizes, and is equipped with required flushing devices, disinfection devices, and audio-video devices, and an arm operation hole is also provided.

[0011] The sample processing component is used for fixing and microbial inactivation treatment of the taken pathological samples, and the sample conveying component conveys the inactivated samples without biosafety hazards to the next-level pathological technology room.

[0012] The pathological technology room contains tissue dehydrators, microtomes, and staining machines in a biological safety cabinet structure, and uploads the image information to the monitoring and control room wirelessly through a slice scanning device, and the monitoring and control room collates and summarizes it to the pathological information analysis center.

[0013] Further, the specimen pretreatment component, the specimen sampling component, the sample processing component, the specimen retention room after sampling, and the sample transmission component of the organ specimen sampling room are successively a functional part, an operation part, and a control part from top to bottom.

[0014] Further, the functional part of the specimen pretreatment component is equipped with a negative pressure device, a fixing solution filling component, and a disinfection component. The operation part is a conveyor belt for placing the specimen fixing container, and the control part includes control buttons for fixing solution filling and the specimen fixing container.

[0015] The control buttons include an automatic or manual button for adding fixing liquid, an automatic or manual control button for disinfection, and a timing or manual / automatic transfer button for preprocessing specimens, with corresponding indicators above each button.

[0016] Furthermore, the functional part of the specimen sampling assembly includes a disinfection device, a flushing induction device, an audio-video device, and a cleaning and storage device for dissection instruments. The operating part includes multiple groups of automatic / semi-automatic auxiliary material sampling devices and two arm operation channels;

[0017] The flushing induction device and the instrument cleaning and storage device include sensing elements and actuating elements, and the audio-video device is located between them; the automatic / semi-automatic material sampling devices include a parallel section device, a standard size section device, and an irregular section device.

[0018] Furthermore, the functional part of the sample processing assembly includes an inactivation device. Samples for section sampling are placed on the conveyor belt in the operating part. The control part includes an inactivation function selection, a time setting, and a flushing button, and corresponding indicator lights are provided;

[0019] The inactivation device includes a liquid filling device and an ultraviolet irradiation device.

[0020] Furthermore, the sample conveying assembly conveys samples through a conveyor belt. The functional part of the specimen retention room after sampling is a fixing liquid filling device and a low-temperature holding device; the specimen retention room after sampling and the organ specimen sampling room are transmitted by a circular conveyor belt.

[0021] Furthermore, the specimen preprocessing assembly, the specimen sampling assembly, the sample processing assembly, the specimen retention room after sampling, and the sample conveying assembly are installed with induction opening and closing windows to achieve conduction and sealing with each other, and there are aisles between the opening and closing windows at all levels; the logic between the induction opening and closing windows is: when performing the next-level transfer, the induction transfer door at the next level is preferentially opened and closed after the transfer is completed, and the induction opening and closing window at the previous level does not react at all.

[0022] Another object of the present invention is to provide an application of a semi-automatic pathological examination negative pressure system for infectious specimens in the autopsy of human infectious disease corpses.

[0023] Another object of the present invention is to provide an application of a semi-automatic pathological examination negative pressure system for infectious specimens in the autopsy of experimental animals.

[0024] The beneficial effects of the present invention:

[0025] The automated disposal system for pathological anatomy of infectious diseases of the present invention includes an autopsy room, an organ specimen sampling room, a specimen storage room after sampling, a pathological technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, the pathological technology room, and the monitoring and control room are sequentially connected through an assembly line system. The rear side of the organ specimen sampling room is connected to the specimen storage room after sampling, and the automated disposal of pathological anatomy is carried out through the disposal system with an integrated structure;

[0026] The organ specimen sampling room of the present invention is an enclosed cabinet as a whole. The specimen pretreatment component, the specimen sampling component, the sample processing component, and the sample conveying component are conducted through induction opening and closing windows. The operating tables of each component are located on the same plane and are installed with conveyor belts for conveying between each processing component. The conveyor belts operate independently; the specimen pretreatment component is used for automatic or manual filling of the fixing liquid and timed or manual / automatic conveying of the pretreated specimen; the specimen sampling component is used for sampling, flushing, disinfecting, and photographing of the specimen, and at the same time, an operation channel is set for manual sampling operation; the sample processing component is used for selective inactivation treatment of the taken sample, and the sample conveying component conveys the inactivated sample to the next one. The pathological anatomy is carried out from autopsy, pathological specimen sampling, specimen storage, and specimen processing through an integrated automated pathological anatomy system. The pathological anatomy material collection is carried out through a closed automated assembly line mode, which is suitable for the application of pathological anatomy material collection;

[0027] For the autopsy room, the organ specimen sampling room, the specimen storage room after sampling, the pathological technology room, and the monitoring and control room of the present invention, relevant operations are carried out through the monitoring and control room to obtain relevant image data information of pathological specimens. At the same time, manual assistance can be coordinated. The whole system is a pathological anatomy material collection system in an automated assembly line mode and has a closed structure with gradually decreasing negative pressure, which is suitable for the application of organ and tissue pathological examinations;

[0028] The pathological technology room of the present invention is unidirectionally connected through an assembly line system and a transfer channel. The negative pressure in the above-mentioned rooms gradually decreases, making the internal gas flow unidirectional. An air inlet, exhaust, and purification system is set at the autopsy room and the pathological technology room ends to achieve unidirectional transmission of specimens and negative pressure; at the same time, the design of the air inlet, exhaust system, and purification system can ensure that the gas entering and discharged from the system is harmless, and also ensure the safety of pathological anatomy of infectious diseases.

[0029] Of course, it is not necessary for any product implementing the present invention to simultaneously achieve all the above-mentioned advantages. Description of the Drawings

[0030] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0031] Figure 1 Schematic structural diagram of the automated disposal system for infectious disease pathological anatomy according to the embodiment of the present invention;

[0032] Figure 2 Schematic structural diagram of the organ specimen sampling room according to the embodiment of the present invention;

[0033] Figure 3 Schematic plan view of the organ specimen sampling room according to the embodiment of the present invention;

[0034] Figure 4 Schematic plan view of the specimen pretreatment component, specimen sampling component, sample processing component and sample conveying component according to the embodiment of the present invention;

[0035] Figure 5 Schematic internal structure diagram of the pretreatment component, specimen sampling component, sample processing component and sample conveying component according to the embodiment of the present invention;

[0036] Figure 6 Schematic structural diagram of the specimen sampling component according to the embodiment of the present invention;

[0037] Figure 7 Schematic plan view of the specimen storage room after sampling according to the embodiment of the present invention;

[0038] Figure 8 Working flowchart of the automated disposal system for infectious disease pathological anatomy according to the embodiment of the present invention;

[0039] In the drawings, the list of components represented by each reference numeral is as follows:

[0040] 1 - Autopsy room, 2 - Organ specimen sampling room, 201 - Enclosed cabinet, 202 - Specimen pretreatment component, 2021 - Negative pressure device, 2022 - Fixative filling component, 2023 - Specimen fixing container, 2024 - Automatic or manual filling button, 2025 - Timed or manual / automatic transfer button, 203 - Specimen sampling component, 2031 - Flushing induction device, 2032 - Instrument cleaning and storage device, 2033 - Audio-video device, 2034 - Operation channel, 2035 - Automatic / semi-automatic material extraction device, 204 - Sample processing component, 2041 - Liquid filling device, 2042 - Ultraviolet irradiation device, 2043 - Function selection button, 2044 - Time setting button, 2045 - Flushing button, 205 - Sample conveying component, 206 - Conveyor belt, 207 - Opening and closing window, 208 - Aisle, 3 - Specimen retention room after sampling, 301 - Fixative filling device, 302 - Low-temperature holding device, 4 - Pathology technology room, 5 - Monitoring and control room. Detailed implementation manners

[0041] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0042] Embodiment 1

[0043] As Figure 1-6 shown

[0044] A negative-pressure transmission pathological examination whole-process system for infectious specimens, including an autopsy room, an organ specimen sampling room, a specimen retention room after sampling, a pathology technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, and the pathology technology room are unidirectionally connected through a pipeline system and a transmission channel, and the negative pressure in each of the above rooms gradually decreases so that the internal gas flow direction is unidirectional; the organ specimen sampling room is bidirectionally connected to the specimen retention room after sampling through a pipeline system and a transmission channel. The monitoring and control room is connected to each room through a video conversation system and a remote operation system, and uploads the graphic and text information of the pathological examination to the pathological data analysis center through a wireless information system; an air inlet, air outlet, and purification system are provided at the autopsy room and the pathology technology room ends.

[0045] A semi-automatic pathological examination negative pressure system for infectious specimens, including an autopsy room 1, an organ specimen sampling room 2, a post-sampling specimen retention room 3, a pathological technology room 4, and a monitoring and control room 5. The autopsy room 1, the organ specimen sampling room 2, and the pathological technology room 4 are unidirectionally connected through a pipeline system and a transfer channel. The negative pressure in each of the above rooms gradually decreases, making the internal gas flow unidirectional. The organ specimen sampling room 2 is bidirectionally connected to the post-sampling specimen retention room 3 through a pipeline system and a transfer channel. The monitoring and control room 5 is connected to each room through a video dialogue system and a remote operation system, and uploads the graphic and text information of the pathological examination to the pathological data analysis center through a wireless information system. An air intake, exhaust, and purification system is provided at the autopsy room and the pathological technology room ends.

[0046] The above exhaust and purification system meets the national P3 laboratory air intake and exhaust standards, and purification systems are provided in both the air intake and exhaust systems.

[0047] The whole of the organ specimen sampling room 2 is an enclosed cabinet 201, which is internally divided into a specimen pretreatment component 202, a specimen sampling component 203, a sample processing component 204, and a sample conveying component 205 that are mutually conductive. The operating tables of each component are on the same plane and are equipped with a conveyor belt 206.

[0048] The specimen pretreatment component 202 is used for automatic or manual injection of the organ specimen fixing solution, specimen barcode numbering, and timed or manual / auto conveyance of the specimen.

[0049] The specimen sampling component 203 is used for gross examination and sampling of the specimen, assisting in continuous tissue sectioning of different thicknesses and processing of batch tissue blocks of different sizes, and is equipped with the required flushing device, disinfection device, and audio-video device, and at the same time, an arm operation hole is provided.

[0050] The sample processing component 204 is used for fixing and microbial inactivation treatment of the taken pathological samples, and the sample conveying component 205 conveys the inactivated samples without biosafety hazards to the next-level pathological technology room 4.

[0051] The pathological technology room 4 contains a tissue dehydrator, a microtome, and a staining machine device within a biosafety cabinet structure, and uploads the image information to the monitoring and control room 5 wirelessly through a slice scanning device, and the monitoring and control room 5 collates and summarizes it to the pathological information analysis center.

[0052] The specimen pretreatment component 202, the specimen sampling component 203, the sample processing component 204, the post-sampling specimen retention room 3, and the sample conveying component 205 of the organ specimen sampling room 2 are, from top to bottom, a functional part, an operating part, and a control part.

[0053] The functional part of the specimen pretreatment component 202 is equipped with a negative pressure device 2021 and a fixing solution filling component 2022. The operating part is a conveyor belt 206 for placing the specimen fixing container 2023. The control part includes control buttons for fixing solution filling and the specimen fixing container;

[0054] The control buttons include an automatic or manual fixing solution filling button 2024, and a timing or manual / automatic transfer button 2025 for pretreating the specimen. There is a corresponding indicator light above each button.

[0055] The functional part of the specimen sampling component 203 includes a flushing induction device 2031, an audio-video device 2033, and an instrument cleaning and storage device 2032. The operating part includes multiple groups of automatic / semi-automatic sampling devices 2035 and two operating channels 2034;

[0056] The flushing induction device 2031 and the instrument cleaning and storage device 2032 include induction elements and execution elements, and the audio-video device 2033 is located between them; the automatic / semi-automatic sampling devices 2035 include a parallel section device, a standard size section device, and an irregular section device.

[0057] The functional part of the sample processing component 204 includes an inactivation device. The sample for section sampling is placed on the conveyor belt 206 of the operating part. The control part includes an inactivation function selection button 2043, a time setting button 2044, and a flushing button 2045, and corresponding indicator lights are set;

[0058] The inactivation device includes a liquid filling device 2041 and an ultraviolet irradiation device 2042.

[0059] The sample conveying component 205 conveys the sample through a conveyor belt. The functional part of the specimen retention room 3 after sampling is a fixing solution filling device 301 and a low-temperature maintaining device 302; the specimen retention room 3 after sampling and the organ specimen sampling room 2 are transmitted by a circular conveyor belt.

[0060] The specimen pretreatment component 202, the specimen sampling component 203, the sample processing component 204, the specimen retention room 3 after sampling, and the sample conveying component 205 are installed with induction opening and closing windows to achieve conduction and sealing with each other.

[0061] The transmission systems between the autopsy room 1, the organ specimen sampling room 2, the specimen retention room 3 after sampling, the pathological technology room 4, and the monitoring and control room 5 are independent of each other;

[0062] It should be noted that in the technical solution of this application, the overall structure includes an autopsy room, an organ specimen sampling room, a specimen storage room after sampling, a pathological technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, the pathological technology room, and the monitoring and control room are sequentially connected through a pipeline system. The rear side of the organ specimen sampling room is connected to the specimen storage room after sampling, and the automatic disposal of pathological autopsy is carried out through a disposal system with an integrated structure. The parameters of the negative pressure system comply with the relevant requirements of national regulations, and the safety facilities and equipment, waste liquid, etc. shall be implemented with reference to the relevant national standards. The entire system is completely sealed, and each room inside the system is in a negative pressure state and changes gradually, so that the gas inside each room will not leak to the outside and cause pollution, and it can meet the relevant standards of a secondary or tertiary biosafety protection laboratory.

[0063] In the technical solution of this application, it also includes a ventilation system that meets national standards. The inside is relatively in a negative pressure state, the discharge and ventilation are equipped with a standard purification system, and a high-efficiency filtration system is set. Both the incoming air and the exhaust air adopt high-efficiency filtration; at the same time, ensure that the pressure is relatively appropriate; the relative pressure inside the space is -30 Pa to -40 Pa, and the air cleanliness is from Class 7 to Class 8 in the "Code for Design of Clean Plant" GB 50073-2001. The lighting is uniform and non-dazzling, and the illuminance is not less than 500 lx;

[0064] Embodiment 2

[0065] Application of a semi-automatic pathological examination negative pressure system for infectious specimens in pathological autopsy of infectious diseases.

[0066] Due to its particularity, pathological autopsy of infectious diseases is not suitable for corresponding operations compared with ordinary pathological autopsies or in ordinary pathological autopsy rooms;

[0067] The automatic disposal system for pathological autopsy of infectious diseases of the present invention includes an autopsy room, an organ specimen sampling room, a specimen storage room after sampling, a pathological technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, the pathological technology room, and the monitoring and control room are sequentially connected through a pipeline system. The rear side of the organ specimen sampling room is connected to the specimen storage room after sampling, and the automatic disposal of pathological autopsy is carried out through a disposal system with an integrated structure;

[0068] When performing pathological autopsy of infectious diseases, the autopsy of the corpse is carried out in the autopsy room and transmitted to the organ specimen sampling room for corresponding operations;

[0069] The above-mentioned organ specimen sampling room is a closed cabinet as a whole, including a specimen pretreatment component, a specimen sampling component, a sample processing component, and a sample conveying component, which are conducted through an induction opening and closing window. The operating tables of each component are on the same plane and are installed with conveyors for conveying between each processing component. The conveyors operate independently;

[0070] The specimen pretreatment component performs automatic or manual filling of the fixing solution and timed or manual / automatic transfer of the pretreated specimen through the designed negative pressure device and fixing solution filling device. The filling of the fixing solution is achieved by manually or automatically filling the fixing solution for the visceral specimen placed in the specimen fixing container through sensing; at the same time, through the corresponding control buttons, the pretreated specimen is transferred in a timed or manual / automatic manner to the specimen sampling component;

[0071] The functional part of the specimen sampling component includes a flushing induction device, an audio-video device, and an instrument cleaning and storage device, and the operation part includes multiple groups of automatic / semi-automatic sampling devices and two operation channels; it is used for sampling, flushing, disinfecting, and photographing of specimens, and at the same time, operation channels are set for manual sampling operations;

[0072] That is, during specific operations, the flushing induction device and the instrument cleaning and storage device flush and disinfect the viscera and operating instruments. At the same time, the audio-video device records the sampling process, and at the same time, corresponding operations are carried out through multiple groups of automatic / semi-automatic sampling devices. The automatic / semi-automatic sampling devices include a parallel section device, a standard size section device, and an irregular section device, which perform regular or irregular section operations according to the size of the pathological specimen as needed. The automatic / semi-automatic sampling devices can save physical strength and are convenient for operation. After that, a part of the sliced pathological specimen is transferred to the specimen retention room after sampling for filling and low-temperature preservation of the fixing solution, and the other part is transferred to the sample processing component for selective inactivation treatment of the sampled sample;

[0073] The inactivation device of the sample processing component includes a liquid filling device and an ultraviolet irradiation device. The samples taken by slicing are placed on the conveyor belt of the operation part. The control part includes inactivation function selection, time setting, and flushing buttons, and corresponding indicator lights are set. Corresponding inactivation operations are carried out through function selection and then transmitted to the next level;

[0074] Pathological dissection is carried out from autopsy, pathological specimen sampling, specimen retention, and specimen processing through an integrated automated pathological dissection system. Pathological dissection and sampling are carried out through a closed automated pipeline mode, which is suitable for pathological dissection and sampling applications.

[0075] Embodiment 3

[0076] Application of a semi-automatic pathological examination negative pressure system for infectious specimens in pathological dissection;

[0077] Based on the above embodiments, the automated disposal system for pathological dissection of infectious diseases of the present invention can be applied to ordinary pathological dissection;

[0078] This system is designed as an automatic or semi-automatic system, which can adaptively process pathological dissection specimens and is relatively convenient to operate.

[0079] The automated pathological dissection system for infectious diseases of the present invention includes an autopsy room, an organ specimen sampling room, a specimen storage room after sampling, a pathological technology room, and a monitoring and control room. The autopsy room, the organ specimen sampling room, the pathological technology room, and the monitoring and control room are sequentially connected through a pipeline system. The rear side of the organ specimen sampling room is connected to the specimen storage room after sampling, and the automated dissection of pathological anatomy is carried out through a disposal system with an integrated structure;

[0080] The organ specimen sampling room of the present invention is an enclosed cabinet as a whole. The specimen pretreatment component, the specimen sampling component, the sample processing component, and the sample conveying component are conducted through an induction opening and closing window. The operation countertops of each component are on the same plane and are installed with conveyor belts for conveying between each processing component, and the conveyor belts operate independently; the specimen pretreatment component is used for automatic or manual filling of the fixing liquid and timed or manual / automated conveying of the pretreated specimen; the specimen sampling component is used for sampling, rinsing, disinfecting, and photographing of the specimen, and at the same time, an operation channel is set for manual sampling operation; the sample processing component is used for selective inactivation treatment of the taken sample, and the sample conveying component conveys the inactivated sample to the next one. The pathological anatomy from autopsy, pathological specimen sampling, specimen storage, and specimen processing is carried out through an integrated automated pathological dissection system, and the pathological dissection material collection in a closed automated pipeline mode is suitable for the application of pathological dissection material collection.

[0081] In the description of this specification, the description with reference to terms such as "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0082] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of this specification. These embodiments are selected and specifically described in this specification in order to better explain the principle and practical application of the present invention, so that those skilled in the art can understand and utilize the present invention well. The present invention is only limited by the claims and their full scope and equivalents.

Claims

1. A full-process system for negative-pressure transmission pathological examination of infectious specimens, characterized in that: It includes a corpse dissection room, an organ specimen sampling room, a specimen storage room after sampling, a pathology technology room and a monitoring and control room. The corpse dissection room, the organ specimen sampling room and the pathology technology room are connected in one direction through an assembly line system and a transmission channel. The negative pressure in each of the above rooms is gradually reduced to make the internal gas flow in one direction; the organ specimen sampling room is connected in two directions with the specimen storage room after sampling through an assembly line system and a transmission channel, the monitoring and control room is connected with each room through a video dialogue system and a remote operation system, and the graphic information of the pathological examination is uploaded to the pathology data analysis center through a wireless information system; the corpse dissection room and the pathology technology room are provided with an air intake and exhaust and purification system; The organ specimen sampling room is a closed cabinet structure as a whole, and is internally divided into a specimen pretreatment component, a specimen sampling component, a sample processing component and a sample conveying component that are interconnected. The operating tables of each component are located on the same plane and are equipped with independent conveyor belts. The specimen pretreatment component is used for automatic or manual filling of organ specimen fixative, specimen code scanning and numbering, and timed or manual / automatic transmission of specimens; The specimen sampling assembly is used for specimen inspection and sampling, assisting in the processing of continuous tissue sections of different thicknesses and batch tissue blocks of different sizes, and is equipped with the required flushing device, disinfection device and audio and video device, and is also provided with an arm operation hole; The sample processing component is used to fix and inactivate microorganisms on the taken pathological samples, and the sample transport component transports the inactivated samples without biosafety hazards to the next-level pathological technical room; The pathology technology room contains tissue dehydrators, slicers, and stainers in the biosafety cabinet structure. The image information is wirelessly uploaded to the monitoring and control room through the slice scanning equipment, and the monitoring and control room organizes and summarizes it to the pathology information analysis center; The specimen pretreatment component, specimen sampling component, sample processing component, post-sampling specimen storage chamber and sample transport component of the organ specimen sampling chamber are respectively a functional part, an operating part and a control part from top to bottom; The sample transport assembly transports the sample via a conveyor belt, and the functional parts of the post-sampling specimen storage chamber are a fixative filling device and a low-temperature holding device; the post-sampling specimen storage chamber and the organ specimen sampling chamber are transported via a circular conveyor belt; The specimen pretreatment component, the specimen sampling component, the sample processing component, the specimen retention chamber after sampling and the sample conveying component are installed with induction opening and closing windows to achieve conduction and sealing, and there are passages between the opening and closing windows.

2. The whole process system for negative pressure transmission pathological examination of infectious specimens as described in claim 1, wherein: The functional part of the specimen pretreatment component is equipped with a negative pressure device, a fixative filling component and a disinfection component, the operating part is a conveyor belt for placing the specimen fixation container, and the control part includes control buttons for fixing the fixative and the specimen fixation container; The control buttons include an automatic or manual filling button for fixative, an automatic or manual control button for disinfection, and a timing or manual / automatic transfer button for pre-processing specimens, and there are corresponding instructions above each button.

3. The whole process system for negative pressure transmission pathological examination of infectious specimens according to claim 1, characterized in that: The functional part of the specimen sampling assembly includes a disinfection device, a flushing sensor device, an audio and video device, and an instrument cleaning and storage device, and the operating part includes multiple sets of automatic / semi-automatic sampling devices and two arm operating channels; The rinsing induction device and the instrument cleaning and storage device include an induction element and an execution element, and the audio-video device is located between the two; the automatic / semi-automatic sampling device includes a parallel section device, a standard size slicing device, and an irregular slicing device.

4. The whole-process system for negative-pressure transmission pathological examination of infectious specimens according to claim 1, wherein: The functional part of the sample processing component includes an inactivation device. Samples for slicing and sampling are placed on the conveyor belt of the operation part. The control part includes an inactivation function selection button, a time setting button, and a rinsing button, and corresponding indicator lights are set; The inactivation device includes a liquid filling device and an ultraviolet irradiation device.

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