Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors

Abstract

The present application relates to a compound of formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof, which modulates the activity of adenosine receptors such as subtypes A2A and A2B receptors and can be used to treat diseases associated with the activity of adenosine receptors, including, for example, cancer, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. #imgabs0#

Description

Technical Field

[0001] The present invention provides imidazopyrimidine and triazolopyrimidine compounds that modulate the activity of adenosine receptors, such as subtypes A2A and A2B, and are useful for treating diseases associated with the activity of adenosine receptors, including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Background Art

[0002] Adenosine is an extracellular signaling molecule that can modulate immune responses in many immune cell types. Adenosine was first identified by Drury and Adenosine was identified as a physiological regulator of coronary vascular tone (Sachdeva, S. and Gupta, M. Saudi Pharmaceutical Journal, 2013, 21, 245-253), however it was not until 1970 that Sattin and Rall showed that adenosine regulates cellular function by occupying specific receptors on the cell surface (Sattin, A. and Rall, TW, 1970. Mol. Pharmacol. 6, 13-23; Hasko′, G. et al., 2007, Pharmacol. Ther. 113, 264-275).

[0003] Adenosine plays an important role in various other physiological functions. Adenosine participates in the synthesis of nucleic acids when connected to three phosphate groups; nucleosides form the complete component ATP of the cell energy system. Adenosine can be generated by enzymatic decomposition of extracellular ATP, or it can also be released from damaged neurons and glial cells by passing through damaged plasma membranes (Tautenhahn, M. et al. Neuropharmacology, 2012, 62, 1756-1766). Adenosine produces various pharmacological effects in the peripheral and central nervous systems by acting on specific receptors located on the cell membrane (Matsumoto, T. et al., Pharmacol. Res., 2012, 65, 81-90). Alternative pathways for extracellular adenosine generation have been described. These pathways include the production of adenosine from nicotinamide dinucleotide (NAD) instead of ATP through the coordinated action of CD38, CD203a and CD73. The production of adenosine independent of CD73 can also occur through other phosphates such as alkaline phosphatase or prostate-specific phosphatase.

[0004] There are four known subtypes of adenosine receptors in humans, including A1, A2A, A2B and A3 receptors. A1 and A2A are high affinity receptors, while A2B and A3 are low affinity receptors. Adenosine and its agonists can act via one or more of these receptors and can regulate the activity of the enzyme adenylate cyclase responsible for increasing cyclic AMP (cAMP). Different receptors have different stimulatory and inhibitory effects on this enzyme. Increased intracellular concentrations of cAMP can inhibit the activity of immune and inflammatory cells (Livingston, M. et al., Inflamm. Res., 2004, 53, 171-178).

[0005] A2A adenosine receptors can send signals in the periphery and CNS, with agonists being explored as anti-inflammatory drugs and antagonists being explored for neurodegenerative diseases (Carlsson, J. et al., J. Med. Chem., 2010, 53, 3748-3755). In most cell types, the A2A subtype suppresses intracellular calcium levels, while A2B enhances these levels. A2A receptors generally appear to suppress inflammatory responses from immune cells (Borrmann, T. et al., J. Med. Chem., 2009, 52 (13), 3994-4006).

[0006] A2B receptors are highly expressed in the gastrointestinal tract, bladder, lungs and on obese cells (Antonioli, L. et al., Nature Reviews Cancer, 2013, 13, 842-857). Although the A2B receptor is closely related to the A2A receptor in structure and can activate adenylate cyclase, it is functionally different. It has been hypothesized that this subtype can utilize signal transduction systems other than adenylate cyclase (Livingston, M. et al., Inflamm. Res., 2004, 53, 171-178). Among all adenosine receptors, the A2B adenosine receptor is a low-affinity receptor that is believed to remain silent under physiological conditions and activated due to increased extracellular adenosine levels (Ryzhov, S. et al., Neoplasia, 2008, 10, 987-995). Activation of the A2B adenosine receptor can stimulate adenylate cyclase and phospholipase C by activating Gs and Gq proteins, respectively. Coupling to mitogen-activated protein kinases has also been described (Borrmann, T. et al., J. Med. Chem., 2009, 52(13), 3994-4006).

[0007] In the immune system, the involvement of adenosine signaling can be a key regulatory mechanism to prevent excessive immune responses in tissues. Adenosine can negatively regulate immune responses through many immune cell types, including T-cells, natural killer cells, macrophages, dendritic cells, obese cells, and myeloid-derived suppressor cells (Allard, B. et al., Current Opinion in Pharmacology, 2016, 29, 7-16).

[0008] In tumors, this pathway is intercepted by the tumor microenvironment and undermines the anti-tumor capacity of the immune system, thereby promoting cancer progression. In the tumor microenvironment, adenosine is mainly generated from extracellular ATP via CD39 and CD73. Various cell types can generate adenosine by expressing CD39 and CD73. This is the case for tumor cells, T effector cells, T regulatory cells, tumor-associated macrophages, myeloid-derived suppressor cells (MDSC), endothelial cells, cancer-associated fibroblasts (CAFs), and mesenchymal stromal / stem cells (MSCs). Hypoxia, inflammation, and other immunosuppressive signaling in the tumor microenvironment can induce the expression of CD39, CD73, and subsequent adenosine production. Therefore, adenosine levels in solid tumors are abnormally high compared to normal physiological conditions.

[0009] A2A is primarily expressed on bone marrow-derived cells, including T effector cells, T regulatory cells, and natural killer cells. Blocking the A2A receptor prevents downstream immunosuppressive signals that temporarily inactivate T cells. The A2B receptor is primarily expressed on monocyte-derived cells, including dendritic cells, tumor-associated macrophages, myeloid-derived suppressor cells (MDSC), and mesenchymal stromal / stem cells (MSC). Blocking the A2B receptor inhibits tumor growth, blocks metastasis, and increases tumor antigen presentation in preclinical models.

[0010] In terms of the safety profile of ADORA2A / ADORA2B (A2A / A2B) blockade, all A2A and A2B receptor knockout mice were viable, showed no growth abnormalities, and were fertile (Allard, B. et al., Current Opinion in Pharmacology, 2016, 29, 7-16). A2A KO mice only showed increased levels of proinflammatory cytokines when challenged with LPS and no evidence of inflammation at baseline (Antonioli, L. et al., Nature Reviews Cancer, 2013, 13, 842-857). A2B KO mice showed normal platelet, red blood cell and white blood cell counts, but increased inflammation at baseline (TNF-α, IL-6) in naive A2B KO mice (Antonioli, L. et al., Nature Reviews Cancer, 2013, 13, 842-857). Increased production of TNF-α and IL-6 was detected after LPS treatment. A2B KO mice also display increased vascular adhesion molecules that mediate inflammation and leukocyte adhesion / rolling; enhanced adipocyte activation; increased sensitivity to IgE-mediated allergic reactions, and increased vascular leakage and neutrophil influx under ischemia (Antonioli, L. et al., Nature Reviews Cancer, 2013, 13, 842-857).

[0011] In summary, there is a need to develop new adenosine receptor selective ligands, such as ligands for subtypes A2A and A2B, for use in treating diseases such as cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. The present application is directed to this need and others. Summary of the invention

[0012] The present invention particularly relates to compounds of formula (I):

[0013]

[0014] or a pharmaceutically acceptable salt thereof, wherein the constituent members are defined herein.

[0015] The present invention further provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

[0016] The present invention further provides a method for inhibiting the activity of an adenosine receptor, the method comprising contacting the receptor with a compound of formula (I) or a pharmaceutically acceptable salt thereof.

[0017] The present invention further provides a method for treating a disease or condition associated with abnormal expression of adenosine receptors, the method comprising administering to the patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

[0018] The present invention further provides a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in any of the methods described herein.

[0019] The present invention further provides the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the preparation of a medicament for use in any of the methods described herein. DETAILED DESCRIPTION

[0020] Compound

[0021] The present invention particularly relates to compounds of formula (I):

[0022]

[0023] or a pharmaceutically acceptable salt thereof; wherein:

[0024] X is N or CR 3 ;

[0025] R 1 Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、C(=NR e1 )R b1 、C(=NR e1 )NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O) 2 R b1 and S(O) 2 NR c1 R d1 , where R 1 C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R B Substituent substitution;

[0026] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )Rb2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)NR c2 R d2 NR c2 S(O)R b2 NR c2 S(O) 2 R b2 NR c2 S(O)(=NR e2 )R b2 NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 , SF 5 、P(O)R f2 R g2 OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0027] R 3 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a3 , SR a3 NHOR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)NR c3 (OR a3 )、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R d3 NR c3 NR c3 R d3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )R b3NR c3 S(O)NR c3 R d3 NR c3 S(O)R b3 NR c3 S(O) 2 R b3 NR c3 S(O)(=NR e3 )R b3 NR c3 S(O) 2 NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O) 2 R b3 、S(O) 2 NR c3 R d3 、OS(O)(=NR e3 )R b3 、OS(O) 2 R b3 , SF 5 、P(O)R f3 R g3 OP(O)(OR h3 )(OR i3 )、P(O)(OR h3 )(OR i3 ) and BR j3 R k3 , where R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R D Substituent substitution;

[0028] Cy 1 C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E Substituent substitution;

[0029] The condition is that when X is N and Cy 1 When it is a 4-14 membered heterocycloalkyl group, Cy 1 The 4-14 membered heterocycloalkyl group is not an unsubstituted morpholinyl group;

[0030] The condition is Cy 1 Not optional R selected by 1, 2, 3 or 4 independently E Substituent substituted pyridin-4-yl;

[0031] The condition is Cy 1 Not optional R selected by 1, 2 or 3 independently E Substituent substituted pyrimidin-4-yl;

[0032] The condition is Cy 1 Not optionally selected by 1, 2, 3, 4, 5 or 6 independently selected R E Substituent substituted quinolin-4-yl;

[0033] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0034] Each R a1 , R c1 , R d1 , R a2 , R c2 , R d2 , R a3 , R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a1 , R c1 , R d1 , R a2 , R c2 , R d2 , R a3 , R c3 and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0035] Alternatively, any R attached to the same N atom c1 and R d1 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0036] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0037] Alternatively, any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R GSubstituent substitution;

[0038] Each R b1 , R b2 and R b3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b1 , R b2 and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0039] Each R e1 , R e2 and R e3 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0040] Each R f2 , R g2 , R f3 and R g3 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0041] Each R h2 , R i2 , R h3 and R i3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0042] Each R j2 , R k2 , R j3 and R k3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0043] Alternatively, any R attached to the same B atom j2 and R k2Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0044] Alternatively, any R attached to the same B atom j3 and R k3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0045] Each R B , R C , R D , R E , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NRc4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e4 )NR c4 R d4 、NR c4 C(=NR e4 )NR c4 R d4 、NR c4 C(=NR e4 )R b4 、NR c4 S(O)R b4 、NR c4 S(O)NR c4 R d4 、NR c4 S(O) 2 R b4 、NR c4 S(O)(=NR e4 )R b4 、NR c4 S(O) 2 NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O) 2 R b4 、S(O) 2 NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O) 2 R b4 、SF 5 、P(O)R f4 R g4 、OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 wherein R B 、R C 、R D 、R E 、R F and R G are C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-14Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0046] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0047] Alternatively, any R attached to the same N atom c4 and R d4Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0048] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0049] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0050] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0051] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0052] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0053] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0054] Each R Hare independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)NR c5 R d5 NR c5 S(O)2 R b5 NR c5 S(O)(=NR e5 )R b5 NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0055] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0056] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0057] Each R b5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0058] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0059] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0060] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0061] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0062] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0063] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 Rd6 , NR c6 R d6 , NR c6 NR c6 R d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c5 R d6 , C(=NR e6 )R b6 , C(=NR e6 )NR c6 R d6 , NR c6 C(=NR e6 )NR c6 R d6 , NR c6 C(=NR e6 )R b6 , NR c6 S(O)R b6 , NR c6 S(O)NR c6 R d6 , NR c6 S(O) 2 R b6 , NR c6 S(O)(=NR e6 )R b6 , NR c6 S(O) 2 NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O) 2 R b6 , S(O) 2 NR c6 R d6 , OS(O)(=NR e6 )R b6 , OS(O) 2 R b6 , SF 5 , P(O)R f6 R g6 , OP(O)(OR h6 )(OR i6 ), P(O)(OR h6 )(OR i6 ) and BR j6 Rk6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0064] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0065] Alternatively, any R attached to the same N atomc6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0066] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0067] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0068] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0069] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0070] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0071] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0072] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0073] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0074] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0075] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0076] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0077] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0078] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0079] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0080] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0081] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0082] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0083] In some embodiments,

[0084] X is N or CR 3 ;

[0085] R 1 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl and C 1-6 Haloalkyl;

[0086] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)NR c2 Rd2 NR c2 S(O)R b2 NR c2 S(O) 2 R b2 NR c2 S(O)(=NR e2 )R b2 NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 , SF 5 、P(O)R f2 R g2 OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0087] R 3 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a3 , SR a3 NHOR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)NR c3 (OR a3 )、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R d3 NR c3 NR c3 R d3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )R b3 NR c3 S(O)NR c3 R d3 NR c3 S(O)R b3 NR c3 S(O) 2 R b3 NR c3 S(O)(=NR e3 )R b3 NR c3 S(O) 2NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O) 2 R b3 、S(O) 2 NR c3 R d3 、OS(O)(=NR e3 )R b3 、OS(O) 2 R b3 , SF 5 、P(O)R f3 R g3 OP(O)(OR h3 )(OR i3 )、P(O)(OR h3 )(OR i3 ) and BR j3 R k3 , where R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R D Substituent substitution;

[0088] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E Substituent substitution;

[0089] The condition is that when X is N and Cy 1 When it is a 4-14 membered heterocycloalkyl group, Cy 1 The 4-14 membered heterocycloalkyl group is not an unsubstituted morpholinyl group;

[0090] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0091] Each R a2 , R c2 , R d2 , R a3 , R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a2 , R c2 , R d2 , R a3 , R c3 and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0092] Alternatively, any R attached to the same N atom c2 and R d2Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0093] Alternatively, any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0094] Each R b2 and R b3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b2 and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0095] Each R e2 and R e3 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0096] Each R f2 , R g2 , R f3 and R g3 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0097] Each R h2 , R i2 , R h3 and R i3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0098] Each Rj2 , R k2 , R j3 and R k3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0099] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0100] Alternatively, any R attached to the same B atom j3 and R k3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0101] Each R C , R D , R E , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4, NR c4 R d4 , NR c4 NR c4 R d4 、 NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , C(=NR e4 )R b4 , C(=NR e4 )NR c4 R d4 , NR c4 C(=NR e4 )NR c4 R d4 , NR c4 C(=NR e4 )R b4 , NR c4 S(O)R b4 , NR c4 S(O)NR c4 R d4 , NR c4 S(O) 2 R b4 , NR c4 S(O)(=NR e4 )R b4 , NR c4 S(O) 2 NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 , S(O) 2 R b4 , S(O) 2 NR c4 R d4 , OS(O)(=NR e4 )R b4 , OS(O) 2 R b4 , SF 5 , P(O)R f4 R g4 , OP(O)(OR h4 )(OR i4 ), P(O)(OR h4 )(OR i4 ) and BR j4 Rk4 , where R C , R D , R E , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0102] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0103] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0104] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0105] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0106] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0107] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0108] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0109] Alternatively, any R attached to the same B atom j4 and R k4Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0110] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 NR c5 R d5 、 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NRe5 )R b5 NR c5 S(O)R b5 NR c5 S(O)NR c5 R d5 NR c5 S(O) 2 R b5 NR c5 S(O)(=NR e5 )R b5 NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0111] Each R a5 , R c5 and R d5 Independently selected from H, C1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0112] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0113] Each R b5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0114] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0115] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0116] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0117] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0118] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0119] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 、NR c6 R d6 、NR c6 NR c6 R d6 、NR c6 C(O)R b6 、NR c6 C(O)OR a6 、NR c6 C(O)NR c5 R d6 、C(=NR e6 )R b6 、C(=NR e6 )NR c6 R d6 、NR c6 C(=NR e6 )NR c6 R d6 、NR c6 C(=NR e6 )R b6 、NR c6 S(O)R b6 、NR c6 S(O)NR c6 R d6 、NR c6 S(O) 2 R b6 、NR c6 S(O)(=NR e6 )R b6 、NR c6 S(O) 2 NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O) 2 R b6 、S(O) 2 NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 、SF 5、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0120] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0121] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0122] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0123] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0124] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0125] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0126] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0127] Alternatively, any R attached to the same B atomj6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0128] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 、 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7 NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0129] Each R a7 , R c7and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0130] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0131] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0132] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0133] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0134] Each R h7 and R i7 Independently selected from H, C 1-6Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0135] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0136] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0137] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0138] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0139] In some embodiments,

[0140] X is CR 3 ;

[0141] R 1 Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、C(=NR e1 )R b1 、C(=NR e1 )NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O) 2 R b1 and S(O) 2 NR c1 R d1 , where R 1 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R B Substituent substitution;

[0142] R 2 Selected from H, D, halogen, C 1-6Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)NR c2 R d2 NR c2 S(O)R b2 NR c2 S(O) 2 R b2 NRc2 S(O)(=NR e2 )R b2 NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 , SF 5 、P(O)R f2 R g2 OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0143] R 3 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a3 , SR a3 NHOR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)NR c3 (OR a3 )、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R d3 NR c3 NR c3 R d3 NR c3 C(O)R b3 NR c3 C(O)OR a3 NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )NR c3 R d3 NR c3 C(=NR e3 )R b3 NR c3 S(O)NR c3 R d3 NR c3 S(O)R b3 NR c3 S(O) 2 R b3 NR c3 S(O)(=NR e3 )R b3 NR c3 S(O) 2 NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O)2 R b3 、S(O) 2 NR c3 R d3 、OS(O)(=NR e3 )R b3 、OS(O) 2 R b3 , SF 5 、P(O)R f3 R g3 OP(O)(OR h3 )(OR i3 )、P(O)(OR h3 )(OR i3 ) and BR j3 R k3 , where R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R D Substituent substitution;

[0144] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E Substituent substitution;

[0145] The condition is Cy 1 Not optional R selected by 1, 2, 3 or 4 independently E Substituent substituted pyridin-4-yl;

[0146] The condition is Cy 1 Not optional R selected by 1, 2 or 3 independently E Substituent substituted pyrimidin-4-yl;

[0147] The condition is Cy 1 Not optionally selected by 1, 2, 3, 4, 5 or 6 independently selected R E Substituent substituted quinolin-4-yl;

[0148] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0149] Each R a1 , R c1 , R d1 , R a2 , R c2 , R d2 , R a3 , R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a1 , R c1 , R d1 , R a2 , R c2 , R d2 , R a3 , R c3 and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0150] Alternatively, any R attached to the same N atom c1 and R d1 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0151] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0152] Alternatively, any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0153] Each R b1 , R b2 and R b3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b1 , R b2 and R b3 C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0154] Each R e1 , R e2 and R e3 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0155] Each R f2 , R g2 , R f3 and R g3 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C1-6 alkyl-;

[0156] Each R h2 , R i2 , R h3 and R i3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0157] Each R j2 , R k2 , R j3 and R k3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0158] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0159] Alternatively, any R attached to the same B atom j3 and R k3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0160] Each R B , R C , R D , R E , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 NR c4 R d4 、 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )R b4 NR c4 S(O)R b4 NR c4 S(O)NR c4 R d4 NR c4 S(O) 2 R b4 NR c4 S(O)(=NR e4 )R b4 NRc4 S(O) 2 NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O) 2 R b4 、S(O) 2 NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O) 2 R b4 , SF 5 、P(O)R f4 R g4 OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R B , R C , R D , R E , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0161] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0162] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0163] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0164] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0165] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0166] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0167] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0168] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0169] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NRc5 R d5 、NR c5 R d5 、NR c5 NR c5 R d5 、 NR c5 C(O)R b5 、NR c5 C(O)OR a5 、NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 、NR c5 C(=NR e5 )NR c5 R d5 、NR c5 C(=NR e5 )R b5 、NR c5 S(O)R b5 、NR c5 S(O)NR c5 R d5 、NR c5 S(O) 2 R b5 、NR c5 S(O)(=NR e5 )R b5 、NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 、SF 5 、P(O)R f5 R g5 、OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0170] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0171] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0172] Each R b5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0173] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0174] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0175] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0176] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0177] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0178] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c5 R d6 、C(=NR e6 )R b6 、C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)NR c6 Rd6 NR c6 S(O) 2 R b6 NR c6 S(O)(=NR e6 )R b6 NR c6 S(O) 2 NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O) 2 R b6 、S(O) 2 NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 , SF 5 、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0179] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0180] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0181] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0182] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0183] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0184] Each R h6 and R i6 Independently selected from H, C 1-6Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0185] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0186] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0187] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7、OC(O)NR c7 R d7 、NR c7 R d7 、NR c7 NR c7 R d7 、NR c7 C(O)R b7 、NR c7 C(O)OR a7 、NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 、NR c7 C(=NR e7 )NR c7 R d7 、NR c7 C(=NR e7 )R b7 、NR c7 S(O)R b7 、NR c7 S(O)NR c7 R d7 、NR c7 S(O) 2 R b7 、NR c7 S(O)(=NR e7 )R b7 、NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 、SF 5 、P(O)R f7 R g7 、OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0188] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0189] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0190] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0191] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0192] Each R f7 and R g7Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0193] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0194] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0195] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0196] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0197] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0198] In some embodiments,

[0199] X is CR 3 ;

[0200] R 1 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl;

[0201] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)ORa2 、OC(O)R b2 、OC(O)NR c2 R d2 、NR c2 R d2 、NR c2 NR c2 R d2 、NR c2 C(O)R b2 、NR c2 C(O)OR a2 、NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )R b2 、NR c2 S(O)NR c2 R d2 、NR c2 S(O)R b2 、NR c2 S(O) 2 R b2 、NR c2 S(O)(=NR e2 )R b2 、NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 、SF 5 、P(O)R f2 R g2 、OP(O)(OR h2 )(OR i2 )、P(O)(ORh2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0202] R 3 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a3 , SR a3 NHOR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)NR c3 (OR a3 )、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 NR c3 R d3 NR c3 NR c3 R d3 NR c3 C(O)R b3, NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R d3 , C(=NR e3 )R b3 , C(=NR e3 )NR c3 R d3 , NR c3 C(=NR e3 )NR c3 R d3 , NR c3 C(=NR e3 )R b3 , NR c3 S(O)NR c3 R d3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O)(=NR e3 )R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , S(O) 2 NR c3 R d3 , OS(O)(=NR e3 )R b3 , OS(O) 2 R b3 , SF 5 , P(O)R f3 R g3 , OP(O)(OR h3 )(OR i3 ), P(O)(OR h3 )(OR i3 ) and BR j3 R k3 , wherein R 3 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-14 aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R D Substituent substitution;

[0203] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E or R M Substituent substitution;

[0204] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0205] Each R a2 , R c2 , R d2 , R a3 , R c3 and R d3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a2, R c2 , R d2 , R a3 , R c3 and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0206] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0207] Alternatively, any R attached to the same N atom c3 and R d3 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0208] Each R b2 and R b3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where Rb2 and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0209] Each R e2 and R e3 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0210] Each R f2 , R g2 , R f3 and R g3 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0211] Each R h2 , R i2 , R h3 and R i3 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0212] Each R j2 , R k2 , R j3 and R k3 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0213] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0214] Alternatively, any R attached to the same B atom j3 and R k3 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0215] Each R C , R D , R E , R M , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )R b4 NR c4 S(O)R b4 NR c4 S(O)NR c4 R d4 NR c4 S(O) 2 R b4 NR c4S(O)(=NR e4 )R b4 NR c4 S(O) 2 NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O) 2 R b4 、S(O) 2 NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O) 2 R b4 , SF 5 、P(O)R f4 R g4 OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R C , R D , R E , R M , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0216] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0217] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0218] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0219] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0220] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0221] Each R h4 and Ri4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0222] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0223] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0224] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)ORa5 、OC(O)R b5 、OC(O)NR c5 R d5 、NR c5 R d5 、NR c5 NR c5 R d5 、NR c5 C(O)R b5 、NR c5 C(O)OR a5 、NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 、NR c5 C(=NR e5 )NR c5 R d5 、NR c5 C(=NR e5 )R b5 、NR c5 S(O)R b5 、NR c5 S(O)NR c5 R d5 、NR c5 S(O) 2 R b5 、NR c5 S(O)(=NR e5 )R b5 、NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 、SF 5 、P(O)R f5 R g5 、OP(O)(OR h5 )(OR i5 )、P(O)(ORh5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0225] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0226] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0227] Each R b5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0228] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0229] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0230] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0231] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0232] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0233] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c5 R d6 、C(=NR e6 )R b6 、C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6S(O)NR c6 R d6 NR c6 S(O) 2 R b6 NR c6 S(O)(=NR e6 )R b6 NR c6 S(O) 2 NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O) 2 R b6 、S(O) 2 NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 , SF 5 、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0234] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0235] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0236] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0237] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0238] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0239] Each R h6 and Ri6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0240] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0241] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0242] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)ORa7 、OC(O)R b7 、OC(O)NR c7 R d7 、NR c7 R d7 、NR c7 NR c7 R d7 、NR c7 C(O)R b7 、NR c7 C(O)OR a7 、NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 、NR c7 C(=NR e7 )NR c7 R d7 、NR c7 C(=NR e7 )R b7 、NR c7 S(O)R b7 、NR c7 S(O)NR c7 R d7 、NR c7 S(O) 2 R b7 、NR c7 S(O)(=NR e7 )R b7 、NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 、SF 5 、P(O)R f7 R g7 、OP(O)(OR h7 )(OR i7 )、P(O)(ORh7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0243] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0244] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0245] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0246] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0247] Each Rf7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0248] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0249] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0250] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0251] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0252] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0253] In some embodiments:

[0254] X is N;

[0255] R 1 Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、C(=NR e1 )R b1 、C(=NR e1 )NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O) 2 R b1 and S(O) 2 NRc1 R d1 , where R 1 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R B Substituent substitution;

[0256] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)NR c2 R d2 NR c2 S(O)R b2 NR c2 S(O) 2 R b2 NR c2 S(O)(=NR e2 )R b2 NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 , SF 5 、P(O)R f2 R g2 OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0257] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E Substituent substitution;

[0258] The condition is that when Cy 1 When it is a 4-14 membered heterocycloalkyl group, Cy 1 The 4-14 membered heterocycloalkyl is not an unsubstituted morpholinyl;

[0259] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0260] Each R a1 , R c1 , R d1 , R a2 , R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a1 , R c1 , R d1 , R a2 , R c2 and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0261] Alternatively, any R attached to the same N atom c1 and R d1 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0262] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0263] Each R b1 and R b2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b1 , R b2 and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0264] Each R e1 and R e2 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0265] Each R f2 and R g2 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0266] Each R h2 and R i2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0267] Each R j2 and R k2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0268] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0269] Each R B , R C , R E , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6alkyl-, (4- to 14-membered heterocycloalkyl)-C 1-6 alkyl-, CN, NO 2 , OR a4 , SR a4 , NHOR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)NR c4 (OR a4 ), C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4 , NR c4 NR c4 R d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , C(=NR e4 )R b4 , C(=NR e4 )NR c4 R d4 , NR c4 C(=NR e4 )NR c4 R d4 , NR c4 C(=NR e4 )R b4 , NR c4 S(O)R b4 , NR c4 S(O)NR c4 R d4 , NR c4 S(O) 2 R b4 , NR c4 S(O)(=NR e4 )R b4 , NR c4 S(O) 2 NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 , S(O) 2 R b4 , S(O) 2NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O) 2 R b4 , SF 5 、P(O)R f4 R g4 OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R B , R C , R E , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0270] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0271] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0272] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0273] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0274] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0275] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0276] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0277] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0278] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)NR c5 R d5 NR c5 S(O) 2 R b5 NR c5 S(O)(=NR e5 )R b5 NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0279] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0280] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0281] Each R b5Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0282] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0283] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0284] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0285] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0286] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0287] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c5 R d6 、C(=NR e6 )R b6 、C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)NR c6 R d6 NR c6 S(O) 2 R b6 NR c6 S(O)(=NR e6 )R b6 NR c6 S(O) 2 NR c6 R d6 、S(O)Rb6 、S(O)NR c6 R d6 、S(O) 2 R b6 、S(O) 2 NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 , SF 5 、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0288] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , Rc6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0289] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0290] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0291] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0292] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0293] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0294] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0295] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0296] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)ORa7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7 NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0297] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0298] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0299] Each Rb7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0300] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0301] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0302] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0303] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0304] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0305] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0306] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0307] In some embodiments:

[0308] X is N;

[0309] R 1 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl;

[0310] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 NR c2 R d2 NR c2 C(O)R b2 NRc2 C(O)OR a2 、NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )R b2 、NR c2 S(O)NR c2 R d2 、NR c2 S(O)R b2 、NR c2 S(O) 2 R b2 、NR c2 S(O)(=NR e2 )R b2 、NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 、SF 5 、P(O)R f2 R g2 、OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 ,where R 2 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-14 aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0311] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E or R M Substituent substitution;

[0312] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0313] Each R a2 , R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a2 , R c2 and R d2 C 1-6Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0314] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0315] Each R b2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0316] Each R e2 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0317] Each R f2 and R g2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0318] Each R h2 and R i2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0319] Each R j2 and R k2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0320] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0321] Each R C , R E , R M , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 NR c4 Rd4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , C(=NR e4 )R b4 , C(=NR e4 )NR c4 R d4 , NR c4 , C(=NR e4 )NR c4 R d4 , NR c4 , C(=NR e4 )R b4 , NR c4 S(O)R b4 , NR c4 S(O)NR c4 R d4 , NR c4 S(O) 2 R b4 , NR c4 , S(O)(=NR e4 )R b4 , NR c4 S(O) 2 NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 , S(O) 2 R b4 , S(O) 2 NR c4 R d4 , OS(O)(=NR e4 )R b4 , OS(O) 2 R b4 , SF 5 , P(O)R f4 R g4 , OP(O)(OR h4 )(OR i4 ), P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R C , R E , R M , R F and RG C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0322] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0323] Alternatively, any R attached to the same N atomc4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0324] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0325] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0326] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0327] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0328] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0329] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0330] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)NR c5 R d5NR c5 S(O) 2 R b5 NR c5 S(O)(=NR e5 )R b5 NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0331] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0332] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0333] Each R b5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0334] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0335] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0336] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0337] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0338] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0339] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6R d6 , NR c6 R d6 , NR c6 NR c6 R d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c5 R d6 , C(=NR e6 )R b6 , C(=NR e6 )NR c6 R d6 , NR c6 C(=NR e6 )NR c6 R d6 , NR c6 C(=NR e6 )R b6 , NR c6 S(O)R b6 , NR c6 S(O)NR c6 R d6 , NR c6 S(O) 2 R b6 , NR c6 S(O)(=NR e6 )R b6 , NR c6 S(O) 2 NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O) 2 R b6 , S(O) 2 NR c6 R d6 , OS(O)(=NR e6 )R b6 , OS(O) 2 R b6 , SF 5 , P(O)R f6 R g6 , OP(O)(OR h6 )(OR i6 ), P(O)(OR h6 )(OR i6 ) and BR j6 Rk6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0340] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0341] Alternatively, any R attached to the same N atomc6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0342] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0343] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0344] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0345] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0346] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0347] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0348] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0349] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0350] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0351] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0352] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0353] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0354] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0355] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0356] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0357] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0358] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0359] In some embodiments,

[0360] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7 NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 ;

[0361] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0362] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or a 4-14-membered heterocycloalkyl; and

[0363] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-.

[0364] In some embodiments,

[0365] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c5 R d6 、C(=NR e6 )R b6 、C(=NR e6 )NR c6 Rd6 NR c6 C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)NR c6 R d6 NR c6 S(O) 2 R b6 NR c6 S(O)(=NR e6 )R b6 NR c6 S(O) 2 NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O) 2 R b6 、S(O) 2 NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 , SF 5 、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 ;

[0366] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0367] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or a 4-14-membered heterocycloalkyl; and

[0368] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-.

[0369] In some embodiments, each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, C 1-6 Alkoxy, C 1-6 Haloalkoxy, amino, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkylsulfonyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl, di-C 1-6 Alkylaminosulfonyl and C 1-6 Alkylsulfonylamino; wherein the C1-6 alkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected halo groups.

[0370] In some embodiments, each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4-7 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4-7 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0371] Each R b5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4-7 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4-7 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0372] Each R e5Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl and C 1-6 Haloalkoxy;

[0373] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4-7 membered heterocycloalkyl)-C 1-6 alkyl-;

[0374] Each R h5 and R i5 Independently selected from H, C 1-6 Haloalkyl, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4-7 membered heterocycloalkyl)-C 1-6 alkyl-;

[0375] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 haloalkoxy; and

[0376] Each R I D, halogen, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, C 1-6 Alkoxy, C 1-6 Haloalkoxy, amino, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkylsulfonyl, aminosulfonyl, C 1-6Alkylaminosulfonyl, di-C 1-6 Alkylaminosulfonyl and C 1-6 Alkylsulfonylamino.

[0377] In some embodiments, each R I and R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, C 1-6 Alkoxy, C 1-6 Haloalkoxy, amino, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkylsulfonyl, aminosulfonyl, C 1-6 Alkylaminosulfonyl, di-C 1-6 Alkylaminosulfonyl and C 1-6 Alkylsulfonylamino; and

[0378] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Alkynyl.

[0379] In some embodiments:

[0380] X is N;

[0381] R 1 Selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a1 、C(O)R b1、C(O)NR c1 R d1 、C(O)OR a1 、C(=NR e1 )R b1 、C(=NR e1 )NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O) 2 R b1 and S(O) 2 NR c1 R d1 , where R 1 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R B Substituent substitution;

[0382] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NRc2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 、NR c2 R d2 、NR c2 NR c2 R d2 、NR c2 C(O)R b2 、NR c2 C(O)OR a2 、NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )R b2 、NR c2 S(O)NR c2 R d2 、NR c2 S(O)R b2 、NR c2 S(O) 2 R b2 、NR c2 S(O)(=NR e2 )R b2 、NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 、SF 5 、P(O)R f2 R g2 、OP(O)(ORh2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0383] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E Substituent substitution;

[0384] The condition is that when Cy 1 When it is a 4-14 membered heterocycloalkyl group, Cy 1 The 4-14 membered heterocycloalkyl is not an unsubstituted morpholinyl;

[0385] The condition is Cy 1 Not optional R selected by 1, 2, 3 or 4 independently E Substituent substituted pyridin-4-yl;

[0386] The condition is Cy 1 Not optional R selected by 1, 2 or 3 independently E Substituent substituted pyrimidin-4-yl;

[0387] The condition is Cy 1 Not optionally selected by 1, 2, 3, 4, 5 or 6 independently selected R E Substituent substituted quinolin-4-yl;

[0388] Cy 2 C6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0389] Each R a1 , R c1 , R d1 , R a2 , R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a1 , R c1 , R d1 , R a2 , R c2 and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0390] Alternatively, any R attached to the same N atom c1 and R d1Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0391] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0392] Each R b1 and R b2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b1 , R b2 and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0393] Each R e1 and R e2 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0394] Each R f2 and R g2 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0395] Each R h2 and R i2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0396] Each R j2 and R k2 Independently selected from OH, C 1-6Alkoxy and C 1-6 Haloalkoxy;

[0397] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0398] Each R B , R C , R E , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4、C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )R b4 NR c4 S(O)R b4 NR c4 S(O)NR c4 R d4 NR c4 S(O) 2 R b4 NR c4 S(O)(=NR e4 )R b4 NR c4 S(O) 2 NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O) 2 R b4 、S(O) 2 NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O) 2 R b4 , SF 5 、P(O)R f4 R g4 OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R B , R C , R E , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0399] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0400] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0401] Each R b4 Independently selected from H, C1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0402] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0403] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0404] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0405] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0406] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0407] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 NR c5 R d5 、 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)NR c5 R d5 NR c5 S(O) 2 R b5 NR c5 S(O)(=NR e5 )R b5 NR c5 S(O) 2 NR c5 Rd5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0408] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where Ra5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0409] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0410] Each R b5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0411] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0412] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0413] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0414] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0415] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0416] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 NR c6 R d6 NR c6 C(O)R b6 NRc6 C(O)OR a6 , NR c6 C(O)NR c5 R d6 , C(=NR e6 )R b6 , C(=NR e6 )NR c6 R d6 , NR c6 C(=NR e6 )NR c6 R d6 , NR c6 C(=NR e6 )R b6 , NR c6 S(O)R b6 , NR c6 S(O)NR c6 R d6 , NR c6 S(O) 2 R b6 , NR c6 S(O)(=NR e6 )R b6 , NR c6 S(O) 2 NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O) 2 R b6 , S(O) 2 NR c6 R d6 , OS(O)(=NR e6 )R b6 , OS(O) 2 R b6 , SF 5 , P(O)R f6 R g6 , OP(O)(OR h6 )(OR i6 ), P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , wherein R I 's C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-14 aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0417] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0418] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0419] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0420] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0421] Each R f6 and R g6 Independently selected from H, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0422] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0423] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0424] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0425] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 、 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7 NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7 S(O)2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0426] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0427] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0428] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0429] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0430] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0431] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0432] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0433] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0434] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0435] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0436] In some embodiments:

[0437] X is N;

[0438] R 1 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl;

[0439] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 NR c2 R d2 NR c2 NR c2 R d2 NR c2 C(O)R b2 NR c2 C(O)OR a2 NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )NR c2 R d2 NR c2 C(=NR e2 )R b2 NR c2 S(O)NR c2 R d2 NR c2 S(O)R b2 NR c2 S(O) 2 R b2 NR c2 S(O)(=NR e2 )R b2NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O) 2 R b2 , SF 5 、P(O)R f2 R g2 OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0440] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E or R M Substituent substitution;

[0441] The condition is that when Cy 1 When it is a 4-14 membered heterocycloalkyl group, Cy1 The 4-14 membered heterocycloalkyl is not an unsubstituted morpholinyl;

[0442] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0443] Each R a2 , R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a2 , R c2 and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0444] Alternatively, any R attached to the same N atom c2 and R d2Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0445] Each R b2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0446] Each R e2 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0447] Each R f2 and R g2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0448] Each R h2 and R i2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0449] Each R j2 and R k2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0450] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0451] Each R C , R E , R M , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 NR c4 R d4 、 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )R b4 NR c4 S(O)Rb4 NR c4 S(O)NR c4 R d4 NR c4 S(O) 2 R b4 NR c4 S(O)(=NR e4 )R b4 NR c4 S(O) 2 NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O) 2 R b4 、S(O) 2 NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O) 2 R b4 , SF 5 、P(O)R f4 R g4 OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R C , R E , R M , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0452] Each R a4 , R c4 and Rd4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0453] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0454] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0455] Each R e4 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0456] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0457] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0458] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0459] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0460] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHORa5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 、NR c5 R d5 、NR c5 NR c5 R d5 、NR c5 C(O)R b5 、NR c5 C(O)OR a5 、NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NR e5 )NR c5 R d5 、NR c5 C(=NR e5 )NR c5 R d5 、NR c5 C(=NR e5 )R b5 、NR c5 S(O)R b5 、NR c5 S(O)NR c5 R d5 、NR c5 S(O) 2 R b5 、NR c5 S(O)(=NR e5 )R b5 、NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 Rb5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0461] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0462] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0463] Each R b5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0464] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0465] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0466] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0467] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0468] Alternatively, any R attached to the same B atomj5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0469] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 NHOR a6 、C(O)R b6 、C(O)NR c6 R d6 、C(O)NR c6 (OR a6 )、C(O)OR a6 、OC(O)R b6 、OC(O)NR c6 R d6 NR c6 R d6 NR c6 NR c6 R d6 NR c6 C(O)R b6 NR c6 C(O)OR a6 NR c6 C(O)NR c5 R d6 、C(=NR e6 )R b6 、C(=NR e6 )NR c6 R d6 NR c6 C(=NR e6 )NR c6 R d6 NRc6 C(=NR e6 )R b6 NR c6 S(O)R b6 NR c6 S(O)NR c6 R d6 NR c6 S(O) 2 R b6 NR c6 S(O)(=NR e6 )R b6 NR c6 S(O) 2 NR c6 R d6 、S(O)R b6 、S(O)NR c6 R d6 、S(O) 2 R b6 、S(O) 2 NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 , SF 5 、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0470] Each R a6 , R c6 and Rd6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0471] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0472] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0473] Each R e6 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0474] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0475] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0476] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0477] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0478] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHORa7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 、NR c7 R d7 、NR c7 NR c7 R d7 、NR c7 C(O)R b7 、NR c7 C(O)OR a7 、NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NR e7 )NR c7 R d7 、NR c7 C(=NR e7 )NR c7 R d7 、NR c7 C(=NR e7 )R b7 、NR c7 S(O)R b7 、NR c7 S(O)NR c7 R d7 、NR c7 S(O) 2 R b7 、NR c7 S(O)(=NR e7 )R b7 、NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 Rb7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0479] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0480] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0481] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0482] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0483] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0484] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0485] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0486] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0487] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-; and

[0488] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0489] In some embodiments:

[0490] X is N;

[0491] R 1 Selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and C 1-6 Haloalkyl;

[0492] R 2 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2、NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 R d2 、NR c2 R d2 、NR c2 NR c2 R d2 、NR c2 C(O)R b2 、NR c2 C(O)OR a2 、NR c2 C(O)NR c2 R d2 、C(=NR e2 )R b2 、C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )NR c2 R d2 、NR c2 C(=NR e2 )R b2 、NR c2 S(O)NR c2 R d2 、NR c2 S(O)R b2 、NR c2 S(O) 2 R b2 、NR c2 S(O)(=NR e2 )R b2 、NR c2 S(O) 2 NR c2 R d2 、S(O)R b2 、S(O)NR c2 R d2 、S(O) 2 R b2 、S(O) 2 NR c2 R d2 、OS(O)(=NR e2 )R b2 、OS(O)2 R b2 , SF 5 、P(O)R f2 R g2 OP(O)(OR h2 )(OR i2 )、P(O)(OR h2 )(OR i2 ) and BR j2 R k2 , where R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution;

[0493] Cy 1 C 6-14 Aryl, C 3-14 Cycloalkyl or 5-14 membered heteroaryl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl or 5-14 membered heteroaryl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R E or R M Substituent substitution;

[0494] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution;

[0495] Each R a2 , R c2 and R d2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a2 , R c2 and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0496] Alternatively, any R attached to the same N atom c2 and R d2 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0497] Each R b2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where Rb2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R G Substituent substitution;

[0498] Each R e2 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0499] Each R f2 and R g2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C1-6 alkyl-;

[0500] Each R h2 and R i2 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0501] Each R j2 and R k2 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0502] Alternatively, any R attached to the same B atom j2 and R k2 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0503] Each R C , R E , R M , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a4 , SR a4、NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)NR c4 (OR a4 )、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 、NR c4 R d4 、NR c4 NR c4 R d4 、NR c4 C(O)R b4 、NR c4 C(O)OR a4 、NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e4 )NR c4 R d4 、NR c4 C(=NR e4 )NR c4 R d4 、NR c4 C(=NR e4 )R b4 、NR c4 S(O)R b4 、NR c4 S(O)NR c4 R d4 、NR c4 S(O) 2 R b4 、NR c4 S(O)(=NR e4 )R b4 、NR c4 S(O) 2 NR c4 R d4 、S(O)R b4 、S(O)NR c4 R d4 、S(O) 2 R b4 、S(O) 2 NR c4 R d4 、OS(O)(=NR e4 )R b4 、OS(O)2 R b4 , SF 5 、P(O)R f4 R g4 OP(O)(OR h4 )(OR i4 )、P(O)(OR h4 )(OR i4 ) and BR j4 R k4 , where R C , R E , R M , R F and R G C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0504] Each R a4 , R c4 and R d4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a4 , R c4 and R d4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0505] Alternatively, any R attached to the same N atom c4 and R d4 Together with the N atom to which it is attached, it is optionally taken together to form a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally replaced by 1, 2, 3 or 4 independently selected R H Substituent substitution;

[0506] Each R b4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b4 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R H Substituent substitution;

[0507] Each R e4Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0508] Each R f4 and R g4 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0509] Each R h4 and R i4 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0510] Each R j4 and R k4 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0511] Alternatively, any R attached to the same B atom j4 and R k4 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0512] Each R H are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a5 , SR a5 NHOR a5 、C(O)R b5 、C(O)NR c5 R d5 、C(O)NR c5 (OR a5 )、C(O)OR a5 、OC(O)R b5 、OC(O)NR c5 R d5 NR c5 R d5 NR c5 NR c5 R d5 NR c5 C(O)R b5 NR c5 C(O)OR a5 NR c5 C(O)NR c5 R d5 、C(=NR e5 )R b5 、C(=NRe5 )NR c5 R d5 NR c5 C(=NR e5 )NR c5 R d5 NR c5 C(=NR e5 )R b5 NR c5 S(O)R b5 NR c5 S(O)NR c5 R d5 NR c5 S(O) 2 R b5 NR c5 S(O)(=NR e5 )R b5 NR c5 S(O) 2 NR c5 R d5 、S(O)R b5 、S(O)NR c5 R d5 、S(O) 2 R b5 、S(O) 2 NR c5 R d5 、OS(O)(=NR e5 )R b5 、OS(O) 2 R b5 , SF 5 、P(O)R f5 R g5 OP(O)(OR h5 )(OR i5 )、P(O)(OR h5 )(OR i5 ) and BR j5 R k5 , where R H C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0513] Each R a5 , R c5 and R d5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a5 , R c5 and R d5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0514] Alternatively, any R attached to the same N atom c5 and R d5 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0515] Each R b5 Independently selected from H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b5 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R I Substituent substitution;

[0516] Each R e5 Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0517] Each R f5 and R g5 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0518] Each R h5 and R i5 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0519] Each R j5 and R k5 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0520] Alternatively, any R attached to the same B atom j5 and R k5 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0521] Each R I are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4- to 14-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a6 , SR a6 , NHOR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)NR c6 (OR a6 ), C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R d6 , NR c6 R d6 , NR c6 , NR c6 R d6 , NR c6 , C(O)R b6 , NR c6 , C(O)OR a6 , NR c6 , C(O)NR c5 R d6 , C(=NR e6 )R b6 , C(=NR e6 ), NR c6 R d6 , NR c6 , C(=NR e6 ), NR c6 R d6 , NR c6 , C(=NR e6 )R b6 , NR c6 , S(O)R b6 , NR c6 , S(O)NR c6 R d6 , NR c6 , S(O) 2 R b6 , NR c6 , S(O)(=NR e6 )R b6 , NR c6 , S(O) 2 , NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O) 2 R b6 , S(O) 2NR c6 R d6 、OS(O)(=NR e6 )R b6 、OS(O) 2 R b6 , SF 5 、P(O)R f6 R g6 OP(O)(OR h6 )(OR i6 )、P(O)(OR h6 )(OR i6 ) and BR j6 R k6 , where R I C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0522] Each R a6 , R c6 and R d6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a6 , R c6 and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0523] Alternatively, any R attached to the same N atom c6 and R d6 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0524] Each R b6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R J Substituent substitution;

[0525] Each R e6Independently selected from H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0526] Each R f6 and R g6 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0527] Each R h6 and R i6 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0528] Each R j6 and R k6 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0529] Alternatively, any R attached to the same B atom j6 and R k6 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0530] Each R J are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a7 , SR a7 NHOR a7 、C(O)R b7 、C(O)NR c7 R d7 、C(O)NR c7 (OR a7 )、C(O)OR a7 、OC(O)R b7 、OC(O)NR c7 R d7 NR c7 R d7 NR c7 NR c7 R d7 NR c7 C(O)R b7 NR c7 C(O)OR a7 NR c7 C(O)NR c7 R d7 、C(=NR e7 )R b7 、C(=NRe7 )NR c7 R d7 NR c7 C(=NR e7 )NR c7 R d7 NR c7 C(=NR e7 )R b7 NR c7 S(O)R b7 NR c7 S(O)NR c7 R d7 NR c7 S(O) 2 R b7 NR c7 S(O)(=NR e7 )R b7 NR c7 S(O) 2 NR c7 R d7 、S(O)R b7 、S(O)NR c7 R d7 、S(O) 2 R b7 、S(O) 2 NR c7 R d7 、OS(O)(=NR e7 )R b7 、OS(O) 2 R b7 , SF 5 、P(O)R f7 R g7 OP(O)(OR h7 )(OR i7 )、P(O)(OR h7 )(OR i7 ) and BR j7 R k7 , where R J C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0531] Each R a7 , R c7 and R d7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R a7 , R c7 and R d7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0532] Alternatively, any R attached to the same N atom c7 and R d7 Together with the N atom to which it is attached, it forms a 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl, wherein the 5- or 6-membered heteroaryl or 4-14-membered heterocycloalkyl is optionally substituted by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0533] Each R b7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where R b7 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3 or 4 independently selected R K Substituent substitution;

[0534] Each R e7 Independently selected from H, OH, CN, C 1-6 Alkyl, C 2-6 Alkenyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl;

[0535] Each R f7 and R g7 Independently selected from H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0536] Each R h7 and R i7 Independently selected from H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;

[0537] Each R j7 and R k7 Independently selected from OH, C 1-6 Alkoxy and C 1-6 Haloalkoxy;

[0538] Alternatively, any R attached to the same B atom j7 and R k7 Together with the B atom to which it is attached, it forms a 1-6 Alkyl and C 1-6 A 5-membered or 6-membered heterocycloalkyl group substituted with a haloalkyl group;

[0539] Each R K independently selected from H, D, OH, halo, oxo, CN, C(O)OH, NH 2 、NO 2 , SF 5 , C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C1-6 Alkyl-; and

[0540] Any heteroaryl group of any of the above substituents optionally contains an N-oxide on any ring nitrogen.

[0541] In some embodiments, the compound of formula (I) is a compound of formula (II):

[0542]

[0543] or a pharmaceutically acceptable salt thereof.

[0544] In some embodiments, the compound of formula (I) is a compound of formula (III):

[0545]

[0546] or a pharmaceutically acceptable salt thereof.

[0547] In some embodiments, Cy 1 C 6-14 Aryl, wherein the C 6-14 Aryl is optionally substituted with 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0548] In some embodiments, Cy 1 C 3-14 Cycloalkyl, wherein the C 3-14 Cycloalkyl is optionally substituted with 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0549] In some embodiments, Cy 1 is a 5-14 membered heteroaryl group, wherein the 5-14 membered heteroaryl group is optionally substituted by 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0550] In some embodiments, Cy 1 is a 4-14 membered heterocycloalkyl group, wherein the 4-14 membered heterocycloalkyl group is optionally substituted by 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0551] In some embodiments, Cy 1 C 6-10 Aryl, wherein the C 6-10 Aryl is optionally substituted with 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0552] In some embodiments, Cy 1 C 3-7 Cycloalkyl, wherein the C3-7 Cycloalkyl is optionally substituted with 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0553] In some embodiments, Cy 1 is a 5-10 membered heteroaryl group, wherein the 5-10 membered heteroaryl group is optionally substituted by 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0554] In some embodiments, Cy 1 is a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted by 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0555] In some embodiments, Cy 1 is phenyl or 5-10 membered heteroaryl, wherein the phenyl or 5-10 membered heteroaryl is optionally substituted by 1, 2, 3 or 4 independently selected R E Substituent substitution.

[0556] In some embodiments, Cy 1 is optionally 1, 2, 3 or 4 independently selected R M Substituent-substituted phenyl or C 7-14 aryl or 5-14 membered heteroaryl, wherein the C 7-14 Aryl and 5-14 membered heteroaryl are optionally substituted with 1, 2, 3 or 4 independently selected R E Substituents are substituted, and

[0557] Each R M are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 2-CN, 3-CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)OR a4 、OC(O)R b4 、OC(O)NR c4 R d4 NR c4 R d4 NRc4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e4 )NR c4 R d4 NR c4 C(=NR e4 )NR c4 R d4 NR c4 S(O)R b4 NR c4 S(O) 2 R b4 and NR c4 S(O) 2 NR c4 R d4 , where R M C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, each optionally substituted with 1, 2, 3 or 4 independently selected R H Substituent substitution.

[0558] In some embodiments, Cy 1 selected from phenyl, pyridyl, furyl, benzofuranyl and pyrazolyl, each of which is optionally substituted by 1, 2 or 3 selected from C 1-3 Alkyl, halide, CN and C 1-3 The substituents of the alkoxy group are substituted.

[0559] In some embodiments, the optionally substituted Cy 1 is selected from cyanophenyl, cyanofluorophenyl, 2,3-dihydro-1H-pyrrolo[2,3,-b]pyridine, phenyl, methoxyphenyl, fluorophenyl, pyridyl, methylfuranyl, benzofuranyl and methyl-1H-pyrazolyl.

[0560] In some embodiments, the optionally substituted Cy 1 is selected from cyanophenyl, 2,3-dihydro-1H-pyrrolo[2,3,-b]pyridine, phenyl, methoxyphenyl, fluorophenyl, pyridyl, methylfuranyl, benzofuranyl and methyl-1H-pyrazolyl.

[0561] In some embodiments, Cy 1 Selected from 2-cyanophenyl, 3-cyanophenyl, 3-cyano-2-fluorophenyl, 2,3-dihydro-1H-pyrrolo[2,3,-b]pyridine, phenyl, 3-methoxyphenyl, 2-fluorophenyl, pyridin-4-yl, 2-methylfuran-3-yl, benzofuran-2-yl and 1-methyl-1H-pyrazol-4-yl.

[0562] In some embodiments, the optionally substituted Cy 1 Selected from 2-cyanophenyl, 3-cyanophenyl, 2,3-dihydro-1H-pyrrolo[2,3,-b]pyridine, phenyl, 3-methoxyphenyl, 2-fluorophenyl, pyridin-4-yl, 2-methylfuran-3-yl, benzofuran-2-yl and 1-methyl-1H-pyrazol-4-yl.

[0563] In some embodiments, the optionally substituted Cy 1 Selected from 3-cyanophenyl and phenyl.

[0564] In some embodiments, Cy 1 It is 3-cyanophenyl.

[0565] In some embodiments, Cy 2 C 6-14 Aryl, C 4-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein C 6-14 Aryl, C 4-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl are optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R F Substituent substitution.

[0566] In some embodiments, Cy 2 C 6-14 Aryl, wherein the C 6-14 Aryl is optionally substituted with 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0567] In some embodiments, Cy 2 C 3-14 Cycloalkyl, wherein the C 3-14 Cycloalkyl is optionally substituted with 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0568] In some embodiments, Cy 2 is a 5-14 membered heteroaryl group, wherein the 5-14 membered heteroaryl group is optionally substituted by 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0569] In some embodiments, Cy 2 is a 4-14 membered heterocycloalkyl group, wherein the 4-14 membered heterocycloalkyl group is optionally substituted by 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0570] In some embodiments, Cy 2 C 6-10 Aryl, wherein the C 6-10 Aryl is optionally substituted with 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0571] In some embodiments, Cy 2 C 3-7 Cycloalkyl, wherein the C 3-7 Cycloalkyl is optionally substituted with 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0572] In some embodiments, Cy 2 is a 5-10 membered heteroaryl group, wherein the 5-10 membered heteroaryl group is optionally substituted by 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0573] In some embodiments, Cy 2 is a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted by 1, 2, 3 or 4 independently selected R F Substituent substitution.

[0574] In some embodiments, Cy 2 Selected from C 3-6 Cycloalkyl, phenyl, 5-10 membered heteroaryl and 5-10 membered heterocycloalkyl;

[0575] wherein the 5-10 membered heteroaryl and the 5-10 membered heterocycloalkyl each contain one, two or three nitrogen atoms as ring-forming heteroatoms, wherein one of the one or two nitrogen atoms is optionally an N-oxide, and wherein the ring-forming carbon atoms are optionally substituted with oxo; and

[0576] Wherein C 3-6 Cycloalkyl, phenyl, 5-10 membered heteroaryl and 5-10 membered heterocycloalkyl are each optionally substituted by 1, 2 or 3 groups selected from C 1-3 Alkyl, C 1-3 Alkyl-OH, halogen, CN, C 1-3 Alkoxy and C(O)NH 2 substituted by a substituent.

[0577] In some embodiments, Cy 2 Selected from C 3-6Cycloalkyl, phenyl, 5-10 membered heteroaryl and 5-10 membered heterocycloalkyl;

[0578] wherein the 5-10 membered heteroaryl and the 5-10 membered heterocycloalkyl each contain one or two nitrogen atoms as ring-forming heteroatoms, wherein one of the one or two nitrogen atoms is optionally an N-oxide, and wherein the ring-forming carbon atoms are optionally substituted with oxo; and

[0579] Wherein C 3-6 Cycloalkyl, C 6 -aryl, 5-10 membered heteroaryl and 5-10 membered heterocycloalkyl are each optionally substituted by 1, 2 or 3 groups selected from C 1-3 Alkyl, halogen, CN, C 1-3 Alkoxy and C(O)NH 2 substituted by a substituent.

[0580] In some embodiments, Cy 2 selected from pyridyl, tetrahydropyridyl, piperidinyl, pyridine-N-oxide, oxo-dihydropyridinyl, phenyl, pyrazolo[1,5-a]pyridin-3-yl, pyrazolo[1,5-b]pyridazinyl, pyrazolyl, pyrimidinyl, quinolyl, oxazolyl, 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl and triazolyl, each of which is optionally substituted by 1, 2 or 3 selected from C 1-3 Alkyl, C 1-3 Alkyl-OH, halogen, CN, C 1-3 Alkoxy and C(O)NH 2 Substituent substitution

[0581] In some embodiments, Cy 2 selected from pyridyl, tetrahydropyridyl, piperidinyl, pyridine-N-oxide, oxo-dihydropyridinyl, phenyl, pyrazolo[1,5-a]pyridin-3-yl, pyrazolo[1,5-b]pyridazinyl, pyrazolyl, pyrimidinyl, quinolyl, oxazolyl and 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl, each of which is optionally substituted by 1, 2 or 3 selected from C 1-3 Alkyl, halogen, CN, C 1-3 Alkoxy and C(O)NH 2 substituted by a substituent.

[0582] In some embodiments, Cy 2 selected from pyridinyl, tetrahydropyridinyl, piperidinyl, pyridine-N-oxide, oxo-dihydropyridinyl, phenyl, pyrazolo[1,5-a]pyridin-3-yl, pyrazolyl, pyrimidinyl and 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl, each of which is optionally substituted by 1, 2 or 3 selected from C 1-3 Alkyl, halogen, CN, C1-3 Alkoxy and C(O)NH 2 substituted by a substituent.

[0583] In some embodiments, Cy 2 is optionally 1, 2 or 3 selected from C 1-3 Alkyl, halogen, CN, C 1-3 Alkoxy and C(O)NH 2 substituted by a substituent.

[0584] In some embodiments, the optionally substituted Cy 2 selected from 2,6-dimethylpyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 1-carbamoyl-1,2,3,6-tetrahydropyridin-4-yl, 1-carbamoylpiperidin-4-yl, 2-methoxypyridin-4-yl, 2-methoxy-6-methylpyridin-4-yl, 2,6-dimethylpyridin-4-yl-1-oxide, 1-ethyl-6-oxo-1,6-dihydropyridin-3-yl, 3-methylpyridin-4-yl, 3-fluoropyridin-4-yl, 3-chloropyridin-4-yl, 3-methoxypyridin-4-yl, 3-cyanopyridin-4-yl, 4-carbamoylphenyl, pyrazolo[1,5-a]pyridin-3-yl, pyrazolo[1,5- b]pyridazin-3-yl, 5-methyl-1H-pyrazol-4-yl, 1-ethyl-1H-pyrazol-5-yl, 1-isopropyl-1H-pyrazol-5-yl, 1-propyl-1H-pyrazol-5-yl, pyrimidin-4-yl, 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl, quinolin-5-yl, 5-fluoropyrimidin-4-yl, oxazol-5-yl, 4-methyloxazol-5-yl, 4-ethyloxazol-5-yl, 4-(hydroxymethyl)-2-methyloxazol-5-yl, 4-(methoxymethyl)-2-methyloxazol-5-yl, 4-(hydroxymethyl)-2-methyloxazol-5-yl, 1-ethyl-1H-1,2,3-triazol-5-yl and cyclopropyl

[0585] In some embodiments, the optionally substituted Cy 2Selected from 2,6-dimethylpyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 1-carbamoyl-1,2,3,6-tetrahydropyridin-4-yl, 1-carbamoylpiperidin-4-yl, 2-methoxypyridin-4-yl, 2-methoxy-6-methylpyridin-4-yl, 2,6-dimethylpyridin-4-yl-1-oxide, 1-ethyl-6-oxo-1,6-dihydropyridin-3-yl, 3-methylpyridin-4-yl, 3-fluoropyridin-4-yl, 3-chloropyridin-4-yl, 3-methoxypyridin-4-yl, 3-cyanopyridin-4-yl, 4-carbamoyl Phenyl, pyrazolo[1,5-a]pyridin-3-yl, pyrazolo[1,5-b]pyridazin-3-yl, 5-methyl-1H-pyrazol-4-yl, 1-ethyl-1H-pyrazol-5-yl, 1-isopropyl-1H-pyrazol-5-yl, 1-propyl-1H-pyrazol-5-yl, pyrimidin-4-yl, 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl, quinolin-5-yl, 5-fluoropyrimidin-4-yl, 4-methyloxazol-5-yl, 4-(hydroxymethyl)-2-methyloxazol-5-yl, 4-(methoxymethyl)-2-methyloxazol-5-yl and cyclopropyl.

[0586] In some embodiments, the optionally substituted Cy 2 Selected from 2,6-dimethylpyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 1-carbamoyl-1,2,3,6-tetrahydropyridin-4-yl, 1-carbamoylpiperidin-4-yl, 2-methoxypyridin-4-yl, 2,6-dimethylpyridin-4-yl-1-oxide, 1-ethyl-6-oxo-1,6-dihydropyridin-3-yl, 3-methylpyridin-4-yl, 3-fluoropyridin-4-yl, 3-chloropyridin- 4-yl, 3-methoxypyridin-4-yl, 3-cyanopyridin-4-yl, 4-carbamoylphenyl, pyrazolo[1,5-a]pyridin-3-yl, 5-methyl-1H-pyrazol-4-yl, 1-ethyl-1H-pyrazol-5-yl, 1-isopropyl-1H-pyrazol-5-yl, 1-propyl-1H-pyrazol-5-yl, pyrimidin-4-yl, 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl and cyclopropyl.

[0587] In some embodiments, R 1 Selected from H, D, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a1 、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、C(=NR e1 )R b1 、C(=NR e1 )NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O) 2 R b1 and S(O) 2 NR c1 R d1 , where R 1 C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R B Substituent substitution.

[0588] In some embodiments, R 1 Selected from H, D, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-8 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-8 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a1、C(O)R b1 、C(O)NR c1 R d1 、C(O)OR a1 、C(=NR e1 )R b1 、C(=NR e1 )NR c1 R d1 、S(O)R b1 、S(O)NR c1 R d1 、S(O) 2 R b1 and S(O) 2 NR c1 R d1 , where R 1 C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-8 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-8 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R B Substituent substitution.

[0589] In some embodiments, R 1 Selected from H, C 1-6 alkyl and 5-8 membered heteroaryl, wherein the 5-8 membered heteroaryl is optionally substituted by 1 or 2 independently selected R B Substituent substitution.

[0590] In some embodiments, R 1 H, C 1-6 Alkyl or 5-8 membered heteroaryl

[0591] In some embodiments, R 1 H or C 1-6 alkyl.

[0592] In some embodiments, R 1 H or C 1-3 alkyl.

[0593] In some embodiments, R 1 It is H, ethyl or nicotine nitrile.

[0594] In some embodiments, R1 It is H or ethyl.

[0595] In some embodiments, R 1 For H.

[0596] In some embodiments, R 1 is 1 or 2 independently selected R B The substituent is a 5- to 8-membered heteroaryl group substituted with a substituent.

[0597] In some embodiments, R 1 It is a 5-8 membered heteroaryl group.

[0598] In some embodiments, R 1 Optional 1 or 2 R B The substituent is substituted pyridinyl.

[0599] In some embodiments, R 1 is pyridinyl optionally substituted by cyano.

[0600] In some embodiments, R 1 It is nicotine nitrile.

[0601] In some embodiments, R 1 It is 3-cyanopyridinyl.

[0602] In some embodiments, R 2 Selected from halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a2 , SR a2 NHOR a2 、C(O)R b2 、C(O)NR c2 R d2 、C(O)NR c2 (OR a2 )、C(O)OR a2 、OC(O)R b2 、OC(O)NR c2 Rd2 , NR c2 R d2 , NR c2 NR c2 R d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , C(=NR e2 )R b2 , C(=NR e2 )NR c2 R d2 , NR c2 C(=NR e2 )NR c2 R d2 , NR c2 C(=NR e2 )R b2 , NR c2 S(O)NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O)(=NR e2 )R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , S(O) 2 NR c2 R d2 , OS(O)(=NR e2 )R b2 , OS(O) 2 R b2 , SF 5 , P(O)R f2 R g2 , OP(O)(OR h2 )(OR i2 ), P(O)(OR h2 )(OR i2 ) and BR j2 Rk2 , wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituents are substituted; and

[0603] Wherein C 1-6 The alkyl group is replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R C Substituent substitution.

[0604] In some embodiments, R 2 Selected from C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b2 、C(O)NR c2 R d2 、C(O)OR a2 and NR c2 R d2 , where C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4 or 5 independently selected R C Substituents are substituted; and

[0605] Wherein C1-6 The alkyl group is replaced by 1, 2, 3, 4 or 5 independently selected R C Substituent substitution.

[0606] In some embodiments, R 2 Selected from C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b2 、C(O)NR c2 R d2 、C(O)OR a2 and NR c2 R d2 , where C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4 or 5 independently selected R C Substituent substitution.

[0607] In some embodiments, R 2 Selected from C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, where C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4 or 5 independently selected R C Substituent substitution.

[0608] In some embodiments, R 2 Selected from H, C 1-6 Alkyl, C 3-14 Cycloalkyl, C 6-14 Aryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-、NR c2 R d2 、C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where C 1-6 Alkyl, C 3-14 Cycloalkyl, C 6-14 Aryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2 or 3 independently selected R C Substituent substitution.

[0609] In some embodiments, R 2 Selected from H, C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a2 NR c2 R d2 、C(O)R b2 、C(O)NRc2 R d2 and C(O)OR a2 , where C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2 or 3 independently selected R C Substituent substitution.

[0610] In some embodiments, R 2 Selected from H, C 1-6 Alkyl, C 6-14 Aryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-、NR c2 R d2 、C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where C 1-6 Alkyl, C 6-14 Aryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2 or 3 independently selected R C Substituent substitution.

[0611] In some embodiments, R 2 Selected from H, C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a2 NR c2 R d2 、C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl - each of which is independently selected by 1, 2 or 3 R C Substituent substitution

[0612] In some embodiments, R 2 Selected from H, C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-、NR c2 R d2 、C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where C 1-6 Alkyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl - each of which is independently selected by 1, 2 or 3 R C Substituent substitution.

[0613] In some embodiments, R 2 Selected from H, C 6-14 Aryl, 5-14 membered heteroaryl, C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where C 6-14 Aryl and 5-14 membered heteroaryl are each optionally substituted with 1, 2 or 3 independently selected R C Substituent substitution.

[0614] In some embodiments, R 2 Selected from H, C 1-6 Alkyl, phenyl, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-、NR c2 R d2 、C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where C 1-6 Alkyl, phenyl, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4-10 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1 or 2 independently selected R C In some embodiments, R 2 Selected from H, phenyl, 5-6 membered heteroaryl, C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 wherein the phenyl and 5-6 membered heteroaryl groups are each optionally substituted by 1 or 2 independently selected R C Substituent substitution.

[0615] In some embodiments, R 2 Selected from H, C(O)OEt, CONH 2 and C(O)NHEt.

[0616] In some embodiments, R 2 is selected from phenyl and 5-6 membered heteroaryl, each of which is optionally substituted with C(O)OMe.

[0617] In some embodiments, the optionally substituted R 2 is selected from the group consisting of pyridylmethyl, hydroxy(phenyl)methyl, hydroxyethylamino(phenyl)ethyl, cyclohexylmethyl, fluorobenzyl, hydroxy(fluorophenyl)methyl, (methylpyridyl)methyl, (fluoropyridyl)methyl, (trifluoromethylpyridyl)methyl, ((hydroxymethyl)pyridyl)methyl, (methoxypyridyl)methyl, (methylpyrazolyl)benzyl, (methylpyrazolyl)methyl, benzisoxazolylmethyl, (methylindazolyl)methyl, (hydroxyazetidinyl)methyl, benzoyl, phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuranyl, phenyl(pyridyloxy)methyl, Fluoro((fluorohydroxypyrrolidinyl)methyl)benzyl, ((carboxypiperidinyl)methyl)fluorobenzyl, fluoro((N-methylmethylsulfonylamino)methyl)benzyl, ((dioxoimidazolidinyl)methyl)fluorobenzyl, (difluorophenyl)(hydroxy)methyl, (pyridinyl-1H-tetrazolyl)methyl, (pyrazolyl-1H-tetrazolyl)methyl, (thiazolyl-1H-tetrazolyl)methyl, (methyltrifluoromethylpyrazolyl)methyl, ((1,1-dioxoisothiazolidinyl)methyl)fluorobenzyl, ((methyl-2,5-dioxoimidazolidinyl)methyl)benzyl, and (cyanophenoxy)methyl.

[0618] In some embodiments, the optionally substituted R 2 is selected from pyridylmethyl, hydroxy(phenyl)methyl, hydroxyethylamino(phenyl)ethyl, cyclohexylmethyl, fluorobenzyl, hydroxy(fluorophenyl)methyl, (methylpyridyl)methyl, (fluoropyridyl)methyl, (methoxypyridyl)methyl, (methylpyrazolyl)benzyl, benzisoxazolylmethyl, (methylindazolyl)methyl, (hydroxyazetidinyl)methyl, benzoyl, phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuranyl, phenyl(pyridyloxy)methyl, fluoro((fluorohydroxypyrrolidinyl)methyl)benzyl, ((carboxypiperidinyl)methyl)fluorobenzyl, fluoro((N-methylmethylsulfonylamino)methyl)benzyl, ((dioxoimidazolidinyl)methyl)fluorobenzyl and (difluorophenyl)(hydroxy)methyl.

[0619] In some embodiments, R 2 Selected from pyridylmethyl, hydroxy(phenyl)methyl, hydroxyethylamino(phenyl)ethyl, cyclohexylmethyl, fluorobenzyl, hydroxy(fluorophenyl)methyl, (methylpyridyl)methyl, (fluoropyridyl)methyl, (methoxypyridyl)methyl, (methylpyrazolyl)benzyl, benzisoxazolylmethyl, (methylindazolyl)methyl, (hydroxyazetidinyl)methyl, benzoyl, phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuranyl and phenyl(pyridyloxy)methyl.

[0620] In some embodiments, R 2 for

[0621] In some embodiments, R 2 pyridin-2-ylmethyl, hydroxy(phenyl)methyl, (2-hydroxyethylamino)(phenyl)methyl, cyclohexylmethyl, 2-fluorobenzyl, (2-fluorophenyl)(hydroxy)methyl, (6-methylpyridin-2-yl)methyl, (3-fluoropyridin-2-yl)methyl, (3-methoxypyridin-2-yl)methyl, 2-(1-methyl-1H-pyrazol-4-yl)benzyl, benzo[d]isoxazol-3-ylmethyl, (1-methyl-1H-indazol-3-yl)methyl, (3-hydroxy azetidin-1-yl)methyl, benzoyl, 1-phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-yl, phenyl(pyridin-2-yloxy)methyl, 2-fluoro-6-(((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methyl)benzyl, 2-((4-carboxypiperidin-1-yl)methyl)-6-fluorobenzyl, 2-fluoro-6-((N-methylmethylsulfonylamino)methyl)benzyl, 2-((2,5-dioxolidin-1-yl)imidazolidin-1-yl)methyl -yl)methyl)-6-fluorobenzyl, (2,6-difluorophenyl)(hydroxy)methyl, (5-(pyridin-2-yl)-1H-tetrazol-1-yl)methyl, (5-(1H-pyrazol-1-yl)-1H-tetrazol-1-yl)methyl, (5-(thiazol-4-yl)-1H-tetrazol-1-yl)methyl, (5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl, (3-methylpyridin-2-yl)methyl, 2-((1,1-dioxoisothiazolidine- 2-((3-methyl-2,5-dioxolidin-1-yl)methyl)benzyl, (6-(trifluoromethyl)pyridin-2-yl)methyl, (3-(hydroxymethyl)pyridin-2-yl)methyl, (1-methyl-1H-pyrazol-3-yl)methyl and (2-cyanophenoxy)methyl, (3-methylpyridin-2-yl)methoxy, (6-methylpyridin-2-yl)methoxy and ((3-methylpyridin-2-yl)methyl)amino.

[0622] In some embodiments, R 2methyl, (2-hydroxyethylamino)(phenyl)methyl, cyclohexylmethyl, 2-fluorobenzyl, (2-fluorophenyl)(hydroxy)methyl, (6-methylpyridin-2-yl)methyl, (3-fluoropyridin-2-yl)methyl, (3-methoxypyridin-2-yl)methyl, 2-(1-methyl-1H-pyrazol-4-yl)benzyl, benzo[d]isoxazol-3-ylmethyl, (1-methyl-1H-indazol-3-yl)methyl, (3-hydroxyazetidin-1-yl)methyl, phenyl acyl, 1-phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-yl, phenyl(pyridin-2-yloxy)methyl, 2-fluoro-6-(((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methyl)benzyl, 2-((4-carboxypiperidin-1-yl)methyl)-6-fluorobenzyl, 2-fluoro-6-((N-methylmethylsulfonylamino)methyl)benzyl, 2-((2,5-dioxoimidazolidin-1-yl)methyl)-6-fluorobenzyl and (2,6-difluorophenyl)(hydroxy)methyl.

[0623] In some embodiments, R 2 selected from pyridin-2-ylmethyl, hydroxy(phenyl)methyl, 2-hydroxyethylamino)(phenyl)methyl, cyclohexylmethyl, 2-fluorobenzyl, 2-fluorophenyl)(hydroxy)methyl, 6-methylpyridin-2-yl)methyl, 3-fluoropyridin-2-yl)methyl, 3-methoxypyridin-2-yl)methyl, 2-(1-methyl-1H-pyrazol-4-yl)benzyl, benzo[d]isoxazol-3-ylmethyl, 1-methyl-1H-indazol-3-yl)methyl, 3-hydroxyazetidin-1-yl)methyl, benzoyl, 1-phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-yl and phenyl(pyridin-2-yloxy)methyl.

[0624] In some embodiments, R a2 Selected from H and C 1-6 Alkyl, wherein the C 1-6 The alkyl group is optionally substituted with 1, 2 or 3 independently selected R H Substituent substitution.

[0625] In some embodiments, R b2 Selected from H, C 1-6 Alkyl, C 6-14 Aryl and 4-14 membered heterocycloalkyl, wherein the C 1-6 Alkyl, C 6-14 Aryl and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2 or 3 independently selected R G Substituent substitution.

[0626] In some embodiments, R c2 and Rd2 Each independently selected from H, C 1-6 Alkyl, 5-14 membered heteroaryl and C 6-14 Aryl-C 1-6 Alkyl-, wherein the C 1-6 Alkyl, 5-14 membered heteroaryl and C 6-14 Aryl-C 1-6 alkyl-each optionally replaced by 1, 2 or 3 independently selected R G Substituent substitution.

[0627] In some embodiments, each R G Independently selected from CN, OR a4 and C 1-6 Alkyl, wherein the C 1-6 The alkyl group is optionally substituted with 1, 2 or 3 independently selected R H Substituent substitution.

[0628] In some embodiments, each R C independently selected from halogen, C 1-6 Alkyl, C 6-14 Aryl, 5-14 membered heteroaryl, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a4 、C(O)OR a4 and NR c4 R d4 , wherein the C 1-6 alkyl, 5-14 membered heteroaryl and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl - optionally replaced by 1, 2 or 3 independently selected R H Substituent substitution.

[0629] In some embodiments, each R C independently selected from halogen, C 1-6 Alkyl, C 6-14 Aryl, 5-14 membered heteroaryl, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, OR a4 、C(O)OR a4 and NR c4 R d4 , wherein the C 1-6 alkyl, 5-14 membered heteroaryl and (4-14 membered heterocycloalkyl)-C 1-6 Alkyl - 1, 2 or 3 independently selected R H Substituent substitution.

[0630] In some embodiments, R a4 Selected from H, C 1-6 Alkyl, C 6-14Aryl and 5-14 membered heteroaryl.

[0631] In some embodiments, each R c4 and R d4 Independently selected from H and C 1-6 Alkyl, wherein the C 1-6 The alkyl group is optionally substituted with 1, 2 or 3 independently selected R H Substituent substitution.

[0632] In some embodiments, each R H are independently selected from halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, OR a5 、C(O)OR a5 and NR c5 S(O) 2 R b5 .

[0633] In some embodiments, each R a5 and R c5 Selected from H and C 1-6 alkyl.

[0634] In some embodiments, R b5 Selected from H and C 1-6 alkyl.

[0635] In some embodiments, R 3 Selected from H, D, halogen, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl-, (4-14 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO 2 , OR a3 , SR a3 NHOR a3 、C(O)R b3 、C(O)NR c3 R d3 、C(O)NR c3 (OR a3 )、C(O)OR a3 、OC(O)Rb3 、 OC(O)NR c3 R d3 、 NR c3 NR c3 R d3 、 NR c3 C(O)R b3 、 NR c3 C(O)OR a3 、 NR c3 C(O)NR c3 R d3 、 C(=NR e3 )R b3 、 C(=NR e3 )NR c3 R d3 、 NR c3 C(=NR e3 )NR c3 R d3 、 NR c3 C(=NR e3 )R b3 、 NR c3 S(O)NR c3 R d3 、 NR c3 S(O)R b3 、 NR c3 S(O) 2 R b3 、 NR c3 S(O)(=NR e3 )R b3 、 NR c3 S(O) 2 NR c3 R d3 、 S(O)R b3 、 S(O)NR c3 R d3 、 S(O) 2 R b3 、 OS(O)(=NR e3 )R b3 、 OS(O) 2 R b3 、 SF 5 、 P(O)R f3 R g3 、 OP(O)(OR f3 )(OR g3 )、 P(O)(OR f3 )(OR g3 )、 B(OR h3 ) 2 and S(O) 2 NR c3 Rd3 , where R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 6-14 Aryl-C 1-6 Alkyl-, C 3-14 Cycloalkyl-C 1-6 Alkyl-, (5-14 membered heteroaryl)-C 1-6 Alkyl- and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-each optionally replaced by 1, 2, 3, 4, 5, 6, 7 or 8 independently selected R D Substituent substitution.

[0636] In some embodiments, R 3 Selected from H, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 6-14 Aryl, 5-14 membered heteroaryl, CN and OR a3 , wherein the C 1-6 Alkyl, C 6-14 Aryl and 5-14 membered heteroaryl are each optionally substituted with 1, 2 or 3 independently selected R D Substituent substitution.

[0637] In some embodiments, R 3 Selected from H, C 1-3 Alkyl, halo, CN, morpholinomethyl, 4-ethoxyphenyl, 2-hydroxyethoxy and pyridinyl.

[0638] In some embodiments, R 3 Selected from H, methyl, bromo, CN, morpholinomethyl, 4-ethoxyphenyl, 2-hydroxyethoxy and pyridyl.

[0639] In some embodiments, X is CR 3 ; and R 1 H or C 1-6 alkyl.

[0640] In some embodiments, X is CR 3 ; and R 1 H or C 1-3 alkyl.

[0641] In some embodiments,

[0642] X is CR 3 ;

[0643] R1 Selected from H and C 1-6 alkyl;

[0644] R 2 Selected from H, D, C 6-14 Aryl, 5-14 membered heteroaryl, C(O)R b2 、C(O)NR c2 R d2 and C(O)OR a2 , where R 2 C 6-14 Aryl and 5-14 membered heteroaryl are each optionally substituted with 1, 2, 3 or 4 independently selected R C Substituent substitution;

[0645] R 3 Selected from H, D, halogen, C 1-6 Alkyl, C 1-6 Haloalkyl, C 6-14 Aryl, 5-14 membered heteroaryl, CN and OR a3 , where R 3 C 1-6 Alkyl, C 6-14 Aryl and 5-14 membered heteroaryl are each optionally substituted with 1, 2, 3 or 4 independently selected R D Substituent substitution;

[0646] Cy 1 is optionally 1, 2, 3 or 4 independently selected R M Substituent-substituted phenyl, or C 10-14 Aryl or 5-14 membered heteroaryl, wherein Cy 1 C 10-14 Aryl and 5-14 membered heteroaryl are optionally substituted with 1, 2, 3 or 4 independently selected R E Substituent substitution;

[0647] Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein Cy 2 C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3 or 4 independently selected R F Substituent substitution;

[0648] Each R a2 , R c2 , R d2 and R a3 Independently selected from H, C 1-6 Alkyl, C 1-6Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl, wherein R a2 , R c2 , R d2 and R a3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0649] Each R b2 Independently selected from C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl, wherein the C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3 or 4 independently selected R G Substituent substitution;

[0650] Each R C , R D , R E , R F and R G are independently selected from D, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-14 Aryl, C 3-14 Cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, NO 2 , OR a4 , SR a4 NHOR a4 、C(O)R b4 、C(O)NR c4 R d4 、C(O)OR a4 、OC(O)Rb4 、OC(O)NR c4 R d4 NR c4 R d4 NR c4 C(O)R b4 NR c4 C(O)OR a4 NR c4 C(O)NR c4 R d4 、C(=NR e4 )R b4 、C(=NR e...

Claims

1. A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein: X is N; R 1 is H; R 2 is selected from the group consisting of pyridylmethyl, hydroxy(phenyl)methyl, hydroxyethylamino(phenyl)ethyl, cyclohexylmethyl, fluorobenzyl, hydroxy(fluorophenyl)methyl, (methylpyridyl)methyl, (fluoropyridyl)methyl, (trifluoromethylpyridyl)methyl, ((hydroxymethyl)pyridyl)methyl, (methoxypyridyl)methyl, (methylpyrazolyl)benzyl, (methylpyrazolyl)methyl, benzisoxazolylmethyl, (methylindazolyl)methyl, (hydroxyazetidinyl)methyl, benzoyl, phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuranyl, phenyl(pyridyloxy)methyl, fluoro((fluorohydroxypyrrolidinyl)methyl)benzyl, ((carboxypiperidinyl)methyl)fluorobenzyl, fluoro((N-methylmethylsulfonylamino)methyl)benzyl, ((dioxoimidazolidinyl)methyl)fluorobenzyl, (difluorophenyl)(hydroxy)methyl, (pyridinyl-1H-tetrazolyl)methyl, (pyrazolyl-1H-tetrazolyl)methyl, (thiazolyl-1H-tetrazolyl)methyl, (methyltrifluoromethylpyrazolyl)methyl, ((1,1-dioxoisothiazolidinyl)methyl)fluorobenzyl, ((methyl-2,5-dioxoimidazolidinyl)methyl)benzyl, and (cyanophenoxy)methyl; Cy 1 is 3-cyanophenyl; and Cy 2 Selected from 2,6-dimethylpyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 2-methoxypyridin-4-yl, 2-methoxy-6-methylpyridin-4-yl, 3-methylpyridin-4-yl, 3-fluoropyridin-4-yl, 3-chloropyridin-4-yl, 3-methoxypyridin-4-yl, 3-cyanopyridin-4-yl, pyrazolo[1,5-a]pyridin-3-yl, pyrazolo[1,5-b]pyridazin-3-yl, 5-methyl-1H-pyrazol-4 -yl, 1-ethyl-1H-pyrazol-5-yl, 1-isopropyl-1H-pyrazol-5-yl, 1-propyl-1H-pyrazol-5-yl, pyrimidin-4-yl, quinolin-5-yl, 5-fluoropyrimidin-4-yl, oxazol-5-yl, 4-methyloxazol-5-yl, 4-ethyloxazol-5-yl, 4-(hydroxymethyl)-2-methyloxazol-5-yl, 4-(methoxymethyl)-2-methyloxazol-5-yl and 1-ethyl-1H-1,2,3-triazol-5-yl.

2. The compound according to claim 1, which is selected from: 3-(5-amino-2-(pyridin-2-ylmethyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-ethyl-1H-pyrazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-propyl-1H-pyrazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(pyridin-2-ylmethyl)-8-(quinolin-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(5-fluoropyrimidin-4-yl)-2-(hydroxy(phenyl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(5-fluoropyrimidin-4-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(cyclohexylmethyl)-8-(1-ethyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(2-fluorobenzyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((2-fluorophenyl)(hydroxy)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((6-methylpyridin-2-yl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-ethyl-1H-pyrazol-5-yl)-2-((3-fluoropyridin-2-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-ethyl-1H-pyrazol-5-yl)-2-((3-methoxypyridin-2-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(2-(1-methyl-1H-pyrazol-4-yl)benzyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(benzo[d]isoxazol-3-ylmethyl)-8-(1-ethyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-ethyl-1H-pyrazol-5-yl)-2-((1-methyl-1H-indazol-3-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((3-hydroxyazetidin-1-yl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(3-methylpyridin-4-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(2-methoxy-6-methylpyridin-4-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(pyrazolo[1,5-b]pyridazin-3-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-(hydroxymethyl)-2-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-(methoxymethyl)-2-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; (S)-3-(5-amino-2-(hydroxy(phenyl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; (R)-3-(5-amino-2-(hydroxy(phenyl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-benzoyl-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-ethyl-1H-pyrazol-5-yl)-2-(1-phenylcyclopropyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((cyano(phenyl)methyl)amino)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(pyridin-4-yl)-2-(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; and 3-(5-amino-2-(phenyl(pyridin-2-yloxy)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 1, which is selected from: 3-(5-amino-2-(2-fluoro-6-(((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methyl)benzyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 1-(2-((5-amino-7-(3-cyanophenyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)-3-fluorobenzyl)piperidine-4-carboxylic acid; N-(2-((5-amino-7-(3-cyanophenyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)-3-fluorobenzyl)-N-methylmethanesulfonamide; 3-(5-amino-2-(2-((2,5-dioxoimidazolidin-1-yl)methyl)-6-fluorobenzyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; and 3-(5-amino-2-((2,6-difluorophenyl)(hydroxy)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 1, which is selected from: 3-(5-amino-2-((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-ethyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(1-ethyl-1H-1,2,3-triazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-methyloxazol-5-yl)-2-((3-methylpyridin-2-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-8-(4-(hydroxymethyl)-2-methyloxazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(2-((1,1-dioxoisothiazolidin-2-yl)methyl)-6-fluorobenzyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-methyloxazol-5-yl)-2-((6-(trifluoromethyl)pyridin-2-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((3-(hydroxymethyl)pyridin-2-yl)methyl)-8-(4-methyloxazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((1-methyl-1H-pyrazol-3-yl)methyl)-8-(4-methyloxazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-((1-methyl-1H-pyrazol-3-yl)methyl)-8-(oxazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; and 2-((5-amino-7-(3-cyanophenyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methoxy)benzonitrile; or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 1, which is selected from: 3-(5-amino-2-((5-(pyridin-2-yl)-1H-tetrazol-1-yl)methyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(2-((5-(1H-pyrazol-1-yl)-1H-tetrazol-1-yl)methyl)-5-amino-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; and 3-(5-amino-8-(pyrimidin-4-yl)-2-((5-(thiazol-4-yl)-1H-tetrazol-1-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; or a pharmaceutically acceptable salt thereof.

6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound is 3-(5-amino-2-(pyridin-2-ylmethyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile.

7. A compound, which is: 3-(5-amino-2-((2-hydroxyethylamino)(phenyl)methyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(2-fluoro-6-((3-methyl-2,5-dioxoimidazolidin-1-yl)methyl)benzyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-2-(((3-methylpyridin-2-yl)methyl)amino)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; 3-(5-amino-8-(4-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile; 3-(5-amino-2-((3-methylpyridin-2-yl)methoxy)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; or 3-(5-amino-2-((6-methylpyridin-2-yl)methoxy)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; or a pharmaceutically acceptable salt thereof.

8. A pharmaceutical composition comprising the compound according to any one of claims 1 to 7 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.

9. Use of a compound as claimed in any one of claims 1 to 7 or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating a disease or condition in a patient, wherein the disease or condition is bladder cancer, lung cancer, breast cancer, ovarian cancer, colorectal cancer, pancreatic cancer, prostate cancer or head and neck cancer.

10. The use according to claim 9, wherein the disease or condition is head and neck cancer. The use according to claim 10 , wherein the head and neck cancer is head and neck squamous cell carcinoma.

12. The use according to claim 9, wherein the disease or disorder is lung cancer.

13. The use according to claim 12, wherein the lung cancer is non-small cell lung cancer (NSCLC).

14. The use according to claim 9, wherein the disease or condition is ovarian cancer.

15. The use according to claim 9, wherein the disease or condition is prostate cancer.

16. The use according to claim 15, wherein the prostate cancer is metastatic castration-resistant prostate cancer.

17. The use according to claim 9, wherein the disease or condition is breast cancer.

18. The use according to claim 9, wherein the disease or disorder is bladder cancer.

19. The use according to claim 9, wherein the disease or disorder is colorectal cancer.

20. The use according to claim 9, wherein the disease or disorder is pancreatic cancer.

Images